Clozapine Safety Reports submitted to FDA

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Total Clozapine reports: 993.
Clozapine FDA safety alerts: 2002 2004 2006 .
Reported deaths: 139 Reported hospitalizations: 169.
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FDA Reported Clozapine Side Effects: granulocytopenia, leukopenia, death, pyrexia, agranulocytosis, neutrophil count decreased, c-reactive protein increased, white blood cell count decreased, condition aggravated, diarrhoea, treatment noncompliance.
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Clozapine Side Effects Report #5061870-X
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 15, 2005. Female patient, 47 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with RISPERIDONE, VALPROATE. Patient recovered.

Clozapine Side Effects Report #5061871-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 19, 2005. Male patient, 27 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5061872-3
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 21, 2005. Female patient, 37 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with VALPROATE, SETRALINE. Patient recovered.

Clozapine Side Effects Report #5061873-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 21, 2005. Male patient, 35 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG;HS;ORAL. Patient recovered.

Clozapine Side Effects Report #5061874-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 22, 2005. Male patient, 27 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG;HS;ORAL. During the same period patient was treated with VALPROATE, GEMFIBROZIL. Patient recovered.

Clozapine Side Effects Report #5061877-2
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 22, 2005. Female patient, 30 years of age, weighting 178.0 lb, was diagnosed with bipolar i disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with LAMOTRIGINE. Patient recovered.

Clozapine Side Effects Report #5061878-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 21, 2005. Male patient, 51 years of age, weighting 260.0 lb, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 300 MG;BID;ORAL. During the same period patient was treated with DEPAKOTE ER, METHYLCELLULOSE, ATORVASTATIN CALCIUM, RANITIDINE, HYDROCHLORIDE CLOPIDOGREL SULPHATE. Patient recovered.

Clozapine Side Effects Report #5061879-6
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 23, 2005. Female patient, 53 years of age, weighting 233.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 150 MG;HS;ORAL. Patient recovered.

Clozapine Side Effects Report #5061880-2
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 23, 2005. Male patient, 42 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 600 MG;QD;ORAL. Patient recovered.

Clozapine Side Effects Report #5061886-3
CLOZAPINE problem was reported by a Health Professional from SOUTH AFRICA on July 19, 2006. Male patient, 56 years of age, was diagnosed with schizophrenia, hypertension and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: constipation, convulsion, delusion, diarrhoea, hiccups, intestinal obstruction, malignant neoplasm progression, morbid thoughts, weight decreased. CLOZAPINE dosage: 300-400 MG/D. During the same period patient was treated with ENALAPRIL MALEATE. Patient was hospitalized. Patient died.

Clozapine Side Effects Report #5061891-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 22, 2005. Male patient, 57 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, granulocytopenia, leukopenia, pneumonia. CLOZAPINE dosage: 200 MG;BID;ORAL. Patient was hospitalized. Patient recovered.

Clozapine Side Effects Report #5061909-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 14, 2005. Male patient, 33 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with INSULIN, PIOGLITAZONE, VALPROATE, SIMVASTATIN, LISINOPRIL, GEMFIBROZIL, OXYBUTYNIN. Patient recovered.

Clozapine Side Effects Report #5061910-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 12, 2005. Female patient, 58 years of age, was diagnosed with schizophrenia, undifferentiated type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with ACETYLSALICYLIC ACID SRT, ALBUTEROL SPIROS, ATORVASTATIN CALCIUM, DONEPEZIL HYDROCHLORIDE, OXYBUTYNIN HYDROCHLORIDE, VALPROATE. Patient recovered.

Clozapine Side Effects Report #5061913-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 08, 2005. Male patient, 44 years of age, weighting 163.0 lb, was diagnosed with psychotic disorder, schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: eosinophil count increased, granulocytopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5061915-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 14, 2005. Female patient, 33 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5061917-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 14, 2005. Male patient, 48 years of age, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 550 MG;HS;ORAL. During the same period patient was treated with LAMOTRIGINE, DOCUSATE, VALPROATE, PHENYLEPHRINE HYDROCHLORIDE. Patient recovered.

Clozapine Side Effects Report #5061919-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 13, 2005. Female patient, 53 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with VALPROATE, BUPROPION, ZIPRASIDONE, FERROUS SULPHATE, DOCUSATE. Patient recovered.

Clozapine Side Effects Report #5061921-2
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 16, 2005. Male patient, 31 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with CHLORPROMAZINE HYDROCHLORIDE, PARACETAMOL. Patient recovered.

Clozapine Side Effects Report #5061924-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 19, 2005. Male patient, 35 years of age, weighting 275.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG;HS;ORAL. During the same period patient was treated with ZIPRASIDONE, QUETIAPINE FUMARATE, HALOPERIDOL. Patient recovered.

Clozapine Side Effects Report #5061926-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 15, 2005. Female patient, 37 years of age, weighting 209.0 lb, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with BENZTROPINE MESYLATE, FLUOXETINE HYDROCHLORIDE, FERROUS SULPHATE, LISINOPRIL. Patient recovered.

Clozapine Side Effects Report #5061928-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 19, 2005. Male patient, 32 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG;HS;ORAL. During the same period patient was treated with FLUPHENAZINE. Patient recovered.

Clozapine Side Effects Report #5061929-7
CLOZAPINE problem was reported by a Health Professional from UNITED STATES on Oct 24, 2005. Male patient, 27 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; BID; PO. Patient recovered.

Clozapine Side Effects Report #5061981-9
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 20, 2005. Female patient, 59 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, granulocytopenia, leukopenia. CLOZAPINE dosage: 100 MG; BID; PO. During the same period patient was treated with LISINOPRIL, METFORMIN, RISPERIDONE. Patient recovered.

Clozapine Side Effects Report #5061983-2
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Male patient, 64 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 600 MG; Q24; PO. Patient recovered.

Clozapine Side Effects Report #5061984-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 20, 2005. Female patient, 33 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; QAM; PO; SEE IMAGE. Patient recovered.

Clozapine Side Effects Report #5061989-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 25, 2005. Male patient, 51 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; HS; PO. During the same period patient was treated with OXYBUTYNIN, LITHIUM CARBONATE, FLUPHENAZINE DECANOATE. Patient recovered.

Clozapine Side Effects Report #5061990-X
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 25, 2005. Female patient, 45 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with DEXAMETHASONE SULPHATE, AMFETAMINE SULPHATE, SACCHARATE, VALPROATE, HALOPERIDOL DECANOATE, CLONAZEPAM. Patient recovered.

Clozapine Side Effects Report #5061993-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Male patient, 36 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; QAM; PO; SEE IMAGE. During the same period patient was treated with PROPRANOLOL, CLONAZEPAM, FLUOXETINE, CLOMIPRAMINE. Patient recovered.

Clozapine Side Effects Report #5061995-9
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 26, 2005. Female patient, 26 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; BID; PO. During the same period patient was treated with VALPROATE, NALTREXONE, PROPRANOLOL, SETRALINE. Patient recovered.

Clozapine Side Effects Report #5061996-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 25, 2005. Male patient, 40 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG; HS; PO; SEE IMAGE. During the same period patient was treated with HALOPERIDOL. Patient recovered.

Clozapine Side Effects Report #5061999-6
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 25, 2005. Female patient, 49 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; QAM; PO; SEE IMAGE. During the same period patient was treated with QUETIAPINE FUMARATE, PAROXETINE HYDROCHLORIDE. Patient recovered.

Clozapine Side Effects Report #5062007-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Female patient, 43 years of age, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 50 MG; HS; PO. During the same period patient was treated with TRIAMTERENE, ADIPEX, VENLAFAXINE, HALOPERIDOL. Patient recovered.

Clozapine Side Effects Report #5062008-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 13, 2005. Female patient, 51 years of age, was diagnosed with bipolar i disorder, schizoaffective disorder, schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, granulocytopenia. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with BENZTROPINE MESYLATE, TERBINAFINE, METOPROLOL TARTRATE, CLONAZEPAM, TOCOPHEROL CONCENTRATE CAP, LISINOPRIL. Patient recovered.

Clozapine Side Effects Report #5062010-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 13, 2005. Male patient, 29 years of age, weighting 155.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; HS; PO. During the same period patient was treated with PHENOBARBITAL, PHENYTOIN, HALOPERIDOL, BENZTROPINE MESYLATE, CLONAZEPAM, OLANZAPINE. Patient recovered.

Clozapine Side Effects Report #5062012-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 20, 2005. Male patient, 61 years of age, weighting 173.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; BID; PO. During the same period patient was treated with CLONAZEPAM, VALPROATE, FUROSEMIDE, GABAPENTIN, LEVOTHYROXINE, DOCUSATE, VITAMINS NOS. Patient recovered.

Clozapine Side Effects Report #5062014-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 13, 2005. Male patient, 22 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 150 MG; HS; ORAL. Patient recovered.

Clozapine Side Effects Report #5062015-2
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 20, 2005. Male patient, 43 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; QAM; ORAL; SEE IMAGE. Patient recovered.

Clozapine Side Effects Report #5062020-6
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 24, 2005. Male patient, 46 years of age, was diagnosed with psychotic disorder, schizoaffective disorder, schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 100 MG; QAM; PO; SEE IMAGE. During the same period patient was treated with PEGASYS, RISPERIDONE, CLONAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062023-1
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 24, 2005. Female patient, 20 years of age, was diagnosed with psychotic disorder, suicidal behaviour and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 10 MG; HS; PO. During the same period patient was treated with VALPROATE, LAMOTRIGINE, ARIPIPRAZOLE, LISINOPRIL, HYDROCHLOROTHIAZIDE, ZAFIRLUKAST, PANTOPRAZOLE. Patient recovered.

Clozapine Side Effects Report #5062024-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Male patient, 35 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG; Q24; PO. Patient recovered.

Clozapine Side Effects Report #5062026-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 21, 2005. Male patient, 64 years of age, weighting 177.0 lb, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 350 MG; BID; PO. During the same period patient was treated with ACETAMINOPHEN, IPRATROPIUM BROMIDE, ATENOLOL, BICALUTAMIDE, BISACODYL, CLONAZEPAM, DOCUSATE, PHOSPHATE DIBASIC. Patient recovered.

Clozapine Side Effects Report #5062028-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 04, 2005. Male patient, 52 years of age, was diagnosed with psychotic disorder, schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 100 MG;BID;PO. Patient recovered.

Clozapine Side Effects Report #5062039-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Sept 29, 2005. Female patient, 54 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG;QD;PO. Patient recovered.

Clozapine Side Effects Report #5062045-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 04, 2005. Female patient, 49 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with QUETIAPINE FUMARATE, THIAMINE, VITAMINS NOS. Patient recovered.

Clozapine Side Effects Report #5062050-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Sept 29, 2005. Male patient, 36 years of age, weighting 259.0 lb, was diagnosed with bipolar disorder, schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with DESMOPRESSIN, NICOTINIC ACID, VALPROIC ACID, VALPROATE, CLONAZEPAM, LITHIUM CARBONATE, GEMFIBROZIL. Patient recovered.

Clozapine Side Effects Report #5062052-8
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 30, 2005. Male patient, 51 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5062053-X
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 04, 2005. Male patient, 43 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 600 MG;HS;PO. During the same period patient was treated with IPRATROPIUM BROMIDE, LITHIUM CARBONATE, LORAZEPAM, BENZTROPINE MESYLATE, PROPRANOLOL. Patient recovered.

Clozapine Side Effects Report #5062058-9
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 30, 2005. Female patient, 21 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: leukopenia. CLOZAPINE dosage: 400 MG;HS;PO. During the same period patient was treated with HALOPERIDOL, TOPIRAMATE, ALPRAZOLAM, ATENOLOL, QUETIAPINE FUMARATE. Patient recovered.

Clozapine Side Effects Report #5062071-1
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Sept 30, 2005. Male patient, 44 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with LAMOTRIGINE, INSULIN, PROPRANOLOL, LISINOPRIL, OXCARBAZEPINE. Patient recovered.

Clozapine Side Effects Report #5062072-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 30, 2005. Female patient, 77 years of age, weighting 134.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 50 MG;BID;PO. During the same period patient was treated with FENTANYL, RISEDRONATE, GABAPENTIN, CALCIUM CARBONATE, FLUOXETINE. Patient recovered.

Clozapine Side Effects Report #5062073-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 04, 2005. Male patient, 73 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG;QID;PO. During the same period patient was treated with SALMETEROL XINAFOATE, VENLAFAXINE, ALPRAZOLAM, MIRTAZAPINE, DOXAZOSIN MESYLATE, ACETYLSALICYLIC ACID SRT, FAMOTIDINE, VITAMINS NOS. Patient recovered.

Clozapine Side Effects Report #5062074-7
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 05, 2005. Male patient, 46 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; HS; PO. Patient recovered.

Clozapine Side Effects Report #5062081-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 04, 2005. Female patient, 31 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with PROPRANOLOL HYDROCHLORIDE, PHENYTOIN, CLONIDINE, FLUOXETINE HYDROCHLORIDE. Patient recovered.

Clozapine Side Effects Report #5062082-6
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 04, 2005. Male patient, 32 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; QD; PO. During the same period patient was treated with FLUOXETINE, CLONAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062083-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 04, 2005. Male patient, 44 years of age, weighting 197.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, granulocytopenia, leukopenia. CLOZAPINE dosage: 200 MG; HS; PO. During the same period patient was treated with VITAMINS NOS, DOCUSATE, VALPROATE, BENZTROPINE MESYLATE. Patient recovered.

Clozapine Side Effects Report #5062117-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 04, 2005. Male patient, 50 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: asthenia, granulocytopenia, lethargy, malaise. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with INSULIN, LEVOTHYROXINE. Patient was hospitalized. Patient recovered.

Clozapine Side Effects Report #5062122-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 05, 2005. Female patient, 30 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5062124-8
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 05, 2005. Male patient, 47 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with GEMFIBROZIL, ATORVASTATIN CALCIUM, ZIPRASIDONE, VALPROATE, PANTOPRAZOLE, METOPROLOL TARTRATE, GLYCERYL TRINITRATE, CLEMASTINE. Patient recovered.

Clozapine Side Effects Report #5062125-X
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 07, 2005. Male patient, 72 years of age, weighting 263.0 lb, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, granulocytopenia, leukopenia. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with ACETYLSALICYLIC ACID SRT, RISPERIDONE, LEVOTHYROXINE, DOCUSATE, LACTULOSE, VITAMINS, CALCIUM GLUCONATE, DIMETICONE. Patient recovered.

Clozapine Side Effects Report #5062126-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Male patient, 22 years of age, weighting 180.0 lb, was diagnosed with schizoaffective disorder, schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with VALPROATE, DOCUSATE, FISH OIL. Patient recovered.

Clozapine Side Effects Report #5062127-3
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 07, 2005. Female patient, 54 years of age, weighting 136.9 lb, was diagnosed with bipolar disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 300 MG;BID;ORAL. During the same period patient was treated with LAMOTRIGINE, DESMOPRESSIN, DOCUSATE. Patient recovered.

Clozapine Side Effects Report #5062128-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Female patient, 44 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with RISPERIDONE, OLANZAPINE, VALPROATE, CLONAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062129-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 11, 2005. Male patient, 41 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG;QD;PO. During the same period patient was treated with VALPROATE, ZIPRASIDONE, METFORMIN HYDROCHLORIDE, PROPRANOLOL, VITAMINS. Patient recovered.

Clozapine Side Effects Report #5062130-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Male patient, 42 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with HALOPERIDOL, VALPROATE, BENZTROPINE MESYLATE, CLONAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062131-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 05, 2005. Male patient, 17 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG;HS;PO. During the same period patient was treated with VALPROATE, HYDROCHLOROTHIAZIDE, LEVOTHYROXINE, TRAZODONE, ARIPIPRAZOLE, BENZATROPINE, NALTREXONE, IBUPROFEN. Patient recovered.

Clozapine Side Effects Report #5062158-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Male patient, 46 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with TOLTERIDONE L, FENOFIBRATE, RANITIDINE HYDROCHLORIDE, LEVOTHYROXINE, ALLOPURINOL, LITHIUM CARBONATE, VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062162-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 11, 2005. Male patient, 42 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with OLANZAPINE, RABEPRAZOLE, VALPROATE, TAMSULOSIN HYDROCHLORIDE, SIMVASTATIN, POTASSIUM CHLORIDE, FAMOTIDINE. Patient recovered.

Clozapine Side Effects Report #5062164-9
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Female patient, 28 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG;BID;ORAL. During the same period patient was treated with LANSOPRAZOLE, CLONAZEPAM, POTASSIUM CHLORIDE, TEGASEROD, RISPERIDONE, PHENYTOIN, RANITIDINE. Patient recovered.

Clozapine Side Effects Report #5062165-0
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 11, 2005. Male patient, 47 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with BENZTROPINE MESYLATE, VALPROATE, OLANZAPINE. Patient recovered.

Clozapine Side Effects Report #5062173-X
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Male patient, 53 years of age, weighting 372.1 lb, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with VALPROATE, ATORVASTATIN CALCIUM, FAMOTIDINE, AMLODIPINE BESYLATE, ATENOLOL. Patient recovered.

Clozapine Side Effects Report #5062209-6
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 11, 2005. Male patient, 48 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; QAM; PO; SEE IMAGE. Patient recovered.

Clozapine Side Effects Report #5062243-6
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 07, 2005. Male patient, 51 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG; Q24; PO. Patient recovered.

Clozapine Side Effects Report #5062257-6
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 13, 2005. Female patient, 72 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; HS; PO. During the same period patient was treated with VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062263-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 13, 2005. Female patient, 26 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. Patient recovered.

Clozapine Side Effects Report #5062266-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 14, 2005. Male patient, 22 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: 100 MG; TID;PO. During the same period patient was treated with VALPROIC ACID, HALOPERIDOL, LACTULOSE, PARACETAMOL. Patient recovered.

Clozapine Side Effects Report #5062268-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 14, 2005. Female patient, 45 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with BENZTROPINE MESYLATE, DIPHENHYDRAMINE HYDROCHLORIDE, GLIBENCLAMIDE, METFORMIN HYDROCHLORIDE, ATORVASTATIN CALCIUM, ENALAPRIL MALEATE, OMEPRAZOLE. Patient recovered.

Clozapine Side Effects Report #5062270-9
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 17, 2005. Male patient, 35 years of age, weighting 269.0 lb, was diagnosed with psychotic disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with VALPROIC ACID, CHLORPROMAZINE, BENZTROPEINE, GLIPIZIDE, TOCOPHEROL CONCENTRATE CAP, LACTULOSE, DOCUSATE. Patient recovered.

Clozapine Side Effects Report #5062273-4
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Male patient, 21 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062276-X
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 17, 2005. Female patient, 45 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with ATORVASTATIN CALCIUM, METFORMIN, METHYLCELLULOSE, DOCUSATE. Patient recovered.

Clozapine Side Effects Report #5062279-5
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Male patient, 44 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG ; HS; PO. During the same period patient was treated with MIRTAZAPINE, RISPERIDONE, ZALEPLON, VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062282-5
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 14, 2005. Male patient, 30 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 550 MG; HS; PO. During the same period patient was treated with VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062286-2
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 11, 2005. Female patient, 44 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 150 MG; HS; ORAL. During the same period patient was treated with AMITRIPTYLINE, LORAZEPAM, ESOMEPRAZOLE MAGNESIUM, MACROGOL, MIRTAZAPINE, LEVOTHYROXINE, DOCUSATE. Patient recovered.

Clozapine Side Effects Report #5062290-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 17, 2005. Male patient, 37 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 600 MG; HS; ORAL. Patient recovered.

Clozapine Side Effects Report #5062293-X
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Male patient, 22 years of age, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG; HS; PO. Patient recovered.

Clozapine Side Effects Report #5062295-3
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 20, 2005. Male patient, 17 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG; HS; PO. During the same period patient was treated with BUPROPION, TOPIRAMATE, GALANTAMINE HYDROBROMIDE, SETRALINE. Patient recovered.

Clozapine Side Effects Report #5062298-9
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 17, 2005. Male patient, 27 years of age, was diagnosed with schizoaffective disorder, schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 700 MG; HS; ORAL. Patient recovered.

Clozapine Side Effects Report #5062300-4
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 17, 2005. Male patient, 40 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 300 MG; QAM; ORAL; SEE IMAGE. During the same period patient was treated with FLUOXETINE HYDROCHLORIDE, TRAZODONE. Patient recovered.

Clozapine Side Effects Report #5062301-6
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 19, 2005. Male patient, 31 years of age, was diagnosed with schizophrenia, paranoid type and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 100 MG; QAM; PO; SEE IMAGE. Patient recovered.

Clozapine Side Effects Report #5062302-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Oct 17, 2005. Male patient, 32 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with RISPERIDONE, CARBAMAZEPINE, LORAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062304-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 20, 2005. Male patient, 52 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG; HS; PO. Patient recovered.

Clozapine Side Effects Report #5062309-0
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 09, 2005. Male patient, 45 years of age, weighting 190.0 lb, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with OLANZAPINE. Patient recovered.

Clozapine Side Effects Report #5062312-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 09, 2005. Female patient, 26 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG;HS;ORAL. During the same period patient was treated with BENZTROPINE MESYLATE, VALPROATE, HALOPERIDOL, LORAZEPAM, PANTOPRAZOLE. Patient recovered.

Clozapine Side Effects Report #5062315-6
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 08, 2005. Male patient, 47 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 200 MG;BID;ORAL. During the same period patient was treated with TOCOPHEROL CONCENTRATE CAP, BENZTROPINE MESYLATE, ZALEPLON, VALPROATE, VITAMINS NOS, DOCUSATE, RANITIDINE. Patient recovered.

Clozapine Side Effects Report #5062318-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 08, 2005. Male patient, 50 years of age, weighting 201.0 lb, was diagnosed with schizoaffective disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with DEPAKOTE, FOLIC ACID, OLANZAPINE, LORAZEPAM. Patient recovered.

Clozapine Side Effects Report #5062319-3
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 08, 2005. Male patient, 24 years of age, was diagnosed with bipolar disorder and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with BUPROPION, MODAFINIL, VALPROATE. Patient recovered.

Clozapine Side Effects Report #5062321-1
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 08, 2005. Male patient, 35 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, leukopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with TRAZODONE, ESCITALOPRAM, TOLTERODINE TARTRATE, MAPROTILINE, HYDROCHLORIDE, BUPROPION. Patient recovered.

Clozapine Side Effects Report #5062324-7
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 12, 2005. Male patient, 24 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 150 MG;HS;ORAL. During the same period patient was treated with LORAZEPAM, QUETIAPINE FUMARATE. Patient recovered.

Clozapine Side Effects Report #5062326-0
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 09, 2005. Male patient, 60 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: 400 MG;Q24;ORAL. Patient recovered.

Clozapine Side Effects Report #5062333-8
Consumer or non-health professional from UNITED STATES reported CLOZAPINE problem on Dec 14, 2005. Male patient, 32 years of age, was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with ZITHROMAX, ACETYLSALICYLIC ACID SRT, DOCUSATE, QUETIAPINE FUMARATE, SENNA FRUIT, VALPROIC ACID. Patient recovered.

Clozapine Side Effects Report #5062336-3
CLOZAPINE problem was reported by a Consumer or non-health professional from UNITED STATES on Dec 14, 2005. Female patient, 51 years of age, was diagnosed with schizophrenia and was treated with CLOZAPINE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia. CLOZAPINE dosage: unknown. During the same period patient was treated with PIOGLITAZONE, EZETIMIBE, FLUOXETINE, HYDROCHLORIDE, VALPROATE, GEMFIBROZIL, PROPRANOLOL. Patient recovered.

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Drug Information: Clozapine

URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a691001.html

(kloe' za peen)

IMPORTANT WARNING:

Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you start your treatment, during your treatment, and for at least 4 weeks after your treatment. Your doctor will order the lab tests once a week at first and may order the tests less often as your treatment continues. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; weakness; fever, sore throat, chills, or other signs of flu or infection; or sores in your mouth or throat. A program has been set up by the manufacturers of clozapine to be sure that people do not take clozapine without the necessary monitoring. You, your doctor, and your pharmacist must be registered with the program, and your pharmacist will not dispense your medication unless he or she has received the results of your blood tests. Ask your doctor for more information about this program and how you will receive your medication. Clozapine may cause seizures. Tell your doctor if you have or have ever had seizures. Do not drive a car, operate machinery, swim, or climb while taking clozapine, because if you suddenly lose consciousness, you could harm yourself or others.Clozapine may cause myocarditis (swelling of the heart muscle that may be dangerous). If you experience any of the following symptoms, call your doctor immediately: extreme tiredness; difficulty breathing or fast breathing; fever; chest pain; or fast, irregular, or pounding heartbeat.Clozapine may cause dizziness, lightheadedness, or fainting when you stand up, especially when you first start taking it or when your dose is increased. Tell your doctor if you are taking medications for anxiety such as diazepam (Valium), sleeping pills, or other medications for schizophrenia. Your doctor will probably start you on a low dose of clozapine and gradually increase your dose to give your body time to adjust to the medication and decrease the chance that you will experience this side effect. Talk to your doctor if you do not take clozapine for 2 days or longer. Your doctor will probably tell you to restart your treatment with a low dose of clozapine.Use in Older Adults:Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as clozapine have an increased chance of death during treatment. If you experience any of the following symptoms, call your doctor immediately: slow or difficult speech, sudden dizziness or faintness, or weakness or numbness of an arm or leg.Clozapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed clozapine if you, a family member, or someone you care for has dementia and is taking this medication. For more information visit the FDA website: http://www.fda.gov/cder

Why is this medication prescribed?

Clozapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in patients who have not been helped by other medications or who have tried to kill themselves and are likely to try to kill or harm themselves again. Clozapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.

How should this medicine be used?

Clozapine comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken one to three times a day. Take clozapine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clozapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not try to push the orally disintegrating tablet through the foil packaging. Instead, use dry hands to peel back the foil. Immediately take out the tablet and place it on your tongue. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow disintegrating tablets.

Clozapine controls schizophrenia but does not cure it. It may take several weeks or longer before you feel the full benefit of clozapine. Continue to take clozapine even if you feel well. Do not stop taking clozapine without talking to your doctor. Your doctor will probably want to decrease your dose gradually.

Other uses for this medicine

This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking clozapine,

tell your doctor and pharmacist if you are allergic to clozapine or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention those listed in the IMPORTANT WARNING section and any of the following: antihistamines; benztropine (Cogentin); cimetidine (Tagamet); ciprofloxacin (Cipro); dicyclomine (Bentyl); epinephrine; erythromycin (E.E.S., E-Mycin, others); medications for high blood pressure, mental illness, or nausea; medications for irregular heartbeat such as encainide, flecainide (Tambocor), propafenone (Rythmol), and quinidine (Quinidex);medications for seizures such as carbamazepine (Tegretol) or phenytoin (Dilantin); rifampin (Rifadin, Rimactane); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft);sleeping pills; tranquilizers; and trihexyphenidyl (Artane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
in addition to the condition listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had problems with your urinary system or prostate (a male reproductive gland); paralytic ileus (condition in which food cannot move through the intestine); glaucoma; irregular heartbeat; high or low blood pressure; or heart, kidney, lung, or liver disease; or if you or anyone in your family has or has ever had diabetes. Also tell your doctor if you have ever had to stop taking a medication for mental illness because of severe side effects.
tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking clozapine, call your doctor. Do not breast-feed while you are taking this medication.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clozapine.
you should know that alcohol can add to the drowsiness caused by this medication.
tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking clozapine or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking clozapine: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the orally disintegrating tablets contain phenylalanine.

What special dietary instructions should I follow?

Talk to your doctor about drinking caffeinated beverages while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you miss taking clozapine for more than 2 days, you should call your doctor before taking any more medication. Your doctor may want to restart your medication at a lower dose.

What side effects can this medication cause?

Clozapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness
dizziness
increased salivation
constipation
dry mouth
restlessness
headache

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS sections, call your doctor immediately:

shaking hands that you cannot control
seizures
fainting
difficulty urinating or loss of bladder control
confusion
changes in vision
shakiness
fever
severe muscle stiffness
sweating
confusion
changes in behavior
sore throat
unusual bleeding or bruising
loss of appetite
upset stomach
yellowing of the skin or eyes
pain in the upper right part of the stomach
flu-like symptoms
lack of energy

Clozapine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed and any orally disintegrating tablets that you removed from the blister pack but did not use immediately. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

dizziness
fainting
slow breathing
change in heartbeat
loss of consciousness

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to clozapine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

Clozaril®

FazaClo®

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