Clozapine Safety Questions, Clozapine Answers
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Clozapine Safety Reports
Total Clozapine reports: 993.Clozapine FDA safety alerts: 2002 2004 2006 .
Reported deaths: 139 Reported hospitalizations: 169.
Take Clozapine Side Effects Survey or Share Your Clozapine Story.
Reported Clozapine Side Effects: granulocytopenia, leukopenia, death, pyrexia, agranulocytosis, neutrophil count decreased, c-reactive protein increased, white blood cell count decreased, condition aggravated, diarrhoea, treatment noncompliance.
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Clozapine Side Effects Report #5295772-0Physician from AUSTRIA reported CLOZAPINE problem on Apr 02, 2007. Male patient was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood calcium increased, blood chloride increased, blood cholesterol increased, blood creatinine increased, blood uric acid increased, eosinopenia, mean cell haemoglobin concentration. CLOZAPINE dosage: 150MG ONCE DAILY. Patient recovered.
Clozapine Side Effects Report #5297363-4
CLOZAPINE problem was reported by a Physician from DENMARK on Apr 03, 2007. Male patient, 23 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: leukopenia, lymphocyte count decreased, neutropenia, platelet count increased. CLOZAPINE dosage: 250 MG/D. During the same period patient was treated with ABILIFY, RITALIN, TRUXAL, METHYLPHENIDATE, STRATTERA, EGAZIL DURETTER, NEXIUM. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5297728-0
Consumer or non-health professional from UNITED KINGDOM reported CLOZAPINE problem on Mar 19, 2007. Male patient, 30 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: abdominal distension, eructation, flatulence, ileus paralytic. CLOZAPINE dosage: unknown. During the same period patient was treated with SERTRALINE. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5298759-7
CLOZAPINE problem was reported by a Physician from FINLAND on Apr 04, 2007. Female patient, 53 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood creatinine increased, hypertension, renal impairment. CLOZAPINE dosage: unknown. Patient recovered.
Clozapine Side Effects Report #5298764-0
Physician from FRANCE reported CLOZAPINE problem on Apr 04, 2007. Male patient, 48 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: leukocytosis, lymphocyte count increased, lymphocytic leukaemia. CLOZAPINE dosage: 400 MG PER DAY. During the same period patient was treated with LOXAPAC, LEPTICUR, MYOLASTAN, DAFLON. Patient recovered.
Clozapine Side Effects Report #5299700-3
CLOZAPINE problem was reported by a Consumer or non-health professional from GERMANY on Mar 29, 2007. Male patient, 30 years of age, weighting 246.9 lb, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: obsessive-compulsive disorder. CLOZAPINE dosage: unknown. During the same period patient was treated with CLOMIPRAMINE. Patient was hospitalized and became disabled. Patient recovered.
Clozapine Side Effects Report #5300188-4
Pharmacist from UNITED STATES reported CLOZAPINE problem on Apr 03, 2007. Male patient, 63 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: sepsis. CLOZAPINE dosage: (450 MG), ORAL. Patient died on 03/13/2007.
Clozapine Side Effects Report #5300312-3
CLOZAPINE problem was reported by a Health Professional from UNITED STATES on Apr 11, 2007. Male patient, 45 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: anion gap increased, blood bicarbonate decreased, blood glucose increased, blood ketone body increased, blood ph decreased, diabetes mellitus, diabetic ketoacidosis, glycosylated haemoglobin increased. CLOZAPINE dosage: 400 MG/D. During the same period patient was treated with LISINOPRIL, WARFARIN, FUROSEMIDE. Patient died.
Clozapine Side Effects Report #5300318-4
Physician from SLOVENIA reported CLOZAPINE problem on Apr 05, 2007. Male patient, weighting 220.5 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: erectile dysfunction. CLOZAPINE dosage: unknown. During the same period patient was treated with LORSILAN, AKINETON. Patient recovered.
Clozapine Side Effects Report #5300321-4
CLOZAPINE problem was reported by a Health Professional from UNITED KINGDOM on Apr 13, 2007. Male patient, 47 years of age, weighting 154.3 lb, was diagnosed with schizophrenia, depression and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: colectomy total, intestinal perforation, malaise, megacolon, pain, renal failure, sepsis. CLOZAPINE dosage: unknown. During the same period patient was treated with LOFEPRAMINE, SIMVASTATIN, TERBINAFINE, GLICLAZIDE, LISINOPRIL, NIFEDIPINE. Patient was hospitalized. Patient died on 03/17/2007.
Clozapine Side Effects Report #5300337-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Apr 11, 2007. Male patient, 29 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: anion gap increased, blood bicarbonate decreased, blood glucose increased, blood ketone body increased, blood ph decreased, diabetes mellitus, diabetic ketoacidosis, myocardial infarction, urine ketone body present. CLOZAPINE dosage: 400 MG/D. During the same period patient was treated with DIVALPROEX. Patient died.
Clozapine Side Effects Report #5300435-9
CLOZAPINE problem was reported by a Health Professional from UNITED STATES on Mar 30, 2007. Female patient, 46 years of age, weighting 187.0 lb, was diagnosed with bipolar disorder, schizophrenia, hepatitis and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: bipolar disorder, condition aggravated, granulocytopenia, influenza like illness, leukopenia, thrombocytopenia. CLOZAPINE dosage: 100 MG; 3 TIMES A DAY; ORAL. During the same period patient was treated with PEGASYS, METFORMIN, TRAZODONE, RIBAVIRIN, NORFLOXACIN. Patient was hospitalized and became disabled. Patient recovered.
Clozapine Side Effects Report #5301706-2
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Apr 11, 2007. Male patient, 29 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: anion gap increased, blood bicarbonate decreased, blood glucose increased, blood ketone body increased, blood ph decreased, diabetes mellitus, diabetic ketoacidosis, myocardial infarction, urine ketone body present. CLOZAPINE dosage: 400 MG/D. During the same period patient was treated with DIVALPROEX. Patient died.
Clozapine Side Effects Report #5303139-1
CLOZAPINE problem was reported by a Consumer or non-health professional from FINLAND on Apr 10, 2007. Female patient, 58 years of age, was diagnosed with schizophrenia, paranoid type, diabetes mellitus non-insulin-dependent and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, alanine aminotransferase increased, blood alkaline phosphatase increased, c-reactive protein increased, decreased appetite, diarrhoea, enterococcal infection, gastrointestinal inflammation. CLOZAPINE dosage: 300 MG/DAY. During the same period patient was treated with AMARYL, DIFORMIN, SIMVASTATIN, PROTAPHAN. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5304131-3
Health Professional from SINGAPORE reported CLOZAPINE problem on Apr 11, 2007. Female patient, 31 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: obsessive-compulsive disorder. CLOZAPINE dosage: 250 MG/D. Patient recovered.
Clozapine Side Effects Report #5304287-2
CLOZAPINE problem was reported by a Health Professional from SINGAPORE on Apr 11, 2007. Male patient, 44 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: compulsions. CLOZAPINE dosage: 400 MG/D. Patient recovered.
Clozapine Side Effects Report #5305304-6
Consumer or non-health professional from VENEZUELA reported CLOZAPINE problem on Apr 13, 2007. Male patient, 29 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: lymphocyte count increased, neutrophil count decreased, white blood cell count decreased. CLOZAPINE dosage: 100 MG, UNK. Patient recovered.
Clozapine Side Effects Report #5305846-3
CLOZAPINE problem was reported by a Consumer or non-health professional from VENEZUELA on Apr 13, 2007. Male patient, 29 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: lymphocyte count increased, neutrophil count decreased, white blood cell count decreased. CLOZAPINE dosage: 100 MG, UNK. Patient recovered.
Clozapine Side Effects Report #5307280-9
Physician from UNITED STATES reported CLOZAPINE problem on Apr 23, 2007. Female patient, weighting 190.0 lb, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: eosinophil count increased. CLOZAPINE dosage: 50MG QAM + 50MG Q1PM + 175MG HS PO. During the same period patient was treated with ATIVAN, LITHOBID, PREMARIN, PROCARDIA. Patient recovered.
Clozapine Side Effects Report #5307868-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 05, 2007. Male patient, 48 years of age, was diagnosed with bipolar disorder, schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: anaemia, granulocytopenia, leukopenia, lymphoma, shock. CLOZAPINE dosage: unknown. During the same period patient was treated with PAXIL, GLYBURIDE, PREVACID, ACTOS, CRESTOR, LISINOPRIL, LANTUS. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5308128-9
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Apr 12, 2007. Female patient was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: chills. CLOZAPINE dosage: MATERNAL DOSE: 100 MG/D. During the same period patient was treated with RISPERDAL. Patient recovered.
Clozapine Side Effects Report #5309463-0
CLOZAPINE problem was reported by a Physician from BELGIUM on Apr 18, 2007. Female patient was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: condition aggravated, fall, pain in extremity. CLOZAPINE dosage: unknown. Patient recovered.
Clozapine Side Effects Report #5309846-9
Physician from GERMANY reported CLOZAPINE problem on Apr 16, 2007. Male patient was diagnosed with schizophrenia, disorganised type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: cough, influenza, leukopenia, malaise, monocyte count increased, neutropenia, pyrexia. CLOZAPINE dosage: 400MG/DAY. Patient recovered.
Clozapine Side Effects Report #5309849-4
CLOZAPINE problem was reported by a Physician from MALTA on Apr 17, 2007. Female patient, 33 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: full blood count decreased, leukaemia. CLOZAPINE dosage: 400MG DAILY. Patient recovered.
Clozapine Side Effects Report #5311330-3
Consumer or non-health professional from UNITED KINGDOM reported CLOZAPINE problem on Apr 19, 2007. Male patient, 26 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood prolactin increased, fatigue, sedation, weight increased. CLOZAPINE dosage: unknown. During the same period patient was treated with RISPERDAL. Patient recovered.
Clozapine Side Effects Report #5311347-9
CLOZAPINE problem was reported by a Physician from MALTA on Apr 17, 2007. Female patient, 33 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: full blood count decreased, leukaemia. CLOZAPINE dosage: 400MG DAILY. Patient recovered.
Clozapine Side Effects Report #5311845-8
Pharmacist from UNITED STATES reported CLOZAPINE problem on Apr 27, 2007. Male patient, 21 years of age, weighting 222.0 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: neutrophil count decreased, white blood cell count decreased. CLOZAPINE dosage: 150 MG DAILY PO. Patient recovered.
Clozapine Side Effects Report #5314287-4
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 10, 2007. Male patient, 49 years of age, weighting 212.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident, neutrophil count decreased, white blood cell count decreased. CLOZAPINE dosage: unknown. During the same period patient was treated with FLUOXETINE, HYDROCHLORIDE, ARIPIPRAZOLE, DESMOPRESSIN, OMEPRAZOLE, DILTIAZEM, FUROSEMIDE. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5314880-9
Pharmacist from UNITED STATES reported CLOZAPINE problem on Apr 11, 2007. Female patient, child 9 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: cyanosis, fatigue, mood altered, nausea, neutrophil count decreased, skin discolouration, white blood cell count decreased. CLOZAPINE dosage: unknown. During the same period patient was treated with LITHIUM CARBONATE, LAMOTRIGINE, ARIPIPRAZOLE, SERTRALINE. Patient recovered.
Clozapine Side Effects Report #5314361-2
CLOZAPINE problem was reported by a Physician from AUSTRIA on Apr 27, 2007. Female patient was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood glucose increased, c-reactive protein increased, condition aggravated, glucose tolerance impaired, platelet count increased, white blood cell count increased. CLOZAPINE dosage: 50 MG. During the same period patient was treated with EUTHYROX, KEMADRIN, TRITTICO, TEMESTA, NEXIUM, DOMINALTE. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5314362-4
Consumer or non-health professional from FINLAND reported CLOZAPINE problem on Apr 23, 2007. Female patient, 58 years of age, was diagnosed with schizophrenia, paranoid type, diabetes mellitus non-insulin-dependent and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, alanine aminotransferase increased, blood alkaline phosphatase increased, blood sodium decreased, c-reactive protein increased, decreased appetite, diarrhoea, enterococcal infection, gastrointestinal inflammation. CLOZAPINE dosage: 300 MG/DAY. During the same period patient was treated with AMARYL, DIFORMIN, SIMVASTATIN, PROTAPHAN, DUREKAL. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5317605-6
CLOZAPINE problem was reported by a Physician from AUSTRIA on May 02, 2007. Female patient was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood glucose increased, c-reactive protein increased, condition aggravated, glucose tolerance impaired, platelet count increased, white blood cell count increased. CLOZAPINE dosage: 50 MG. During the same period patient was treated with EUTHYROX, KEMADRIN, TRITTICO, TEMESTA, NEXIUM, DOMINALTE. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5318666-0
Consumer or non-health professional from FRANCE reported CLOZAPINE problem on May 02, 2007. Female patient, 46 years of age, weighting 149.9 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: abdominal pain lower, acquired cardiac septal defect, acute pulmonary oedema, alveolitis, anxiety, blood gases abnormal, blood lactic acid increased, blood pressure immeasurable, bronchial obstruction. CLOZAPINE dosage: 200 MG/DAY. During the same period patient was treated with SEGLOR, TAHOR, AVLOCARDYL, GLUCOPHAGE. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5321168-9
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Apr 20, 2007. Female patient, 33 years of age, weighting 208.0 lb, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: accidental overdose, balance disorder, hallucination, auditory, incorrect dose administered. CLOZAPINE dosage: unknown. During the same period patient was treated with GEODON, HALOPERIDOL DECANOATE, SEROQUEL, XANAX, WELLBUTRIN. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5321995-8
Consumer or non-health professional from UNITED KINGDOM reported CLOZAPINE problem on May 01, 2007. Male patient, 26 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: blood prolactin increased, fatigue, sedation, weight increased. CLOZAPINE dosage: unknown. During the same period patient was treated with RISPERDAL. Patient recovered.
Clozapine Side Effects Report #5322182-X
CLOZAPINE problem was reported by a Health Professional from UNITED STATES on May 03, 2007. Male patient, 38 years of age, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, affect lability, aggression, agitation, atrophy, coordination abnormal, delirium, electroencephalogram abnormal. CLOZAPINE dosage: 600 MG/D. During the same period patient was treated with ZIPRASIDONE, VALPROIC ACID, CHLORAL HYDRATE, CLONAZEPAM. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5323345-X
Health Professional from UNITED STATES reported CLOZAPINE problem on May 03, 2007. Male patient, 38 years of age, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, affect lability, aggression, agitation, atrophy, coordination abnormal, delirium, electroencephalogram abnormal. CLOZAPINE dosage: 600 MG/D. During the same period patient was treated with ZIPRASIDONE, VALPROIC ACID, CHLORAL HYDRATE, CLONAZEPAM. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5323446-6
CLOZAPINE problem was reported by a Physician from GERMANY on May 07, 2007. Female patient, weighting 154.3 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: benign intracranial hypertension. CLOZAPINE dosage: unknown. During the same period patient was treated with IODINE. Patient recovered.
Clozapine Side Effects Report #5323461-2
Physician from GERMANY reported CLOZAPINE problem on May 08, 2007. Male patient, 52 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, pyrexia, urinary tract infection. CLOZAPINE dosage: 150 MG/DAY. Patient recovered.
Clozapine Side Effects Report #5324568-6
CLOZAPINE problem was reported by a Consumer or non-health professional from INDIA on Apr 24, 2007. Male patient, 46 years of age, was diagnosed with mania and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: angioedema, blister, flushing, neutrophilia, periorbital oedema, pyrexia, skin exfoliation, white blood cell count increased. CLOZAPINE dosage: (50 MG QD ORAL). Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5325321-X
Consumer or non-health professional from INDIA reported CLOZAPINE problem on Apr 24, 2007. Male patient, 45 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: angioedema, neutrophilia, white blood cell count increased. CLOZAPINE dosage: (150 MG QD ORAL). Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5327190-0
CLOZAPINE problem was reported by a Physician from GERMANY on May 15, 2007. Male patient was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: groin pain, pleurothotonus. CLOZAPINE dosage: 900 MG/DAY. During the same period patient was treated with FLUANXOL. Patient recovered.
Clozapine Side Effects Report #5328154-3
Physician from INDIA reported CLOZAPINE problem on May 01, 2007. Female patient, child 1 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: dysphemia, speech disorder developmental. CLOZAPINE dosage: unknown. Patient recovered.
Clozapine Side Effects Report #5331016-9
CLOZAPINE problem was reported by a Pharmacist from UNITED STATES on May 18, 2007. Female patient, 48 years of age, weighting 123.5 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: neutrophil count decreased. CLOZAPINE dosage: 125 MG BID PO. Patient recovered.
Clozapine Side Effects Report #5331118-7
Pharmacist from UNITED STATES reported CLOZAPINE problem on May 18, 2007. Female patient, 31 years of age, weighting 196.2 lb, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: tachycardia. CLOZAPINE dosage: 25 MG DAILY PO. Patient recovered.
Clozapine Side Effects Report #5331703-2
CLOZAPINE problem was reported by a Physician from UNITED STATES on May 07, 2007. Male patient, 63 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, respiratory failure, sepsis. CLOZAPINE dosage: 450 MG, ORAL. Patient died on 03/12/2007.
Clozapine Side Effects Report #5331775-5
Health Professional from UNITED STATES reported CLOZAPINE problem on May 04, 2007. Female patient, 71 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: pneumonia, small intestinal obstruction. CLOZAPINE dosage: (12.5MG). Patient was hospitalized. Patient died on 03/01/2007.
Clozapine Side Effects Report #5331792-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on May 02, 2007. Male patient, 48 years of age, was diagnosed with bipolar disorder, schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: anaemia, granulocytopenia, haemodynamic instability, leukopenia, lymphoma, shock. CLOZAPINE dosage: unknown. During the same period patient was treated with PAXIL, GLYBURIDE AND METFORMIN, PREVACID, ACTOS, CRESTOR. Patient was hospitalized. Patient recovered.
Clozapine Side Effects Report #5331795-0
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on May 02, 2007. Female patient, 46 years of age, weighting 187.0 lb, was diagnosed with bipolar disorder, schizophrenia, hepatitis and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: bipolar disorder, granulocytopenia, influenza like illness, leukopenia, liver disorder, thrombocytopenia. CLOZAPINE dosage: 100 MG 3 TIMES A DAY, ORAL. During the same period patient was treated with PEGASYS, METFORMIN, TRAZODONE, RIBAVIRIN, NORFLOXACIN. Patient was hospitalized and became disabled. Patient recovered.
Clozapine Side Effects Report #5331979-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on May 04, 2007. Male patient, 49 years of age, weighting 212.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident, dyspnoea, neutrophil count decreased, white blood cell count decreased. CLOZAPINE dosage: unknown. During the same period patient was treated with FLUOXETINE, HYDROCHLORIDE, ARIPIPRAZOLE, DESMOPRESSIN, OMEPRAZOLE, DILTIAZEM, FUROSEMIDE. Patient was hospitalized. Patient recovered.
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Drug Information: Clozapine
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a691001.html
(kloe' za peen)IMPORTANT WARNING:
| Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you start your treatment, during your treatment, and for at least 4 weeks after your treatment. Your doctor will order the lab tests once a week at first and may order the tests less often as your treatment continues. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; weakness; fever, sore throat, chills, or other signs of flu or infection; or sores in your mouth or throat. A program has been set up by the manufacturers of clozapine to be sure that people do not take clozapine without the necessary monitoring. You, your doctor, and your pharmacist must be registered with the program, and your pharmacist will not dispense your medication unless he or she has received the results of your blood tests. Ask your doctor for more information about this program and how you will receive your medication. Clozapine may cause seizures. Tell your doctor if you have or have ever had seizures. Do not drive a car, operate machinery, swim, or climb while taking clozapine, because if you suddenly lose consciousness, you could harm yourself or others.Clozapine may cause myocarditis (swelling of the heart muscle that may be dangerous). If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; difficulty breathing or fast breathing; fever; chest pain; or fast, irregular, or pounding heartbeat.Clozapine may cause dizziness, lightheadedness, or fainting when you stand up, especially when you first start taking it or when your dose is increased. Tell your doctor if you are taking medications for anxiety such as diazepam (Valium), sleeping pills, or other medications for schizophrenia. Your doctor will probably start you on a low dose of clozapine and gradually increase your dose to give your body time to adjust to the medication and decrease the chance that you will experience this side effect. Talk to your doctor if you do not take clozapine for 2 days or longer. Your doctor will probably tell you to restart your treatment with a low dose of clozapine.Use in Older Adults:Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as clozapine have an increased chance of death during treatment. If you experience any of the following symptoms, call your doctor immediately: slow or difficult speech, sudden dizziness or faintness, or weakness or numbness of an arm or leg.Clozapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed clozapine if you, a family member, or someone you care for has dementia and is taking this medication. For more information visit the FDA website: http://www.fda.gov/cder |
Why is this medication prescribed?
Clozapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in patients who have not been helped by other medications or who have tried to kill themselves and are likely to try to kill or harm themselves again. Clozapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
How should this medicine be used?
Clozapine comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken one to three times a day. Take clozapine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clozapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not try to push the orally disintegrating tablet through the foil packaging. Instead, use dry hands to peel back the foil. Immediately take out the tablet and place it on your tongue. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow disintegrating tablets.
Clozapine controls schizophrenia but does not cure it. It may take several weeks or longer before you feel the full benefit of clozapine. Continue to take clozapine even if you feel well. Do not stop taking clozapine without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Other uses for this medicine
This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking clozapine,
- tell your doctor and pharmacist if you are allergic to clozapine or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention those listed in the IMPORTANT WARNING section and any of the following: antihistamines; benztropine (Cogentin); cimetidine (Tagamet); ciprofloxacin (Cipro); dicyclomine (Bentyl); epinephrine; erythromycin (E.E.S., E-Mycin, others); medications for high blood pressure, mental illness, or nausea; medications for irregular heartbeat such as encainide, flecainide (Tambocor), propafenone (Rythmol), and quinidine (Quinidex);medications for seizures such as carbamazepine (Tegretol) or phenytoin (Dilantin); rifampin (Rifadin, Rimactane); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft);sleeping pills; tranquilizers; and trihexyphenidyl (Artane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- in addition to the condition listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had problems with your urinary system or prostate (a male reproductive gland); paralytic ileus (condition in which food cannot move through the intestine); glaucoma; irregular heartbeat; high or low blood pressure; or heart, kidney, lung, or liver disease; or if you or anyone in your family has or has ever had diabetes. Also tell your doctor if you have ever had to stop taking a medication for mental illness because of severe side effects.
- tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking clozapine, call your doctor. Do not breast-feed while you are taking this medication.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clozapine.
- you should know that alcohol can add to the drowsiness caused by this medication.
- tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
- you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking clozapine or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking clozapine: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
- if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the orally disintegrating tablets contain phenylalanine.
What special dietary instructions should I follow?
Talk to your doctor about drinking caffeinated beverages while taking this medicine.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
If you miss taking clozapine for more than 2 days, you should call your doctor before taking any more medication. Your doctor may want to restart your medication at a lower dose.
What side effects can this medication cause?
Clozapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness
- dizziness
- increased salivation
- constipation
- dry mouth
- restlessness
- headache
Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS sections, call your doctor immediately:
- shaking hands that you cannot control
- seizures
- fainting
- difficulty urinating or loss of bladder control
- confusion
- changes in vision
- shakiness
- fever
- severe muscle stiffness
- sweating
- confusion
- changes in behavior
- sore throat
- unusual bleeding or bruising
- loss of appetite
- upset stomach
- yellowing of the skin or eyes
- pain in the upper right part of the stomach
- flu-like symptoms
- lack of energy
Clozapine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed and any orally disintegrating tablets that you removed from the blister pack but did not use immediately. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- dizziness
- fainting
- slow breathing
- change in heartbeat
- loss of consciousness
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to clozapine.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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