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Benadryl Side Effects

PatientsVille

Common Benadryl Side Effects


The most commonly reported Benadryl side effects (click to view or check a box to report):

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Rash (68)
Headache (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Feeling Abnormal (49)
Heart Rate Increased (49)
Hallucination (48)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Benadryl Side Effects Reported to FDA



Benadryl Side Effect Report#9603837
Dyspnoea, Chest Pain, Swelling Face, Lip Swelling, Acne, Paraesthesia Oral, Off Label Use, Hypersensitivity, Chest Discomfort
This is a report of a 54-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: insomnia, who was treated with Benadryl Allergy Ultratab (dosage: NA, start time:
Aug 16, 2013), combined with: NA. and developed a serious reaction and side effect(s): Dyspnoea, Chest Pain, Swelling Face, Lip Swelling, Acne, Paraesthesia Oral, Off Label Use, Hypersensitivity, Chest Discomfort after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Ultratab treatment in female patients, resulting in Dyspnoea side effect. The patient was hospitalized.
Benadryl Side Effect Report#9570851
Dyspnoea, Hypersensitivity
This report suggests a potential Benadryl Allergy Ultratab Dyspnoea side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypersensitivity and used Benadryl Allergy Ultratab (dosage: NA) starting NS. After starting Benadryl Allergy Ultratab the patient began experiencing various side effects, including: Dyspnoea, HypersensitivityAdditional drugs used concurrently: NA.The patient was hospitalized. Although Benadryl Allergy Ultratab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dyspnoea, may still occur.
Benadryl Side Effect Report#9563921
Unevaluable Event, Delusion, Heart Rate Increased
This Unevaluable Event problem was reported by a health professional from CA. A 16-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: euphoric mood. On
Sep 20, 2013 this consumer started treatment with Benadryl (dosage: NA). The following drugs were being taken at the same time: NA. When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Unevaluable Event, Delusion, Heart Rate IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Unevaluable Event, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9554581
Erectile Dysfunction, Product Label Issue
This Erectile Dysfunction side effect was reported by a consumer or non-health professional from US. A 38-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on
Aug 25, 2013. Concurrently used drugs: NA..After starting to take Benadryl the consumer reported adverse symptoms, such as: Erectile Dysfunction, Product Label IssueThese side effects may potentially be related to Benadryl.
Benadryl Side Effect Report#9553700
Cardiac Failure, Hypercapnia
This is a report of a 46-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: insomnia, who was treated with Benadryl (dosage: NA, start time: NS), combined with:
  • Unisom
and developed a serious reaction and side effect(s): Cardiac Failure, Hypercapnia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in male patients, resulting in Cardiac Failure side effect.
Benadryl Side Effect Report#9530818
Application Site Reaction, Swelling Face, Eye Swelling, Off Label Use, Rash, Rash
This report suggests a potential Benadryl Allergy Ultratab Application Site Reaction side effect(s) that can have serious consequences. A 31-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: pruritus,anxiety and used Benadryl Allergy Ultratab (dosage: NA) starting 2012. After starting Benadryl Allergy Ultratab the patient began experiencing various side effects, including: Application Site Reaction, Swelling Face, Eye Swelling, Off Label Use, Rash, RashAdditional drugs used concurrently:
  • Prozac
Although Benadryl Allergy Ultratab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Application Site Reaction, may still occur.
Benadryl Side Effect Report#9526115
Anaphylactic Shock, Condition Aggravated, Anxiety
This Anaphylactic Shock problem was reported by a health professional from CA. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: eye pruritus,swelling face. On
Sep 11, 2011 this consumer started treatment with Benadryl Rs Allergy (dosage: 1-2). The following drugs were being taken at the same time: NA. When using Benadryl Rs Allergy, the patient experienced the following unwanted symptoms/side effects: Anaphylactic Shock, Condition Aggravated, AnxietyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Anaphylactic Shock, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9526019
Anaphylactic Shock, Dyspnoea
This Anaphylactic Shock side effect was reported by a consumer or non-health professional from US. A 61-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Benadryl the consumer reported adverse symptoms, such as: Anaphylactic Shock, DyspnoeaThese side effects may potentially be related to Benadryl.
Benadryl Side Effect Report#9520679
Accidental Exposure To Product
This is a report of a 3-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: accidental exposure to product, who was treated with Benadryl (dosage: NA, start time:
Jan 14, 2013), combined with: NA. and developed a serious reaction and side effect(s): Accidental Exposure To Product after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in female patients, resulting in Accidental Exposure To Product side effect. The patient was hospitalized.
Benadryl Side Effect Report#9517924
Hypersensitivity, Swelling Face, Eye Swelling, Pruritus, Pruritus, Skin Exfoliation
This report suggests a potential Benadryl Hypersensitivity side effect(s) that can have serious consequences. A 55-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Benadryl (dosage: NA) starting NS. After starting Benadryl the patient began experiencing various side effects, including: Hypersensitivity, Swelling Face, Eye Swelling, Pruritus, Pruritus, Skin ExfoliationAdditional drugs used concurrently: NA. Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypersensitivity, may still occur.
Benadryl Side Effect Report#9517870
Dysphemia, Fear
This Dysphemia problem was reported by a consumer or non-health professional from US. A 65-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: multiple allergies. On
Jul 29, 2013 this consumer started treatment with Benadryl (dosage: 1 Pill). The following drugs were being taken at the same time:
  • Enalapril
  • Hydrochlorothiazide
  • Arcapta
  • Evista
  • Fish Oil
When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Dysphemia, FearAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dysphemia, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9517562
Coeliac Disease
This Coeliac Disease side effect was reported by a consumer or non-health professional from US. A 48-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Benadryl Allergy Ultratab (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Benadryl Allergy Ultratab the consumer reported adverse symptoms, such as: Coeliac DiseaseThese side effects may potentially be related to Benadryl Allergy Ultratab.
Benadryl Side Effect Report#9499349
Pneumonia, Arthritis, Gait Disturbance, Off Label Use
This is a report of a 92-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Benadryl (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pneumonia, Arthritis, Gait Disturbance, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in female patients, resulting in Pneumonia side effect. The patient was hospitalized.
Benadryl Side Effect Report#9493153
Food Allergy, Local Swelling, Arthralgia, Off Label Use, Urticaria, Diarrhoea, Dyspepsia, Headache
This report suggests a potential Benadryl Rs Allergy 25mg Caplets Food Allergy side effect(s) that can have serious consequences. A 58-year-old female patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: allergy to arthropod sting and used Benadryl Rs Allergy 25mg Caplets (dosage: 1-2 Caplets) starting
Aug 12, 2013. After starting Benadryl Rs Allergy 25mg Caplets the patient began experiencing various side effects, including: Food Allergy, Local Swelling, Arthralgia, Off Label Use, Urticaria, Diarrhoea, Dyspepsia, HeadacheAdditional drugs used concurrently: NA. Although Benadryl Rs Allergy 25mg Caplets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Food Allergy, may still occur.
Benadryl Side Effect Report#9479585
Amphetamines Positive
This Amphetamines Positive problem was reported by a consumer or non-health professional from US. A 47-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: seasonal allergy. On NS this consumer started treatment with Benadryl Allergy Ultratab (dosage: NA). The following drugs were being taken at the same time: NA. When using Benadryl Allergy Ultratab, the patient experienced the following unwanted symptoms/side effects: Amphetamines PositiveAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Amphetamines Positive, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9475543
Lip Swelling, Respiratory Arrest
This Lip Swelling side effect was reported by a consumer or non-health professional from US. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: food allergy.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Benadryl the consumer reported adverse symptoms, such as: Lip Swelling, Respiratory ArrestThese side effects may potentially be related to Benadryl.
Benadryl Side Effect Report#9472106
Dyspnoea, Local Swelling, Product Packaging Issue
This is a report of a 80-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: pruritus,arthropod bite, who was treated with Benadryl Extra Strength Itch Cooling Spray. (dosage: Covered Entire Ankle Area, Once, start time: 1998), combined with: NA. and developed a serious reaction and side effect(s): Dyspnoea, Local Swelling, Product Packaging Issue after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Extra Strength Itch Cooling Spray. treatment in female patients, resulting in Dyspnoea side effect.
Benadryl Side Effect Report#9466045
Head Discomfort, Loss Of Consciousness, Gait Disturbance, Malaise
This report suggests a potential Benadryl Allergy Dye-free Head Discomfort side effect(s) that can have serious consequences. A 80-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple allergies,hypersensitivity and used Benadryl Allergy Dye-free (dosage: One Softgel) starting 2012. After starting Benadryl Allergy Dye-free the patient began experiencing various side effects, including: Head Discomfort, Loss Of Consciousness, Gait Disturbance, MalaiseAdditional drugs used concurrently:
  • Singulair
  • Claritin
Although Benadryl Allergy Dye-free demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Head Discomfort, may still occur.
Benadryl Side Effect Report#9456965
Hypersensitivity, Blister, Rash, Local Swelling, Off Label Use, Therapeutic Response Unexpected, Pruritus
This Hypersensitivity problem was reported by a consumer or non-health professional from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: rash,pruritus. On
Jul 31, 2013 this consumer started treatment with Benadryl (dosage: A Pea Size Amount On Each Hand Twice). The following drugs were being taken at the same time: NA. When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Hypersensitivity, Blister, Rash, Local Swelling, Off Label Use, Therapeutic Response Unexpected, PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypersensitivity, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9454840
Disorientation, Euphoric Mood, Overdose
This Disorientation side effect was reported by a consumer or non-health professional from US. A 16-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Benadryl Allergy (drug dosage: NA), which was initiated on
Jul 27, 2013. Concurrently used drugs: NA..After starting to take Benadryl Allergy the consumer reported adverse symptoms, such as: Disorientation, Euphoric Mood, OverdoseThese side effects may potentially be related to Benadryl Allergy.
Benadryl Side Effect Report#9454838
Anaphylactic Reaction
This is a report of a 62-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Benadryl (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Anaphylactic Reaction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl treatment in female patients, resulting in Anaphylactic Reaction side effect.
Benadryl Side Effect Report#9436236
Completed Suicide, Mechanical Ventilation, Unresponsive To Stimuli, Overdose, Convulsion
This report suggests a potential Benadryl Completed Suicide side effect(s) that can have serious consequences. A 41-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Benadryl (dosage: NA) starting NS. After starting Benadryl the patient began experiencing various side effects, including: Completed Suicide, Mechanical Ventilation, Unresponsive To Stimuli, Overdose, ConvulsionAdditional drugs used concurrently:
  • Xanax
The patient was hospitalized. Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Benadryl Side Effect Report#9433923
Failure To Thrive, Cachexia, Malnutrition, Dehydration, Renal Failure Acute, Hepatorenal Syndrome
This Failure To Thrive problem was reported by a physician from US. A 51-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hypersensitivity. On
Apr 25, 2013 this consumer started treatment with Benadryl (dosage: 50 Mg, Cyclic (day 1, 8 And 15) Every 21 Days). The following drugs were being taken at the same time: NA. When using Benadryl, the patient experienced the following unwanted symptoms/side effects: Failure To Thrive, Cachexia, Malnutrition, Dehydration, Renal Failure Acute, Hepatorenal SyndromeThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Failure To Thrive, may become evident only after a product is in use by the general population.
Benadryl Side Effect Report#9431518
Urinary Tract Infection, Pruritus
This Urinary Tract Infection side effect was reported by a consumer or non-health professional from US. A 59-year-old female patient (weight:NA) experienced the following symptoms/conditions: insomnia,pruritus.The patient was prescribed Benadryl (drug dosage: NA), which was initiated on 2000. Concurrently used drugs: NA..After starting to take Benadryl the consumer reported adverse symptoms, such as: Urinary Tract Infection, PruritusThese side effects may potentially be related to Benadryl.
Benadryl Side Effect Report#9426275
Dyspnoea
This is a report of a 63-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: multiple allergies, who was treated with Benadryl Allergy Dye-free Soft (dosage: 2 Weeks, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Dyspnoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Dye-free Soft treatment in female patients, resulting in Dyspnoea side effect.


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The appearance of Benadryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Benadryl Side Effects for Women?

Women Side EffectsReports
Dyspnoea 99
Off Label Use 95
Hypersensitivity 77
Nausea 73
Urticaria 60
Dizziness 56
Headache 52
Vomiting 52
Somnolence 51
Pain 50

What are common Benadryl Side Effects for Men?

Men Side EffectsReports
Off Label Use 44
Dyspnoea 38
Loss Of Consciousness 32
Overdose 29
Nausea 27
Somnolence 27
Urticaria 25
Vomiting 23
Hypersensitivity 21
Infusion Related Reaction 21

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Benadryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Benadryl for You?

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    Benadryl Safety Alerts, Active Ingredients, Usage Information

    NDC21695-811
    TypeHUMAN OTC DRUG
    Proprietary NameBenadryl Allergy
    NameDiphenhydramine Hydrochloride
    Dosage FormTABLET, COATED
    RouteORAL
    On market since20090101
    LabelerRebel Distributors Corp
    Active Ingredient(s)DIPHENHYDRAMINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma Class

    Benadryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1568

    Benadryl safety alerts: 2010

    Reported deaths: 82

    Reported hospitalizations: 340

    Latest Benadryl clinical trials