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Total Bosentan reports: 5.
Bosentan FDA safety alerts: 2006 .
   Reported hospitalizations: 3.
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FDA Reported Bosentan Side Effects: fatigue, constipation, hepatitis chronic active, autoimmune hepatitis, aspartate aminotransferase increased, alanine aminotransferase increased, epstein-barr virus antibody positive, diaphragmatic hernia, splenomegaly, hepatitis, hepatic steatosis.
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Bosentan Side Effects Report #5211793-8
Physician from KOREA, REPUBLIC OF reported BOSENTAN problem on Jan 05, 2007. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension and was treated with BOSENTAN. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation, fatigue, gamma-glutamyltransferase increased. BOSENTAN dosage: unknown. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5245902-1
BOSENTAN problem was reported by a Physician from KOREA, REPUBLIC OF on Jan 31, 2007. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension and was treated with BOSENTAN. After drug was administered, patient experienced the following problems/side effects: constipation, fatigue, hepatic steatosis, hepatitis, splenomegaly. BOSENTAN dosage: unknown. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5196466-2
Health Professional from KOREA, REPUBLIC OF reported BOSENTAN problem on Dec 13, 2006. Female patient, 51 years of age, weighting 130.1 lb, was diagnosed with pulmonary hypertension and was treated with BOSENTAN. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, constipation, fatigue. BOSENTAN dosage: unknown. Patient was hospitalized. Patient recovered.

Bosentan Side Effects Report #5412057-X
BOSENTAN problem was reported by a Physician from UNITED STATES on July 25, 2007. Female patient, child 2 years of age, weighting 27.34 lb, was diagnosed with pulmonary hypertension and was treated with BOSENTAN. After drug was administered, patient experienced the following problems/side effects: autoimmune hepatitis, hepatitis chronic active. BOSENTAN dosage: 48 MG, BID, ORAL, 24 MG, BID, ORAL; 40 MG, BID, ORAL, 24 MG, BID, ORAL, 24 MG, BID, ORAL. During the same period patient was treated with SYNTHROID, LASIX. Patient recovered.

Bosentan Side Effects Report #5463787-5
Physician from UNITED STATES reported BOSENTAN problem on Sept 06, 2007. Female patient, child 2 years of age, weighting 27.34 lb, was diagnosed with pulmonary hypertension and was treated with BOSENTAN. After drug was administered, patient experienced the following problems/side effects: autoimmune hepatitis, diaphragmatic hernia, epstein-barr virus antibody positive, hepatitis chronic active. BOSENTAN dosage: 48 MG, BID, ORAL, 24 MG, BID, ORAL, 40 MGM BID, ORAL. During the same period patient was treated with SYNTHROID, LASIX. Patient recovered.

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