Community-reported Dasatinib side effects:
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Total Dasatinib reports: 229.Dasatinib FDA safety alerts: No.
Reported deaths: 82 Reported hospitalizations: 160.
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FDA Reported Dasatinib Side Effects: pleural effusion, malignant neoplasm progression, pyrexia, respiratory failure, dyspnoea, chronic myeloid leukaemia, pneumonia, dyspnoea exertional, hypoxia, vomiting, infection.
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Dasatinib Side Effects Report #5386355-2Physician from SPAIN reported DASATINIB problem on July 09, 2007. Male patient, 73 years of age, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: laryngeal oedema. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5386682-9
DASATINIB problem was reported by a Health Professional from DENMARK on July 10, 2007. Male patient, 69 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, pleural effusion. DASATINIB dosage: unknown. During the same period patient was treated with SIMVASTATIN, METOPROLOL SUCCINATE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5386685-4
Consumer or non-health professional from JAPAN reported DASATINIB problem on July 11, 2007. Male patient, 42 years of age, was diagnosed with chronic myeloid leukaemia, insomnia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: overdose. DASATINIB dosage: unknown. During the same period patient was treated with MYSLEE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5387408-5
DASATINIB problem was reported by a Health Professional from FRANCE on July 12, 2007. Female patient, 58 years of age, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: osteonecrosis. DASATINIB dosage: unknown. During the same period patient was treated with IMATINIB MESYLATE, GLUCOPHAGE, LEVOTHYROXINE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5388012-5
Health Professional from UNITED STATES reported DASATINIB problem on July 13, 2007. Female patient, 82 years of age, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: pericardial effusion, pericardial neoplasm, pleural effusion. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5397980-7
DASATINIB problem was reported by a Consumer or non-health professional from UNITED STATES on July 23, 2007. Female patient, 29 years of age, weighting 105.8 lb, was diagnosed with sarcoma and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: back pain, ventricular tachycardia. DASATINIB dosage: unknown. During the same period patient was treated with OXYCODONE, LORAZEPAM, PHENERGAN. Patient was hospitalized. Patient died on 07/19/2007.
Dasatinib Side Effects Report #5400631-6
Consumer or non-health professional from UNITED STATES reported DASATINIB problem on July 25, 2007. Female patient, 29 years of age, weighting 105.8 lb, was diagnosed with sarcoma and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: back pain, ventricular tachycardia. DASATINIB dosage: unknown. During the same period patient was treated with OXYCODONE, LORAZEPAM, PHENERGAN. Patient was hospitalized. Patient died on 07/19/2007.
Dasatinib Side Effects Report #5403294-9
DASATINIB problem was reported by a Consumer or non-health professional from PERU on July 30, 2007. Female patient, 49 years of age, was diagnosed with leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: anaemia, gastrointestinal infection. DASATINIB dosage: unknown. During the same period patient was treated with COTRIM. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5413353-2
Health Professional from UNITED STATES reported DASATINIB problem on Aug 09, 2007. Female patient, 61 years of age, weighting 169.8 lb, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, hypoxia, pneumonitis, pyrexia, skin exfoliation. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5418122-5
DASATINIB problem was reported by a Health Professional from UNITED STATES on Aug 14, 2007. Female patient, 62 years of age, weighting 178.6 lb, was diagnosed with colon cancer, pancreatic carcinoma and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: infection, neutropenia. DASATINIB dosage: unknown. During the same period patient was treated with CETUXIMAB, GEMCITABINE, LANTUS, LISINOPRIL. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5419389-X
Health Professional from UNITED STATES reported DASATINIB problem on Aug 16, 2007. Female patient, weighting 167.3 lb, was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, hypercalcaemia, lethargy, metastases to central nervous system, visual disturbance. DASATINIB dosage: 100MG QD PO. During the same period patient was treated with CETUXIMAB. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5420653-9
DASATINIB problem was reported by a Health Professional from UNITED STATES on Aug 14, 2007. Female patient, 62 years of age, weighting 178.6 lb, was diagnosed with colon cancer, pancreatic carcinoma and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: infection, neutropenia. DASATINIB dosage: unknown. During the same period patient was treated with CETUXIMAB, GEMCITABINE, LANTUS, LISINOPRIL. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5420880-0
Health Professional from UNITED STATES reported DASATINIB problem on Aug 17, 2007. Female patient, weighting 167.3 lb, was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: dehydration, disease progression, headache, hypercalcaemia, lethargy, metastases to central nervous system, visual disturbance. DASATINIB dosage: 100MG QDAY PO. During the same period patient was treated with CETUXIMAB. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5421016-2
DASATINIB problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 16, 2007. Female patient, 67 years of age, weighting 172.0 lb, was diagnosed with glioblastoma multiforme and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: angina pectoris, hyperkalaemia, myocardial infarction, troponin i. DASATINIB dosage: INTIAL DOSE 100MG,BID,ON 06 JUN 07 DOSE REDUCED TO 75MGBID. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5423523-5
Health Professional from DENMARK reported DASATINIB problem on Aug 20, 2007. Male patient, 69 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, pleural effusion. DASATINIB dosage: unknown. During the same period patient was treated with SIMVASTATIN, METOPROLOL SUCCINATE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5423835-5
DASATINIB problem was reported by a Health Professional from UNITED STATES on Aug 13, 2007. Female patient, 46 years of age, weighting 138.9 lb, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: cor pulmonale, pericardial effusion. DASATINIB dosage: unknown. During the same period patient was treated with ANAGRELIDE, POTASSIUM CHLORIDE, ACTIVELLA, ARANESP, ALEVE, NEUPOGEN, CLOBETASOL PROPIONATE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5423844-6
Health Professional from UNITED STATES reported DASATINIB problem on Aug 22, 2007. Male patient, 52 years of age, was diagnosed with leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: nausea, vomiting. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5425933-9
DASATINIB problem was reported by a Health Professional from DENMARK on Aug 23, 2007. Male patient, 69 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, pleural effusion. DASATINIB dosage: unknown. During the same period patient was treated with SIMVASTATIN, METOPROLOL SUCCINATE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5441653-9
Health Professional from DENMARK reported DASATINIB problem on Aug 30, 2007. Male patient, 69 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: atrial fibrillation, pleural effusion. DASATINIB dosage: unknown. During the same period patient was treated with SIMVASTATIN, METOPROLOL SUCCINATE. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5446071-5
DASATINIB problem was reported by a Health Professional from UNITED STATES on Sept 05, 2007. Female patient, 61 years of age, weighting 169.8 lb, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, hypoxia, pneumonitis, pulmonary oedema, pyrexia, skin exfoliation. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5446075-2
Consumer or non-health professional from JAPAN reported DASATINIB problem on Sept 03, 2007. Male patient, 65 years of age, weighting 92.59 lb, was diagnosed with chronic myeloid leukaemia, pleural effusion, fluid replacement and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dyspnoea, lung injury, multiple fractures, oesophagitis, oral intake reduced, pleural effusion, pneumonia. DASATINIB dosage: STOPPED ON 12-JUN-07. RESTARTED ON 25-JUN-07 @50MG BID TILL 30-AUG-07.. During the same period patient was treated with LASIX, ALDACTONE, BROCIN CODEINE, SOLULACT. Patient was hospitalized. Patient died on 09/02/2007.
Dasatinib Side Effects Report #5449040-4
DASATINIB problem was reported by a Health Professional from UNITED STATES on Sept 06, 2007. Female patient, 14 years of age, weighting 99.21 lb, was diagnosed with neoplasm and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: apnoea, chest pain, hypoalbuminaemia, hypotension, hypoxia, lymphopenia, pleural effusion, pyrexia. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5449088-X
Health Professional from UNITED STATES reported DASATINIB problem on Sept 07, 2007. Female patient, 52 years of age, weighting 187.4 lb, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: abdominal pain, dehydration, diarrhoea, vomiting. DASATINIB dosage: unknown. Patient was hospitalized. Patient recovered.
Dasatinib Side Effects Report #5451180-0
DASATINIB problem was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Male patient, 65 years of age, weighting 92.59 lb, was diagnosed with chronic myeloid leukaemia, pleural effusion, fluid replacement and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dyspnoea, gastric cancer, pneumonia, respiratory failure. DASATINIB dosage: STARTED ON 26-JUL @ 70MG BID.STOPPED ON 12-JUN-07. RESTARTED ON 25-JUN-07 @50MG BID TILL 30-AUG-07.. During the same period patient was treated with LASIX, ALDACTONE, SOLULACT. Patient was hospitalized. Patient died on 09/02/2007.
Dasatinib Side Effects Report #5453721-6
Physician from BRAZIL reported DASATINIB problem on Sept 10, 2007. Male patient, 51 years of age, was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: white blood cell count decreased. DASATINIB dosage: unknown. Patient died.
Dasatinib Side Effects Report #5455209-5
DASATINIB problem was reported by a Consumer or non-health professional from JAPAN on Sept 10, 2007. Male patient, 65 years of age, weighting 92.59 lb, was diagnosed with chronic myeloid leukaemia, pleural effusion, fluid replacement and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dyspnoea, gastric cancer, pneumonia, respiratory failure. DASATINIB dosage: STARTED ON 26-JUL @ 70MG BID.STOPPED ON 12-JUN-07. RESTARTED ON 25-JUN-07 @50MG BID TILL 30-AUG-07.. During the same period patient was treated with LASIX, ALDACTONE, SOLULACT. Patient was hospitalized. Patient died on 09/02/2007.
Dasatinib Side Effects Report #5465289-9
Health Professional from UNITED STATES reported DASATINIB problem on Sept 19, 2007. Female patient, weighting 116.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: bruxism, loose tooth, temporomandibular joint syndrome, tooth disorder. DASATINIB dosage: unknown. Patient recovered.
Dasatinib Side Effects Report #5467207-6
DASATINIB problem was reported by a Consumer or non-health professional from JAPAN on Sept 21, 2007. Male patient, 65 years of age, weighting 92.59 lb, was diagnosed with chronic myeloid leukaemia, pleural effusion, fluid replacement and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: anorexia, dyspnoea, gastric cancer, pneumonia, respiratory failure, squamous cell carcinoma. DASATINIB dosage: STARTED ON 26-JUL @ 70MG BID.STOPPED ON 12-JUN-07. RESTARTED ON 25-JUN-07 @50MG BID TILL 30-AUG-07.. During the same period patient was treated with LASIX, ALDACTONE, SOLULACT. Patient was hospitalized. Patient died on 09/02/2007.
Dasatinib Side Effects Report #5469322-X
Health Professional from UNITED STATES reported DASATINIB problem on Sept 20, 2007. Female patient, 47 years of age, weighting 224.9 lb, was diagnosed with leiomyosarcoma and was treated with DASATINIB. After drug was administered, patient experienced the following problems/side effects: hyponatraemia, malignant neoplasm progression, pleural effusion. DASATINIB dosage: RESTARTED 16AUG-07,50MG BID,LAST DOSE WAS ON 05-SEP-07.. During the same period patient was treated with LASIX, POTASSIUM CHLORIDE, SYNTHROID, XANAX, COMPAZINE, TYLENOL, IMODIUM, CIPRO. Patient died on 09/19/2007.
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Drug Information: Dasatinib
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a607063.html
(da sa' ti nib)Why is this medication prescribed?
Dasatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) in people who can no longer benefit from other medications for leukemia including imatinib (Gleevec) or who cannot take these medications because of severe side effects. Dasatinib is in a class of medications called protein-tyrosine kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
How should this medicine be used?
Dasatinib comes as a tablet to take by mouth. It is usually taken twice a day, in the morning and the evening, with or without food. Take dasatinib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dasatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole; do not split, chew, or crush them.
Your doctor may adjust your dose of dasatinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.
Continue to take dasatinib even if you feel well. Do not stop taking dasatinib without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking dasatinib,
- tell your doctor and pharmacist if you are allergic to dasatinib or any other medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: alfentanil (Alfenta), anticoagulants ("blood thinners") such as warfarin (Coumadin), anthracycline medications for cancer such as daunorubicin (Cerubidine), doxorubicin (Doxil), and epirubicin (Ellence); aspirin; certain antifungals such as ketoconazole (Nizoral), and itraconazole (Sporanox); astemizole (Hismanal) (not available in the United States; cisapride (Propulsid) (not available in the United States); clarithromycin (Biaxin); dexamethasone (Decadron); cyclosporine (Sandimmune); ergot alkaloids such as ergotamine (Ergomar), and dihydroergotamine (D.H.E. 45, Migranal); erythromycin (E.E.S., E-Mycin, Erythrocin); fentanyl (Duragesic, Actiq); certain medications used to treat human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); certain medications for irregular heartbeat such as amiodarone (Cordarone), disopyramide (Norpace),dofetilide (Tikosyn), flecainide (Tambocor), mexiletine (Mexitil), moricizine (Ethmozine), procainamide (Procanbid, Pronestyl), propafenone (Rythmol), quinidine (Quinidex), sotalol (Betapace, Betapace AF), and tocainide (Tonocard); medications to reduce stomach acid such as cimetidine (Tagamet®), famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal), and phenytoin (Dilantin); moxifloxacin (Avelox); nefazodone; pimozide (Orap); rifampicin (Rimactane); simvastatin (Zocor); sirolimus (Rapamune), tacrolimus (Prograf); telithromycin (Ketek); terfenadine (Seldane) (not available in the United States); and thioridazine (Mellaril). Other medications may also interact with dasatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking antacids, such as aluminium hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums) or calcium carbonate and magnesium (Rolaids), take them 2 hours before or 2 hours after you take dasatinib.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had lactose intolerance (inability to digest dairy products), low levels of potassium or magnesium in your blood, long QT syndrome (a heart condition that may cause dizziness, fainting, or irregular heartbeat), or liver or heart disease.
- tell your doctor if you are pregnant or plan to become pregnant, or if your partner may become pregnant. You or your partner should not become pregnant while you are taking dasatinib. You should use birth control to prevent pregnancy in yourself or your partner during your treatment with dasatinib. Talk to your doctor about birth control methods that will work for you. If you or your partner becomes pregnant while taking dasatinib, call your doctor. Dasatinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breastfeed while you are taking dasatinib.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
What should I do if I forget a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Dasatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- muscle pain
- tiredness
- weakness
- dizziness
- joint pain
- pain, burning or tingling in the hands or the feet
- skin rash
- skin redness
- peeling skin
- swelling, redness and pain inside the mouth
- mouth sores
- diarrhea
- nausea
- vomiting
- constipation
- stomach pain or swelling
- loss of appetite
- weight loss
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- fever, sore throat, chills, and other signs of infection
- swelling of the eyes, hands, arms, feet, ankles or lower legs
- sudden weight gain
- difficulty breathing, especially when lying down
- coughing up pink or bloody mucus
- dry cough
- chest pain that gets worse when coughing, sneezing or breathing deeply
- chest pressure
- dizziness
- fainting
- rapid, irregular, or pounding heartbeat
- unusual bruising or bleeding
- black and tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
- slow or difficult speech
- weakness or numbness of an arm or leg
- sudden severe headache
Dasatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dasatinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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