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Chlorpromazine Side Effects

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Common Chlorpromazine Side Effects


The most commonly reported Chlorpromazine side effects (click to view or check a box to report):

Neuroleptic Malignant Syndrome (19)
Completed Suicide (16)
Blood Alkaline Phosphatase Increased (14)
Aspartate Aminotransferase Increased (13)
Alanine Aminotransferase Increased (11)
Depression (11)
Toxicity To Various Agents (10)
Lethargy (9)
Fall (9)
Liver Injury (9)
Blood Pressure Decreased (8)
Blood Bilirubin Increased (8)
Blood Creatine Phosphokinase Increased (8)
Confusional State (8)
Renal Failure Acute (8)
Depressed Level Of Consciousness (8)
Overdose (8)
Metabolic Acidosis (8)
Pyrexia (7)
Tachycardia (7)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Chlorpromazine Side Effects Reported to FDA



Chlorpromazine Side Effect Report#9917052
Spasmodic Dysphonia
This is a report of a 14-year-old female patient (weight: NA) from TR, suffering from the following health symptoms/conditions: stress, who was treated with Chlorpromazine Hydrochloride (watson Laboratories) (dosage: Unk, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Spasmodic Dysphonia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine Hydrochloride (watson Laboratories) treatment in female patients, resulting in Spasmodic Dysphonia side effect. The patient was hospitalized.
Chlorpromazine Side Effect Report#9871021
Neuroleptic Malignant Syndrome
This report suggests a potential Chlorpromazine Neuroleptic Malignant Syndrome side effect(s) that can have serious consequences. A 22-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: mania,agitation and used Chlorpromazine (dosage: NA) starting
Oct 10, 2007. After starting Chlorpromazine the patient began experiencing various side effects, including: Neuroleptic Malignant SyndromeAdditional drugs used concurrently:
  • Olanzapine
  • Paliperidone Xr
Although Chlorpromazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neuroleptic Malignant Syndrome, may still occur.
Chlorpromazine Side Effect Report#9842042
Neuroleptic Malignant Syndrome, Body Temperature Increased
This Neuroleptic Malignant Syndrome problem was reported by a health professional from US. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: agitation. On NS this consumer started treatment with Chlorpromazine (dosage: NA). The following drugs were being taken at the same time: NA. When using Chlorpromazine, the patient experienced the following unwanted symptoms/side effects: Neuroleptic Malignant Syndrome, Body Temperature IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Neuroleptic Malignant Syndrome, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#9712960
Painful Erection
This Painful Erection side effect was reported by a health professional from US. A 31-year-old male patient (weight:NA) experienced the following symptoms/conditions: agitation,aggression,bipolar disorder.The patient was prescribed Chlorpromazine Hcl (drug dosage: NA), which was initiated on
Nov 06, 2013. Concurrently used drugs: NA..After starting to take Chlorpromazine Hcl the consumer reported adverse symptoms, such as: Painful ErectionThese side effects may potentially be related to Chlorpromazine Hcl. The patient was hospitalized.
Chlorpromazine Side Effect Report#9692629
Swollen Tongue, Dysphagia, Speech Disorder
This is a report of a 11-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: aggression,agitation, who was treated with Chlorpromazine (dosage: NA, start time:
Nov 12, 2013), combined with: NA. and developed a serious reaction and side effect(s): Swollen Tongue, Dysphagia, Speech Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine treatment in male patients, resulting in Swollen Tongue side effect.
Chlorpromazine Side Effect Report#9687949
Hypophagia, Hiccups, Asthenia, Skin Discolouration
This report suggests a potential Chlorpromazine Hypophagia side effect(s) that can have serious consequences. A 71-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Chlorpromazine (dosage: NA) starting NS. After starting Chlorpromazine the patient began experiencing various side effects, including: Hypophagia, Hiccups, Asthenia, Skin DiscolourationAdditional drugs used concurrently: NA. Although Chlorpromazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypophagia, may still occur.
Chlorpromazine Side Effect Report#9668127
Sexually Inappropriate Behaviour, Aggression, Ataxia, Posture Abnormal, Pleurothotonus
This Sexually Inappropriate Behaviour problem was reported by a pharmacist from US. A 31-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: obsessive-compulsive disorder,autism spectrum disorder. On NS this consumer started treatment with Chlorpromazine (dosage: NA). The following drugs were being taken at the same time:
  • Risperidone (2 To 4 Mg; Hs)
  • Clomipramine
  • Quetiapine
  • Atenolol
  • Divalproex Sodium
  • Docusate
  • Glatiramer
  • Hydrochlorothiazide
When using Chlorpromazine, the patient experienced the following unwanted symptoms/side effects: Sexually Inappropriate Behaviour, Aggression, Ataxia, Posture Abnormal, PleurothotonusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Sexually Inappropriate Behaviour, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#9518180
Depression, Suicidal Ideation
This Depression side effect was reported by a consumer or non-health professional from US. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: psychotic disorder,insomnia.The patient was prescribed Chlorpromazine (drug dosage: NA), which was initiated on
Dec 29, 2012. Concurrently used drugs: NA..After starting to take Chlorpromazine the consumer reported adverse symptoms, such as: Depression, Suicidal IdeationThese side effects may potentially be related to Chlorpromazine. The patient was hospitalized and became disabled.
Chlorpromazine Side Effect Report#9486775
Treatment Noncompliance, Schizophrenia, Abnormal Behaviour, Sneezing, Screaming, Feeling Hot, Stereotypy, Tension, Tic
This is a report of a 59-year-old female patient (weight: NA) from SG, suffering from the following health symptoms/conditions: schizophrenia, who was treated with Chlorpromazine (dosage: NA, start time: NS), combined with:
  • Fluphenazine Decanoate (30-35 Years 30 Mg;q2-4w;im)
and developed a serious reaction and side effect(s): Treatment Noncompliance, Schizophrenia, Abnormal Behaviour, Sneezing, Screaming, Feeling Hot, Stereotypy, Tension, Tic after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine treatment in female patients, resulting in Treatment Noncompliance side effect. The patient was hospitalized.
Chlorpromazine Side Effect Report#9461602
Tardive Dyskinesia, Tourette^s Disorder
This report suggests a potential Chlorpromazine Tardive Dyskinesia side effect(s) that can have serious consequences. A 59-year-old female patient (weight: NA) from SG was diagnosed with the following symptoms/conditions: schizophrenia and used Chlorpromazine (dosage: 100mg Daily, Then Gradually Increased To 600 Mg/day) starting NS. After starting Chlorpromazine the patient began experiencing various side effects, including: Tardive Dyskinesia, Tourette^s DisorderAdditional drugs used concurrently: NA.The patient was hospitalized. Although Chlorpromazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Tardive Dyskinesia, may still occur.
Chlorpromazine Side Effect Report#9432264
This Death problem was reported by a consumer or non-health professional from US. A 70-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hiccups. On
Apr 11, 2013 this consumer started treatment with Chlorpromazine Hcl (dosage: 25mg 4 Times A Day). The following drugs were being taken at the same time: NA. When using Chlorpromazine Hcl, the patient experienced the following unwanted symptoms/side effects:Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Death, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#9393489
Lethargy
This Lethargy side effect was reported by a pharmacist from US. A 24-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Chlorpromazine (drug dosage: NA), which was initiated on
May 02, 2013. Concurrently used drugs: NA..After starting to take Chlorpromazine the consumer reported adverse symptoms, such as: LethargyThese side effects may potentially be related to Chlorpromazine.
Chlorpromazine Side Effect Report#9368071
Rash Erythematous, Pruritus
This is a report of a 52-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression, who was treated with Chlorpromazine Hydrochloride (dosage: 50 Mg, Qd, start time: 201305), combined with:
  • Klonopin (Unk)
  • Prozac (Unk)
  • Advil (Unk)
and developed a serious reaction and side effect(s): Rash Erythematous, Pruritus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine Hydrochloride treatment in female patients, resulting in Rash Erythematous side effect.
Chlorpromazine Side Effect Report#9368069
Memory Impairment
This report suggests a potential Chlorpromazine Hydrochloride Memory Impairment side effect(s) that can have serious consequences. A 70-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: schizophrenia,blood cholesterol increased,diabetes mellitus,hypertension and used Chlorpromazine Hydrochloride (dosage: 50 Mg, Qd) starting 1965. After starting Chlorpromazine Hydrochloride the patient began experiencing various side effects, including: Memory ImpairmentAdditional drugs used concurrently:
  • Lovastatin (Unk)
  • Metformin (Unk)
  • Lisinopril (Unk)
  • Glipizide (Unk)
  • Chondroitin W/glucosamine (Unk)
  • Aspirin (Unk)
Although Chlorpromazine Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Memory Impairment, may still occur.
Chlorpromazine Side Effect Report#9321369
Toxicity To Various Agents, Completed Suicide
This Toxicity To Various Agents problem was reported by a health professional from JP. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Chlorpromazine (dosage: NA). The following drugs were being taken at the same time:
  • Sertraline
  • Zolpidem
  • Mirtazapine
  • Amoxapine
When using Chlorpromazine, the patient experienced the following unwanted symptoms/side effects: Toxicity To Various Agents, Completed SuicideAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#9292896
Hallucination, Auditory, Neutropenia, Leukopenia, Suicide Attempt
This Hallucination, Auditory side effect was reported by a physician from US. A 12-year-old female patient (weight:NA) experienced the following symptoms/conditions: schizophrenia, paranoid type.The patient was prescribed Chlorpromazine (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Escitalopram
  • Bupropion
  • Clozapine
.After starting to take Chlorpromazine the consumer reported adverse symptoms, such as: Hallucination, Auditory, Neutropenia, Leukopenia, Suicide AttemptThese side effects may potentially be related to Chlorpromazine.
Chlorpromazine Side Effect Report#9200810
Lethargy
This is a report of a 39-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Chlorpromazine (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Lethargy after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine treatment in male patients, resulting in Lethargy side effect.
Chlorpromazine Side Effect Report#9174476
Corneal Deposits, Ocular Toxicity
This report suggests a potential Chlorpromazine Corneal Deposits side effect(s) that can have serious consequences. A 62-year-old patient (weight: NA) from US was diagnosed with the following symptoms/conditions: schizophrenia and used Chlorpromazine (dosage: NA) starting NS. After starting Chlorpromazine the patient began experiencing various side effects, including: Corneal Deposits, Ocular ToxicityAdditional drugs used concurrently: NA. Although Chlorpromazine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Corneal Deposits, may still occur.
Chlorpromazine Side Effect Report#9032516
Toxicity To Various Agents, Altered State Of Consciousness, Respiratory Depression, Bezoar
This Toxicity To Various Agents problem was reported by a health professional from JP. A 37-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Chlorpromazine (dosage: NA). The following drugs were being taken at the same time:
  • Phenobarbital
  • Promethazine
When using Chlorpromazine, the patient experienced the following unwanted symptoms/side effects: Toxicity To Various Agents, Altered State Of Consciousness, Respiratory Depression, BezoarThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#9004773
Psychomotor Skills Impaired, Overdose
This Psychomotor Skills Impaired side effect was reported by a physician from IT. A 32-year-old female patient (weight:NA) experienced the following symptoms/conditions: bipolar ii disorder.The patient was prescribed Chlorpromazine Hydrochloride (drug dosage: NA), which was initiated on
Nov 28, 2012. Concurrently used drugs:
  • Bupropion Hydrochloride
  • Alprazolam
  • Lamotrigine
.After starting to take Chlorpromazine Hydrochloride the consumer reported adverse symptoms, such as: Psychomotor Skills Impaired, OverdoseThese side effects may potentially be related to Chlorpromazine Hydrochloride. The patient was hospitalized.
Chlorpromazine Side Effect Report#8988748
Overdose, Psychomotor Skills Impaired
This is a report of a 32-year-old female patient (weight: NA) from DK, suffering from the following health symptoms/conditions: NA, who was treated with Chlorpromazine Hydrochloride (dosage: NA, start time:
Nov 28, 2012), combined with:
  • Bupropion Hydrochloride Extended Release (xl)
  • Alprazolam Tablets Usp, 2 Mg (purepac) (alprazolam)
  • Lamotrigine (lamotrigine)
and developed a serious reaction and side effect(s): Overdose, Psychomotor Skills Impaired after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine Hydrochloride treatment in female patients, resulting in Overdose side effect. The patient was hospitalized.
Chlorpromazine Side Effect Report#8978287
Psychomotor Skills Impaired, Overdose
This report suggests a potential Chlorpromazine Hydrochloride Psychomotor Skills Impaired side effect(s) that can have serious consequences. A 32-year-old female patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: bipolar ii disorder and used Chlorpromazine Hydrochloride (dosage: NA) starting
Nov 28, 2012. After starting Chlorpromazine Hydrochloride the patient began experiencing various side effects, including: Psychomotor Skills Impaired, OverdoseAdditional drugs used concurrently:
  • Bupropion Hydrochloride (watson Laboratories)
The patient was hospitalized. Although Chlorpromazine Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Psychomotor Skills Impaired, may still occur.
Chlorpromazine Side Effect Report#8961878
Conjunctival Hyperaemia, Palpitations, Eye Swelling, Conjunctival Oedema, Dizziness, Off Label Use
This Conjunctival Hyperaemia problem was reported by a health professional from US. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: eye pain. On NS this consumer started treatment with Chlorpromazine (dosage: 2 Ml, Unk). The following drugs were being taken at the same time: NA. When using Chlorpromazine, the patient experienced the following unwanted symptoms/side effects: Conjunctival Hyperaemia, Palpitations, Eye Swelling, Conjunctival Oedema, Dizziness, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Conjunctival Hyperaemia, may become evident only after a product is in use by the general population.
Chlorpromazine Side Effect Report#8888870
Pulmonary Embolism, Hyperprolactinaemia
This Pulmonary Embolism side effect was reported by a health professional from BA. A 31-year-old male patient (weight:NA) experienced the following symptoms/conditions: schizophrenia, paranoid type.The patient was prescribed Chlorpromazine (drug dosage: 300mg Daily), which was initiated on NS. Concurrently used drugs:
  • Olanzapine (10mg Daily)
  • Haloperidol (15mg Daily)
.After starting to take Chlorpromazine the consumer reported adverse symptoms, such as: Pulmonary Embolism, HyperprolactinaemiaThese side effects may potentially be related to Chlorpromazine. The patient was hospitalized.
Chlorpromazine Side Effect Report#8880405
Hyperprolactinaemia, Pulmonary Embolism, Sinus Tachycardia, Blood Pressure Increased, Cerebral Artery Embolism
This is a report of a 31-year-old male patient (weight: NA) from BA, suffering from the following health symptoms/conditions: schizophrenia, paranoid type, who was treated with Chlorpromazine (dosage: 300 Mg, start time: NS), combined with:
  • Olanzapine (10 Mg)
  • Haloperidol (15 Mg)
and developed a serious reaction and side effect(s): Hyperprolactinaemia, Pulmonary Embolism, Sinus Tachycardia, Blood Pressure Increased, Cerebral Artery Embolism after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Chlorpromazine treatment in male patients, resulting in Hyperprolactinaemia side effect. The patient was hospitalized.


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The appearance of Chlorpromazine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Chlorpromazine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Chlorpromazine Side Effects

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    Chlorpromazine Safety Alerts, Active Ingredients, Usage Information

    NDC0615-1546
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameChlorpromazine
    NameChlorpromazine Hydrochloride
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since19730103
    LabelerNCS HealthCare of KY, Inc dba Vangard Labs
    Active Ingredient(s)CHLORPROMAZINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassPhenothiazine [EPC],Phenothiazines [Chemical/Ingredient]

    Chlorpromazine Dosage, Warnings, Usage.

    Side Effects reported to FDA: 249

    Chlorpromazine safety alerts: No

    Reported deaths: 29

    Reported hospitalizations: 66

    Latest Chlorpromazine clinical trials