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Benadryl Side Effects

Common Benadryl Side Effects


The most commonly reported Benadryl side effects (click to view or check a box to report):

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Rash (68)
Headache (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Feeling Abnormal (49)
Heart Rate Increased (49)
Hallucination (48)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Benadryl Side Effects Reported to FDA

The following Benadryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Benadryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Jaundice, Hepatic Enzyme Increased, Hepatic Pain, Renal Pain, Off Label Use
This is a report of a 55-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: nasal congestion,multiple allergies, who was treated with Benadryl Allergy Dye-free (dosage: NA, start time: Jan 11, 2014), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Jaundice
  • Hepatic Enzyme Increased
  • Hepatic Pain
  • Renal Pain
  • Off Label Use
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Dye-free treatment in male patients, resulting in jaundice side effect.

Hypotension
This report suggests a potential Benadryl Allergy Hypotension side effect(s) that can have serious consequences. A 73-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Benadryl Allergy (dosage: Nightly At 9pm) starting Oct 10, 2006. Soon after starting Benadryl Allergy the patient began experiencing various side effects, including:
  • Hypotension
Drugs used concurrently:
  • Bayer Aspirin
  • Amlodipine (3 Years Ago)
  • Coreg (2 Years Ago)
  • Simvastatin (3 Years Ago)
  • Doxazosin (5 Years Ago)
Although Benadryl Allergy demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hypotension, may still occur.

Cough, Wheezing, Swollen Tongue, Pharyngeal Oedema
This Cough, Wheezing, Swollen Tongue, Pharyngeal Oedema problem was reported by a health professional from US. A 57-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Aug 28, 2013 this consumer started treatment with Benadryl (dosage: NA). The following drugs were being taken at the same time:
  • Solu-medrol
  • Albuterol
  • Plavix
  • Pepcid
  • Lexapro
  • Aspirin
  • Isovue 370
  • Lipitor
When commencing Benadryl, the patient experienced the following unwanted symptoms/side effects:
  • Cough
  • Wheezing
  • Swollen Tongue
  • Pharyngeal Oedema
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as cough, may become evident only after a product is in use by the general population.

Confusional State
This is a report of a 72-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Benadryl (dosage: NA) starting Feb 07, 2013. Concurrently used drugs:
  • Prednisone
  • Isovue 300
Soon after that, the consumer experienced the following side effects:
  • Confusional State
The patient was hospitalized. This opens a possibility that Benadryl treatment could cause the above reactions, including confusional state, and some female subjects may be more susceptible.


Perirectal Abscess, Urinary Retention, Constipation
A 60-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Benadryl treatment (dosage: NA) on NS. Soon after starting Benadryl treatment, the subject experienced various side effects, including:
  • Perirectal Abscess
  • Urinary Retention
  • Constipation
Concurrently used drugs:
  • Furosemide
  • Gabapentin
  • Diphenhydramine/paracetamol/ Pseudoephedrine
This finding indicates that some male patients could be more vulnerable to Benadryl.

Hallucination, Abnormal Behaviour
A 74-year-old female patient from US (weight: NA) experienced symptoms, such as: multiple allergies and was treated with Benadryl Ultra Tab(dosage: NA). The treatment was initiated on 2010. After that a consumer reported the following side effect(s):
  • Hallucination
  • Abnormal Behaviour
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Benadryl Ultra Tab efficacy: NA.

Neuropathy Peripheral, Chills
In this report, Benadryl Allergy Dye-free Soft Gel was administered for the following condition: NA.A 55-year-old male consumer from US (weight: NA) started Benadryl Allergy Dye-free Soft Gel treatment (dosage: NA) on Dec 26, 2013.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Neuropathy Peripheral
  • Chills
A possible interaction with other drugs could have contributed to this reaction:
  • Copaxone
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Benadryl Allergy Dye-free Soft Gel treatment could be related to the listed above side effect(s).

Blood Pressure Increased, Palpitations, Hyperhidrosis, Tremor
This is a report of the following Benadryl D side effect(s):
  • Blood Pressure Increased
  • Palpitations
  • Hyperhidrosis
  • Tremor
A 74-year-old female patient from US (weight: NA) presented with the following condition: nasal congestion,sinus disorder and received a treatment with Benadryl D (dosage: Nightly) starting: Dec 18, 2013.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Benadryl D treatment could be associated with the listed above side effect(s).

Syncope, Thermal Burn
This Benadryl Rs Allergy 25 Mg report was submitted by a 27-year-old female consumer from CA (weight: NA). The patient was diagnosed with: hypersensitivity,transient ischaemic attack,vitamin supplementation,blood pressure and Benadryl Rs Allergy 25 Mg was administered (dosage: Half Tablet As Needed Every 12 To 24 Hours) starting: NS. The consumer developed a set of symptoms:
  • Syncope
  • Thermal Burn
Other drugs used simultaneously:
  • Aspirin
  • Vitamin D3
  • Indapamide
  • Apo-ramipril
Those unexpected symptoms could be linked to a Benadryl Rs Allergy 25 Mg treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Formication, Dysuria, Off Label Use, Pruritus
This is a report of a possible correlation between Benadryl Allergy Kapgels use and the following symptoms/side effect(s):
  • Formication
  • Dysuria
  • Off Label Use
  • Pruritus
which could contribute to an assessment of Benadryl Allergy Kapgels risk profile.A 65-year-old female consumer from CA (weight: NA) was suffering from headache,insomnia and was treated with Benadryl Allergy Kapgels (dosage: 1 Kapgel 2 Or 3 Times) starting NS.Other concurrent medications: NA.


A 10-year-old female patient from CA (weight: NA) presented with the following symptoms: NA and after a treatment with Benadryl (dosage: NA) experienced the following side effect(s):
    The treatment was started on NS. Benadryl was used in combination with the following drugs: NA.This report could alert potential Benadryl consumers.

    Suprapubic Pain, Nephropathy Toxic, Renal Impairment, Electrocardiogram Change, Urinary Retention
    In this report, a 61-year-old male patient from US (weight: NA) was affected by a possible Benadryl side effect.The patient was diagnosed with pruritus. After a treatment with Benadryl (dosage: NA, start date: NS), the patient experienced the following side effect(s):
    • Suprapubic Pain
    • Nephropathy Toxic
    • Renal Impairment
    • Electrocardiogram Change
    • Urinary Retention
    The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Benadryl treatment.

    Convulsion, Psychotic Disorder
    This is a report of a 22-year-old male patient from US (weight: NA), who used Benadryl (dosage: NA) for a treatment of NA. After starting a treatment on Oct 24, 2013, the patient experienced the following side effect(s):
    • Convulsion
    • Psychotic Disorder
    The following drugs could possibly have interacted with the Benadryl treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Benadryl treatment could be related to side effect(s), such as Convulsion, Psychotic Disorder.

    Diabetes Mellitus, Blood Cholesterol Abnormal, Dry Throat, Hunger
    This diabetes mellitus side effect was reported by a health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: multiple allergies,depression,hypotonia,fluid retention,anxiety,dizziness. The patient was prescribed Benadryl (dosage: NA), which was started on NS. Concurrently used drugs:
    • Pristiq
    • Zanaflex
    • Lasix
    • Vistaril (50 Mg Oral Capsule 3 Times A Day And 2 Capsules Of 50 Mg During Bed Time)
    • Meclizine (As Needed)
    When starting to take Benadryl the consumer reported the following symptoms:
    • Diabetes Mellitus
    • Blood Cholesterol Abnormal
    • Dry Throat
    • Hunger
    These side effects may potentially be related to Benadryl.

    Blister, Pain In Extremity
    This is a Benadryl Topical Extra Strength Cream side effect report of a 54-year-old female patient (weight:NA) from US, suffering from the following symptoms/conditions: rash,gastrooesophageal reflux disease,routine health maintenance, who was treated with Benadryl Topical Extra Strength Cream (dosage:A Pea Size, start time: 2003), combined with:
    • Omeprazole
    • Centrum Nos
    , and developed a serious reaction and a blister side effect. The patient presented with:
    • Blister
    • Pain In Extremity
    which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Benadryl Topical Extra Strength Cream treatment in female patients suffering from rash,gastrooesophageal reflux disease,routine health maintenance, resulting in blister.

    Oxygen Saturation Decreased, Sensation Of Foreign Body, Off Label Use, Blood Pressure Decreased, Periorbital Oedema
    This report suggests a potential Benadryl oxygen saturation decreased side effect(s) that can have serious consequences. A 57-year-old female patient from CA (weight:NA) was diagnosed with the following health condition(s): hypersensitivity,psoriatic arthropathy and used Benadryl (dosage: NA) starting Feb 27, 2013. Soon after starting Benadryl the patient began experiencing various side effects, including:
    • Oxygen Saturation Decreased
    • Sensation Of Foreign Body
    • Off Label Use
    • Blood Pressure Decreased
    • Periorbital Oedema
    Drugs used concurrently:
    • Remicade
    • Epinephrine
    Although Benadryl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as oxygen saturation decreased, may still occur.

    Mental Disorder, Disturbance In Attention, Memory Impairment, Dysarthria
    This mental disorder problem was reported by a consumer or non-health professional from US. A 42-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Benadryl Allergy Dye Free (dosage: NA). The following drugs/medications were being taken at the same time:
    • Ambien
    • Lamictal
    • Haldol
    When commencing Benadryl Allergy Dye Free, the patient experienced the following unwanted symptoms /side effects:
    • Mental Disorder
    • Disturbance In Attention
    • Memory Impairment
    • Dysarthria
    Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as mental disorder, may become evident only after a product is in use by the general population.

    Neoplasm Malignant, Haemoglobin Decreased, Blood Creatinine Increased, Agitation, Pain In Extremity, Paraesthesia, Musculoskeletal Stiffness, Abdominal Discomfort
    This is a Benadryl side effect report of a 64-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Benadryl (dosage: NA) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
    • Neoplasm Malignant
    • Haemoglobin Decreased
    • Blood Creatinine Increased
    • Agitation
    • Pain In Extremity
    • Paraesthesia
    • Musculoskeletal Stiffness
    • Abdominal Discomfort
    This opens a possibility that Benadryl could cause neoplasm malignant and that some male patients may be more susceptible.

    Faeces Discoloured, Hyperhidrosis
    A 70-year-old female patient (weight: NA) from US with the following symptoms: NA started Benadryl treatment (dosage: NA) on Oct 25, 2013. Soon after starting Benadryl treatment, the consumer experienced several side effects, including:
    • Faeces Discoloured
    • Hyperhidrosis
    . Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Benadryl side effects, such as faeces discoloured.

    Mania, Insomnia, Logorrhoea, Formication
    This mania side effect was reported by a consumer or non-health professional from CA. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: rhinorrhoea,eye pruritus,multiple allergies.The patient was prescribed Benadryl Nightime Es Allergy (dosage: Taken At Night), which was started on Oct 29, 2013. Concurrently used drugs: NA..When starting to take Benadryl Nightime Es Allergy the consumer reported symptoms, such as:
    • Mania
    • Insomnia
    • Logorrhoea
    • Formication
    These side effects may potentially be related to Benadryl Nightime Es Allergy.

    Tremor, Off Label Use
    This is a report of a 50-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: restlessness,psychotic disorder,anxiety, who was treated with Benadryl Allergy Ultratab (dosage: 1/4 Tablet, start time: Oct 14, 2013), combined with:
    • Latuda
    • Zoloft
    • Zoloft
    and developed a serious reaction and side effect(s). The consumer presented with:
    • Tremor
    • Off Label Use
    which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Benadryl Allergy Ultratab treatment in male patients, resulting in tremor side effect.

    Loss Of Consciousness, Urinary Incontinence
    This report suggests a potential Benadryl Allergy Ultratab Loss Of Consciousness, Urinary Incontinence side effect(s) that can have serious consequences. A 40-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: urticaria and used Benadryl Allergy Ultratab (dosage: When Needed) starting Oct 12, 2013. Soon after starting Benadryl Allergy Ultratab the patient began experiencing various side effects, including:
    • Loss Of Consciousness
    • Urinary Incontinence
    Drugs used concurrently:
    • Benadryl Topical Extra Strength (When Needed)
    Although Benadryl Allergy Ultratab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as loss of consciousness, may still occur.

    Retinal Vascular Thrombosis, Optic Neuropathy, Hypotension, Product Label Issue
    This Retinal Vascular Thrombosis, Optic Neuropathy, Hypotension, Product Label Issue problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: upper-airway cough syndrome,allergic sinusitis. On NS this consumer started treatment with Benadryl Liquid (dosage: Many Years Ago). The following drugs were being taken at the same time: NA. When commencing Benadryl Liquid, the patient experienced the following unwanted symptoms/side effects:
    • Retinal Vascular Thrombosis
    • Optic Neuropathy
    • Hypotension
    • Product Label Issue
    Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as retinal vascular thrombosis, may become evident only after a product is in use by the general population.

    Intestinal Haemorrhage
    This is a report of a 46-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: seasonal allergy and was treated with Benadryl Allergy (dosage: 4-6 Hours) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
    • Intestinal Haemorrhage
    This opens a possibility that Benadryl Allergy treatment could cause the above reactions, including intestinal haemorrhage, and some male subjects may be more susceptible.

    Dyspnoea, Pharyngeal Oedema, Lip Swelling, Eye Swelling, Hypersensitivity
    A 25-year-old female patient (weight: NA) from US with the following symptoms/conditions: seasonal allergy started Benadryl Allergy Kapgels treatment (dosage: 1 Kapgel Once) on NS. Soon after starting Benadryl Allergy Kapgels treatment, the subject experienced various side effects, including:
    • Dyspnoea
    • Pharyngeal Oedema
    • Lip Swelling
    • Eye Swelling
    • Hypersensitivity
    Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Benadryl Allergy Kapgels.

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    Top 10 Benadryl Side Effects for Women

    Women Side EffectsReports
    Dyspnoea 99
    Off Label Use 95
    Hypersensitivity 77
    Nausea 73
    Urticaria 60
    Dizziness 56
    Headache 52
    Vomiting 52
    Somnolence 51
    Pain 50

    Top 10 Benadryl Side Effects for Men

    Men Side EffectsReports
    Off Label Use 44
    Dyspnoea 38
    Loss Of Consciousness 32
    Overdose 29
    Nausea 27
    Somnolence 27
    Urticaria 25
    Vomiting 23
    Hypersensitivity 21
    Infusion Related Reaction 21

    Keep Track of Side Effects

    Note Your Observations

    It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

    Why Your Notes are Important

    Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Benadryl Side Effects

    Did You Have a Benadryl Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Benadryl for You?

    Exceeded Expectations
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    Benadryl Safety Alerts, Active Ingredients, Usage Information

    NDC21695-811
    TypeHUMAN OTC DRUG
    Proprietary NameBenadryl Allergy
    NameDiphenhydramine Hydrochloride
    Dosage FormTABLET, COATED
    RouteORAL
    On market since20090101
    LabelerRebel Distributors Corp
    Active Ingredient(s)DIPHENHYDRAMINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma Class

    Benadryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1568

    Benadryl safety alerts: 2010

    Reported deaths: 82

    Reported hospitalizations: 340

    Benadryl Extra Strength Itch Stopping Gel: Packaging Changes to Reduce Use Errors

    Audience: Consumers, Pharmacists

    [Posted 05/12/2010] Johnson & Johnson and FDA notified consumers and healthcare professionals of changes to the graphics and information displayed on the front of the product container to reduce the risk of serious side effects from swallowing the topical Benadryl Extra Strength Itch Stopping Gel intended ??For Skin Use Only". FDA received reports of consumers ingesting the gel rather than using it topically. Swallowing the gel can result in people receiving dangerously large amounts of the active ingredient diphenhydramine.

    Between 2001 and 2009, 121 cases of ingestion of Benadryl Extra Strength Itch Relief Gel were reported to the manufacturer. Of these cases, 7 were considered serious because patients required treatment in the emergency room, hospitalization, or admission to the intensive care unit. Others reported adverse events included hallucinations, unconsciousness, sleepiness, difficulty walking, dizziness and inability to speak.

    [05/12/2010 - Drug Safety Communication - FDA]

    [05/12/2010 - Consumer Update - FDA]

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