Comtan Side Effects
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Comtan Safety Reports reported to FDA
Total Comtan reports: 124.Comtan FDA safety alerts: No.
Reported deaths: 14 Reported hospitalizations: 55.
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Reported Comtan Side Effects: pyrexia, hallucination, interstitial lung disease, dyspnoea, fall, hallucination, visual, neuroleptic malignant syndrome, pneumonia, blood pressure increased, pneumonia aspiration, muscle rigidity.
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Comtan Side Effects Report #5410832-9Consumer or non-health professional from FRANCE reported COMTAN problem on Aug 09, 2007. Male patient, 70 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: bleeding time prolonged, cerebral haematoma, cerebral haemorrhage, coagulopathy, deep brain stimulation, incision site haemorrhage, mydriasis, pupils unequal. COMTAN dosage: unknown. During the same period patient was treated with FLURBIPROFEN, PAROXETINE, SINEMET, REQUIP, MODOPAR, IMOVANE, MOTILIUM. Patient was hospitalized. Patient died.
Comtan Side Effects Report #5411728-9
COMTAN problem was reported by a Physician from JAPAN on Aug 06, 2007. Male patient, 52 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour. COMTAN dosage: 100 MG, TID. During the same period patient was treated with LEVODOPA W. Patient recovered.
Comtan Side Effects Report #5414853-1
Physician from JAPAN reported COMTAN problem on Aug 07, 2007. Female patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cough, eye pain, interstitial lung disease, pneumonia, productive cough, retinal haemorrhage, rhinalgia, rhinorrhoea, vitreous floaters. COMTAN dosage: 100 MG, QID. During the same period patient was treated with DEPAS, NEO DOPASTON, CABERGOLINE, RETICOLAN, SELBEX. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5422980-8
COMTAN problem was reported by a Health Professional from FRANCE on July 31, 2007. Male patient, 70 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cerebral haematoma, coagulopathy, delayed recovery from anaesthesia, incision site haemorrhage, mydriasis, post procedural haemorrhage, pupils unequal. COMTAN dosage: unknown. During the same period patient was treated with PANTOPRAZOLE, FLURBIPROFEN, PAROXETINE, SINEMET, REQUIP, MODOPAR, TAMSULOSIN, IMOVANE. Patient was hospitalized. Patient died.
Comtan Side Effects Report #5424443-2
Health Professional from JAPAN reported COMTAN problem on Aug 07, 2007. Male patient was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: pneumonia aspiration, somnolence. COMTAN dosage: unknown. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5424444-4
COMTAN problem was reported by a Health Professional from JAPAN on Aug 07, 2007. Female patient, 63 years of age, was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage. COMTAN dosage: 300 MG. During the same period patient was treated with DOPACOL, FERROMIA. Patient died.
Comtan Side Effects Report #5424446-8
Health Professional from JAPAN reported COMTAN problem on Aug 07, 2007. Female patient, 77 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease. COMTAN dosage: 200 MG. During the same period patient was treated with MENESIT, FLUVOXAMINE MALEATE, CLONAZEPAM, PERMAX. Patient recovered.
Comtan Side Effects Report #5424492-4
COMTAN problem was reported by a Consumer or non-health professional from FRANCE on Aug 10, 2007. Male patient, 70 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cerebral haematoma, cerebral haemorrhage, coagulopathy, incision site haemorrhage, mydriasis, post procedural complication, pupils unequal, somnolence. COMTAN dosage: unknown. During the same period patient was treated with LOXEN, INIPOMP, FLURBIPROFEN, PAROXETINE, SINEMET, REQUIP, MODOPAR. Patient was hospitalized. Patient died.
Comtan Side Effects Report #5424826-0
Consumer or non-health professional from UNITED STATES reported COMTAN problem on Aug 07, 2007. Female patient, 68 years of age, weighting 127.5 lb, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: hallucination. COMTAN dosage: 600 MG, 3 IN 1 D, ORAL. During the same period patient was treated with SINEMET, SINEMET CR, EFFEXOR, ACTONEL. Patient recovered.
Comtan Side Effects Report #5427222-5
COMTAN problem was reported by a Pharmacist from AUSTRALIA on Aug 20, 2007. Male patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: choking, dysphagia. COMTAN dosage: 200 MG, QID. During the same period patient was treated with SINEMET, RANITIDINE, SINEMET CR, MICARDIS HCT, MOVEX, NORVASC, KALMA. Patient recovered.
Comtan Side Effects Report #5427481-9
Physician from JAPAN reported COMTAN problem on Aug 21, 2007. Female patient, 77 years of age, was diagnosed with parkinson's disease, depression, constipation and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, chest x-ray abnormal, dyspnoea, eosinophilia, interstitial lung disease, oxygen saturation decreased, pneumonia, pyrexia, respiratory disorder. COMTAN dosage: 100 MG, BID. During the same period patient was treated with MENESIT, FLUVOXAMINE MALEATE, CLONAZEPAM, PERMAX, ARICEPT, SIFROL, MAGLAX. Patient recovered.
Comtan Side Effects Report #5427677-6
COMTAN problem was reported by a Physician from JAPAN on Aug 21, 2007. Female patient, 77 years of age, was diagnosed with parkinson's disease, depression, constipation and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, chest x-ray abnormal, dyspnoea, eosinophilia, interstitial lung disease, oxygen saturation decreased, pneumonia, pyrexia, respiratory disorder. COMTAN dosage: 100 MG, BID. During the same period patient was treated with MENESIT, FLUVOXAMINE MALEATE, CLONAZEPAM, PERMAX, ARICEPT, SIFROL, MAGLAX. Patient recovered.
Comtan Side Effects Report #5427814-3
Pharmacist from AUSTRALIA reported COMTAN problem on Aug 20, 2007. Male patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: choking, dysphagia. COMTAN dosage: 200 MG, QID. During the same period patient was treated with SINEMET, RANITIDINE, SINEMET CR, MICARDIS HCT, MOVEX, NORVASC, KALMA. Patient recovered.
Comtan Side Effects Report #5430536-6
COMTAN problem was reported by a Physician from JAPAN on Aug 23, 2007. Female patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cough, eye pain, interstitial lung disease, pneumonia, productive cough, retinal haemorrhage, rhinalgia, rhinorrhoea, vitreous floaters. COMTAN dosage: 100 MG, QID. During the same period patient was treated with DEPAS, NEO DOPASTON, CABERGOLINE, RETICOLAN, SELBEX. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5430948-0
Physician from JAPAN reported COMTAN problem on Aug 23, 2007. Female patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cough, eye pain, interstitial lung disease, pneumonia, productive cough, retinal haemorrhage, rhinalgia, rhinorrhoea, vitreous floaters. COMTAN dosage: 100 MG, QID. During the same period patient was treated with DEPAS, NEO DOPASTON, CABERGOLINE, RETICOLAN, SELBEX. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5441717-X
COMTAN problem was reported by a Consumer or non-health professional from JAPAN on Aug 11, 2007. Male patient, 52 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, delusional disorder, persecutory type. COMTAN dosage: 300 MG (100 MG, 3 IN 1 D) ORAL. During the same period patient was treated with LEVODOPA W. Patient recovered.
Comtan Side Effects Report #5441722-3
Consumer or non-health professional from JAPAN reported COMTAN problem on Aug 14, 2007. Female patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: eye haemorrhage, lymphocyte stimulation test positive, pneumonia, retinal haemorrhage, rhinalgia, rhinorrhoea, vitreous floaters. COMTAN dosage: 400 MG (100 MG, 4 IN 1 D) ORAL ; 400 MG (100 MG, 4 IN 1 D) ORAL. During the same period patient was treated with DEPAS, NEO DOPASTON, CABERGOLINE, RETICOLAN, SELBEX. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5448286-9
COMTAN problem was reported by a Physician from JAPAN on Sept 04, 2007. Male patient, 72 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: cough, pneumonia aspiration, somnolence. COMTAN dosage: 300 MG/D. During the same period patient was treated with NEO DOPASTON, CABERGOLINE, WARFARIN. Patient was hospitalized. Patient recovered.
Comtan Side Effects Report #5449597-3
Physician from JAPAN reported COMTAN problem on Sept 04, 2007. Male patient, 71 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: arrhythmia, blood pressure systolic increased, palpitations, tachycardia. COMTAN dosage: 300 MG/D. Patient recovered.
Comtan Side Effects Report #5451836-X
COMTAN problem was reported by a Physician from JAPAN on Aug 29, 2007. Female patient, 77 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: pneumonia, respiratory failure. COMTAN dosage: 200 MG (100 MG, 2 IN 1 D); 400 MG (100 MG, 4 IN 1D). During the same period patient was treated with MENESIT, FLUVOXAMINE MALEATE, RIVOTRIL, PERMAX, ARICEPT, SIFROL, MAGLAX. Patient recovered.
Comtan Side Effects Report #5455228-9
Consumer or non-health professional from BRAZIL reported COMTAN problem on Sept 10, 2007. Female patient, 67 years of age, was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, convulsion, disease progression, dizziness, nervousness, splenomegaly. COMTAN dosage: 200 MG/D. Patient recovered.
Comtan Side Effects Report #5455688-3
COMTAN problem was reported by a Physician from UNITED STATES on Sept 11, 2007. Female patient, 71 years of age, was diagnosed with parkinson's disease, hypertension and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, feeling jittery, hot flush, palpitations, vision blurred. COMTAN dosage: 100 MG, QID. During the same period patient was treated with SINEMET, PRAMIPEXOLE DIHYDROCHLORIDE, SELEGILINE, TRIHEXYPHENIDYL, AMLODIPINE, METOPROLOL. Patient recovered.
Comtan Side Effects Report #5455948-6
Physician from UNITED STATES reported COMTAN problem on Sept 11, 2007. Female patient, 71 years of age, was diagnosed with parkinson's disease, hypertension and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: blood pressure increased, feeling jittery, hot flush, palpitations, vision blurred. COMTAN dosage: 100 MG, QID. During the same period patient was treated with SINEMET, PRAMIPEXOLE DIHYDROCHLORIDE, SELEGILINE, TRIHEXYPHENIDYL, AMLODIPINE, METOPROLOL. Patient recovered.
Comtan Side Effects Report #5469209-2
COMTAN problem was reported by a Consumer or non-health professional from AUSTRALIA on Aug 29, 2007. Male patient was diagnosed with parkinson's disease and was treated with COMTAN. After drug was administered, patient experienced the following problems/side effects: choking, dysphagia. COMTAN dosage: 800 MG (200 MG, 4 IN 1 D) ORAL. During the same period patient was treated with SINEMET, RANITIDINE, SINEMET CR, MICARDIS HCT, MOVEX, NORVASC, KALMA, MADOPAR. Patient recovered.
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Drug Information: Entacapone
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601236.html
(en ta' ka pone)Why is this medication prescribed?
Entacapone is an inhibitor of catechol-O-methyltransferase (COMT). It is used in combination with levodopa and carbidopa (Sinemet) to treat the end-of-dose 'wearing-off' symptoms of Parkinson's disease. Entacapone helps the levodopa and carbidopa work better by allowing more of it to reach the brain, where it has its effects.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Entacapone comes as a tablet to take by mouth. It is taken with every dose of levodopa and carbidopa, up to 8 times a day. Entacapone may be taken with or without food. Read your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take entacapone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Entacapone helps control the symptoms of Parkinson's disease, but it does not cure it. Continue to take entacapone even if you feel well. Do not stop taking entacapone without talking to your doctor. Stopping entacapone suddenly may make your Parkinson's disease worse and could have other dangerous effects. Your doctor probably will decrease your dose gradually if necessary.
What special precautions should I follow?
Before taking entacapone,
- tell your doctor and pharmacist if you are allergic to entacapone or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially ampicillin, apomorphine (Zydis), bitolterol (Tornalate), chloramphenicol (AK-Chlor, Chloromycetin), cholestyramine (Cholybar, Questran, Questran Light, others), medications that cause drowsiness (including medications for anxiety and sleeping pills), dobutamine (Dobutrex), epinephrine (AsthmaHaler, EpiPen Auto-Injector, Primatene Mist, others), erythromycin (E-Base, E.E.S., E-Mycin, others), isoetharine (Arm-a-Med Isoetharine, Beta-2, Bronkometer, others), isoproterenol (Dispos-a-Med Isoproterenol, Isuprel, Medihaler-Iso, others), methyldopa (Aldomet), phenelzine (Nardil), probenecid (Benemid), rifampin (Rifadin, Rimactane), tranylcypromine (Parnate), and vitamins and herbal products.
- tell your doctor if you have or have ever had liver disease or a history of alcoholism.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking entacapone, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking entacapone.
- you should know that this medication may make you drowsy. Do not drive a car or operate heavy machinery until you know how entacapone affects you.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed dose.
What side effects can this medication cause?
Entacapone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness
- diarrhea
- upset stomach
- movements you cannot control
- stomach pain
- drowsiness
If you experience any of the following symptoms, call your doctor immediately:
- difficulty breathing
- hallucinations
- high fever
- confusion
- muscle stiffness
- weakness with or without a fever
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory.You may become dizzy when you get up after sitting or lying down, especially when you begin taking entacapone. To avoid this problem, make sure to get up slowly, especially if you have been sitting or lying down for a long time.
Entacapone may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.
Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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