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Amilorid Side Effects

Common Amilorid Side Effects


The most commonly reported Amilorid side effects (click to view or check a box to report):

Hyperkalaemia (11)
Renal Failure Acute (10)
Hyponatraemia (8)
Hypokalaemia (8)
Oedema Peripheral (6)
Asthenia (5)
Blood Creatinine Increased (5)
Cardiac Arrest (5)
Hypotension (4)
Diarrhoea (4)
Abdominal Pain (4)
Dyspnoea (3)
Dizziness (3)
Malaise (3)
Renal Failure Chronic (3)
Pneumoperitoneum (2)
Presyncope (2)
Pain (2)
Melaena (2)
Pleural Effusion (2)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Amilorid Side Effects Reported to FDA

The following Amilorid reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Amilorid on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Heart Rate Decreased, Dizziness
This is a report of a 70-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: blood pressure increased, who was treated with Amiloride Hydrochloride And Hydrochlorothiazide Tablets, Usp (dosage: NA, start time: Aug 25, 2013), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Heart Rate Decreased
  • Dizziness
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amiloride Hydrochloride And Hydrochlorothiazide Tablets, Usp treatment in female patients, resulting in heart rate decreased side effect.

Pulmonary Oedema, Shock
This report suggests a potential Amiloride/hydrochlorothiazide Pulmonary Oedema, Shock side effect(s) that can have serious consequences. A 74-year-old female patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: NA and used Amiloride/hydrochlorothiazide (dosage: 1 Df, Single) starting NS. Soon after starting Amiloride/hydrochlorothiazide the patient began experiencing various side effects, including:
  • Pulmonary Oedema
  • Shock
Drugs used concurrently: NA. Although Amiloride/hydrochlorothiazide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pulmonary oedema, may still occur.

Hyperkalaemia, Pulmonary Embolism, Renal Impairment
This Hyperkalaemia, Pulmonary Embolism, Renal Impairment problem was reported by a pharmacist from US. A 64-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: cardiac failure congestive. On Jul 02, 1998 this consumer started treatment with Amiloride (dosage: 2 Tab Every Day Po). The following drugs were being taken at the same time:
  • Lisinopril (1 Tab Every Day Po)
When commencing Amiloride, the patient experienced the following unwanted symptoms/side effects:
  • Hyperkalaemia
  • Pulmonary Embolism
  • Renal Impairment
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hyperkalaemia, may become evident only after a product is in use by the general population.

Urinary Retention, Weight Increased, Abdominal Distension, Oedema Peripheral
This is a report of a 55-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Amiloride Hcl (dosage: NA) starting 201205. Concurrently used drugs:
  • Amiloride Hydrochloride
  • Thyroid
Soon after that, the consumer experienced the following side effects:
  • Urinary Retention
  • Weight Increased
  • Abdominal Distension
  • Oedema Peripheral
This opens a possibility that Amiloride Hcl treatment could cause the above reactions, including urinary retention, and some female subjects may be more susceptible.


Dysgeusia, Weight Decreased
A 66-year-old male patient (weight: NA) from US with the following symptoms/conditions: blood pressure high started Amiloride treatment (dosage: NA) on May 01, 2012. Soon after starting Amiloride treatment, the subject experienced various side effects, including:
  • Dysgeusia
  • Weight Decreased
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Amiloride.

Transient Ischaemic Attack, Aphasia, Facial Paresis
A female patient from GERMANY (weight: NA) experienced symptoms, such as: NA and was treated with Amiloride Hydrochloride(dosage: NA). The treatment was initiated on Mar 27, 2012. After that a consumer reported the following side effect(s):
  • Transient Ischaemic Attack
  • Aphasia
  • Facial Paresis
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Amiloride Hydrochloride efficacy:
  • Bisoprolol Fumarate (5 Mg)
  • Amitriptyline Hcl
  • Memantine Hcl (5 Mg)
  • Pantoprazole
  • Tensoflux
  • Simvastatin (40 Mg)
  • Dytide
The patient was hospitalized.

Duodenal Ulcer Perforation, Abdominal Pain, Pneumoperitoneum
In this report, Amiloride Hcl was administered for the following condition: NA.A 82-year-old male consumer from (weight: NA) started Amiloride Hcl treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Duodenal Ulcer Perforation
  • Abdominal Pain
  • Pneumoperitoneum
A possible interaction with other drugs could have contributed to this reaction:
  • Bendroflumethiazide (bendroflumethiazide)
  • Calceos (lekovit Ca)
  • Acetaminophen W/ Codeine
  • Warfarin Sodium
  • Amlodipine
  • Digoxin
  • Alendronic Acid (alendronic Acid) (10 Mg (70 Mg, 1 In 1 Wk), Oral)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Amiloride Hcl treatment could be related to the listed above side effect(s).

Pneumoperitoneum, Abdominal Pain, Duodenal Ulcer Perforation
This is a report of the following Amiloride Hydrochloride side effect(s):
  • Pneumoperitoneum
  • Abdominal Pain
  • Duodenal Ulcer Perforation
A 82-year-old male patient from UNITED KINGDOM (weight: NA) presented with the following condition: NA and received a treatment with Amiloride Hydrochloride (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions:
  • Amlodipine Besylate
  • Warfarin Sodium
  • Alendronate Sodium (70 Mg, Qw)
  • Bendroflumethiazide
  • Calceos
  • Acetaminophen And Codeine Phosphate
  • Digoxin
The patient was hospitalized.This report suggests that a Amiloride Hydrochloride treatment could be associated with the listed above side effect(s).

Diarrhoea, Hyperhidrosis, Hypoaesthesia Oral, Feeling Abnormal, Nausea, Communication Disorder
This Amiloride report was submitted by a 41-year-old female consumer from HUNGARY (weight: NA). The patient was diagnosed with: blood glucose and Amiloride was administered (dosage: Unk) starting: Jun 01, 2011. The consumer developed a set of symptoms:
  • Diarrhoea
  • Hyperhidrosis
  • Hypoaesthesia Oral
  • Feeling Abnormal
  • Nausea
  • Communication Disorder
Other drugs used simultaneously:
  • Letrox (Unk)
  • Lyrica (75 Mg, 2x/day)
  • Lyrica (75 Mg, 2x/day)
  • Lyrica (150 Mg, 2x/day)
Those unexpected symptoms could be linked to a Amiloride treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Sclerosing Encapsulating Peritonitis, Hyperkalaemia, Ascites, Gynaecomastia
This is a report of a possible correlation between Amiloride Hydrochloride use and the following symptoms/side effect(s):
  • Sclerosing Encapsulating Peritonitis
  • Hyperkalaemia
  • Ascites
  • Gynaecomastia
which could contribute to an assessment of Amiloride Hydrochloride risk profile.A 48-year-old male consumer from UNITED KINGDOM (weight: NA) was suffering from NA and was treated with Amiloride Hydrochloride (dosage: NA) starting NS.Other concurrent medications:
  • Propranolol Hydrochloride (40 Mg / Twice Per Day)
  • Spironolactone
  • Atenolol
The patient was hospitalized.

Hypokalaemia, Hyponatraemia
A 75-year-old female patient from SWEDEN (weight: NA) presented with the following symptoms: NA and after a treatment with Amiloride Hcl And Hydrochlorothiazide (dosage: NA) experienced the following side effect(s):
  • Hypokalaemia
  • Hyponatraemia
The treatment was started on NS. Amiloride Hcl And Hydrochlorothiazide was used in combination with the following drugs:
  • Ibuprofen
  • Citalopram Hydrobromide
This report could alert potential Amiloride Hcl And Hydrochlorothiazide consumers.

Renal Failure Chronic
In this report, a 75-year-old female patient from SWITZERLAND (weight: NA) was affected by a possible Amiloride Hcl And Hydrochlorothiazide side effect.The patient was diagnosed with NA. After a treatment with Amiloride Hcl And Hydrochlorothiazide (dosage: 1 Df, Uid/qd, start date: Apr 07, 2011), the patient experienced the following side effect(s):
  • Renal Failure Chronic
The following simultaneously used drugs could have led to this reaction:
  • Marcumar (3 Mg, Prn)
  • Prograf (1 Df, Uid/qd)
  • Prograf (6 Mg, Uid/qd)
  • Floxapen (2 G, Tid)
  • Prograf (3 Mg, Uid/qd)
  • Allopurinol (Unk Mg, Uid/qd)
  • Prograf (3.5 Mg, Uid/qd)
  • Zestril (30 Mg, Uid/qd)
The findings here stress that side effects should be taken into consideration when evaluating a Amiloride Hcl And Hydrochlorothiazide treatment.

Rash, Dyspnoea, Periorbital Oedema, Pericardial Effusion, Diarrhoea, Disease Progression
This is a report of a 77-year-old female patient from UNITED STATES (weight: NA), who used Amiloride (amiloride) (dosage: NA) for a treatment of NA. After starting a treatment on Jun 01, 2005, the patient experienced the following side effect(s):
  • Rash
  • Dyspnoea
  • Periorbital Oedema
  • Pericardial Effusion
  • Diarrhoea
  • Disease Progression
The following drugs could possibly have interacted with the Amiloride (amiloride) treatment
  • Zyrtec
  • Pravachol
  • Gleevec (400 Mg, Bid, Oral)
  • Gleevec (400 Mg, Bid, Oral)
  • Ambien
  • Fosamax
Taken together, these observations suggest that a Amiloride (amiloride) treatment could be related to side effect(s), such as Rash, Dyspnoea, Periorbital Oedema, Pericardial Effusion, Diarrhoea, Disease Progression.

Fatigue, Rash Maculo-papular, Diarrhoea, Pruritus, Loss Of Consciousness, Dyspnoea
This fatigue side effect was reported by a health professional from SERBIA. A 61-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Amiloride Hcl And Hydrochlorothiazide (dosage: NA), which was started on Feb 03, 2012. Concurrently used drugs:
  • Spironolactone
  • Doxorubicin Hcl
  • Metoprolol Succinate
  • Cyclophosphamide
When starting to take Amiloride Hcl And Hydrochlorothiazide the consumer reported the following symptoms:
  • Fatigue
  • Rash Maculo-papular
  • Diarrhoea
  • Pruritus
  • Loss Of Consciousness
  • Dyspnoea
These side effects may potentially be related to Amiloride Hcl And Hydrochlorothiazide.

Lactic Acidosis, Renal Failure Acute, Hyponatraemia, Hypokalaemia, Constipation, Hypocalcaemia, Endocrine Disorder
This is a Amiloride Hcl And Hydrochlorothiazide side effect report of a 36-year-old female patient (weight:NA) from GERMANY, suffering from the following symptoms/conditions: NA, who was treated with Amiloride Hcl And Hydrochlorothiazide (dosage:1 Df = Hydrochlorothiazide 5mg+ Amiloride 50mg, start time: NS), combined with:
  • Bisacodyl
  • Metformin Hcl
  • Levothyroxine Sodium
  • Metformin Hcl
, and developed a serious reaction and a lactic acidosis side effect. The patient presented with:
  • Lactic Acidosis
  • Renal Failure Acute
  • Hyponatraemia
  • Hypokalaemia
  • Constipation
  • Hypocalcaemia
  • Endocrine Disorder
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Amiloride Hcl And Hydrochlorothiazide treatment in female patients suffering from NA, resulting in lactic acidosis.

Pulmonary Embolism, Post-traumatic Stress Disorder, Mental Disorder, Emotional Distress, Fear, Musculoskeletal Chest Pain, Anxiety
This report suggests a potential Amiloride Hydrochloride pulmonary embolism side effect(s) that can have serious consequences. A 24-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): NA and used Amiloride Hydrochloride (dosage: Unk) starting Jan 01, 2002. Soon after starting Amiloride Hydrochloride the patient began experiencing various side effects, including:
  • Pulmonary Embolism
  • Post-traumatic Stress Disorder
  • Mental Disorder
  • Emotional Distress
  • Fear
  • Musculoskeletal Chest Pain
  • Anxiety
Drugs used concurrently:
  • Motrin (800 Mg, Unk)
  • Lisinopril (Unk)
  • Ascorbic Acid (Unk)
  • Percocet (Unk)
  • Yasmin (Unk)
  • Morphine Sulfate (Unk)
The patient was hospitalized. Although Amiloride Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pulmonary embolism, may still occur.

Lactic Acidosis, Hypokalaemia, Renal Failure Acute, Hyponatraemia
This lactic acidosis problem was reported by a health professional from ITALY. A 36-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): oedema peripheral,constipation,hyperthyroidism,insulin resistance.On NS a consumer started treatment with Amiloride Hcl And Hydrochlorothiazide (dosage: 5/50mg Day). The following drugs/medications were being taken at the same time:
  • Bisacodyl
  • Levothyroxine Sodium (100 Microg/day)
  • Metformin Hcl (1000mg Three Times Daily)
When commencing Amiloride Hcl And Hydrochlorothiazide, the patient experienced the following unwanted symptoms /side effects:
  • Lactic Acidosis
  • Hypokalaemia
  • Renal Failure Acute
  • Hyponatraemia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as lactic acidosis, may become evident only after a product is in use by the general population.

Gastroenteritis, Febrile Neutropenia
This is a Amiloride side effect report of a 79-year-old male patient (weight: NA) from BRAZIL. The patient developed the following symptoms/conditions: hypertension,prostate cancer,metastases to bone and was treated with Amiloride (dosage: 5 Mg, 1x/day) starting Jan 01, 2010. Concurrently used drugs:
  • Prednisone Tab (5 Mg, Twice Daily)
  • Calcium (500 Mg, 1x/day)
  • Zoledronic Acid (3 Mg, Monthly)
  • Sunitinib Malate (37.5 Mg, Daily)
  • Hydrochlorothiazide (50 Mg, 1x/day)
  • Dipyrone Inj (40 Drops, As Needed)
Soon after that, the consumer experienced the following of symptoms:
  • Gastroenteritis
  • Febrile Neutropenia
The patient was hospitalized. This opens a possibility that Amiloride could cause gastroenteritis and that some male patients may be more susceptible.

Abdominal Pain, Fluid Retention
A 72-year-old male patient (weight: NA) from SPAIN with the following symptoms: hypertension,benign prostatic hyperplasia started Amiloride Hcl And Hydrochlorothiazide treatment (dosage: NA) on Aug 27, 2011. Soon after starting Amiloride Hcl And Hydrochlorothiazide treatment, the consumer experienced several side effects, including:
  • Abdominal Pain
  • Fluid Retention
. Concurrently used drugs:
  • Dutasteride/tamsulosin Hydrochloride
This finding indicates that some patients can be more vulnerable to developing Amiloride Hcl And Hydrochlorothiazide side effects, such as abdominal pain.

Cardiac Arrest, Hyperkalaemia, Renal Injury
This cardiac arrest side effect was reported by a health professional from AUSTRIA. A 73-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Amiloride Hcl And Hydrochlorothiazide (dosage: 50/5mg Once Daily), which was started on NS. Concurrently used drugs:
  • Furosemide (30 Mg, Qd)
  • Spironolactone (100 Mg, Qd)
  • Enalapril Maleate (10 Mg, Qd)
.When starting to take Amiloride Hcl And Hydrochlorothiazide the consumer reported symptoms, such as:
  • Cardiac Arrest
  • Hyperkalaemia
  • Renal Injury
These side effects may potentially be related to Amiloride Hcl And Hydrochlorothiazide.

Blood Creatinine Increased, Azotaemia, Sepsis, Renal Failure Acute
This is a report of a 61-year-old male patient (weight: NA) from INDIA, suffering from the following symptoms/conditions: NA, who was treated with Amiloride Hydrochloride (dosage: 40 Mg, start time: NS), combined with:
  • Furosemide (80 Mg)
  • Arteether (150 Mg)
  • Torsemide (40 Mg)
  • Cefotaxime (2 G)
  • Caspofungin Acetate (50 Mg)
  • Tazobactam
  • Meropenem
  • Atenolol (75 Mg)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Blood Creatinine Increased
  • Azotaemia
  • Sepsis
  • Renal Failure Acute
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Amiloride Hydrochloride treatment in male patients, resulting in blood creatinine increased side effect. The patient was hospitalized.

Renal Failure Chronic, Cardiac Arrest, Hyperkalaemia
This report suggests a potential Amiloride Hcl And Hydrochlorothiazide Renal Failure Chronic, Cardiac Arrest, Hyperkalaemia side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from AUSTRIA was diagnosed with the following symptoms/conditions: NA and used Amiloride Hcl And Hydrochlorothiazide (dosage: 50/5mg Once Daily) starting NS. Soon after starting Amiloride Hcl And Hydrochlorothiazide the patient began experiencing various side effects, including:
  • Renal Failure Chronic
  • Cardiac Arrest
  • Hyperkalaemia
Drugs used concurrently:
  • Enalapril Maleate
  • Spironolactone
  • Furosemide
Although Amiloride Hcl And Hydrochlorothiazide demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as renal failure chronic, may still occur.

Palmar-plantar Erythrodysaesthesia Syndrome, Asthenia, Off Label Use, Lower Respiratory Tract Infection, Toxicity To Various Agents, Cardiac Failure Congestive
This Palmar-plantar Erythrodysaesthesia Syndrome, Asthenia, Off Label Use, Lower Respiratory Tract Infection, Toxicity To Various Agents, Cardiac Failure Congestive problem was reported by a health professional from SOUTH AFRICA. A 59-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Oct 04, 2011 this consumer started treatment with Amilorid/hctz (amiloride Hydrochloride, Hydrochlorothiazide) (dosage: NA). The following drugs were being taken at the same time:
  • Spiractin (spironolactone)
  • Analgesics (analgesics)
  • Asthavent (salbutamol)
  • Erlotinib Hydrochloride (See Image)
  • Erlotinib Hydrochloride (See Image)
  • Erlotinib Hydrochloride (See Image)
  • Erlotinib Hydrochloride (See Image)
  • Erlotinib Hydrochloride (See Image)
When commencing Amilorid/hctz (amiloride Hydrochloride, Hydrochlorothiazide), the patient experienced the following unwanted symptoms/side effects:
  • Palmar-plantar Erythrodysaesthesia Syndrome
  • Asthenia
  • Off Label Use
  • Lower Respiratory Tract Infection
  • Toxicity To Various Agents
  • Cardiac Failure Congestive
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as palmar-plantar erythrodysaesthesia syndrome, may become evident only after a product is in use by the general population.

Hyponatraemia, Renal Failure Acute, Depressed Level Of Consciousness, Urinary Tract Infection, Hypochromic Anaemia, Dehydration, Fall, Renal Failure Chronic
This is a report of a 72-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Amiloride Hydrochloride (dosage: NA) starting NS. Concurrently used drugs:
  • Hydrochlorothiazide (50 Mg;qd)
  • Bisoprolol Fumarate
  • Lisinopril
  • Levothyroxine Sodium
Soon after that, the consumer experienced the following side effects:
  • Hyponatraemia
  • Renal Failure Acute
  • Depressed Level Of Consciousness
  • Urinary Tract Infection
  • Hypochromic Anaemia
  • Dehydration
  • Fall
  • Renal Failure Chronic
The patient was hospitalized. This opens a possibility that Amiloride Hydrochloride treatment could cause the above reactions, including hyponatraemia, and some female subjects may be more susceptible.

Haemoptysis, Alanine Aminotransferase Increased, Thrombocytopenia, Hypofibrinogenaemia, Asthenia, Oedema Peripheral, Constipation, Hypoalbuminaemia, Leukopenia
A 48-year-old female patient (weight: NA) from ITALY with the following symptoms/conditions: NA started Amiloride Hcl And Hydrochlorothiazide treatment (dosage: 1 Df, 1x/day) on Oct 30, 2011. Soon after starting Amiloride Hcl And Hydrochlorothiazide treatment, the subject experienced various side effects, including:
  • Haemoptysis
  • Alanine Aminotransferase Increased
  • Thrombocytopenia
  • Hypofibrinogenaemia
  • Asthenia
  • Oedema Peripheral
  • Constipation
  • Hypoalbuminaemia
  • Leukopenia
Concurrently used drugs:
  • Calcium Carbonate (1000 Mg, Unk)
  • Colecalciferol (1 Df, Every 2 Weeks)
  • Crizotinib (200 Mg, 2x/day (every 12 Hours))
  • Ranitidine (150 Mg, Every 12 Hours)
  • Fentanyl Citrate (25 Mcg/h Every 72 Hours)
  • Levetiracetam (500 Mg, Every 12 Hours)
  • Macrogol (17.5 G, 2x/day)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Amiloride Hcl And Hydrochlorothiazide.

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    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
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    Amilorid Safety Alerts, Active Ingredients, Usage Information

    NDC0378-0577
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameAmiloride Hydrochloride and Hydrochlorothiazide
    Nameamiloride hydrochloride and hydrochlorothiazide
    Dosage FormTABLET
    RouteORAL
    On market since19911031
    LabelerMylan Pharmaceuticals Inc.
    Active Ingredient(s)AMILORIDE HYDROCHLORIDE; HYDROCHLOROTHIAZIDE
    Strength(s)5; 50
    Unit(s)mg/1; mg/1
    Pharma ClassDecreased Renal K+ Excretion [PE],Increased Diuresis [PE],Potassium-sparing Diuretic [EPC],Increased

    More About Amilorid

    Side Effects reported to FDA: 64

    Amilorid safety alerts: No

    Reported deaths: 3

    Reported hospitalizations: 15

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