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Clotiazepam Side Effects

Common Clotiazepam Side Effects


The most commonly reported Clotiazepam side effects (click to view or check a box to report):

Eye Pain (3)
Corneal Oedema (3)
Conjunctival Hyperaemia (3)
Fall (3)
Flat Anterior Chamber Of Eye (3)
Transient Ischaemic Attack (3)
Loss Of Consciousness (3)
Mydriasis (3)
Iris Atrophy (3)
Blood Pressure Systolic Decreased (2)
Altered State Of Consciousness (2)
Convulsion (2)
Overdose (2)
Eye Rolling (2)
Hypotension (2)
Intraocular Pressure Increased (1)
Lenticular Opacities (1)
Incorrect Dose Administered (1)
Hyperglycaemia (1)
Intentional Self-injury (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Clotiazepam Side Effects Reported to FDA

The following Clotiazepam reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Clotiazepam on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Toxicity To Various Agents
This is a report of a 41-year-old female patient (weight: NA) from IT, suffering from the following symptoms/conditions: NA, who was treated with Clotiazepam (dosage: 20 Ml, Single, start time: Jan 01, 2013), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Toxicity To Various Agents
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Clotiazepam treatment in female patients, resulting in toxicity to various agents side effect. The patient was hospitalized and became disabled.

Intentional Self-injury, Bradykinesia, Hypotension, Bradyphrenia
This report suggests a potential Clotiazepam Intentional Self-injury, Bradykinesia, Hypotension, Bradyphrenia side effect(s) that can have serious consequences. A 40-year-old female patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: intentional self-injury and used Clotiazepam (dosage: 10 Mg, 1x/day) starting Feb 05, 2013. Soon after starting Clotiazepam the patient began experiencing various side effects, including:
  • Intentional Self-injury
  • Bradykinesia
  • Hypotension
  • Bradyphrenia
Drugs used concurrently: NA.The patient was hospitalized. Although Clotiazepam demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as intentional self-injury, may still occur.

Pyrexia, Rash, Depression, Constipation, Anaemia, White Blood Cell Count Decreased, Hyperglycaemia
This Pyrexia, Rash, Depression, Constipation, Anaemia, White Blood Cell Count Decreased, Hyperglycaemia problem was reported by a physician from JAPAN. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Apr 18, 2012 this consumer started treatment with Clotiazepam (dosage: 15 Mg, Uid/qd). The following drugs were being taken at the same time:
  • Loxoprofen /00890702/ (60-120 Mg / Day)
  • Lansoprazole (15 Mg, Uid/qd)
  • Granisetron Hydrochloride (1 Mg, Uid/qd)
  • Erlotinib Hydrochloride (100 Mg, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Gemcitabine (1000 Mg/m2, Uid/qd)
  • Loxoprofen /00890702/ (180 Mg, Uid/qd)
When commencing Clotiazepam, the patient experienced the following unwanted symptoms/side effects:
  • Pyrexia
  • Rash
  • Depression
  • Constipation
  • Anaemia
  • White Blood Cell Count Decreased
  • Hyperglycaemia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as pyrexia, may become evident only after a product is in use by the general population.

Incorrect Dose Administered, Electrocardiogram Qt Prolonged
This is a report of a 71-year-old male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: NA and was treated with Clotiazepam (dosage: NA) starting NS. Concurrently used drugs:
  • Phenobarbital Tab
  • Sertraline Hydrochloride
  • Amiodarone Hcl (11.4 Gm;x1;po; 4gm;x1;po)
Soon after that, the consumer experienced the following side effects:
  • Incorrect Dose Administered
  • Electrocardiogram Qt Prolonged
This opens a possibility that Clotiazepam treatment could cause the above reactions, including incorrect dose administered, and some male subjects may be more susceptible.


Angle Closure Glaucoma
A 71-year-old female patient (weight: NA) from UNITED KINGDOM with the following symptoms/conditions: depression started Clotiazepam treatment (dosage: NA) on NS. Soon after starting Clotiazepam treatment, the subject experienced various side effects, including:
  • Angle Closure Glaucoma
Concurrently used drugs:
  • Alprazolam (Unk)
  • Maprotiline (Unk)
This finding indicates that some female patients could be more vulnerable to Clotiazepam.

Suicide Attempt
A 26-year-old female patient from JAPAN (weight: NA) experienced symptoms, such as: depression and was treated with Clotiazepam(dosage: Daily Dose 5 Mg). The treatment was initiated on Feb 13, 2011. After that a consumer reported the following side effect(s):
  • Suicide Attempt
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Clotiazepam efficacy:
  • Paxil
  • Zoloft
  • Sepazon (Daily Dose 2 Mg)
  • Diazepam (Daily Dose 5 Mg)
  • Ajireru
  • Yaz (1 Df, Once)
  • Amoxapine (Daily Dose 25 Mg)
  • Lorazepam


Back Pain, Cardiac Failure, Headache, Dyspnoea, Restless Legs Syndrome, Arthralgia, Delirium
In this report, Clotiazepam was administered for the following condition: NA.A female consumer from JAPAN (weight: NA) started Clotiazepam treatment (dosage: NA) on Sep 18, 2009.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Back Pain
  • Cardiac Failure
  • Headache
  • Dyspnoea
  • Restless Legs Syndrome
  • Arthralgia
  • Delirium
A possible interaction with other drugs could have contributed to this reaction:
  • Theophylline
  • Tracleer (31.25 Mg, Bid)
  • Tracleer (31.25 Mg, Bid)
  • Ambroxol Hydrochloride
  • Antibiotics-resistant Lactic Acid Bacteriae
  • Salbutamol Sulfate
  • Diflucortolone Valerate
  • Tiquizium Bromide
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Clotiazepam treatment could be related to the listed above side effect(s).

Hepatic Function Abnormal
This is a report of the following Clotiazepam side effect(s):
  • Hepatic Function Abnormal
A 68-year-old male patient from JAPAN (weight: NA) presented with the following condition: NA and received a treatment with Clotiazepam (dosage: NA) starting: Apr 19, 2010.The following concurrently used drugs could have generated interactions:
  • Fenofibrate
  • Bisoprolol Fumarate
  • Nizatidine
  • Octotiamine
  • Silodosin
This report suggests that a Clotiazepam treatment could be associated with the listed above side effect(s).

Altered State Of Consciousness, Convulsion, Overdose, Vocal Cord Paralysis
This Clotiazepam report was submitted by a 16-year-old female consumer from JAPAN (weight: NA). The patient was diagnosed with: intentional self-injury,depression and Clotiazepam was administered (dosage: 100 Mg, Single) starting: Jun 11, 2010. The consumer developed a set of symptoms:
  • Altered State Of Consciousness
  • Convulsion
  • Overdose
  • Vocal Cord Paralysis
Other drugs used simultaneously:
  • Solanax (Unk)
  • Diphenhydramine Hydrochloride (120 Df, Single)
The patient was hospitalized.Those unexpected symptoms could be linked to a Clotiazepam treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Altered State Of Consciousness, Convulsion, Overdose
This is a report of a possible correlation between Clotiazepam use and the following symptoms/side effect(s):
  • Altered State Of Consciousness
  • Convulsion
  • Overdose
which could contribute to an assessment of Clotiazepam risk profile.A 16-year-old female consumer from JAPAN (weight: NA) was suffering from intentional self-injury and was treated with Clotiazepam (dosage: 100 Mg, Single) starting Jun 11, 2010.Other concurrent medications:
  • Solanax (Unk)
  • Diphenhydramine Hydrochloride (120 Df, Single)
The patient was hospitalized.

Eye Rolling, Fall, Hypotension, Loss Of Consciousness, Transient Ischaemic Attack
A 76-year-old female patient from (weight: NA) presented with the following symptoms: autonomic nervous system imbalance and after a treatment with Clotiazepam (dosage: 10 Mg, Unk) experienced the following side effect(s):
  • Eye Rolling
  • Fall
  • Hypotension
  • Loss Of Consciousness
  • Transient Ischaemic Attack
The treatment was started on Aug 28, 2004. Clotiazepam was used in combination with the following drugs:
  • Diovan (80 Mg, Qd)
This report could alert potential Clotiazepam consumers.

Blood Pressure Systolic Decreased, Eye Rolling, Fall, Loss Of Consciousness, Transient Ischaemic Attack
In this report, a 76-year-old female patient from (weight: NA) was affected by a possible Clotiazepam side effect.The patient was diagnosed with autonomic nervous system imbalance,hypertension. After a treatment with Clotiazepam (dosage: 10 Mg, Unk, start date: Aug 28, 2004), the patient experienced the following side effect(s):
  • Blood Pressure Systolic Decreased
  • Eye Rolling
  • Fall
  • Loss Of Consciousness
  • Transient Ischaemic Attack
The following simultaneously used drugs could have led to this reaction:
  • Diovan (80 Mg, Qd)
The findings here stress that side effects should be taken into consideration when evaluating a Clotiazepam treatment.

Blood Pressure Systolic Decreased, Fall, Loss Of Consciousness, Transient Ischaemic Attack
This is a report of a 76-year-old female patient from (weight: NA), who used Clotiazepam (dosage: 5 Mg, Unk) for a treatment of NA. After starting a treatment on Aug 24, 2004, the patient experienced the following side effect(s):
  • Blood Pressure Systolic Decreased
  • Fall
  • Loss Of Consciousness
  • Transient Ischaemic Attack
The following drugs could possibly have interacted with the Clotiazepam treatment
  • Diovan (80 Mg, Qd)
Taken together, these observations suggest that a Clotiazepam treatment could be related to side effect(s), such as Blood Pressure Systolic Decreased, Fall, Loss Of Consciousness, Transient Ischaemic Attack.

Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Intraocular Pressure Increased, Iris Atrophy, Lenticular Opacities, Mydriasis
This conjunctival hyperaemia side effect was reported by a health professional from . A 71-year-old female patient (weight:NA) experienced the following symptoms/conditions: depression. The patient was prescribed Clotiazepam (dosage: NA), which was started on Jan 01, 1996. Concurrently used drugs:
  • Alprazolam (ngx)
  • Maprotiline Hydrochloride
When starting to take Clotiazepam the consumer reported the following symptoms:
  • Conjunctival Hyperaemia
  • Corneal Oedema
  • Eye Pain
  • Flat Anterior Chamber Of Eye
  • Intraocular Pressure Increased
  • Iris Atrophy
  • Lenticular Opacities
  • Mydriasis
These side effects may potentially be related to Clotiazepam.

Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Iris Atrophy, Mydriasis
This is a Clotiazepam side effect report of a 71-year-old female patient (weight:NA) from , suffering from the following symptoms/conditions: depression, who was treated with Clotiazepam (dosage:NA, start time: Jan 01, 1996), combined with:
  • Alprazolam
  • Maprotiline Hydrochloride
, and developed a serious reaction and a conjunctival hyperaemia side effect. The patient presented with:
  • Conjunctival Hyperaemia
  • Corneal Oedema
  • Eye Pain
  • Flat Anterior Chamber Of Eye
  • Iris Atrophy
  • Mydriasis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Clotiazepam treatment in female patients suffering from depression, resulting in conjunctival hyperaemia.

Conjunctival Hyperaemia, Corneal Oedema, Eye Pain, Flat Anterior Chamber Of Eye, Iris Atrophy, Mydriasis
This report suggests a potential Clotiazepam conjunctival hyperaemia side effect(s) that can have serious consequences. A 71-year-old female patient from (weight:NA) was diagnosed with the following health condition(s): depression and used Clotiazepam (dosage: NA) starting Jan 01, 1996. Soon after starting Clotiazepam the patient began experiencing various side effects, including:
  • Conjunctival Hyperaemia
  • Corneal Oedema
  • Eye Pain
  • Flat Anterior Chamber Of Eye
  • Iris Atrophy
  • Mydriasis
Drugs used concurrently:
  • Alprazolam
  • Maprotiline Hydrochloride
Although Clotiazepam demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as conjunctival hyperaemia, may still occur.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Reported hospitalizations: 6

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