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Cercine Side Effects

Common Cercine Side Effects


The most commonly reported Cercine side effects (click to view or check a box to report):

Disseminated Intravascular Coagulation (5)
Hyperthermia (3)
Convulsion (3)
Multi-organ Failure (3)
Musculoskeletal Stiffness (3)
Tonic Convulsion (3)
Pyrexia (3)
Tachycardia (3)
Neuroleptic Malignant Syndrome (3)
Arterial Therapeutic Procedure (2)
Anuria (2)
Graft Dysfunction (2)
Perinephric Collection (2)
Incisional Drainage (2)
Nephrectomy (2)
Ischaemia (1)
Klebsiella Infection (1)
Hypopnoea (1)
Hyperventilation (1)
Infusion Related Reaction (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Cercine Side Effects Reported to FDA

The following Cercine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Cercine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Depressed Level Of Consciousness, Hypopnoea, Therapeutic Response Prolonged
This is a report of a 80-year-old female patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Cercine Injection (diazepam) (dosage: 8 Mg (8 Mg,1 In 1 D), Intravenous, start time: May 27, 2009), combined with:
  • Opystan (pethidine Hydrochloride) (50 Mg (50 Mg, 1 In 1 D), Intravenous)
  • Dezolam (etizolam) (0.5 Mg (0.5 Mg,1 In 1 D), Per Oral)
  • Takepron 0d (lansoprazole)
  • Pravastatin Sodium
and developed a serious reaction and side effect(s). The consumer presented with:
  • Depressed Level Of Consciousness
  • Hypopnoea
  • Therapeutic Response Prolonged
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Cercine Injection (diazepam) treatment in female patients, resulting in depressed level of consciousness side effect.

Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This report suggests a potential Cercine Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion side effect(s) that can have serious consequences. A 82-year-old male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: neuralgia and used Cercine (dosage: NA) starting Nov 19, 2008. Soon after starting Cercine the patient began experiencing various side effects, including:
  • Convulsion
  • Disseminated Intravascular Coagulation
  • Hyperthermia
  • Multi-organ Failure
  • Musculoskeletal Stiffness
  • Neuroleptic Malignant Syndrome
  • Pyrexia
  • Tachycardia
  • Tonic Convulsion
Drugs used concurrently:
  • Artist
  • Paxil
  • Paxil
  • Paxil
  • Serevent (Reported As Salmeterol Xinofoate Accuhaler (diskus). Serevent 50)
  • Frusemide
  • Klaricid
  • Uniphyl
The patient was hospitalized. Although Cercine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as convulsion, may still occur.

Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion problem was reported by a pharmacist from UNITED KINGDOM. A 82-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Nov 19, 2008 this consumer started treatment with Cercine (dosage: NA). The following drugs were being taken at the same time:
  • Artist
  • Digoxin
  • Serevent
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Dogmatyl
  • Frusemide
When commencing Cercine, the patient experienced the following unwanted symptoms/side effects:
  • Convulsion
  • Disseminated Intravascular Coagulation
  • Hyperthermia
  • Multi-organ Failure
  • Musculoskeletal Stiffness
  • Neuroleptic Malignant Syndrome
  • Pyrexia
  • Tachycardia
  • Tonic Convulsion
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as convulsion, may become evident only after a product is in use by the general population.

Convulsion, Disseminated Intravascular Coagulation, Hyperthermia, Multi-organ Failure, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Pyrexia, Tachycardia, Tonic Convulsion
This is a report of a 82-year-old male patient (weight: NA) from UNITED KINGDOM. The patient developed the following symptoms/conditions: NA and was treated with Cercine (dosage: NA) starting Nov 19, 2008. Concurrently used drugs:
  • Artist
  • Digoxin
  • Serevent
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Paroxetine Hydrochloride
  • Dogmatyl
  • Frusemide
Soon after that, the consumer experienced the following side effects:
  • Convulsion
  • Disseminated Intravascular Coagulation
  • Hyperthermia
  • Multi-organ Failure
  • Musculoskeletal Stiffness
  • Neuroleptic Malignant Syndrome
  • Pyrexia
  • Tachycardia
  • Tonic Convulsion
The patient was hospitalized. This opens a possibility that Cercine treatment could cause the above reactions, including convulsion, and some male subjects may be more susceptible.


Liver Disorder, Oculomucocutaneous Syndrome, Sepsis
A 70-year-old male patient (weight: NA) from JAPAN with the following symptoms/conditions: convulsion prophylaxis started Cercine treatment (dosage: NA) on Sep 25, 2006. Soon after starting Cercine treatment, the subject experienced various side effects, including:
  • Liver Disorder
  • Oculomucocutaneous Syndrome
  • Sepsis
Concurrently used drugs:
  • Rohypnol
  • Rohypnol
  • Rohypnol
  • Rohypnol
  • Naproxen
  • Amoban
  • Amoban
  • Amoban
This finding indicates that some male patients could be more vulnerable to Cercine.

Abdominal Distension, Blood Pressure Increased, Chest Discomfort, Fatigue, Hyperventilation, Infusion Related Reaction
A 83-year-old female patient from JAPAN (weight: NA) experienced symptoms, such as: sedation and was treated with Cercine(dosage: NA). The treatment was initiated on Oct 16, 2006. After that a consumer reported the following side effect(s):
  • Abdominal Distension
  • Blood Pressure Increased
  • Chest Discomfort
  • Fatigue
  • Hyperventilation
  • Infusion Related Reaction
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Cercine efficacy:
  • Anexate Tab
  • Saline (Drip; Admixture With Midazolam)
  • Scopolamine (Sporamin)
  • Alosenn
  • Maglax
  • Ferromia
  • Sigmart
  • Miltex (As Needed. Miltax)


Anuria, Arterial Therapeutic Procedure, Decubitus Ulcer, Disseminated Intravascular Coagulation, Graft Dysfunction, Incisional Drainage, Klebsiella Infection, Nephrectomy, Perinephric Collection
In this report, Cercine was administered for the following condition: NA.A 57-year-old male consumer from (weight: NA) started Cercine treatment (dosage: NA) on Jul 26, 2004.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Anuria
  • Arterial Therapeutic Procedure
  • Decubitus Ulcer
  • Disseminated Intravascular Coagulation
  • Graft Dysfunction
  • Incisional Drainage
  • Klebsiella Infection
  • Nephrectomy
  • Perinephric Collection
A possible interaction with other drugs could have contributed to this reaction:
  • Pariet
  • Bup-4
  • Malfa
  • Povidone Iodine
  • Epogin
  • Fty720 Vs Mycophenolate Mofetil
  • Neoral (140 Mg, Bid)
  • Medrol (12 Mg, Qd)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Cercine treatment could be related to the listed above side effect(s).

Anuria, Arterial Therapeutic Procedure, Disseminated Intravascular Coagulation, Graft Dysfunction, Haemodialysis, Incisional Drainage, Ischaemia, Nephrectomy, Perinephric Collection
This is a report of the following Cercine side effect(s):
  • Anuria
  • Arterial Therapeutic Procedure
  • Disseminated Intravascular Coagulation
  • Graft Dysfunction
  • Haemodialysis
  • Incisional Drainage
  • Ischaemia
  • Nephrectomy
  • Perinephric Collection
A 57-year-old male patient from (weight: NA) presented with the following condition: NA and received a treatment with Cercine (dosage: NA) starting: Jul 26, 2004.The following concurrently used drugs could have generated interactions:
  • Rabeprazole Sodium
  • Bup-4
  • Malfa
  • Povidone Iodine
  • Epogin
  • Fty720 Vs Mycophenolate Mofetil
  • Neoral (140 Mg, Bid)
  • Medrol (12 Mg, Qd)
The patient was hospitalized.This report suggests that a Cercine treatment could be associated with the listed above side effect(s).

Alanine Aminotransferase Increased, Blood Creatine Phosphokinase Increased, Gamma-glutamyltransferase Increased
This Cercine report was submitted by a 62-year-old male consumer from (weight: NA). The patient was diagnosed with: convulsion and Cercine was administered (dosage: Route: Ij) starting: Nov 16, 2004. The consumer developed a set of symptoms:
  • Alanine Aminotransferase Increased
  • Blood Creatine Phosphokinase Increased
  • Gamma-glutamyltransferase Increased
Other drugs used simultaneously:
  • Dormicum (inj) (Route Reported As Injection. Dosage: 1ml/h By Continuous Infusion.)
  • Phenytoin
  • Phenytoin
The patient was hospitalized.Those unexpected symptoms could be linked to a Cercine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Cercine Safety Alerts, Active Ingredients, Usage Information

    More About Cercine

    Side Effects reported to FDA: 9

    Cercine safety alerts: No

    Reported deaths: 4

    Reported hospitalizations: 6

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