Avastin Safety Reports submitted to FDA

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Total Avastin reports: 1647.
Avastin FDA safety alerts: 2004 2005 2006 2007 .
Reported deaths: 237 Reported hospitalizations: 894.
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FDA Reported Avastin Side Effects: haemoglobin decreased, dehydration, pyrexia, nausea, detachment of retinal pigment epithelium, disease progression, fatigue, diarrhoea haemorrhagic, asthenia, diarrhoea, vomiting.
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Showing 1-100 of 1647 Next >

Avastin Side Effects Report #5224660-0
Physician from GERMANY reported AVASTIN problem on Jan 11, 2007. Female patient, 68 years of age, weighting 147.7 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: haemolysis. AVASTIN dosage: unknown. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5224661-2
AVASTIN problem was reported by a Physician from DENMARK on Jan 12, 2007. Female patient, 58 years of age, was diagnosed with glioblastoma multiforme and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: fatigue, hemiparesis, lacunar infarction. AVASTIN dosage: 350 MG, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, CETUXIMAB, ATROPIN, TAVEGYL, CENTYL, PERINDOPRIL ERBUMINE. Patient recovered.

Avastin Side Effects Report #5225701-7
Physician from UNITED KINGDOM reported AVASTIN problem on Jan 11, 2007. Male patient, 66 years of age, weighting 173.3 lb, was diagnosed with colon cancer, hypertension, hypercholesterolaemia and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: dyspnoea, haemoptysis, renal failure. AVASTIN dosage: 590 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, VALSARTAN, AMLODIPINE BESYLATE, DOXAZOSIN MESYLATE, ATENOLOL, ASPIRIN, SIMVASTATIN, PERINDOPRIL ERBUMINE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226027-8
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 19, 2007. Male patient, 63 years of age, weighting 220.9 lb, was diagnosed with colon cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: exfoliative rash. AVASTIN dosage: 5 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, IRINOTECAN. Patient recovered.

Avastin Side Effects Report #5226827-4
Health Professional from KOREA, DEMOCRATIC PEOPLE'S REPUBLIC OF reported AVASTIN problem on Jan 27, 2007. Male patient, 69 years of age, weighting 140.0 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anorexia, chest pain. AVASTIN dosage: 480 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, AMLODIPINE BESYLATE, LORAZEPAM, RANITIDINE, ONDANSETRON, MAGNESIUM OXIDE, NITROGLYCERIN. Patient died.

Avastin Side Effects Report #5226828-6
AVASTIN problem was reported by a Physician from GERMANY on Jan 27, 2007. Female patient, 62 years of age, weighting 143.3 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: psoas abscess. AVASTIN dosage: 330 MG, Q2W, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226829-8
Health Professional from GERMANY reported AVASTIN problem on Jan 27, 2007. Female patient, 67 years of age, weighting 154.3 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: visual acuity reduced. AVASTIN dosage: 548 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, IRINOTECAN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226830-4
AVASTIN problem was reported by a Physician from GREECE on Jan 27, 2007. Male patient, 73 years of age, weighting 184.1 lb, was diagnosed with colon cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: haematocrit increased, haemoglobin increased. AVASTIN dosage: 400 MG, 2/MONTH, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, IRINOTECAN. Patient recovered.

Avastin Side Effects Report #5226833-X
Physician from FRANCE reported AVASTIN problem on Jan 27, 2007. Male patient, 73 years of age, weighting 185.2 lb, was diagnosed with hepatic neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, hypertension, mass. AVASTIN dosage: 840 MG, Q2W, INTRAVENOUS. During the same period patient was treated with PULMICORT, SILOMAT, DOMPERIDONE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226835-3
AVASTIN problem was reported by a Physician from NETHERLANDS on Jan 27, 2007. Female patient, 57 years of age, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia. AVASTIN dosage: 512 MG, QD, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, CETUXIMAB. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226837-7
Physician from NETHERLANDS reported AVASTIN problem on Jan 27, 2007. Female patient, 66 years of age, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain, oral intake reduced, vomiting. AVASTIN dosage: 450 MG, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, NEXIUM, PYRIDOXINE, METOCLOPRAMIDE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226838-9
AVASTIN problem was reported by a Health Professional from CANADA on Jan 15, 2007. Female patient, 57 years of age, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, chest discomfort. AVASTIN dosage: 7.5 MG/KG, Q3W. During the same period patient was treated with CAPECITABINE, OXALIPLATIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226840-7
Physician from FRANCE reported AVASTIN problem on Jan 27, 2007. Male patient, 78 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anterograde amnesia. AVASTIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, IRINOTECAN. Patient recovered.

Avastin Side Effects Report #5226847-X
AVASTIN problem was reported by a Health Professional from FRANCE on Jan 11, 2007. Male patient, 52 years of age, weighting 147.7 lb, was diagnosed with neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, cholestasis, condition aggravated, cytolytic hepatitis, hepatitis b. AVASTIN dosage: unknown. During the same period patient was treated with KYTRIL, CARBOPLATIN, TAXOL, RANITIDINE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226849-3
Physician from AUSTRALIA reported AVASTIN problem on Jan 11, 2007. Male patient, 69 years of age, weighting 165.3 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anal fissure. AVASTIN dosage: 360 MG, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL, LEUCOVORIN CALCIUM, TICLOPIDINE, TEVETEN, RAMIPRIL, PANTOPRAZOLE, NITROGLYCERIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226857-2
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 27, 2007. Female patient, 66 years of age, weighting 166.0 lb, was diagnosed with breast cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: hypersensitivity, palmar-plantar erythrodysaesthesia syndrome. AVASTIN dosage: 10 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ABRAXANE, DOXIL. Patient recovered.

Avastin Side Effects Report #5226867-5
Health Professional from FRANCE reported AVASTIN problem on Jan 27, 2007. Female patient, 65 years of age, weighting 125.7 lb, was diagnosed with neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cholecystitis infective, gangrene. AVASTIN dosage: 285 MG, INTRAVENOUS. During the same period patient was treated with ELOXATIN, FLUOROURACIL. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226892-4
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 19, 2007. Female patient, 36 years of age, was diagnosed with breast cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: ascites, dacryostenosis acquired, musculoskeletal disorder, pain, peripheral embolism, pleural effusion, pulmonary embolism, white blood cell count increased. AVASTIN dosage: unknown. During the same period patient was treated with HERCEPTIN, TAXOTERE, DEXAMETHASONE. Patient recovered.

Avastin Side Effects Report #5227107-3
Health Professional from UNITED STATES reported AVASTIN problem on Jan 27, 2007. Male patient, 58 years of age, weighting 159.8 lb, was diagnosed with adenocarcinoma pancreas and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: hyperglycaemia, oesophageal candidiasis, oesophagitis, vomiting. AVASTIN dosage: 720 MG, DAYS 1+15, INTRAVENOUS. During the same period patient was treated with GEMCITABINE, OXALIPLATIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5227108-5
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 23, 2007. Female patient, 60 years of age, weighting 94.14 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cachexia, weight decreased. AVASTIN dosage: 735 MG, Q3W, INTRAVENOUS. During the same period patient was treated with ERLOTINIB. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228465-6
Physician from AUSTRALIA reported AVASTIN problem on Jan 16, 2007. Female patient, 74 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: fall, infection, joint injury, soft tissue injury. AVASTIN dosage: 7.5 MG/KG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, MITOMYCIN, TAMBOCOR, ACETAMINOPHEN. Patient was hospitalized. Patient died on 12/11/2006.

Avastin Side Effects Report #5228467-X
AVASTIN problem was reported by a Health Professional from KOREA, DEMOCRATIC PEOPLE'S REPUBLIC OF on Jan 09, 2007. Male patient, 69 years of age, weighting 140.0 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anorexia, chest pain, myocardial ischaemia. AVASTIN dosage: 480 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, AMLODIPINE BESYLATE, LORAZEPAM, RANITIDINE, ONDANSETRON, MAGNESIUM OXIDE, NITROGLYCERIN. Patient died.

Avastin Side Effects Report #5228471-1
Physician from GERMANY reported AVASTIN problem on Jan 27, 2007. Male patient, 75 years of age, weighting 145.5 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anorexia, colorectal cancer, deep vein thrombosis, dehydration, erosive duodenitis, hypovolaemic shock, malignant neoplasm progression, oesophageal ulcer haemorrhage, oesophagitis ulcerative. AVASTIN dosage: 500 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, IRINOTECAN. Patient was hospitalized. Patient died on 04/12/2006.

Avastin Side Effects Report #5228473-5
AVASTIN problem was reported by a Physician from CANADA on Jan 27, 2007. Male patient, 78 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: pneumonia. AVASTIN dosage: 5 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, FLUOROURACIL, DECADRON, ZOFRAN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228484-X
Physician from FRANCE reported AVASTIN problem on Jan 27, 2007. Female patient, 52 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: blood pressure systolic increased, convulsion, encephalitis. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5228485-1
AVASTIN problem was reported by a Physician from SWITZERLAND on Jan 27, 2007. Male patient, 71 years of age, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal distension, abdominal pain, agitation, constipation, cough, cyanosis, dyspepsia, dyspnoea, fall. AVASTIN dosage: 1380 MG, QD, INTRAVENOUS. During the same period patient was treated with ERLOTINIB, IPRATROPIUM, ASPIRIN, RAMIPRIL, ADALAT, DAFALGAN, PANTOPRAZOLE, HEPARIN. Patient was hospitalized. Patient died on 12/11/2006.

Avastin Side Effects Report #5228487-5
Physician from NEW ZEALAND reported AVASTIN problem on Jan 27, 2007. Male patient, 68 years of age, weighting 147.0 lb, was diagnosed with colorectal cancer, colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: confusional state, gastric perforation, somnolence, wound dehiscence. AVASTIN dosage: 325 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, METOPROLOL TARTRATE, BENDROFLUAZIDE, ALLOPURINOL, LOPERAMIDE, METOCLOPRAMIDE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228506-6
AVASTIN problem was reported by a Physician from AUSTRALIA on Jan 27, 2007. Female patient, 72 years of age, weighting 202.8 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: fistula, scleroderma renal crisis. AVASTIN dosage: 750 MG, Q3W, INTRAVENOUS. During the same period patient was treated with MITOMYCIN, XELODA, PERINDOPRIL ERBUMINE, INDAPAMIDE, SPIRONOLACTONE, PAROXETINE, DESLORATADINE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228515-7
Physician from NETHERLANDS reported AVASTIN problem on Jan 27, 2007. Male patient was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: epilepsy. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5228532-7
AVASTIN problem was reported by a Physician from UNITED KINGDOM on Jan 27, 2007. Male patient, 51 years of age, weighting 159.2 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: haemoglobin decreased, neutropenic sepsis, platelet count decreased. AVASTIN dosage: 362.5 MG, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL, FRAGMIN, CYCLIZINE, METRONIDAZOLE, DIAZEPAM, CEFUROXIME. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228534-0
Physician from CANADA reported AVASTIN problem on Jan 27, 2007. Male patient, 38 years of age, weighting 153.9 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: idiopathic thrombocytopenic purpura. AVASTIN dosage: 524 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN. Patient recovered.

Avastin Side Effects Report #5228538-8
AVASTIN problem was reported by a Health Professional from FRANCE on Jan 27, 2007. Male patient, 69 years of age, weighting 207.2 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anaphylactic shock. AVASTIN dosage: 450 MG, INTRAVENOUS. During the same period patient was treated with ELOXATIN, ELVORINE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228739-9
Consumer or non-health professional from JAPAN reported AVASTIN problem on Jan 15, 2007. Male patient, 57 years of age, weighting 150.4 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain, constipation, rectal stenosis. AVASTIN dosage: 497 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, OXYCODONE, LOXONIN, NORVASC, BLOPRESS, PURSENNID, LAXOBERON. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228747-8
AVASTIN problem was reported by a Physician from NETHERLANDS on Jan 17, 2007. Male patient, 69 years of age, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: aortic aneurysm rupture, constipation, gastric disorder, haemoglobin decreased, hypotension, shock. AVASTIN dosage: 548 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, OMEPRAZOLE, ACETAMINOPHEN, OXAZEPAM, AUGMENTIN, POTASSIUM CHLORIDE. Patient was hospitalized. Patient died on 12/05/2006.

Avastin Side Effects Report #5228749-1
Health Professional from AUSTRALIA reported AVASTIN problem on Jan 27, 2007. Male patient, 68 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: intestinal obstruction, neuropathy, sepsis. AVASTIN dosage: 7.5 MG/KG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, ATENOLOL, KARVEZIDE. Patient was hospitalized. Patient died.

Avastin Side Effects Report #5229271-9
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 27, 2007. Female patient, 68 years of age, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: face oedema, intraocular pressure increased. AVASTIN dosage: unknown. During the same period patient was treated with EYE DROPS NOS. Patient recovered.

Avastin Side Effects Report #5229279-3
Health Professional from UNITED STATES reported AVASTIN problem on Jan 27, 2007. Female patient, 57 years of age, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: dehydration, diarrhoea, herpes virus infection, oesophagitis, throat tightness, weight decreased. AVASTIN dosage: unknown. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL, LEUCOVORIN CALCIUM, OXYCONTIN, ZOFRAN, DURAGEISC. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229282-3
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 18, 2007. Male patient, 63 years of age, weighting 188.9 lb, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, blood pressure increased, dyspnoea, hypersomnia, mental status changes, platelet count decreased, pulmonary embolism, pyrexia, sinus tachycardia. AVASTIN dosage: 868 MG, Q2W, INTRAVENOUS. During the same period patient was treated with PROLEUKIN, LEVOFLOXACIN, RHINOCORT. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229728-0
Health Professional from HONG KONG reported AVASTIN problem on Jan 16, 2007. Female patient, 47 years of age, weighting 102.7 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal wound dehiscence, arrhythmia, ascites, blood albumin increased, blood potassium decreased, disease progression, gastrointestinal perforation, haemoglobin decreased. AVASTIN dosage: 300 MG, Q2W, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, FLUOROURACIL, DOLOGESIC, METHADONE, PROTHIADEN, DIAMICRON, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient died on 07/31/2006.

Avastin Side Effects Report #5236921-X
AVASTIN problem was reported by a Health Professional from NEW ZEALAND on Nov 21, 2006. Male patient, 68 years of age, weighting 124.1 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: confusional state, gastrointestinal perforation, mental status changes, somnolence. AVASTIN dosage: 325 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, METOPROLOL TARTRATE, BENDROFLUAZIDE, ALLOPURINOL, LOPERAMIDE, METOCLOPRAMIDE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226936-X
Pharmacist from UNITED STATES reported AVASTIN problem on Feb 01, 2007. Male patient, 74 years of age, weighting 172.0 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis. AVASTIN dosage: 15MG/KG Q21 DAYS IV. During the same period patient was treated with PACLITAXEL, CARBOPLATIN, PEPCID, BENADRYL, TYLENOL, ATIVAN, DECADRON, ALOXI. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226937-1
AVASTIN problem was reported by a Pharmacist from UNITED STATES on Feb 01, 2007. Female patient, 56 years of age, was diagnosed with colon cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: pneumonia, pulmonary embolism. AVASTIN dosage: 5MG/KG Q14 DAYS IV. During the same period patient was treated with FOLFIRI. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5226977-2
Pharmacist from UNITED STATES reported AVASTIN problem on Feb 01, 2007. Male patient, 70 years of age, weighting 217.8 lb, was diagnosed with colon cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: blood pressure abnormal, deep vein thrombosis. AVASTIN dosage: 5MG/KG Q14D IV. During the same period patient was treated with IRINOTECAN, LEUCOVORIN CALCIUM, FLUOROURACIL, ONDANSETRON, DIOVAN. Patient recovered.

Avastin Side Effects Report #5227132-2
AVASTIN problem was reported by a Health Professional from UNITED STATES on Feb 01, 2007. Male patient, weighting 179.0 lb, was diagnosed with hepatic neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: oesophageal varices haemorrhage. AVASTIN dosage: 5 MG/M2 Q3 WEEKS IV DRIP. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5228923-4
Health Professional from reported AVASTIN problem on Jan 30, 2007. Female patient, weighting 126.1 lb, was diagnosed with neurological symptom and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: asthenia, confusional state, dehydration, hallucination, hallucination, visual, hypokalaemia, infection, syncope. AVASTIN dosage: unknown. During the same period patient was treated with LORTAB, COUMADIN, OXALIPLATIN, LEUCOVORIN CALCIUM, LEXAPRO, FLUOROURACIL, ATIVAN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229635-3
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 27, 2007. Female patient, 68 years of age, weighting 201.9 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: diverticulitis. AVASTIN dosage: 680 MG, Q3W, INTRAVENOUS. During the same period patient was treated with ERLOTINIB. Patient recovered.

Avastin Side Effects Report #5229636-5
Health Professional from UNITED STATES reported AVASTIN problem on Jan 17, 2007. Female patient, 53 years of age, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: hepatic cirrhosis, splenomegaly, splenorenal shunt, varicose vein, venoocclusive liver disease. AVASTIN dosage: 5 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient recovered.

Avastin Side Effects Report #5229637-7
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 19, 2007. Male patient, 71 years of age, was diagnosed with adenocarcinoma pancreas and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abscess, bile duct obstruction, biliary tract disorder, dilatation intrahepatic duct acquired, post procedural bile leak, procedural site reaction. AVASTIN dosage: 10 MG/KG, INTRAVENOUS. During the same period patient was treated with GEMCITABINE, LORTAB, CREON, ERYTHROMYCIN, LOPRESSOR, MEGACE, PRILOSEC. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229638-9
Physician from UNITED STATES reported AVASTIN problem on Jan 23, 2007. Female patient, 56 years of age, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: dyspnoea. AVASTIN dosage: unknown. During the same period patient was treated with PANITUMUMAB, OXALIPLATIN, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient died on 10/15/2006.

Avastin Side Effects Report #5229639-0
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 27, 2007. Female patient, 67 years of age, weighting 121.9 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: enteritis, enterocolitis, infection, intestinal obstruction. AVASTIN dosage: 291 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, XALATAN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229677-8
Health Professional from UNITED STATES reported AVASTIN problem on Jan 10, 2007. Male patient, 70 years of age, weighting 178.1 lb, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: hypotension, necrotising fasciitis, rectal abscess, sepsis. AVASTIN dosage: unknown. During the same period patient was treated with OXALIPLATIN, XELODA, VICODIN, PRILOSEC, HCTZ. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5229739-5
AVASTIN problem was reported by a Consumer or non-health professional from FRANCE on Jan 18, 2007. Male patient, 77 years of age, weighting 156.5 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: memory impairment. AVASTIN dosage: 5 MG/KG INTRAVENOUS. During the same period patient was treated with CAMPTOSAR, FLUOROURACIL. Patient recovered.

Avastin Side Effects Report #5229740-1
Physician from GERMANY reported AVASTIN problem on Jan 16, 2007. Female patient, 67 years of age, weighting 132.3 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anaemia, impaired healing, metastases to lymph nodes, peritonitis, prothrombin time prolonged, rectal perforation, vaginal fistula. AVASTIN dosage: 300 MG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL. Patient recovered.

Avastin Side Effects Report #5230371-8
AVASTIN problem was reported by a Physician from NETHERLANDS on Jan 27, 2007. Female patient was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: thrombotic thrombocytopenic purpura. AVASTIN dosage: unknown. Patient died.

Avastin Side Effects Report #5230373-1
Physician from PHILIPPINES reported AVASTIN problem on Jan 27, 2007. Male patient was diagnosed with neuroendocrine carcinoma and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: acute respiratory distress syndrome. AVASTIN dosage: 500 MG, INTRAVENOUS. During the same period patient was treated with CISPLATIN, ETOPOSIDE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5230770-4
AVASTIN problem was reported by a Physician from CANADA on Dec 05, 2006. Male patient, 55 years of age, weighting 155.6 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: diarrhoea, endocarditis, haemoglobin decreased, metastases to liver, pneumonia, splenomegaly. AVASTIN dosage: 5 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, FLUOROURACIL, LEUCOVORIN CALCIUM, LOSEC, AMLODIPINE BESYLATE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5230772-8
Health Professional from FRANCE reported AVASTIN problem on Jan 18, 2007. Female patient, 49 years of age, weighting 97.00 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, febrile bone marrow aplasia, no therapeutic response, pyrexia. AVASTIN dosage: unknown. During the same period patient was treated with CAMPTOSAR, FLUOROURACIL, CALCIUM LEVOFOLINATE, CALCIUM LEVOFOLINATE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5231631-7
AVASTIN problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 23, 2007. Male patient, 46 years of age, was diagnosed with glioma and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: convulsion, hyponatraemia. AVASTIN dosage: 10 MG/KG, DAYS 1 + 15, INTRAVENOUS. During the same period patient was treated with KEPPRA, TRILEPTAL, HYZAAR. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5231663-9
Physician from UNITED STATES reported AVASTIN problem on Jan 17, 2007. Female patient, 65 years of age, weighting 161.8 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiomyopathy, chest pain, electrocardiogram t wave inversion, procedural pain, sinus tachycardia. AVASTIN dosage: 15 MG/KG, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, ALIMTA, LASIX, XANAX, PRILOSEC, LORAZEPAM, METOCLOPRAMIDE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5231666-4
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 23, 2007. Female patient, 51 years of age, was diagnosed with breast cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: pneumothorax. AVASTIN dosage: 10 MG/KG, QOW. During the same period patient was treated with TAXOL. Patient was hospitalized and became disabled. Patient recovered.

Avastin Side Effects Report #5231670-6
Health Professional from UNITED STATES reported AVASTIN problem on Jan 22, 2007. Male patient, 63 years of age, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: intestinal obstruction, malnutrition, metastases to gastrointestinal tract. AVASTIN dosage: 15 MG/KG, Q3W, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, PEMETREXED. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5231673-1
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 24, 2007. Male patient, 73 years of age, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cervical spinal stenosis, parkinsonism, subdural haematoma. AVASTIN dosage: 650 MG, QOW, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5232082-1
Consumer or non-health professional from UNITED STATES reported AVASTIN problem on Jan 19, 2007. Male patient, 61 years of age, weighting 250.0 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: central line infection, dehydration, diabetic ketoacidosis, malignant pleural effusion, nausea, renal failure acute, staphylococcal infection, staphylococcal sepsis, vomiting. AVASTIN dosage: 852 MG, Q3W; INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, HYDROCHLOROTHIAZIDE, ASPIRIN, NITROGLYCERIN, TENORMIN, VASOTEC, TRICOR. Patient recovered.

Avastin Side Effects Report #5232174-7
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 29, 2007. Female patient, 65 years of age, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain, body temperature decreased, dry eye, fatigue, febrile neutropenia, keratitis herpetic, keratitis interstitial. AVASTIN dosage: 790 MG, Q2W, INTRAVENOUS. During the same period patient was treated with GEMCITABINE, ALIMTA, TAGAMET, ADVAIR DISKUS, PREMARIN, FOLIC ACID, AMBIEN, KYTRIL. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5232176-0
Health Professional from UNITED STATES reported AVASTIN problem on Jan 24, 2007. Male patient, 75 years of age, weighting 196.2 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: asthenia, cough, diarrhoea, hyperhidrosis, oxygen saturation decreased, pyrexia, rash pustular. AVASTIN dosage: 15 MG/KG, Q3W, INTRAVENOUS. During the same period patient was treated with TAXOTERE, OXALIPLATIN, DILAUDID. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5232177-2
AVASTIN problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 23, 2007. Male patient, 32 years of age, was diagnosed with glioma and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: convulsion. AVASTIN dosage: 10 MG/KG, DAYS 1 + 15, INTRAVENOUS. During the same period patient was treated with DILANTIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5232375-8
Pharmacist from CANADA reported AVASTIN problem on Jan 19, 2007. Male patient was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation. AVASTIN dosage: unknown. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5232426-0
AVASTIN problem was reported by a Physician from NEW ZEALAND on Jan 21, 2007. Male patient, 69 years of age, weighting 171.7 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: confusional state, delirium, dysphagia, extradural haematoma, facial palsy, fall, muscle twitching, pulmonary embolism. AVASTIN dosage: 390 MG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, ACETAMINOPHEN, MORPHINE SULPHATE, SENNA, MAXOLON, LACTULOSE, CYCLIZINE. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5233261-X
Physician from UNITED STATES reported AVASTIN problem on Jan 25, 2007. Female patient, 73 years of age, was diagnosed with ovarian cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: back pain, blood glucose increased, blood potassium increased, blood sodium decreased, chest pain, disease progression, dysuria, fall, hydronephrosis. AVASTIN dosage: 660 MG, INTRAVENOUS. During the same period patient was treated with CARBOPLATIN, GEMCITABINE, ANZEMET, DECADRON, CELEBREX, PLAVIX, PLENDIL, LEVOXYL. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5233262-1
AVASTIN problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 26, 2007. Male patient, 70 years of age, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: deafness unilateral. AVASTIN dosage: 420 MG, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, OXALIPLATIN, LEUCOVORIN CALCIUM. Patient recovered.

Avastin Side Effects Report #5233264-5
Health Professional from UNITED STATES reported AVASTIN problem on Jan 24, 2007. Female patient, 77 years of age, was diagnosed with choroidal neovascularisation and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: detachment of retinal pigment epithelium. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5233286-4
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 25, 2007. Female patient, 47 years of age, weighting 89.95 lb, was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: bacteria urine identified, confusional state, culture urine positive, dehydration, disorientation, enterococcal infection, haemoglobin decreased, headache. AVASTIN dosage: 804 MG. During the same period patient was treated with ELOXATIN, ALIMTA, FOLIC ACID, B12, ALEVE, ADVIL, PRILOSEC. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5233287-6
Physician from UNITED STATES reported AVASTIN problem on Jan 25, 2007. Male patient, 68 years of age, weighting 179.7 lb, was diagnosed with bladder cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, haemoglobin decreased, platelet count decreased, urinary tract infection. AVASTIN dosage: 1260 MG DAYS 1+22, INTRAVENOUS. During the same period patient was treated with CISPLATIN, GEMCITABINE, AVINZA, ZOCOR, EFFEXOR, PRILOSEC. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5233417-6
AVASTIN problem was reported by a Consumer or non-health professional from FRANCE on Jan 22, 2007. Male patient, 65 years of age, weighting 207.2 lb, was diagnosed with metastases to liver and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain lower, peritonitis. AVASTIN dosage: 470 MG, UNK, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, ELOXATIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5233420-6
Physician from INDIA reported AVASTIN problem on Jan 24, 2007. Male patient was diagnosed with retinopathy of prematurity and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cataract. AVASTIN dosage: 0.75 MG, UNK, INTRAVITREAL. Patient recovered.

Avastin Side Effects Report #5233484-X
AVASTIN problem was reported by a Health Professional from UNITED KINGDOM on Jan 24, 2007. Male patient, 74 years of age, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: choroidal neovascularisation, detachment of retinal pigment epithelium. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5233487-5
Physician from NETHERLANDS reported AVASTIN problem on Jan 19, 2007. Male patient, 69 years of age, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: aneurysm ruptured, aortic aneurysm rupture, constipation, haemoglobin decreased, hypotension, shock. AVASTIN dosage: 548 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, OMEPRAZOLE, ACETAMINOPHEN, OXAZEPAM, AUGMENTIN, POTASSIUM CHLORIDE. Patient was hospitalized. Patient died on 12/05/2006.

Avastin Side Effects Report #5234205-7
AVASTIN problem was reported by a Physician from UNITED STATES on Jan 22, 2007. Female patient, 83 years of age, weighting 304.2 lb, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, blood pressure increased. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5235151-5
Health Professional from JAPAN reported AVASTIN problem on Jan 24, 2007. Male patient, 57 years of age, weighting 150.4 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: blood glucose increased, haematocrit decreased, haemoglobin decreased, rectal stenosis, red blood cell count decreased. AVASTIN dosage: 497 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, OXYCODONE, LOXONIN, NORVASC, BLOPRESS, PURSENNID, LAXOBERON. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5236339-X
AVASTIN problem was reported by a Physician from SWITZERLAND on Jan 23, 2007. Female patient, 63 years of age, was diagnosed with rectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: vitreous detachment. AVASTIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, OXALIPLATIN. Patient recovered.

Avastin Side Effects Report #5236356-X
Physician from AUSTRALIA reported AVASTIN problem on May 29, 2006. Male patient, 61 years of age, weighting 209.0 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: catheter site infection, wound dehiscence, wound infection staphylococcal. AVASTIN dosage: 475 MG, Q2W, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, LEUCOVORIN CALCIUM, FLUOROURACIL, VENTOLIN INHALER, SYMBICORT, TEMAZEPAM, ATROPINE, DOLASETRON. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5236428-X
AVASTIN problem was reported by a Physician from ITALY on Jan 25, 2007. Female patient, 59 years of age, weighting 123.5 lb, was diagnosed with colon cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiogenic shock, colon cancer, diarrhoea, pyrexia, renal failure acute. AVASTIN dosage: 400 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, IRINOTECAN. Patient was hospitalized. Patient died on 12/10/2006.

Avastin Side Effects Report #5236431-X
Physician from CANADA reported AVASTIN problem on Jan 24, 2007. Male patient, 72 years of age, weighting 198.2 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, embolism, loss of consciousness. AVASTIN dosage: unknown. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL, LEUCOVORIN CALCIUM, SPIRIVA, ADVAIR DISKUS, SALBUTAMOL, VASOTEC. Patient died on 01/18/2007.

Avastin Side Effects Report #5236626-5
AVASTIN problem was reported by a Health Professional from UNITED STATES on Jan 29, 2007. Female patient, 67 years of age, weighting 153.2 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: blood pressure systolic increased, chest pain, creatine phosphokinase decreased. AVASTIN dosage: 5 MG/KG. During the same period patient was treated with OXALIPLATIN, XELODA. Patient recovered.

Avastin Side Effects Report #5236643-5
Physician from UNITED STATES reported AVASTIN problem on Jan 29, 2007. Male patient, 73 years of age, weighting 153.0 lb, was diagnosed with lung neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, asthenia, blood bilirubin increased, haemoglobin decreased, hepatic enzyme increased, platelet count decreased, white blood cell count decreased. AVASTIN dosage: 1090 MG INTRAVENOUS. During the same period patient was treated with VICODIN, POTASSIUM, DECADRON. Patient died on 12/05/2006.

Avastin Side Effects Report #5237932-0
AVASTIN problem was reported by a Physician from JAPAN on Jan 26, 2007. Male patient, 57 years of age, weighting 150.4 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: anastomotic stenosis, blood glucose increased, carcinoembryonic antigen increased, constipation, haematocrit decreased, haemoglobin decreased, hypertrophy, mean cell volume increased, monocyte count increased. AVASTIN dosage: 497 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN, OXYCODONE, LOXONIN, NORVASC, BLOPRESS, PURSENNID, LAXOBERON. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5237933-2
Physician from BULGARIA reported AVASTIN problem on Jan 26, 2007. Male patient, 25 years of age, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: respiratory failure. AVASTIN dosage: 780 MG, Q3W, INTRAVENOUS. During the same period patient was treated with CAPECITABINE, OXALIPLATIN. Patient died on 01/17/2007.

Avastin Side Effects Report #5238991-1
AVASTIN problem was reported by a Health Professional from UNITED STATES on Feb 01, 2007. Male patient, 47 years of age, was diagnosed with lung neoplasm malignant and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: asthenia, lethargy, pneumonia, sepsis. AVASTIN dosage: 5 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with DOCETAXEL, CARBOPLATIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5239002-4
Consumer or non-health professional from UNITED STATES reported AVASTIN problem on Jan 31, 2007. Female patient, 71 years of age, weighting 123.5 lb, was diagnosed with angiosarcoma and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: aortic valve incompetence, chest pain, mitral valve incompetence, pericardial effusion. AVASTIN dosage: 15 MG, Q3W, INTRAVENOUS. During the same period patient was treated with VITAMIN, ANTIOXIDANT, TYLENOL, CALCIUM, ASPIRIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5239003-6
AVASTIN problem was reported by a Pharmacist from UNITED STATES on Feb 01, 2007. Female patient was diagnosed with non-small cell lung cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: retinal detachment. AVASTIN dosage: 15 MG/KG. Patient recovered.

Avastin Side Effects Report #5239005-X
Consumer or non-health professional from UNITED STATES reported AVASTIN problem on Jan 30, 2007. Female patient, 67 years of age, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: eye pain, ocular hyperaemia, photophobia, vision blurred, visual acuity reduced. AVASTIN dosage: unknown. Patient recovered.

Avastin Side Effects Report #5239085-1
AVASTIN problem was reported by a Physician from UNITED KINGDOM on Feb 08, 2007. Male patient, 56 years of age, weighting 138.9 lb, was diagnosed with colorectal cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: bile duct obstruction, cholestasis, diarrhoea, disease progression, metastases to liver. AVASTIN dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, DEXAMETHASONE. Patient recovered.

Avastin Side Effects Report #5242212-3
Consumer or non-health professional from FRANCE reported AVASTIN problem on Jan 29, 2007. Male patient, 79 years of age, was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: ulcerative keratitis. AVASTIN dosage: 0.02 ML, INTRAVITREAL. During the same period patient was treated with INDOMETHACIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5242805-3
AVASTIN problem was reported by a Health Professional from CANADA on Jan 24, 2007. Male patient, 72 years of age, weighting 198.2 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, embolism, loss of consciousness, resuscitation. AVASTIN dosage: 500 MG, Q2W, INTRAVENOUS; 675 MG, Q3W, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, SPIRIVA, LEUCOVORIN CALCIUM, FLUOROURACIL. Patient died on 01/18/2007.

Avastin Side Effects Report #5242808-9
Physician from CANADA reported AVASTIN problem on Jan 29, 2007. Female patient, 76 years of age, weighting 164.5 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: pyrexia. AVASTIN dosage: unknown. During the same period patient was treated with CAPECITABINE, DECADRON, ZOFRAN, OXALIPLATIN, LIPITOR. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5242895-8
AVASTIN problem was reported by a Physician from UNITED STATES on Feb 01, 2007. Female patient, 52 years of age, weighting 130.1 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: nasal septum perforation. AVASTIN dosage: 590 MG, Q4W, INTRAVENOUS. During the same period patient was treated with DIFLUCAN, MILES MAGICTURE, DILAUDID, ZOVIRAX, VISCOUS LIDOCAINE, AMITRIPTYLINE, SANDOSTATIN, FENTANYL CITRATE. Patient died on 10/01/2006.

Avastin Side Effects Report #5242956-3
Health Professional from UNITED STATES reported AVASTIN problem on Feb 05, 2007. Male patient, 58 years of age, weighting 196.0 lb, was diagnosed with glioblastoma multiforme and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: diabetic ketoacidosis, disease progression, haematemesis, hypertension. AVASTIN dosage: 795 MG, DAYS 1 + 22, INTRAVENOUS. During the same period patient was treated with IRINOTECAN, CELEXA, RITALIN, KEPPRA, PREVACID, LANTUS, INSULIN, ATIVAN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5243043-0
AVASTIN problem was reported by a Health Professional from UNITED STATES on Feb 01, 2007. Male patient, 62 years of age, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac failure congestive, cardiomyopathy, dyspnoea. AVASTIN dosage: 1370 MG, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, OXALIPLATIN. Patient was hospitalized. Patient recovered.

Avastin Side Effects Report #5243057-0
Health Professional from UNITED STATES reported AVASTIN problem on Feb 20, 2007. Female patient, 43 years of age, weighting 184.0 lb, was diagnosed with colorectal cancer metastatic and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: intestinal perforation. AVASTIN dosage: 800MG IV Q OTHER WEEK. During the same period patient was treated with DIOVAN ACT, TOPROL, PROZAC, COUMADIN, PREVACID, CELEBREX. Patient was hospitalized and became disabled. Patient recovered.

Avastin Side Effects Report #5243427-0
AVASTIN problem was reported by a Health Professional from CANADA on Jan 24, 2007. Male patient, 72 years of age, weighting 198.2 lb, was diagnosed with colon cancer and was treated with AVASTIN. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, embolism, loss of consciousness. AVASTIN dosage: 500 MG, Q2W, INTRAVENOUS; 675 MG, Q3W, INTRAVENOUS. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL, LEUCOVORIN CALCIUM, SPIRIVA, ADVAIR DISKUS, SALBUTAMOL, VASOTEC. Patient died on 01/18/2007.

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Drug Information: Bevacizumab Injection

URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607001.html

(be va siz' yoo mab)

IMPORTANT WARNING:

Bevacizumab may cause you to develop a hole in the wall of your stomach or intestine. This is a serious and possibly life-threatening condition. If you experience any of the following symptoms, call your doctor immediately: stomach pain, constipation, nausea, vomiting, or fever.Bevacizumab may slow the healing of wounds, such as cuts made by a doctor during surgery. In some cases, bevacizumab may cause a wound that has closed to split open. This is a serious and possibly life-threatening condition. If you experience this problem, call your doctor immediately. Tell your doctor if you have recently had surgery or if you plan to have surgery. If you have recently had surgery, you should not use bevacizumab until at least 28 days have passed and until the area has completed healed. If you are scheduled to have surgery, your doctor will stop your treatment with bevacizumab at least several weeks before the surgery.Bevacizumab may cause severe, life-threatening bleeding in the lungs of people who are using bevacizumab along with chemotherapy to treat lung cancer. Tell your doctor if you have recently coughed up blood or if you cough up blood at any time during your treatment.Talk to your doctor about the risks of using bevacizumab.

Why is this medication prescribed?

Bevacizumab is used with chemotherapy to treat cancer of the colon (large intestine) or rectum that has spread to other parts of the body. Bevacizumab is also used with chemotherapy to treat certain types of lung cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.

How should this medicine be used?

Bevacizumab comes as a solution to administer slowly into a vein. Bevacizumab is administered by a doctor or nurse in a medical office, infusion center, or hospital. Bevacizumab is usually given once every 2 weeks to treat cancer of the colon or rectum and once every 3 weeks to treat lung cancer.

It should take 90 minutes for you to receive your first dose of bevacizumab. A doctor or nurse will watch you closely to see how your body reacts to bevacizumab. If you do not have any serious problems when you receive your first dose of bevacizumab, it will usually take 30 to 60 minutes for you to receive each of your remaining doses of the medication.

Other uses for this medicine

Bevacizumab is also sometimes used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities) and other types of cancer. Talk to your doctor about the risks of using bevacizumab to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving bevacizumab,

tell your doctor and pharmacist if you are allergic to bevacizumab or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (blood thinners) such as warfarin (Coumadin) and irinotecan (Camptosar). Also tell your doctor if you are taking or if you have ever taken an anthracycline (a type of chemotherapy used for breast cancer and some types of leukemia) such as daunorubicin (Cerubidine), doxorubicin (Adriamycin, Rubex), epirubicin (Ellence), or idarubicin (Idamycin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have ever been treated with radiation therapy to the left side of your chest, and if you have or have ever had cancer that spread to your brain or spine, high blood pressure, or any condition that affects your heart or blood vessels (tubes that move blood between the heart and other parts of the body).
tell your doctor if you are pregnant or plan to become pregnant. Bevacizumab may harm the fetus and increase the risk of a pregnancy loss. You should use birth control to prevent pregnancy during your treatment with bevacizumab and for some time after you stop using the medication. If you become pregnant while using bevacizumab, call your doctor.
tell your doctor if you are breast-feeding. You should not breastfeed during your treatment with bevacizumab and for some time after you stop using the medication.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you miss an appointment to receive a dose of bevacizumab, call your doctor as soon as possible.

What side effects can this medication cause?

Bevacizumab may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

dizziness
fainting
nosebleeds
bleeding gums
weakness
loss of appetite
heartburn
change in ability to taste food
diarrhea
weight loss
dry mouth
sores on the skin or in the mouth
voice changes

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

nosebleeds that cause dizziness or fainting or that do not stop after 10 to 15 minutes
unusual bruising or bleeding
black or bloody stools
bright red blood in stools
vomit that is bloody or looks like coffee grounds
coughing, gagging, or choking after eating or drinking
severe vaginal bleeding
headache
neck pain
slow or difficult speech
dizziness or faintness
weakness or numbness of an arm or leg
chest pain
pain in the arms, neck, or upper back
shortness of breath
seizures
extreme tiredness
confusion
change in vision or loss of vision
sore throat, fever, chills, and other signs of infection
swelling of the face, eyes, stomach, hands, feet, ankles, or lower legs
unexplained weight gain
foamy urine
dry, hacking cough
pain, tenderness, warmth, redness, or swelling in one leg only
redness, itching, or scaling of the skin

Bevacizumab may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

What storage conditions are needed for this medicine?

Bevacizumab will be stored in the medical office, infusion center, or hospital.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

headache

What other information should I know?

Keep all appointments with your doctor. Your doctor will check your blood pressure and test your urine regularly during your treatment with bevacizumab.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

Avastin®

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