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Daptomycin Side Effects

Common Daptomycin Side Effects

The most commonly reported Daptomycin side effects (click to view or check a box to report):

Blood Creatine Phosphokinase Increased (52)
Rhabdomyolysis (37)
Eosinophilic Pneumonia (34)
Pyrexia (18)
Dyspnoea (17)
Rash (11)
Myalgia (11)
Eosinophilia (11)
Renal Failure Acute (10)
Blood Creatinine Increased (9)
Lung Infiltration (8)
Pruritus (8)
Pain (6)
Pneumonitis (6)
Nausea (6)
Respiratory Distress (6)
Infection (6)
Aspartate Aminotransferase Increased (6)
Eosinophil Count Increased (6)
Renal Failure (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Daptomycin Side Effects Reported to FDA

The following Daptomycin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Daptomycin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Necrotising Fasciitis, Staphylococcal Infection, Limb Discomfort, Joint Swelling, Chest Pain, Staphylococcal Sepsis
on Feb 03, 2014 Male from GB , weighting 147.7 lb, was diagnosed with and was treated with Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: necrotising fasciitis, staphylococcal infection, limb discomfort, joint swelling, chest pain, staphylococcal sepsis. Daptomycin dosage: 8 Mg/kg, Daily. Patient was hospitalized.

Osteomyelitis, Pneumonia
Patient was taking Daptomycin. Patient felt the following Daptomycin side effects: osteomyelitis, pneumonia on Jan 31, 2014 from US Additional patient health information: Female , 27 years of age, weighting 156.5 lb, was diagnosed with and. Daptomycin dosage: N/A.
Multiple prescriptions taken:
  • Imipenem
Patient was hospitalized.

Blood Creatine Phosphokinase Increased, Myalgia
Adverse event was reported on Jan 27, 2014 by a Female taking Daptomycin (Dosage: N/A) was diagnosed with and. Location: US , 66 years of age, weighting 303.0 lb, After Daptomycin was administered, patient encountered several Daptomycin side effects: blood creatine phosphokinase increased, myalgia.

Diabetes Mellitus Inadequate Control, Oliguria
on Jan 23, 2014 Male from US , 64 years of age, weighting 209.4 lb, was treated with Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: diabetes mellitus inadequate control, oliguria. Daptomycin dosage: N/A. Patient was hospitalized.


Necrotising Fasciitis
on Jan 23, 2014 Male from US , 69 years of age, was treated with Daptomycin. Patient felt the following Daptomycin side effects: necrotising fasciitis. Daptomycin dosage: N/A.

Renal Failure Acute, Hepatitis Acute, Rhabdomyolysis, Haemodialysis
Patient was taking Daptomycin. After Daptomycin was administered, patient encountered several Daptomycin side effects: renal failure acute, hepatitis acute, rhabdomyolysis, haemodialysis on Jan 09, 2014 from US Additional patient health information: Female , 64 years of age, weighting 152.1 lb, was diagnosed with and. Daptomycin dosage: N/A. Patient was hospitalized.

Pyrexia, Mental Status Changes, Dyspnoea, Traumatic Lung Injury, Lung Infiltration
Adverse event was reported on Dec 11, 2013 by a Male taking Daptomycin (cubicin) (Dosage: N/A) was diagnosed with and. Location: US , 76 years of age, weighting 268.5 lb, Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: pyrexia, mental status changes, dyspnoea, traumatic lung injury, lung infiltration. Patient was hospitalized.

Rhabdomyolysis
on Dec 03, 2013 Male from US , 63 years of age, weighting 249.1 lb, was diagnosed with and was treated with Daptomycin. Patient felt the following Daptomycin side effects: rhabdomyolysis. Daptomycin dosage: 900 Mg, Other, Iv.
Multiple prescriptions taken:
  • Atorvastatin (10 Mg, Every Day, Po)
Patient was hospitalized.

Blood Creatine Phosphokinase Increased
on Nov 26, 2013 Female from US , 64 years of age, weighting 211.0 lb, was diagnosed with and was treated with Daptomycin (cubicin). After Daptomycin was administered, patient encountered several Daptomycin side effects: blood creatine phosphokinase increased. Daptomycin (cubicin) dosage: N/A. Patient was hospitalized.

Respiratory Distress, Blood Creatinine Increased
Patient was taking Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: respiratory distress, blood creatinine increased on Nov 25, 2013 from US Additional patient health information: Male , 35 years of age, weighting 233.7 lb, was diagnosed with and. Daptomycin dosage: N/A. Patient was hospitalized.

Blood Creatine Phosphokinase Increased
Adverse event was reported on Nov 18, 2013 by a Female taking Daptomycin (Dosage: N/A) was diagnosed with and. Location: US , 60 years of age, weighting 190.9 lb, Patient felt the following Daptomycin side effects: blood creatine phosphokinase increased.
Multiple prescriptions taken:
  • Linezolid
  • Merrem
  • Flagyl
  • Micafungin
  • Oxacillin
  • Zosyn
  • Rifampin
  • Tygacil


Pruritus, Infusion Site Pruritus, Infusion Site Urticaria
on Nov 08, 2013 Male from US , 22 years of age, was diagnosed with and was treated with Daptomycin. After Daptomycin was administered, patient encountered several Daptomycin side effects: pruritus, infusion site pruritus, infusion site urticaria. Daptomycin dosage: N/A.

Blood Creatine Phosphokinase Increased
on Nov 01, 2013 Male from US , 54 years of age, was treated with Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: blood creatine phosphokinase increased. Daptomycin dosage: N/A.

Blood Creatine Phosphokinase Abnormal
Patient was taking Daptomycin. Patient felt the following Daptomycin side effects: blood creatine phosphokinase abnormal on Oct 22, 2013 from US Additional patient health information: Male , 36 years of age, weighting 233.7 lb, was diagnosed with and. Daptomycin dosage: N/A.

Erythema Multiforme
Adverse event was reported on Oct 18, 2013 by a Female taking Daptomycin (Dosage: N/A) was diagnosed with and. Location: US , 80 years of age, weighting 198.4 lb, After Daptomycin was administered, patient encountered several Daptomycin side effects: erythema multiforme. Patient was hospitalized.

Tendon Rupture, Muscle Spasms
on Oct 18, 2013 Male from US , 57 years of age, weighting 171.0 lb, was diagnosed with and was treated with Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: tendon rupture, muscle spasms. Daptomycin dosage: N/A.
Associated medications used:
  • Rocephin


Eosinophilic Pneumonia Acute, Respiratory Failure, Wound Infection Bacterial, Klebsiella Infection, Escherichia Infection
on Oct 08, 2013 Female from US , 53 years of age, was diagnosed with and was treated with Daptomycin. Patient felt the following Daptomycin side effects: eosinophilic pneumonia acute, respiratory failure, wound infection bacterial, klebsiella infection, escherichia infection. Daptomycin dosage: N/A.
Multiple prescriptions taken:
  • Ceftaroline
Patient was hospitalized.

Liver Function Test Abnormal
Patient was taking Daptomycin. After Daptomycin was administered, patient encountered several Daptomycin side effects: liver function test abnormal on Oct 03, 2013 from US Additional patient health information: Male , 31 years of age, weighting 120.0 lb, was diagnosed with and. Daptomycin dosage: N/A.

Eosinophilic Pneumonia
Adverse event was reported on Oct 02, 2013 by a Male taking Daptomycin (Dosage: N/A) was diagnosed with and. Location: US , 55 years of age, weighting 154.1 lb, Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: eosinophilic pneumonia. Patient was hospitalized.

Thrombocytopenia
on Sep 30, 2013 Male from US , 67 years of age, weighting 180.1 lb, was diagnosed with and was treated with Daptomycin. Patient felt the following Daptomycin side effects: thrombocytopenia. Daptomycin dosage: N/A.
Multiple prescriptions taken:
  • Allopurinol
  • Atenolol
  • Azithromycin
  • Chlorthalidone
  • Clonidine
  • Glipizide
  • Methylprednisone
  • Warfarin


Dyspnoea, Eosinophilic Pneumonia
on Sep 19, 2013 Male from US , 67 years of age, weighting 165.3 lb, was diagnosed with and was treated with Daptomycin. After Daptomycin was administered, patient encountered several Daptomycin side effects: dyspnoea, eosinophilic pneumonia. Daptomycin dosage: 750 Mg Qd Intravenous. Patient was hospitalized.

Alveolitis Allergic, Pyrexia, Respiratory Depression
Patient was taking Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: alveolitis allergic, pyrexia, respiratory depression on Sep 05, 2013 from US Additional patient health information: Female , 61 years of age, weighting 155.9 lb, was diagnosed with and. Daptomycin dosage: Daptomycin 450mg Iv Daily. Patient was hospitalized.

Renal Failure Acute, Rhabdomyolysis
Adverse event was reported on Aug 27, 2013 by a Male taking Daptomycin (Dosage: 390mg, Other, Iv) was diagnosed with and. Location: US , 55 years of age, weighting 212.5 lb, Patient felt the following Daptomycin side effects: renal failure acute, rhabdomyolysis. Patient was hospitalized.

Rash Erythematous, Urticaria
on Aug 23, 2013 Male from US , 61 years of age, weighting 310.0 lb, was diagnosed with and was treated with Daptomycin. After Daptomycin was administered, patient encountered several Daptomycin side effects: rash erythematous, urticaria. Daptomycin dosage: N/A. Patient was hospitalized.

Rash
on Aug 12, 2013 Female from US , 51 years of age, weighting 304.2 lb, was diagnosed with and was treated with Daptomycin. Directly after, patient experienced the unwanted or unexpected Daptomycin side effects: rash. Daptomycin dosage: 2 G, Q8h.
Associated medications used:
  • Vancomycin (1 Unk, Q12h)
  • Doryx /00055701/ (100 Mg, Q12h)
Patient was hospitalized.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


    Track Online

  • User Sign In
  • Register to track your side effects

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Discuss Daptomycin Side Effects

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    Safety Alerts, Active Ingredients, Usage Information

    More About Daptomycin

    Side Effects reported to FDA: 258

    Daptomycin safety alerts: 2013 2010 2008

    Reported deaths: 8

    Reported hospitalizations: 117

    Cubicin (daptomycin): Drug Safety Communication - Risk of Eosinophilic Pneumonia

    [Posted 07/29/2010]

    AUDIENCE: Infectious Disease, Pulmonology

    ISSUE:  FDA notified healthcare professionals and patients about the potential for developing eosinophilic pneumonia during treatment with Cubicin (daptomycin), an intravenous antibacterial drug indicated for use in treatment of serious skin infections and bloodstream infections. Eosinophilic pneumonia is a rare but serious condition where a type of white blood cell (eosinophil) fills the lungs. Symptoms of eosinophilic pneumonia include fever, cough, shortness of breath, and difficulty breathing. Eosinophilic pneumonia may lead to progressive respiratory failure and is potentially fatal if not quickly recognized and appropriately managed. 

    BACKGROUND: FDA has reviewed published case reports of Cubicin-associated eosinophilic pneumonia and conducted a review of post-marketing adverse event reports from the FDA's Adverse Event Reporting System. FDA's review identified 7 cases of eosinophilic pneumonia between 2004 and 2010 that were most likely associated with Cubicin. Based on these reviews, FDA determined that eosinophilic pneumonia can be associated with Cubicin use and requested that the manufacturer of Cubicin include this information in the Warnings and Precautions and Adverse Reactions, Post-Marketing Experience sections of the drug label.

    RECOMMENDATION: Healthcare professionals should closely monitor patients being treated with Cubicin for eosinophilic pneumonia. Patients receiving Cubicin should immediately contact their healthcare professional if they develop a new or worsening fever, cough, shortness of breath, or difficulty breathing.

    Additional information for Healthcare Professionals, Information for Patients, a Data Summary, and References are provided in the Drug Safety Communication at the link below.

    [07/29/2010 - Drug Safety Communication - FDA]
    [Jan 2010 - Cubicin (daptomycin) Prescribing Information - Cubist Pharmaceuticals]

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