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Aredia Safety Reports
Total Aredia reports: 461.Aredia FDA safety alerts: 2005 2007 2008 .
Reported deaths: 31 Reported hospitalizations: 127.
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Reported Aredia Side Effects: osteonecrosis, bone disorder, tooth extraction, osteomyelitis, sequestrectomy, pain in jaw, impaired healing, actinomycosis, dental treatment, osteomyelitis acute, bone debridement.
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Showing 1-50 of 461 Next >
Aredia Side Effects Report #5240618-XPhysician from JAPAN reported AREDIA problem on Feb 07, 2007. Female patient, 66 years of age, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone swelling, oral discomfort, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5240706-8
AREDIA problem was reported by a Physician from JAPAN on Feb 07, 2007. Female patient, 66 years of age, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone swelling, oral discomfort, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5243465-8
Physician from JAPAN reported AREDIA problem on Feb 08, 2007. Male patient, 74 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, pain in jaw, primary sequestrum, sequestrectomy, tooth extraction. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5243534-2
AREDIA problem was reported by a Physician from JAPAN on Feb 08, 2007. Male patient, 74 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, pain in jaw, primary sequestrum, sequestrectomy, tooth extraction. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5243722-5
Consumer or non-health professional from UNITED STATES reported AREDIA problem on Feb 12, 2007. Male patient, 64 years of age, weighting 195.0 lb, was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: alpha haemolytic streptococcal infection, bone debridement, bone disorder, dialysis, excessive granulation tissue, hypoaesthesia oral, mastication disorder, osteomyelitis, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, THALIDOMIDE, NEURONTIN, PAROXETINE, ASPIRIN. Patient recovered.
Aredia Side Effects Report #5243723-7
AREDIA problem was reported by a Consumer or non-health professional from UNITED STATES on Feb 12, 2007. Female patient, 53 years of age, weighting 118.0 lb, was diagnosed with metastases to bone, bone pain, breast cancer, arthritis, hypertension and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: balance disorder, bone disorder, bone lesion, decreased appetite, diarrhoea, disease progression, dysphagia, eczema, fall. AREDIA dosage: 90 MG, UNK. During the same period patient was treated with MS CONTIN, FASLODEX, TAMOXIFEN CITRATE, ZANTAC, NAPROSYN, MONOPRIL, TAGAMET, ELAVIL. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5245159-1
Consumer or non-health professional from UNITED STATES reported AREDIA problem on Feb 12, 2007. Male patient, 63 years of age, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: abscess management, alveolar osteitis, anhedonia, bone disorder, bone fistula, bone fragmentation, bone lesion, carpal tunnel syndrome, decreased interest. AREDIA dosage: 90 MG, QMO. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5247250-2
AREDIA problem was reported by a Consumer or non-health professional from JAPAN on Feb 14, 2007. Female patient, 69 years of age, weighting 127.9 lb, was diagnosed with metastases to bone, breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone swelling, haematocrit abnormal, osteomyelitis, osteonecrosis, pain in jaw, platelet disorder, primary sequestrum, red blood cell abnormality, suture insertion. AREDIA dosage: 45-90 MG. During the same period patient was treated with AROMASIN, EPIDOSIN, ENDOXAN, TAXOL, HERCEPTIN. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5247884-5
Physician from JAPAN reported AREDIA problem on Feb 08, 2007. Male patient, 74 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, pain in jaw, primary sequestrum, sequestrectomy, tooth extraction. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5254886-1
AREDIA problem was reported by a Health Professional from GERMANY on Feb 28, 2007. Female patient, 74 years of age, was diagnosed with breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: endodontic procedure, osteonecrosis, tooth extraction. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient died.
Aredia Side Effects Report #5254893-9
Consumer or non-health professional from JAPAN reported AREDIA problem on Feb 21, 2007. Female patient, 67 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5254894-0
AREDIA problem was reported by a Consumer or non-health professional from GERMANY on Feb 21, 2007. Female patient was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: muscle spasms, thrombosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5254898-8
Consumer or non-health professional from JAPAN reported AREDIA problem on Feb 21, 2007. Male patient, 60 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5254899-X
AREDIA problem was reported by a Consumer or non-health professional from JAPAN on Feb 21, 2007. Female patient, 67 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with INCADRONIC ACID. Patient recovered.
Aredia Side Effects Report #5254900-3
Health Professional from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 73 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: maxillofacial operation, osteonecrosis, primary sequestrum, sequestrectomy. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient died.
Aredia Side Effects Report #5254901-5
AREDIA problem was reported by a Consumer or non-health professional from JAPAN on Feb 21, 2007. Male patient, 70 years of age, weighting 108.0 lb, was diagnosed with hypercalcaemia, hypertension, prophylaxis, constipation and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: anaemia, bacterial infection, blood alkaline phosphatase increased, bone disorder, dental care, gingivitis, haemorrhage, impaired healing, insomnia. AREDIA dosage: 30 MG, EVERY 3 OR 4 WEEKS. During the same period patient was treated with ACINON, NORVASC, FLOMOX, ONCOVIN, ADRIAMYCIN PFS, DECADRON, MAGLAX, MELPHALAN. Patient recovered.
Aredia Side Effects Report #5254907-6
Consumer or non-health professional from JAPAN reported AREDIA problem on Feb 21, 2007. Female patient, 66 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with INCADRONIC ACID. Patient recovered.
Aredia Side Effects Report #5256008-X
AREDIA problem was reported by a Health Professional from on Mar 02, 2007. Female patient, 76 years of age, weighting 114.6 lb, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: chills, loss of consciousness, pyrexia. AREDIA dosage: 30 MG, UNK. Patient recovered.
Aredia Side Effects Report #5256897-9
Physician from DENMARK reported AREDIA problem on Feb 26, 2007. Male patient, 69 years of age, weighting 165.3 lb, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, osteolysis, osteonecrosis, prosthesis implantation. AREDIA dosage: 90 MG, QMO. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256898-0
AREDIA problem was reported by a Health Professional from GERMANY on Feb 28, 2007. Female patient, 53 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: endodontic procedure, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256899-2
Health Professional from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 55 years of age, was diagnosed with breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, primary sequestrum, sequestrectomy. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256900-6
AREDIA problem was reported by a Health Professional from GERMANY on Feb 28, 2007. Female patient, 72 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: endodontic procedure, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with PAMIDRONATE DI. Patient recovered.
Aredia Side Effects Report #5256902-X
Health Professional from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 68 years of age, was diagnosed with breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone trimming, osteonecrosis, tooth extraction. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256904-3
AREDIA problem was reported by a Health Professional from GERMANY on Feb 28, 2007. Male patient, 44 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone trimming, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256905-5
Health Professional from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 70 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, primary sequestrum, sequestrectomy, tooth extraction. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256906-7
AREDIA problem was reported by a Health Professional from GERMANY on Feb 28, 2007. Male patient, 63 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, primary sequestrum, sequestrectomy, tooth extraction. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5256907-9
Health Professional from GERMANY reported AREDIA problem on Feb 28, 2007. Male patient, 58 years of age, was diagnosed with plasmacytoma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: endodontic procedure, osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA. Patient recovered.
Aredia Side Effects Report #5257041-4
AREDIA problem was reported by a Physician from JAPAN on Feb 22, 2007. Female patient, 75 years of age, was diagnosed with breast cancer, diabetes mellitus, hyperlipidaemia, hypertension and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: body temperature increased, osteitis, osteonecrosis, swelling face. AREDIA dosage: unknown. During the same period patient was treated with TAXOTERE, KYTRIL, DECADRON, AMARYL, LORELCO, BASEN, AMLODIPINE. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5258367-0
Consumer or non-health professional from JAPAN reported AREDIA problem on Feb 23, 2007. Female patient, 69 years of age, weighting 127.9 lb, was diagnosed with metastases to bone, breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, bone swelling, dysaesthesia, fistula, gingival swelling, gingivitis, granuloma, haematocrit abnormal, osteomyelitis. AREDIA dosage: 45-90 MG. During the same period patient was treated with AROMASIN, EPIDOSIN, ENDOXAN, TAXOL, HERCEPTIN. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5258368-2
AREDIA problem was reported by a Consumer or non-health professional from UNITED STATES on Feb 23, 2007. Female patient, 53 years of age, weighting 118.0 lb, was diagnosed with metastases to bone, bone pain, breast cancer, arthritis, hypertension and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: balance disorder, bone disorder, bone lesion, decreased appetite, diarrhoea, disease progression, dysphagia, eczema, fall. AREDIA dosage: 90 MG, UNK. During the same period patient was treated with MS CONTIN, FASLODEX, TAMOXIFEN CITRATE, ZANTAC, NAPROSYN, MONOPRIL, TAGAMET, ELAVIL. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5258649-2
Consumer or non-health professional from UNITED STATES reported AREDIA problem on Feb 23, 2007. Male patient, 48 years of age, weighting 180.0 lb, was diagnosed with metastases to bone, prostate cancer, pain and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: abscess, abscess drainage, aphthous stomatitis, atelectasis, bone disorder, calcinosis, computerised tomogram abnormal, dental caries, gingival abscess. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, FOSAMAX, COUMADIN, TAXOTERE, CASODEX, LUPRON, VICODIN. Patient recovered.
Aredia Side Effects Report #5259626-8
AREDIA problem was reported by a Pharmacist from CANADA on Feb 28, 2007. Female patient, 67 years of age, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: back pain, breast pain, dyspepsia, pain in extremity, phlebitis. AREDIA dosage: 90MG EVERY MONTH. During the same period patient was treated with ZOMETA. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5263357-8
Physician from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 72 years of age, weighting 136.7 lb, was diagnosed with metastases to bone, breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, bone fistula, dental operation, ostectomy, osteomyelitis, primary sequestrum, secretion discharge. AREDIA dosage: unknown. During the same period patient was treated with FEMARA, INSULIN, ZOMETA. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5263359-1
AREDIA problem was reported by a Physician from NETHERLANDS on Mar 01, 2007. Female patient, 83 years of age, was diagnosed with hypercalcaemia and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: excessive granulation tissue, osteitis, osteonecrosis, sequestrectomy. AREDIA dosage: 15 MG/ML, QMO. During the same period patient was treated with TEMAZEPAM, METOPROLOL SUCCINATE, PERINDOPRIL ERBUMINE, FUROSEMIDE. Patient recovered.
Aredia Side Effects Report #5263362-1
Physician from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 67 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, dental treatment, osteomyelitis, osteotomy. AREDIA dosage: 60 MG, QMO. Patient recovered.
Aredia Side Effects Report #5263363-3
AREDIA problem was reported by a Physician from DENMARK on Feb 28, 2007. Male patient, 84 years of age, weighting 163.1 lb, was diagnosed with metastases to bone and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, sequestrectomy, tooth extraction. AREDIA dosage: 30 MG OR 90 MG EVERY FOUR WEEKS. During the same period patient was treated with NORVASC, ATACAND, SIMVASTATIN. Patient recovered.
Aredia Side Effects Report #5263364-5
Physician from GERMANY reported AREDIA problem on Feb 28, 2007. Female patient, 43 years of age, weighting 154.3 lb, was diagnosed with breast cancer and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, dental treatment, osteomyelitis, osteonecrosis, osteotomy. AREDIA dosage: 90 MG, QMO. During the same period patient was treated with TAXOTERE. Patient recovered.
Aredia Side Effects Report #5263365-7
AREDIA problem was reported by a Physician from UNITED STATES on Mar 05, 2007. Female patient, 51 years of age, was diagnosed with metastases to bone, breast cancer metastatic, insomnia and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: anaemia, ascites, asthenia, bone disorder, bone pain, bone scan abnormal, bone trimming, breast cancer metastatic, culture positive. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, TAMOXIFEN CITRATE, TAMOXIFEN CITRATE, VALIUM. Patient was hospitalized. Patient died on 09/04/2006.
Aredia Side Effects Report #5264620-7
Health Professional from GERMANY reported AREDIA problem on Mar 05, 2007. Male patient was diagnosed with plasmacytoma, multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: loose tooth, tooth extraction. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, LIPID MODIFYING AGENTS. Patient recovered.
Aredia Side Effects Report #5265886-X
AREDIA problem was reported by a Consumer or non-health professional from FRANCE on Mar 05, 2007. Male patient, 75 years of age, was diagnosed with rheumatoid arthritis and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: computerised tomogram abnormal, granuloma, jaw disorder, lymph nodes scan abnormal, lymphadenopathy, nuclear magnetic resonance imaging abnormal, osteolysis, pain in jaw, x-ray dental. AREDIA dosage: unknown. During the same period patient was treated with FOSAMAX, METHOTREXATE, CORTANCYL. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5265887-1
Consumer or non-health professional from JAPAN reported AREDIA problem on Mar 06, 2007. Female patient, 66 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with INCADRONIC ACID. Patient recovered.
Aredia Side Effects Report #5265888-3
AREDIA problem was reported by a Consumer or non-health professional from JAPAN on Mar 06, 2007. Male patient, 70 years of age, weighting 108.0 lb, was diagnosed with hypercalcaemia, hypertension, prophylaxis, constipation and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: anaemia, bacterial infection, blood alkaline phosphatase increased, bone disorder, dental care, gingivitis, haemorrhage, impaired healing, insomnia. AREDIA dosage: 30 MG, EVERY 3 OR 4 WEEKS. During the same period patient was treated with ACINON, NORVASC, FLOMOX, ONCOVIN, ADRIAMYCIN PFS, DECADRON, MAGLAX, MELPHALAN. Patient recovered.
Aredia Side Effects Report #5265890-1
Consumer or non-health professional from JAPAN reported AREDIA problem on Mar 06, 2007. Male patient, 60 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5265916-5
AREDIA problem was reported by a Consumer or non-health professional from JAPAN on Mar 06, 2007. Female patient, 67 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. AREDIA dosage: unknown. During the same period patient was treated with INCADRONIC ACID. Patient recovered.
Aredia Side Effects Report #5265918-9
Physician from JAPAN reported AREDIA problem on Mar 09, 2007. Female patient, 63 years of age, was diagnosed with metastases to bone, breast cancer recurrent and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: anaemia, gingival infection, haematocrit decreased, haemoglobin decreased, hepatic failure, jaw disorder, limb operation, metastases to liver, neutrophil count decreased. AREDIA dosage: 45 MG. During the same period patient was treated with HERCEPTIN, NAVELBINE, PACLITAXEL, XELODA. Patient was hospitalized. Patient died on 08/13/2006.
Aredia Side Effects Report #5265919-0
AREDIA problem was reported by a Physician from UNITED STATES on Mar 02, 2007. Male patient was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: bone disorder, jaw disorder. AREDIA dosage: unknown. Patient recovered.
Aredia Side Effects Report #5268025-4
Consumer or non-health professional from UNITED STATES reported AREDIA problem on Mar 05, 2007. Female patient, 68 years of age, weighting 218.0 lb, was diagnosed with metastases to bone, anxiety and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: abscess oral, actinomycosis, anaemia, anxiety, arthralgia, bone debridement, bone disorder, breath odour, chronic obstructive pulmonary disease. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, TAMOXIFEN CITRATE, EFFEXOR, FEMARA, HYDROCODONE. Patient was hospitalized. Patient recovered.
Aredia Side Effects Report #5268026-6
AREDIA problem was reported by a Consumer or non-health professional from FRANCE on Mar 07, 2007. Male patient, 84 years of age, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, tooth extraction. AREDIA dosage: 90 MG, QMO. During the same period patient was treated with MELPHALAN, THALIDOMIDE, ZOMETA, PREDNISONE. Patient recovered.
Aredia Side Effects Report #5268029-1
Physician from DENMARK reported AREDIA problem on Mar 08, 2007. Male patient, 84 years of age, weighting 163.1 lb, was diagnosed with multiple myeloma and was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: osteonecrosis, sequestrectomy, tooth extraction. AREDIA dosage: 30 MG OR 90 MG EVERY FOUR WEEKS. During the same period patient was treated with NORVASC, ATACAND, SIMVASTATIN. Patient recovered.
Aredia Side Effects Report #5268031-X
AREDIA problem was reported by a Physician from UNITED STATES on Mar 05, 2007. Female patient, 52 years of age, weighting 136.0 lb, was treated with AREDIA. After drug was administered, patient experienced the following problems/side effects: abscess jaw, actinomycosis, acupuncture, anxiety, aphthous stomatitis, arthralgia, asthma, bone debridement, bone disorder. AREDIA dosage: unknown. During the same period patient was treated with ZOMETA, FASLODEX, DEPAKOTE, TYLENOL, CLONAZEPAM, ALBUTEROL, OXYCODONE, LEXAPRO. Patient was hospitalized. Patient recovered.
Showing 1-50 of 461 Next >
Drug Information: Pamidronate Injection
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601163.html
(pa mi droe' nate)IMPORTANT WARNING:
| [Posted 01/07/2008] FDA informed healthcare professionals and patients of the possibility of severe and sometimes incapacitating bone, joint, and/or muscle (musculoskeletal) pain in patients taking bisphosphonates. Although severe musculoskeletal pain is included in the prescribing information for all bisphosphonates, the association between bisphosphonates and severe musculoskeletal pain may be overlooked by healthcare professionals, delaying diagnosis, prolonging pain and/or impairment, and necessitating the use of analgesics. The severe musculoskeletal pain may occur within days, months, or years after starting a bisphosphonates. Some patients have reported complete relief of symptoms after discontinuing the bisphosphonate, whereas others have reported slow or incomplete resolution. The risk factors for and incidence of severe musculoskeletal pain associated with bisphosphonates are unknown.Healthcare professionals should consider whether bisphosphonate use might be responsible for severe musculoskeletal pain in patients who present with these symptoms and consider temporary or permanent discontinuation of the drug. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Bisphosphonates and http://www.fda.gov/cder/drug/infopage/bisphosphonates/default.htm.[Posted 10/01/2007] FDA issued an early communication about the ongoing review of new safety data regarding the association of atrial fibrillation with the use of bisphosphonates. Bisphosphonates are a class of drugs used primarily to increase bone mass and reduce the risk for fracture in patients with osteoporosis, slow bone turnover in patients with Paget’s disease of the bone, treat bone metastases, and lower elevated levels of blood calcium in patients with cancer.FDA reviewed spontaneous postmarketing reports of atrial fibrillation reported in association with oral and intravenous bisphosphonates and did not identify a population of bisphosphonate users at increased risk of atrial fibrillation. In addition, as part of the data review for the recent approval of once-yearly Reclast for the treatment of postmenopausal osteoporosis, FDA evaluated the possible association between atrial fibrillation and the use of Reclast (zoledronic acid). Most cases of atrial fibrillation occurred more than a month after drug infusion. Also, in a subset of patients monitored by electrocardiogram up to the 11th day following infusion, there was no significant difference in the prevalence of atrial fibrillation between patients who received Reclast and patients who received placebo.Upon initial review, it is unclear how these data on serious atrial fibrillation should be interpreted. Therefore, FDA does not believe that healthcare providers or patients should change either their prescribing practices or their use of bisphosphonates at this time. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2007/safety07.htm#Bisphosphonates and http://www.fda.gov/cder/drug/early_comm/bisphosphonates.htm. |
About your treatment
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Your doctor has ordered pamidronate to help treat your illness. The medication will be added to an intravenous fluid that will drip through a needle or catheter into your vein. You will receive your dose of pamidronate as an infusion (slow injection) that may last 2-24 hours. You may receive an infusion of pamidronate once every 3-4 weeks, once a day for 3 days in a row, or as a single dose that may be repeated after 1 week or longer. The treatment schedule depends on your condition.
Pamidronate is used to treat high levels of calcium in the blood that may be caused by certain types of cancer. Pamidronate is also used along with cancer chemotherapy to treat bone damage caused by multiple myeloma (cancer that begins in the plasma cells [white blood cells that produce substances needed to fight infection]) or by cancer that began in another part of the body but has spread to the bones. Pamidronate is also used to treat Paget's disease (a condition in which healthy bones are broken down and replaced by abnormally thick but weak bones). Pamidronate helps prevent bone breakdown and bone fractures. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor. The length of treatment depends on your condition and on how you respond to the medication.
Precautions
Before administering pamidronate,
- tell your doctor and pharmacist if you are allergic to pamidronate, alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), tiludronate (Skelid), zoledronic acid (Zometa), any other medications, or any of the ingredients in pamidronate infusion. Ask your health care provider for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: amphotericin B (Fungizone); antibiotics such as amikacin (Amikin),bacitracin; dapsone (Avlosulfon);foscarnet (Foscavir); ganciclovir (Cytovene); gentamicin (Garamycin), kanamaycin (Kantrex),methicillin (Staphcillin);neomycin (Neo-Rx, Neo-Fradin), netilmycin (Netromycin), paramomycin (Humatin), pentamidine (NebuPent); polymyxin (Aerosporin);rifampin (Rifadin, Rimactane);sulfonamides such as sulfamethoxazole and trimethoprim (Bactrim);streptomycin, tobramycin (Tobi, Nebcin),and valganciclovir (Valcyte); aspirin and other nonsteroidal anti-inflammatory medications such as ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn); aurothioglucose (Solganal); auranofin (Ridaura); cancer chemotherapy medications captopril (Capoten); cyclophosphamide (Cytoxan, Neosar); cyclosporine (Neoral, Sandimmune); gold sodium thiomalate (Myochrysine); lidocaine (Xylocaine, others); certain medications to treat or prevent malaria; nitrates; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); penicillamine (Cuprimine, Depen); salicylate pain relievers;and tacrolimus (Prograf).
- tell your doctor if you have or have ever had an infection of the mouth or bones, gum disease or other problems with your teeth or mouth, or kidney or liver disease.
- tell your doctor if you are pregnant or are breast-feeding. Use a reliable method of birth control during your treatment with pamidronate. If you become pregnant while using pamidronate, call your doctor. Pamidronate may harm the fetus. Also talk to your doctor if you plan to become pregnant at any time in the future because pamidronate may remain in your body for years after you stop using it.
- if you are having surgery, tell the doctor that you are using pamidronate.
- you should know that pamidronate may cause serious problems with your jaw, especially if you have dental surgery or treatment while you are using the medication. A dentist should examine your teeth and perform any needed treatments before you start to use pamidronate. Be sure to brush your teeth and clean your mouth properly while you are using pamidronate. Talk to your doctor before having any dental treatments while you are using this medication. Call your doctor if you have any of the following symptoms: jaw pain; pain, swelling, or infection of the gums; sores or cuts on the gums that do not heal; loosening of teeth; numbness or a feeling of heaviness in the jaw; drainage of fluid from the gum or jaw; or seeing any exposed bone in your mouth.
- You should make sure your diet contains enough calcium and vitamins. You should discuss this with your health care provider.
Administering your medication
Before you administer pamidronate, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored or if it contains particles. Use a new solution, but show the damaged one to your health care provider.
It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason. Do not administer it more often or for longer periods than your doctor tells you. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.
Side effects
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Pamidronate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- bone, joint, or muscle pain
- slight fever
- loss of appetite
- upset stomach
- vomiting
- stomach pain
- constipation
- heartburn
- weakness
- dizziness
- headache
- increased sweating
If you experience any of the following symptoms, or those mentioned in the PRECAUTIONS section, call your health care provider immediately:
- seizures
- eye pain, swelling, itching, or redness
- blurred vision or changes in vision
- sensitivity to light
- fast or irregular heartbeat
- fainting
- sore throat, high fever, chills, cough, or other signs of infection
- unusual bruising or bleeding
- black and tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
- shortness of breath or fast breathing
- chest pain
- numbness or tingling in the arms, legs, lips, tongue, or the area around the mouth
- muscle cramps, spasms, or sudden muscle tightening
- depression
- personality changes
- difficult, frequent, or painful urination
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty swallowing
- hoarseness
- hives
- rash
- itching
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
Storing your medication
Store your medication only as directed. Make sure you understand how to store your medication properly. Do not use the solution after the expiration date and time written on the label of the medication. Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of the reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- fever
- dizziness or lightheadedness
- blurred vision
- fainting
- changes in the way food tastes
Signs of infection
If you are receiving pamidronate in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these symptoms near your intravenous catheter, tell your health care provider as soon as possible:
- tenderness
- warmth
- irritation
- hardness or bump
- drainage
- redness
- swelling
- pain
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