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Depakote Side Effects

Common Depakote Side Effects

The most commonly reported Depakote side effects (click to view or check a box to report):

Convulsion (327)
Weight Increased (181)
Alopecia (171)
Tremor (152)
Somnolence (149)
Fall (118)
Nausea (110)
Dizziness (105)
Vomiting (102)
Headache (102)
Depression (92)
Fatigue (91)
Confusional State (86)
Abnormal Behaviour (83)
Thrombocytopenia (82)
Diarrhoea (79)
Pancreatitis (77)
Product Substitution Issue (74)
Aggression (73)
Insomnia (71)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Depakote Side Effects Reported to FDA

The following Depakote reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Depakote on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Panic Attack, Anxiety, Mental Disorder, Condition Aggravated, Depression
on Mar 06, 2014 Male from GB , 57 years of age, was diagnosed with and was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: panic attack, anxiety, mental disorder, condition aggravated, depression. Depakote dosage: N/A.
Associated medications used:
  • Cipramil
  • Prednisolone
  • Prednisolone
  • Diazepam
  • Zopiclone


Thrombocytopenia, No Therapeutic Response, Product Substitution Issue
Patient was taking Depakote Er. Patient felt the following Depakote side effects: thrombocytopenia, no therapeutic response, product substitution issue on Mar 04, 2014 from US Additional patient health information: Male , 13 years of age, weighting 86.42 lb, was diagnosed with and. Depakote Er dosage: N/A.

Aura, Convulsion, Vomiting, Product Solubility Abnormal, Blepharospasm, Migraine
Adverse event was reported on Mar 03, 2014 by a Female taking Depakote (Dosage: 3 Tabs In Am And Noc And 2 Tabs In Pm) was diagnosed with and. Location: US , 18 years of age, weighting 680.6 lb, After Depakote was administered, patient encountered several Depakote side effects: aura, convulsion, vomiting, product solubility abnormal, blepharospasm, migraine.

Scoliosis, Convulsion, Back Pain
on Feb 27, 2014 Male from US , 20 years of age, was diagnosed with and was treated with Depakote Er. Directly after, patient experienced the unwanted or unexpected Depakote side effects: scoliosis, convulsion, back pain. Depakote Er dosage: N/A.
Associated medications used:
  • Divalproex Sodium



Hepatic Failure
on Feb 24, 2014 Male from US , 43 years of age, was treated with Depakote. Patient felt the following Depakote side effects: hepatic failure. Depakote dosage: N/A.

Interstitial Lung Disease, Alveolitis, Dyspnoea
Patient was taking Depakote Er. After Depakote was administered, patient encountered several Depakote side effects: interstitial lung disease, alveolitis, dyspnoea on Feb 18, 2014 from FR Additional patient health information: Male , 73 years of age, . Depakote Er dosage: N/A.
Multiple concurrent drugs taken:
  • Mianserine
  • Kardegic
  • Inexium
  • Vesicare
  • Temesta
  • Lovenox
  • Mianserine


Mood Swings
Adverse event was reported on Feb 17, 2014 by a Male taking Depakote (Dosage: N/A) was diagnosed with and. Location: COUNTRY NOT SPECIFIED , 25 years of age, Directly after, patient experienced the unwanted or unexpected Depakote side effects: mood swings. Patient was hospitalized.

Hypertensive Crisis, Increased Appetite
on Feb 19, 2014 Female from BR , 70 years of age, was diagnosed with and was treated with Depakote Er. Patient felt the following Depakote side effects: hypertensive crisis, increased appetite. Depakote Er dosage: N/A. Patient was hospitalized.

Altered State Of Consciousness, Hyponatraemia, Disorientation, Confusional State
on Feb 13, 2014 Female from FR , 61 years of age, was diagnosed with and was treated with Depakote. After Depakote was administered, patient encountered several Depakote side effects: altered state of consciousness, hyponatraemia, disorientation, confusional state. Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Risperdal (Daily)
  • Keppra
  • Effexor
  • Valium (Daily)
  • Levothyrox
  • Mopral
Patient was hospitalized.

Epilepsy
Patient was taking Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: epilepsy on Feb 12, 2014 from US Additional patient health information: Female , child 4 years of age, was diagnosed with and. Depakote dosage: N/A.
Associated medications used:
  • Keppra
  • Phenobarbital
  • Lamictal
  • Topamax
  • Trileptal
  • Vimpat
  • Carbatrol
  • Valium


Somnolence, Hypophagia, Dehydration, Renal Failure Acute
Adverse event was reported on Feb 11, 2014 by a Female taking Depakote (Dosage: 3 Pills Bid Oral) was diagnosed with and. Location: US , 58 years of age, Patient felt the following Depakote side effects: somnolence, hypophagia, dehydration, renal failure acute.
Multiple prescriptions taken:
  • Advair
  • Albuterol
  • Metoprolol
  • Hctz
  • Nexium
  • Kcl
  • Detrol La
  • Asa
Patient was hospitalized.

Affective Disorder, Agitation, Aggression, Suicidal Ideation, Treatment Noncompliance, Hospitalisation
on Jan 30, 2014 Male from US , child 12 years of age, weighting 154.1 lb, was diagnosed with and was treated with Depakote Er. After Depakote was administered, patient encountered several Depakote side effects: affective disorder, agitation, aggression, suicidal ideation, treatment noncompliance, hospitalisation. Depakote Er dosage: N/A. Patient was hospitalized.

Psychiatric Symptom, Decreased Interest, Apathy, Depression, Hunger, Weight Increased, Incorrect Dose Administered
on Jan 29, 2014 Female from US , 46 years of age, weighting 150.1 lb, was diagnosed with and was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: psychiatric symptom, decreased interest, apathy, depression, hunger, weight increased, incorrect dose administered. Depakote dosage: N/A.
Associated medications used:
  • Seroquel
Patient was hospitalized.

Alopecia, Abdominal Pain Upper, Depression, Anxiety, Asthenia, Confusional State, Somnolence, Ataxia, Back Pain
Patient was taking Depakote. Patient felt the following Depakote side effects: alopecia, abdominal pain upper, depression, anxiety, asthenia, confusional state, somnolence, ataxia, back pain on Jan 28, 2014 from US Additional patient health information: Female , 80 years of age, weighting 149.0 lb, was diagnosed with and. Depakote dosage: 1 Tablet, 2x Daily, By Mouth.

Convulsion, Product Substitution Issue
Adverse event was reported on Jan 24, 2014 by a Male taking Depakote (Dosage: 2 Qam 3 Qhs) was diagnosed with and. Location: US , weighting 153.0 lb, After Depakote was administered, patient encountered several Depakote side effects: convulsion, product substitution issue.

Hypersensitivity, Abasia, Balance Disorder, Feeling Drunk, Dizziness, Fall, Off Label Use
on Jan 21, 2014 Patient from US , weighting 250.2 lb, was diagnosed with and was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: hypersensitivity, abasia, balance disorder, feeling drunk, dizziness, fall, off label use. Depakote dosage: N/A.
Associated medications used:
  • Ziprasidone
  • Tegretol
  • Invega
  • Klonopin


Neutropenia
on Jan 21, 2014 Male from FR , 43 years of age, was treated with Depakote. Patient felt the following Depakote side effects: neutropenia. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Olanzapine
  • Lysanxia
Patient was hospitalized.

Neutropenia
Patient was taking Depakote. After Depakote was administered, patient encountered several Depakote side effects: neutropenia on Feb 07, 2014 from FR Additional patient health information: Female , 73 years of age, was diagnosed with and. Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Clozapine
Patient was hospitalized.

Paraesthesia, Convulsion, Drooling, Product Physical Issue
Adverse event was reported on Mar 07, 2014 by a Female taking Depakote Sprinkle (Dosage: N/A) was diagnosed with and. Location: BR , weighting 70.55 lb, Directly after, patient experienced the unwanted or unexpected Depakote side effects: paraesthesia, convulsion, drooling, product physical issue.
Associated medications used:
  • Trileptal


Hypokalaemia
on Jan 15, 2014 Male from COUNTRY NOT SPECIFIED , 60 years of age, weighting 103.0 lb, was diagnosed with and was treated with Depakote. Patient felt the following Depakote side effects: hypokalaemia. Depakote dosage: N/A.
Multiple prescriptions taken:
  • Lurasidone


Inappropriate Antidiuretic Hormone Secretion
on Jan 14, 2014 Female from GB , 65 years of age, was diagnosed with and was treated with Depakote. After Depakote was administered, patient encountered several Depakote side effects: inappropriate antidiuretic hormone secretion. Depakote dosage: N/A.
Multiple concurrent drugs taken:
  • Olanzapine


Convulsion, Coma, Intentional Overdose
Patient was taking Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: convulsion, coma, intentional overdose on Jan 14, 2014 from FR Additional patient health information: Male , 42 years of age, was diagnosed with and. Depakote dosage: N/A. Patient was hospitalized.

Diverticulum, Irritable Bowel Syndrome, Large Intestinal Haemorrhage, Vascular Rupture, Weight Increased, Hypertension, Blood Cholesterol Increased, Glucose Tolerance Impaired, Oedema
Adverse event was reported on Jan 14, 2014 by a Female taking Depakote (Dosage: N/A) was diagnosed with and. Location: US , weighting 227.2 lb, Patient felt the following Depakote side effects: diverticulum, irritable bowel syndrome, large intestinal haemorrhage, vascular rupture, weight increased, hypertension, blood cholesterol increased, glucose tolerance impaired, oedema. Patient was hospitalized.


on Jan 13, 2014 Female from COUNTRY NOT SPECIFIED , 23 years of age, was treated with Depakote Er. . Depakote Er dosage: N/A.
Multiple concurrent drugs taken:
  • Buspirone
  • Neurontin
  • Prozac
  • Seroquel (Every Night)
  • Vistaril (As Needed)
  • Remeron (Every Night)
  • Risperdal (1 In Am 2 Qhs)


Wheelchair User, Incoherent, Dysarthria, Lethargy
on Jan 10, 2014 Male from US , 71 years of age, weighting 180.0 lb, was diagnosed with and was treated with Depakote. Directly after, patient experienced the unwanted or unexpected Depakote side effects: wheelchair user, incoherent, dysarthria, lethargy. Depakote dosage: N/A.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


    Track Online

  • User Sign In
  • Register to track your side effects

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Discuss Depakote Side Effects

    Did You Have a Depakote Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Depakote for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Safety Alerts, Active Ingredients, Usage Information

    Alternative DEPAKOTE Names:DIVALPROE

    Active Ingredient: DIVALPROE

    Depakote Dosage, Warnings, Usage.

    Side Effects reported to FDA: 2896

    Depakote safety alerts: 2002 2000

    Reported deaths: 164

    Reported hospitalizations: 907

    Depakote / Depakene / Depacon (divalproex sodium / valproic acid / valproate sodium)

    Audience: Neuropsychiatric healthcare professionals

    FDA and Abbott strengthened the CONTRAINDICATIONS, WARNINGS and PRECAUTIONS sections of the label for Depakote Tablets, Depakote ER Tablets, Depakote Sprinkle Capsules, Depakene Capsules and Syrup and Depacon for Injection. Healthcare professionals were informed that hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders [UCD], a group of uncommon genetic abnormalities. Patient criteria to consider in evaluation for UCD prior to initiation of valproate therapy are offered.

    [June, 2002 - Letter - Abbott]

    Latest Depakote clinical trials