PatientsVille.com Logo

PatientsVille

Colistin Side Effects

Common Colistin Side Effects


The most commonly reported Colistin side effects (click to view or check a box to report):

Blood Creatinine Increased (6)
Renal Failure Acute (6)
Respiratory Failure (4)
Renal Impairment (4)
Paraesthesia (3)
Pseudomembranous Colitis (3)
Dyspnoea (3)
Pyrexia (3)
Tachycardia (3)
Sepsis (3)
Acute Respiratory Distress Syndrome (2)
Abdominal Distension (2)
Clostridium Difficile Colitis (2)
Condition Aggravated (2)
Renal Disorder (2)
Hypotension (2)
Overdose (1)
Operative Haemorrhage (1)
Neutropenic Colitis (1)
Ocular Vasculitis (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Colistin Side Effects Reported to FDA

The following Colistin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Colistin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Distal Ileal Obstruction Syndrome, Constipation
This is a report of a 33-year-old male patient (weight: NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Colistin (colistin) (dosage: NA, start time: Jan 01, 2010), combined with:
  • Boniva
  • Albuterol
  • Cayston
  • Pulmozyme
  • Hypersol B (budesonide)
  • Mephyton (phytomenadione)
  • Spiriva
  • Vitamin D
and developed a serious reaction and side effect(s). The consumer presented with:
  • Distal Ileal Obstruction Syndrome
  • Constipation
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Colistin (colistin) treatment in male patients, resulting in distal ileal obstruction syndrome side effect. The patient was hospitalized.

Confusional State, Renal Failure, Acute Respiratory Distress Syndrome, Overdose, Condition Aggravated, Hypotension
This report suggests a potential Colistin Sulfate Confusional State, Renal Failure, Acute Respiratory Distress Syndrome, Overdose, Condition Aggravated, Hypotension side effect(s) that can have serious consequences. A 29-year-old male patient (weight: NA) from FRANCE was diagnosed with the following symptoms/conditions: pseudomonas infection and used Colistin Sulfate (dosage: NA) starting Apr 06, 2012. Soon after starting Colistin Sulfate the patient began experiencing various side effects, including:
  • Confusional State
  • Renal Failure
  • Acute Respiratory Distress Syndrome
  • Overdose
  • Condition Aggravated
  • Hypotension
Drugs used concurrently:
  • Pegzerepoetin Alfa
  • Na Polystyrene Sulfonate
  • Azithromycin
  • Posaconazole
  • Valaciclovir Hydrochlorid
  • Pancreatin Triple Strength Cap
  • Colecalciferol
  • Bisoprolol Fumarate
The patient was hospitalized. Although Colistin Sulfate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as confusional state, may still occur.

Respiratory Failure, Neutropenic Colitis, Sepsis
This Respiratory Failure, Neutropenic Colitis, Sepsis problem was reported by a physician from BELGIUM. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: prophylaxis,haematological malignancy. On Jan 10, 2012 this consumer started treatment with Colistin Sulfate (dosage: 100 Mg, Qid). The following drugs were being taken at the same time:
  • Evoltra (10 Mg/m2, Qod, On Days 2, 4, 6, 8, 10)
  • Allopurinol (300 Mg, Qd)
  • Valacyclovir Hydrochloride (500 Mg, Bid)
  • Cytarabine (100 Mg/m2, Qd)
  • Acyclovir (250 Mg, Qd)
  • Ceftazidime (1000 Mg, Qid)
  • Idarubicin Hcl (10 Mg/m2, Qod, On Days 1, 3, 5)
  • Acyclovir (500 Mg, Bid)
When commencing Colistin Sulfate, the patient experienced the following unwanted symptoms/side effects:
  • Respiratory Failure
  • Neutropenic Colitis
  • Sepsis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as respiratory failure, may become evident only after a product is in use by the general population.

Anaphylactic Shock, Dyspnoea, Feeling Hot
This is a report of a female patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: NA and was treated with Colistin Sulfate (dosage: Unk) starting Feb 28, 2012. Concurrently used drugs:
  • Meropenem (Unk)
  • Ambisome (120 Mg, Uid/qd)
Soon after that, the consumer experienced the following side effects:
  • Anaphylactic Shock
  • Dyspnoea
  • Feeling Hot
The patient was hospitalized. This opens a possibility that Colistin Sulfate treatment could cause the above reactions, including anaphylactic shock, and some female subjects may be more susceptible.


Quadriparesis, Rhabdomyolysis, Hypernatraemia
A 62-year-old male patient (weight: NA) from ITALY with the following symptoms/conditions: NA started Colistin treatment (dosage: Unk) on Nov 21, 2011. Soon after starting Colistin treatment, the subject experienced various side effects, including:
  • Quadriparesis
  • Rhabdomyolysis
  • Hypernatraemia
Concurrently used drugs:
  • Amikacin (1g Daily)
  • Tygacil (50 Mg, 2x/day)
  • Tygacil (100 Mg, 2x/day)
This finding indicates that some male patients could be more vulnerable to Colistin.

Dehydration, Hypotension, Tachycardia, Pseudomembranous Colitis, Abdominal Distension
A 34-year-old male patient from UNITED KINGDOM (weight: NA) experienced symptoms, such as: NA and was treated with Colistin Sulfate(dosage: Intravenous). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Dehydration
  • Hypotension
  • Tachycardia
  • Pseudomembranous Colitis
  • Abdominal Distension
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Colistin Sulfate efficacy:
  • Meropenem (Intravenous)
  • Clarithromycin
  • Tobramycin
  • Omeprazole
  • Interferon Gamma Nos (Subcutaneous)
  • Minocycline Hcl
  • Ciprofloxacin
The patient was hospitalized.

Jugular Vein Thrombosis, Chills, Pyrexia
In this report, Colistin was administered for the following condition: NA.A 59-year-old female consumer from ITALY (weight: NA) started Colistin treatment (dosage: NA) on May 29, 2009.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Jugular Vein Thrombosis
  • Chills
  • Pyrexia
A possible interaction with other drugs could have contributed to this reaction:
  • Cubicin
  • Immunoglobulins
  • Meropenem
  • Cubicin
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Colistin treatment could be related to the listed above side effect(s).

Hypoxic-ischaemic Encephalopathy, Metabolic Encephalopathy
This is a report of the following Colistin side effect(s):
  • Hypoxic-ischaemic Encephalopathy
  • Metabolic Encephalopathy
A 21-year-old female patient from BRAZIL (weight: NA) presented with the following condition: convulsion and received a treatment with Colistin (dosage: NA) starting: Sep 01, 2010.The following concurrently used drugs could have generated interactions:
  • Imipenem
  • Amlodipine
  • Atenolol
  • Ranitidine
  • Clonazine
  • Cubicin
  • Clonidine Hydrochloride
  • Solutions For Parenteral Nutrition
This report suggests that a Colistin treatment could be associated with the listed above side effect(s).

Pseudomembranous Colitis, Clostridium Difficile Colitis
This Colistin Sulfate report was submitted by a 34-year-old male consumer from UNITED KINGDOM (weight: NA). The patient was diagnosed with: NA and Colistin Sulfate was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Pseudomembranous Colitis
  • Clostridium Difficile Colitis
Other drugs used simultaneously:
  • Interferon Gamma Nos
  • Clarithromycin
  • Tobi (Unk)
  • Omeprazole (Unk)
  • Meropenem (Unk)
  • Minocycline Hcl (Unk)
  • Tobramycin (Unk)
  • Azithromycin (Unk)
The patient was hospitalized.Those unexpected symptoms could be linked to a Colistin Sulfate treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Liver Disorder
This is a report of a possible correlation between Colistin use and the following symptoms/side effect(s):
  • Liver Disorder
which could contribute to an assessment of Colistin risk profile.A female consumer from HUNGARY (weight: NA) was suffering from sepsis and was treated with Colistin (dosage: Unk Iu, Unk) starting Sep 27, 2010.Other concurrent medications:
  • Solu-medrol
  • Furosemide (Unk)
  • Amikacin (1 G, Uid/qd)
  • Propofol (Unk)
  • Pantoprazole Sodium (40 Mg, Bid)
  • Tobramycin (80 Mg, Tid)
  • Fluconazole (200 Mg, Bid)
  • Vancomycin (0.5 G, Tid)


Macular Oedema, Retinal Artery Occlusion, Ocular Vasculitis, Vision Blurred, Visual Acuity Reduced, Diabetic Retinopathy, Venous Occlusion
A 21-year-old female patient from UNITED KINGDOM (weight: NA) presented with the following symptoms: respiratory tract infection,immunosuppression and after a treatment with Colistin Sulfate (dosage: NA) experienced the following side effect(s):
  • Macular Oedema
  • Retinal Artery Occlusion
  • Ocular Vasculitis
  • Vision Blurred
  • Visual Acuity Reduced
  • Diabetic Retinopathy
  • Venous Occlusion
The treatment was started on NS. Colistin Sulfate was used in combination with the following drugs:
  • Tacrolimus (Unk)
  • Tobramycin
  • Creon (Unk)
  • Cotrim (Unk)
  • Meropenem
  • Ranitidine
This report could alert potential Colistin Sulfate consumers.

Dyspnoea, Flushing, Paraesthesia, Body Temperature Increased, Hypersensitivity
In this report, a 45-year-old female patient from UNITED KINGDOM (weight: NA) was affected by a possible Colistin Sulfate side effect.The patient was diagnosed with NA. After a treatment with Colistin Sulfate (dosage: NA, start date: May 25, 2011), the patient experienced the following side effect(s):
  • Dyspnoea
  • Flushing
  • Paraesthesia
  • Body Temperature Increased
  • Hypersensitivity
The following simultaneously used drugs could have led to this reaction:
  • Adcal D3
  • Meropenem (2 Grams, 1 Day, Intravenous Bolus)
  • Meropenem (2 Grams, 1 Day, Intravenous Bolus)
  • Creon
  • Megestrol Acetate
  • Carbocisteine
  • Pulmozyme
  • Symbicort
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Colistin Sulfate treatment.

C-reactive Protein Increased, Pyrexia, Abdominal Pain, Clostridium Difficile Colitis, Nausea, Abdominal Distension, Pseudomembranous Colitis, Tachycardia
This is a report of a 34-year-old male patient from UNITED KINGDOM (weight: NA), who used Colistin Sulfate (dosage: NA) for a treatment of mycobacterium abscessus infection. After starting a treatment on NS, the patient experienced the following side effect(s):
  • C-reactive Protein Increased
  • Pyrexia
  • Abdominal Pain
  • Clostridium Difficile Colitis
  • Nausea
  • Abdominal Distension
  • Pseudomembranous Colitis
  • Tachycardia
The following drugs could possibly have interacted with the Colistin Sulfate treatment
  • Azithromycin (Not Reported)
  • Tobramycin (Not Reported)
  • Interferon Gamma-1a (Not Reported)
The patient was hospitalized.Taken together, these observations suggest that a Colistin Sulfate treatment could be related to side effect(s), such as C-reactive Protein Increased, Pyrexia, Abdominal Pain, Clostridium Difficile Colitis, Nausea, Abdominal Distension, Pseudomembranous Colitis, Tachycardia.

Pneumonia Klebsiella, Sepsis, Febrile Infection, Urinary Tract Infection
This pneumonia klebsiella side effect was reported by a physician from FRANCE. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Colistin (dosage: NA), which was started on NS. Concurrently used drugs:
  • Primaxin
  • Amikacin
  • Teicoplanin
When starting to take Colistin the consumer reported the following symptoms:
  • Pneumonia Klebsiella
  • Sepsis
  • Febrile Infection
  • Urinary Tract Infection
The patient was hospitalized. These side effects may potentially be related to Colistin.

Acidosis, Blood Creatine Increased, Haemodialysis, Azotaemia, Tubulointerstitial Nephritis
This is a Colistin Sulfate side effect report of a 93-year-old male patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: cellulitis, who was treated with Colistin Sulfate (dosage:200 Mg Q12h Iv, start time: Feb 27, 2011), combined with: NA., and developed a serious reaction and a acidosis side effect. The patient presented with:
  • Acidosis
  • Blood Creatine Increased
  • Haemodialysis
  • Azotaemia
  • Tubulointerstitial Nephritis
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Colistin Sulfate treatment in male patients suffering from cellulitis, resulting in acidosis.

Tracheal Haemorrhage
This report suggests a potential Colistin Sulfate tracheal haemorrhage side effect(s) that can have serious consequences. A 32-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): lung infection pseudomonal and used Colistin Sulfate (dosage: 75 Mg Q 12 Hours Inhal) starting Jan 18, 2011. Soon after starting Colistin Sulfate the patient began experiencing various side effects, including:
  • Tracheal Haemorrhage
Drugs used concurrently:
  • Amikacin
The patient was hospitalized. Although Colistin Sulfate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as tracheal haemorrhage, may still occur.

Renal Failure Acute
This renal failure acute problem was reported by a pharmacist from UNITED STATES. A 84-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): pneumonia,sepsis,urinary tract infection.On Feb 06, 2010 a consumer started treatment with Colistin Sulfate (dosage: 150 Mg Q12h Iv Bolus). The following drugs/medications were being taken at the same time: NA. When commencing Colistin Sulfate, the patient experienced the following unwanted symptoms /side effects:
  • Renal Failure Acute
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as renal failure acute, may become evident only after a product is in use by the general population.

Acinetobacter Infection, Blood Creatinine Increased, Extradural Abscess
This is a Colistin 150mg side effect report of a 31-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: osteomyelitis and was treated with Colistin 150mg (dosage: 100mg Q8h Po) starting NS. Concurrently used drugs:
  • Vancomycin (1000mg Q12h Po)
Soon after that, the consumer experienced the following of symptoms:
  • Acinetobacter Infection
  • Blood Creatinine Increased
  • Extradural Abscess
This opens a possibility that Colistin 150mg could cause acinetobacter infection and that some female patients may be more susceptible.

Blood Creatinine Increased, Paraesthesia, Paraesthesia Oral
A 25-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: cystic fibrosis lung,condition aggravated started Colistin Sulfate treatment (dosage: 150 Mg Q12 Hours Iv Bolus) on Mar 31, 2009. Soon after starting Colistin Sulfate treatment, the consumer experienced several side effects, including:
  • Blood Creatinine Increased
  • Paraesthesia
  • Paraesthesia Oral
. Concurrently used drugs:
  • Trimethoprim-sulfamethoxazole (1 Tablet Bid Po)
The patient was hospitalized and became disabled. This finding indicates that some patients can be more vulnerable to developing Colistin Sulfate side effects, such as blood creatinine increased.

Pneumothorax
This pneumothorax side effect was reported by a pharmacist from UNITED STATES. A 55-year-old female patient (weight:NA) experienced the following symptoms/conditions: pneumonia.The patient was prescribed Colistin 150 Mg Parke-davis (dosage: 75mg 8 Endotracheal), which was started on Oct 10, 2007. Concurrently used drugs: NA..When starting to take Colistin 150 Mg Parke-davis the consumer reported symptoms, such as:
  • Pneumothorax
These side effects may potentially be related to Colistin 150 Mg Parke-davis.

Paraesthesia, Renal Failure Acute
This is a report of a female patient (weight: NA) from UNITED STATES, suffering from the following symptoms/conditions: cystic fibrosis, who was treated with Colistin Sulfate (dosage: 500 Mg Q 8 Hr Iv, start time: Nov 16, 2007), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Paraesthesia
  • Renal Failure Acute
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Colistin Sulfate treatment in female patients, resulting in paraesthesia side effect.

Condition Aggravated, Cystic Fibrosis, Dyspnoea, Lobar Pneumonia, Lung Infiltration, Oxygen Saturation Decreased, Pyrexia, Tachycardia
This report suggests a potential Colistin Sulfate Condition Aggravated, Cystic Fibrosis, Dyspnoea, Lobar Pneumonia, Lung Infiltration, Oxygen Saturation Decreased, Pyrexia, Tachycardia side effect(s) that can have serious consequences. A 37-year-old female patient (weight: NA) from UNITED STATES was diagnosed with the following symptoms/conditions: NA and used Colistin Sulfate (dosage: NA) starting NS. Soon after starting Colistin Sulfate the patient began experiencing various side effects, including:
  • Condition Aggravated
  • Cystic Fibrosis
  • Dyspnoea
  • Lobar Pneumonia
  • Lung Infiltration
  • Oxygen Saturation Decreased
  • Pyrexia
  • Tachycardia
Drugs used concurrently: NA.The patient was hospitalized. Although Colistin Sulfate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as condition aggravated, may still occur.

Renal Failure Acute
This Renal Failure Acute problem was reported by a pharmacist from UNITED STATES. A 54-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pancreatitis. On Jun 21, 2007 this consumer started treatment with Colistin Sulfate (dosage: 160mg Q12h Iv). The following drugs were being taken at the same time: NA. When commencing Colistin Sulfate, the patient experienced the following unwanted symptoms/side effects:
  • Renal Failure Acute
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as renal failure acute, may become evident only after a product is in use by the general population.

Acute Respiratory Distress Syndrome, Multi-organ Failure, Respiratory Failure
This is a report of a 29-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Colistin Aerosol 75 Mg Bid Compounding (dosage: 75 Mg Bid) starting Apr 26, 2007. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Acute Respiratory Distress Syndrome
  • Multi-organ Failure
  • Respiratory Failure
This opens a possibility that Colistin Aerosol 75 Mg Bid Compounding treatment could cause the above reactions, including acute respiratory distress syndrome, and some female subjects may be more susceptible.

Acute Respiratory Failure, Pancreatitis, Renal Failure Acute
A 45-year-old male patient (weight: NA) from UNITED STATES with the following symptoms/conditions: NA started Colistin Sulfate treatment (dosage: 250mg Q12h Iv) on Jun 19, 2006. Soon after starting Colistin Sulfate treatment, the subject experienced various side effects, including:
  • Acute Respiratory Failure
  • Pancreatitis
  • Renal Failure Acute
Concurrently used drugs:
  • Clonidine
  • Lisinopril
  • Premix
  • M.v.i.
  • Docusate
  • Baclofen
  • Tegretol
  • Nsaid
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Colistin Sulfate.

1 of 2 



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Colistin Side Effects

    Did You Have a Colistin Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Colistin for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Colistin Safety Alerts, Active Ingredients, Usage Information

    More About Colistin

    Side Effects reported to FDA: 35

    Colistin safety alerts: No

    Reported deaths: 4

    Reported hospitalizations: 14

    Latest Colistin clinical trials