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Aflibercept Side Effects

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Common Aflibercept Side Effects


The most commonly reported Aflibercept side effects (click to view or check a box to report):

Proteinuria (26)
Death (23)
Dyspnoea (15)
Fatigue (12)
Febrile Neutropenia (11)
Pneumothorax (11)
Pneumonia Necrotising (10)
Neutropenia (9)
Leukopenia (9)
Hyperkalaemia (9)
Vomiting (8)
Adrenal Insufficiency (8)
Hyponatraemia (7)
Dehydration (7)
Intestinal Perforation (7)
Femur Fracture (6)
Syncope (6)
Malaise (6)
Hyperthyroidism (6)
Neutrophil Count (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Aflibercept Side Effects Reported to FDA



Aflibercept Side Effect Report#9981339
Pneumonia
This is a report of a 70-year-old female patient (weight: NA) from BE, suffering from the following health symptoms/conditions: colorectal cancer metastatic, who was treated with Aflibercept (dosage: NA, start time:
Feb 19, 2014), combined with: NA. and developed a serious reaction and side effect(s): Pneumonia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in female patients, resulting in Pneumonia side effect.
Aflibercept Side Effect Report#9890817
Febrile Neutropenia
This report suggests a potential Aflibercept Febrile Neutropenia side effect(s) that can have serious consequences. A 27-year-old male patient (weight: NA) from TH was diagnosed with the following symptoms/conditions: colorectal cancer metastatic and used Aflibercept (dosage: NA) starting
Oct 30, 2013. After starting Aflibercept the patient began experiencing various side effects, including: Febrile NeutropeniaAdditional drugs used concurrently:
  • Fluorouracil
  • Fluorouracil
  • Irinotecan
  • Leucovorin
  • Serotonin Antagonists
  • Corticosteroids
  • Anticholinergics
  • Metoclopramide
Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Febrile Neutropenia, may still occur.
Aflibercept Side Effect Report#9881211
Cardiac Failure Congestive
This Cardiac Failure Congestive problem was reported by a health professional from TH. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: colorectal cancer metastatic. On
Jan 07, 2014 this consumer started treatment with Aflibercept (dosage: NA). The following drugs were being taken at the same time: NA. When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Cardiac Failure CongestiveThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cardiac Failure Congestive, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9844991
This Death side effect was reported by a pharmacist from AU. A 62-year-old patient (weight:NA) experienced the following symptoms/conditions: neoplasm progression.The patient was prescribed Aflibercept (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Aflibercept the consumer reported adverse symptoms, such as: These side effects may potentially be related to Aflibercept.
Aflibercept Side Effect Report#9834292
This is a report of a 62-year-old patient (weight: NA) from AU, suffering from the following health symptoms/conditions: metastatic neoplasm, who was treated with Aflibercept (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in patients, resulting in Death side effect.
Aflibercept Side Effect Report#9830765
Epistaxis
This report suggests a potential Aflibercept Epistaxis side effect(s) that can have serious consequences. A 76-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: colorectal cancer metastatic and used Aflibercept (dosage: NA) starting
Dec 01, 2013. After starting Aflibercept the patient began experiencing various side effects, including: EpistaxisAdditional drugs used concurrently: NA.The patient was hospitalized. Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Epistaxis, may still occur.
Aflibercept Side Effect Report#9825803
Eastern Cooperative Oncology Group Performance Status Worsened, Sepsis, Small Intestinal Obstruction, Deep Vein Thrombosis
This Eastern Cooperative Oncology Group Performance Status Worsened problem was reported by a physician from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: rectal cancer. On
Jan 01, 2011 this consumer started treatment with Aflibercept (dosage: NA). The following drugs were being taken at the same time: NA. When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Eastern Cooperative Oncology Group Performance Status Worsened, Sepsis, Small Intestinal Obstruction, Deep Vein ThrombosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eastern Cooperative Oncology Group Performance Status Worsened, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9822238
Abdominal Pain
This Abdominal Pain side effect was reported by a physician from FR. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: colorectal cancer metastatic.The patient was prescribed Aflibercept (drug dosage: NA), which was initiated on
Dec 12, 2013. Concurrently used drugs:
  • 5 Fu
  • 5 Fu
  • Irinotecan
  • Leucovorin
.After starting to take Aflibercept the consumer reported adverse symptoms, such as: Abdominal PainThese side effects may potentially be related to Aflibercept. The patient was hospitalized.
Aflibercept Side Effect Report#9818598
Cerebral Ischaemia
This is a report of a 85-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: colorectal cancer metastatic, who was treated with Aflibercept (dosage: NA, start time:
Dec 17, 2013), combined with: NA. and developed a serious reaction and side effect(s): Cerebral Ischaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in male patients, resulting in Cerebral Ischaemia side effect.
Aflibercept Side Effect Report#9769009
Hip Fracture, Acute Pulmonary Oedema
This report suggests a potential Aflibercept Hip Fracture side effect(s) that can have serious consequences. A 68-year-old male patient (weight: NA) from ES was diagnosed with the following symptoms/conditions: colorectal cancer and used Aflibercept (dosage: NA) starting
May 31, 2013. After starting Aflibercept the patient began experiencing various side effects, including: Hip Fracture, Acute Pulmonary OedemaAdditional drugs used concurrently:
  • 5-fu (fluorouracil)
  • Irinotecan (irinotecan)
  • Leucovorin (folinic Acid)
The patient was hospitalized. Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hip Fracture, may still occur.
Aflibercept Side Effect Report#9767039
Cholecystitis Chronic
This Cholecystitis Chronic problem was reported by a physician from CN. A 53-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: colorectal cancer metastatic. On
Jan 07, 2013 this consumer started treatment with Aflibercept (dosage: NA). The following drugs were being taken at the same time: NA. When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Cholecystitis ChronicThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cholecystitis Chronic, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9755937
Depression
This Depression side effect was reported by a physician from FR. A 69-year-old male patient (weight:NA) experienced the following symptoms/conditions: colorectal cancer metastatic.The patient was prescribed Aflibercept (drug dosage: NA), which was initiated on
Nov 14, 2013. Concurrently used drugs: NA..After starting to take Aflibercept the consumer reported adverse symptoms, such as: DepressionThese side effects may potentially be related to Aflibercept. The patient was hospitalized.
Aflibercept Side Effect Report#9754511
Herpes Zoster Meningoencephalitis
This is a report of a 77-year-old female patient (weight: NA) from DE, suffering from the following health symptoms/conditions: colorectal cancer metastatic, who was treated with Aflibercept (dosage: NA, start time:
Oct 16, 2013), combined with: NA. and developed a serious reaction and side effect(s): Herpes Zoster Meningoencephalitis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in female patients, resulting in Herpes Zoster Meningoencephalitis side effect. The patient was hospitalized.
Aflibercept Side Effect Report#9681072
Infection
This report suggests a potential Aflibercept Infection side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: colorectal cancer metastatic and used Aflibercept (dosage: NA) starting
Jul 09, 2013. After starting Aflibercept the patient began experiencing various side effects, including: InfectionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Infection, may still occur.
Aflibercept Side Effect Report#9657169
Gallbladder Perforation
This Gallbladder Perforation problem was reported by a physician from SG. A 68-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: colorectal cancer. On
Sep 17, 2013 this consumer started treatment with Aflibercept (dosage: NA). The following drugs were being taken at the same time: NA. When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Gallbladder PerforationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gallbladder Perforation, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9648330
Endophthalmitis, Bacterial Infection
This Endophthalmitis side effect was reported by a physician from GB. A 81-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Aflibercept (drug dosage: Treatment End Date :aug-2013), which was initiated on
Sep 13, 2013. Concurrently used drugs:
  • Eylea
.After starting to take Aflibercept the consumer reported adverse symptoms, such as: Endophthalmitis, Bacterial InfectionThese side effects may potentially be related to Aflibercept. The patient was hospitalized.
Aflibercept Side Effect Report#9643040
Dermatitis Acneiform, Scrotal Ulcer, Pain
This is a report of a 54-year-old male patient (weight: NA) from MY, suffering from the following health symptoms/conditions: colorectal cancer metastatic, who was treated with Aflibercept (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Dermatitis Acneiform, Scrotal Ulcer, Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in male patients, resulting in Dermatitis Acneiform side effect.
Aflibercept Side Effect Report#9612173
Septic Shock
This report suggests a potential Aflibercept Septic Shock side effect(s) that can have serious consequences. A 52-year-old female patient (weight: NA) from TH was diagnosed with the following symptoms/conditions: colorectal cancer metastatic and used Aflibercept (dosage: NA) starting
Aug 15, 2013. After starting Aflibercept the patient began experiencing various side effects, including: Septic ShockAdditional drugs used concurrently: NA.The patient was hospitalized. Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Septic Shock, may still occur.
Aflibercept Side Effect Report#9563657
Ocular Hyperaemia, Eye Pain, Eye Pruritus
This Ocular Hyperaemia problem was reported by a pharmacist from US. A 84-year-old patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jul 02, 2013 this consumer started treatment with Aflibercept (dosage: .05 Ml Once Eye). The following drugs were being taken at the same time: NA. When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Ocular Hyperaemia, Eye Pain, Eye PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Ocular Hyperaemia, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9562593
Cardiomyopathy, Dyspnoea, Fatigue, Cardiac Failure Congestive, Left Ventricular Dysfunction
This Cardiomyopathy side effect was reported by a physician from US. A 66-year-old male patient (weight:NA) experienced the following symptoms/conditions: colorectal cancer metastatic.The patient was prescribed Aflibercept (drug dosage: 2 Doses), which was initiated on NS. Concurrently used drugs:
  • Folinic Acid
  • Fluorouracil
  • Irinotecan
.After starting to take Aflibercept the consumer reported adverse symptoms, such as: Cardiomyopathy, Dyspnoea, Fatigue, Cardiac Failure Congestive, Left Ventricular DysfunctionThese side effects may potentially be related to Aflibercept.
Aflibercept Side Effect Report#9556233
Urinary Retention
This is a report of a 46-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: colorectal cancer metastatic, who was treated with Aflibercept (dosage: NA, start time:
Mar 04, 2013), combined with: NA. and developed a serious reaction and side effect(s): Urinary Retention after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in male patients, resulting in Urinary Retention side effect. The patient was hospitalized.
Aflibercept Side Effect Report#9542298
Cerebral Haemorrhage, Hypertensive Crisis, Headache
This report suggests a potential Aflibercept Cerebral Haemorrhage side effect(s) that can have serious consequences. A 68-year-old female patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: colorectal cancer,antiemetic supportive care,anaemia,hypothyroidism and used Aflibercept (dosage: NA) starting
Jul 31, 2013. After starting Aflibercept the patient began experiencing various side effects, including: Cerebral Haemorrhage, Hypertensive Crisis, HeadacheAdditional drugs used concurrently:
  • Dexamethasone
  • Vitamin B12
  • L-thyroxin
The patient was hospitalized. Although Aflibercept demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cerebral Haemorrhage, may still occur.
Aflibercept Side Effect Report#9542276
Renal Failure Acute, Mouth Ulceration
This Death problem was reported by a physician from GB. A 60-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: colorectal cancer metastatic. On NS this consumer started treatment with Aflibercept (dosage: Dose: Between Cycles 2 And 3). The following drugs were being taken at the same time:
  • Folinic Acid
  • 5-fu
  • Irinotecan
When using Aflibercept, the patient experienced the following unwanted symptoms/side effects: Renal Failure Acute, Mouth UlcerationThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Aflibercept Side Effect Report#9492075
Acute Pulmonary Oedema, Hip Fracture
This Acute Pulmonary Oedema side effect was reported by a physician from ES. A 68-year-old male patient (weight:NA) experienced the following symptoms/conditions: colorectal cancer.The patient was prescribed Aflibercept (drug dosage: NA), which was initiated on
Jun 07, 2013. Concurrently used drugs: NA..After starting to take Aflibercept the consumer reported adverse symptoms, such as: Acute Pulmonary Oedema, Hip FractureThese side effects may potentially be related to Aflibercept. The patient was hospitalized.
Aflibercept Side Effect Report#9470729
Abdominal Pain Upper, Nausea
This is a report of a 30-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: colon cancer metastatic, who was treated with Aflibercept (dosage: NA, start time:
Mar 01, 2013), combined with: NA. and developed a serious reaction and side effect(s): Abdominal Pain Upper, Nausea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Aflibercept treatment in female patients, resulting in Abdominal Pain Upper side effect. The patient was hospitalized.


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The appearance of Aflibercept on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Aflibercept Side Effects for Women?

Women Side EffectsReports
Proteinuria 14
Fatigue 9
Leukopenia 8
Adrenal Insufficiency 7
Neutrophil Count 6
Urinary Tract Infection 4
Diarrhoea 3
Haematoma 3
Hyponatraemia 3
Peritonitis 3

What are common Aflibercept Side Effects for Men?

Men Side EffectsReports
Death 21
Dyspnoea 14
Proteinuria 12
Febrile Neutropenia 11
Pneumothorax 11
Hyperkalaemia 9
Neutropenia 9
Pneumonia Necrotising 8
Vomiting 8
Intestinal Perforation 7

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Aflibercept reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Aflibercept Safety Alerts, Active Ingredients, Usage Information

    More About Aflibercept

    Side Effects reported to FDA: 278

    Aflibercept safety alerts: No

    Reported deaths: 105

    Reported hospitalizations: 204

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