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Benadryl Side Effects

Common Benadryl Side Effects

The most commonly reported Benadryl side effects (click to view or check a box to report):

Off Label Use (140)
Dyspnoea (137)
Nausea (100)
Hypersensitivity (99)
Urticaria (85)
Somnolence (78)
Dizziness (76)
Vomiting (75)
Loss Of Consciousness (72)
Rash (68)
Headache (68)
Pruritus (67)
Pain (66)
Overdose (63)
Product Quality Issue (61)
Condition Aggravated (56)
Insomnia (50)
Feeling Abnormal (49)
Heart Rate Increased (49)
Hallucination (48)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Benadryl Side Effects Reported to FDA

The following Benadryl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Benadryl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Jaundice, Hepatic Enzyme Increased, Hepatic Pain, Renal Pain, Off Label Use
on Mar 06, 2014 Male from US , 55 years of age, was diagnosed with and was treated with Benadryl Allergy Dye-free. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: jaundice, hepatic enzyme increased, hepatic pain, renal pain, off label use. Benadryl Allergy Dye-free dosage: N/A.

Hypotension
Patient was taking Benadryl Allergy. Patient felt the following Benadryl side effects: hypotension on Mar 26, 2014 from US Additional patient health information: Male , 73 years of age, weighting 180.0 lb, . Benadryl Allergy dosage: Nightly At 9pm.
Multiple prescriptions taken:
  • Bayer Aspirin
  • Amlodipine (3 Years Ago)
  • Coreg (2 Years Ago)
  • Simvastatin (3 Years Ago)
  • Doxazosin (5 Years Ago)


Cough, Wheezing, Swollen Tongue, Pharyngeal Oedema
Adverse event was reported on Feb 26, 2014 by a Female taking Benadryl (Dosage: N/A) . Location: US , 57 years of age, weighting 205.0 lb, After Benadryl was administered, patient encountered several Benadryl side effects: cough, wheezing, swollen tongue, pharyngeal oedema.
Multiple concurrent drugs taken:
  • Solu-medrol
  • Albuterol
  • Plavix
  • Pepcid
  • Lexapro
  • Aspirin
  • Isovue 370
  • Lipitor


Confusional State
on Feb 26, 2014 Female from US , 72 years of age, was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: confusional state. Benadryl dosage: N/A.
Associated medications used:
  • Prednisone
  • Isovue 300
Patient was hospitalized.


Perirectal Abscess, Urinary Retention, Constipation
on Feb 05, 2014 Male from US , 60 years of age, was treated with Benadryl. Patient felt the following Benadryl side effects: perirectal abscess, urinary retention, constipation. Benadryl dosage: N/A.
Multiple prescriptions taken:
  • Furosemide
  • Gabapentin
  • Diphenhydramine/paracetamol/ Pseudoephedrine


Hallucination, Abnormal Behaviour
Patient was taking Benadryl Ultra Tab. After Benadryl was administered, patient encountered several Benadryl side effects: hallucination, abnormal behaviour on Jan 21, 2014 from US Additional patient health information: Female , 74 years of age, weighting 157.0 lb, was diagnosed with and. Benadryl Ultra Tab dosage: N/A.

Neuropathy Peripheral, Chills
Adverse event was reported on Jan 22, 2014 by a Male taking Benadryl Allergy Dye-free Soft Gel (Dosage: N/A) . Location: US , 55 years of age, Directly after, patient experienced the unwanted or unexpected Benadryl side effects: neuropathy peripheral, chills.
Associated medications used:
  • Copaxone


Blood Pressure Increased, Palpitations, Hyperhidrosis, Tremor
on Jan 02, 2014 Female from US , 74 years of age, weighting 110.0 lb, was diagnosed with and was treated with Benadryl D. Patient felt the following Benadryl side effects: blood pressure increased, palpitations, hyperhidrosis, tremor. Benadryl D dosage: Nightly.

Syncope, Thermal Burn
on Dec 26, 2013 Female from CA , 27 years of age, weighting 105.0 lb, was diagnosed with and was treated with Benadryl Rs Allergy 25 Mg. After Benadryl was administered, patient encountered several Benadryl side effects: syncope, thermal burn. Benadryl Rs Allergy 25 Mg dosage: Half Tablet As Needed Every 12 To 24 Hours.
Multiple concurrent drugs taken:
  • Aspirin
  • Vitamin D3
  • Indapamide
  • Apo-ramipril


Formication, Dysuria, Off Label Use, Pruritus
Patient was taking Benadryl Allergy Kapgels. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: formication, dysuria, off label use, pruritus on Dec 09, 2013 from CA Additional patient health information: Female , 65 years of age, weighting 138.0 lb, was diagnosed with and. Benadryl Allergy Kapgels dosage: 1 Kapgel 2 Or 3 Times.


Adverse event was reported on Nov 29, 2013 by a Female taking Benadryl (Dosage: N/A) . Location: CA , child 10 years of age, .

Suprapubic Pain, Nephropathy Toxic, Renal Impairment, Electrocardiogram Change, Urinary Retention
on Nov 29, 2013 Male from US , 61 years of age, was diagnosed with and was treated with Benadryl. After Benadryl was administered, patient encountered several Benadryl side effects: suprapubic pain, nephropathy toxic, renal impairment, electrocardiogram change, urinary retention. Benadryl dosage: N/A. Patient was hospitalized.

Convulsion, Psychotic Disorder
on Dec 04, 2013 Male from US , 22 years of age, weighting 191.8 lb, was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: convulsion, psychotic disorder. Benadryl dosage: N/A. Patient was hospitalized.

Diabetes Mellitus, Blood Cholesterol Abnormal, Dry Throat, Hunger
Patient was taking Benadryl. Patient felt the following Benadryl side effects: diabetes mellitus, blood cholesterol abnormal, dry throat, hunger on Nov 27, 2013 from US Additional patient health information: Female , weighting 240.0 lb, was diagnosed with and. Benadryl dosage: N/A.
Multiple prescriptions taken:
  • Pristiq
  • Zanaflex
  • Lasix
  • Vistaril (50 Mg Oral Capsule 3 Times A Day And 2 Capsules Of 50 Mg During Bed Time)
  • Meclizine (As Needed)


Blister, Pain In Extremity
Adverse event was reported on Nov 25, 2013 by a Female taking Benadryl Topical Extra Strength Cream (Dosage: A Pea Size) was diagnosed with and. Location: US , 54 years of age, weighting 145.0 lb, After Benadryl was administered, patient encountered several Benadryl side effects: blister, pain in extremity.
Multiple concurrent drugs taken:
  • Omeprazole
  • Centrum Nos


Oxygen Saturation Decreased, Sensation Of Foreign Body, Off Label Use, Blood Pressure Decreased, Periorbital Oedema
on Nov 19, 2013 Female from CA , 57 years of age, weighting 216.1 lb, was diagnosed with and was treated with Benadryl. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: oxygen saturation decreased, sensation of foreign body, off label use, blood pressure decreased, periorbital oedema. Benadryl dosage: N/A.
Associated medications used:
  • Remicade
  • Epinephrine


Mental Disorder, Disturbance In Attention, Memory Impairment, Dysarthria
on Nov 15, 2013 Female from US , 42 years of age, was treated with Benadryl Allergy Dye Free. Patient felt the following Benadryl side effects: mental disorder, disturbance in attention, memory impairment, dysarthria. Benadryl Allergy Dye Free dosage: N/A.
Multiple prescriptions taken:
  • Ambien
  • Lamictal
  • Haldol


Neoplasm Malignant, Haemoglobin Decreased, Blood Creatinine Increased, Agitation, Pain In Extremity, Paraesthesia, Musculoskeletal Stiffness, Abdominal Discomfort
Patient was taking Benadryl. After Benadryl was administered, patient encountered several Benadryl side effects: neoplasm malignant, haemoglobin decreased, blood creatinine increased, agitation, pain in extremity, paraesthesia, musculoskeletal stiffness, abdominal discomfort on Nov 14, 2013 from US Additional patient health information: Male , 64 years of age, weighting 250.0 lb, . Benadryl dosage: N/A.

Faeces Discoloured, Hyperhidrosis
Adverse event was reported on Nov 11, 2013 by a Female taking Benadryl (Dosage: N/A) . Location: US , 70 years of age, Directly after, patient experienced the unwanted or unexpected Benadryl side effects: faeces discoloured, hyperhidrosis.

Mania, Insomnia, Logorrhoea, Formication
on Nov 20, 2013 Female from CA , 50 years of age, weighting 220.0 lb, was diagnosed with and was treated with Benadryl Nightime Es Allergy. Patient felt the following Benadryl side effects: mania, insomnia, logorrhoea, formication. Benadryl Nightime Es Allergy dosage: Taken At Night.

Tremor, Off Label Use
on Oct 30, 2013 Male from US , 50 years of age, weighting 155.0 lb, was diagnosed with and was treated with Benadryl Allergy Ultratab. After Benadryl was administered, patient encountered several Benadryl side effects: tremor, off label use. Benadryl Allergy Ultratab dosage: 1/4 Tablet.
Multiple concurrent drugs taken:
  • Latuda
  • Zoloft
  • Zoloft


Loss Of Consciousness, Urinary Incontinence
Patient was taking Benadryl Allergy Ultratab. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: loss of consciousness, urinary incontinence on Oct 24, 2013 from US Additional patient health information: Male , 40 years of age, weighting 170.0 lb, was diagnosed with and. Benadryl Allergy Ultratab dosage: When Needed.
Associated medications used:
  • Benadryl Topical Extra Strength (When Needed)


Retinal Vascular Thrombosis, Optic Neuropathy, Hypotension, Product Label Issue
Adverse event was reported on Feb 10, 2014 by a Female taking Benadryl Liquid (Dosage: Many Years Ago) was diagnosed with and. Location: US , weighting 154.0 lb, Patient felt the following Benadryl side effects: retinal vascular thrombosis, optic neuropathy, hypotension, product label issue.

Intestinal Haemorrhage
on Oct 12, 2013 Male from US , 46 years of age, was diagnosed with and was treated with Benadryl Allergy. After Benadryl was administered, patient encountered several Benadryl side effects: intestinal haemorrhage. Benadryl Allergy dosage: 4-6 Hours.

Dyspnoea, Pharyngeal Oedema, Lip Swelling, Eye Swelling, Hypersensitivity
on Oct 09, 2013 Female from US , 25 years of age, weighting 130.0 lb, was diagnosed with and was treated with Benadryl Allergy Kapgels. Directly after, patient experienced the unwanted or unexpected Benadryl side effects: dyspnoea, pharyngeal oedema, lip swelling, eye swelling, hypersensitivity. Benadryl Allergy Kapgels dosage: 1 Kapgel Once.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


    Track Online

  • User Sign In
  • Register to track your side effects

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Discuss Benadryl Side Effects

    Did You Have a Benadryl Side Effect?

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    How Effective is Benadryl for You?

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    Safety Alerts, Active Ingredients, Usage Information

    CAMPHOR ( DIPHENHYD

    Active Ingredient: CAMPHOR ( DIPHENHYD

    Benadryl Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1568

    Benadryl safety alerts: 2010

    Reported deaths: 82

    Reported hospitalizations: 340

    Benadryl Extra Strength Itch Stopping Gel: Packaging Changes to Reduce Use Errors

    Audience: Consumers, Pharmacists

    [Posted 05/12/2010] Johnson & Johnson and FDA notified consumers and healthcare professionals of changes to the graphics and information displayed on the front of the product container to reduce the risk of serious side effects from swallowing the topical Benadryl Extra Strength Itch Stopping Gel intended ??For Skin Use Only". FDA received reports of consumers ingesting the gel rather than using it topically. Swallowing the gel can result in people receiving dangerously large amounts of the active ingredient diphenhydramine.

    Between 2001 and 2009, 121 cases of ingestion of Benadryl Extra Strength Itch Relief Gel were reported to the manufacturer. Of these cases, 7 were considered serious because patients required treatment in the emergency room, hospitalization, or admission to the intensive care unit. Others reported adverse events included hallucinations, unconsciousness, sleepiness, difficulty walking, dizziness and inability to speak.

    [05/12/2010 - Drug Safety Communication - FDA]

    [05/12/2010 - Consumer Update - FDA]

    Latest Benadryl clinical trials