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Dextrose Side Effects

Common Dextrose Side Effects


The most commonly reported Dextrose side effects (click to view or check a box to report):

Pyrexia (30)
Chills (20)
Tremor (18)
Hypotension (14)
Death (13)
Anaphylactic Reaction (10)
Thrombocytopenia (9)
Hyponatraemia (9)
Dizziness (8)
Vomiting (8)
Nausea (7)
Dyspnoea (7)
C-reactive Protein Increased (7)
Convulsion (7)
Back Pain (6)
Bradycardia (6)
Infusion Related Reaction (6)
Chest Pain (6)
Haemoglobin Decreased (6)
Heart Rate Increased (5)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Dextrose Side Effects Reported to FDA

The following Dextrose reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Dextrose on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dizziness, Blood Pressure Decreased, Heart Rate Increased, Product Quality Issue
This is a report of a 54-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Dextrose 5% In Lactated Ringers (dosage: ~800ml?once/continous?intravenous, start time: Mar 05, 2014), combined with:
  • Acetamiophen/hydrocodone
  • Hydromorphone
  • Metoclopramide
  • Pantoprazole
  • Sodium Chloride
and developed a serious reaction and side effect(s). The consumer presented with:
  • Dizziness
  • Blood Pressure Decreased
  • Heart Rate Increased
  • Product Quality Issue
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dextrose 5% In Lactated Ringers treatment in female patients, resulting in dizziness side effect. The patient was hospitalized.

Heparin-induced Thrombocytopenia, Deep Vein Thrombosis, Refusal Of Treatment By Patient, Hypercapnia
This report suggests a potential Dextrose/heparin Heparin-induced Thrombocytopenia, Deep Vein Thrombosis, Refusal Of Treatment By Patient, Hypercapnia side effect(s) that can have serious consequences. A 71-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: pulmonary embolism and used Dextrose/heparin (dosage: NA) starting Nov 12, 2013. Soon after starting Dextrose/heparin the patient began experiencing various side effects, including:
  • Heparin-induced Thrombocytopenia
  • Deep Vein Thrombosis
  • Refusal Of Treatment By Patient
  • Hypercapnia
Drugs used concurrently: NA.The patient was hospitalized. Although Dextrose/heparin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as heparin-induced thrombocytopenia, may still occur.

Infusion Site Pain, Infusion Site Extravasation, Infusion Site Necrosis
This Infusion Site Pain, Infusion Site Extravasation, Infusion Site Necrosis problem was reported by a pharmacist from US. A 34-year-old patient (weight: NA) was diagnosed with the following symptoms/conditions: hyperkalaemia. On Aug 31, 2013 this consumer started treatment with Dextrose (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Dextrose, the patient experienced the following unwanted symptoms/side effects:
  • Infusion Site Pain
  • Infusion Site Extravasation
  • Infusion Site Necrosis
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as infusion site pain, may become evident only after a product is in use by the general population.

Thrombocytopenia, Pulmonary Embolism, Cardio-respiratory Arrest, Cardiac Tamponade
This is a report of a 74-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: surgery and was treated with Dextrose/heparin (dosage: NA) starting Oct 31, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Thrombocytopenia
  • Pulmonary Embolism
  • Cardio-respiratory Arrest
  • Cardiac Tamponade
This opens a possibility that Dextrose/heparin treatment could cause the above reactions, including thrombocytopenia, and some male subjects may be more susceptible.


Corneal Abrasion, Accidental Exposure To Product, Device Malfunction, Syringe Issue
A 43-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Dextrose treatment (dosage: NA) on Nov 06, 2013. Soon after starting Dextrose treatment, the subject experienced various side effects, including:
  • Corneal Abrasion
  • Accidental Exposure To Product
  • Device Malfunction
  • Syringe Issue
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Dextrose.

Thrombocytopenia, Pulmonary Embolism, Haemorrhage
A 74-year-old male patient from US (weight: NA) experienced symptoms, such as: cardiovascular disorder and was treated with Dextrose/heparin(dosage: NA). The treatment was initiated on Oct 31, 2013. After that a consumer reported the following side effect(s):
  • Thrombocytopenia
  • Pulmonary Embolism
  • Haemorrhage
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Dextrose/heparin efficacy: NA.

Peritoneal Dialysis Complication, Fluid Retention, Myocardial Infarction
In this report, Dextrose was administered for the following condition: NA.A 55-year-old male consumer from US (weight: NA) started Dextrose treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Peritoneal Dialysis Complication
  • Fluid Retention
  • Myocardial Infarction
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Dextrose treatment could be related to the listed above side effect(s).

Thrombocytopenia, Heparin-induced Thrombocytopenia
This is a report of the following Dextrose/heparin side effect(s):
  • Thrombocytopenia
  • Heparin-induced Thrombocytopenia
A 73-year-old male patient from US (weight: NA) presented with the following condition: deep vein thrombosis and received a treatment with Dextrose/heparin (dosage: NA) starting: Sep 28, 2013.The following concurrently used drugs could have generated interactions: NA.The patient was hospitalized.This report suggests that a Dextrose/heparin treatment could be associated with the listed above side effect(s).

Blood Glucose Decreased, Syringe Issue, Infusion Site Extravasation, Product Quality Issue
This Dextrose report was submitted by a 81-year-old female consumer from US (weight: NA). The patient was diagnosed with: NA and Dextrose was administered (dosage: (not Otherwise Specified)) starting: NS. The consumer developed a set of symptoms:
  • Blood Glucose Decreased
  • Syringe Issue
  • Infusion Site Extravasation
  • Product Quality Issue
Other drugs used simultaneously:
  • Normal Saline
Those unexpected symptoms could be linked to a Dextrose treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hyponatraemia, Water Intoxication, Brain Oedema, Bradycardia
This is a report of a possible correlation between Dextrose use and the following symptoms/side effect(s):
  • Hyponatraemia
  • Water Intoxication
  • Brain Oedema
  • Bradycardia
which could contribute to an assessment of Dextrose risk profile.A 6-year-old female consumer from US (weight: NA) was suffering from postoperative care and was treated with Dextrose (dosage: NA) starting NS.Other concurrent medications: NA.

Ventricular Arrhythmia, Electrolyte Imbalance
A 5-year-old male patient from US (weight: NA) presented with the following symptoms: hypoglycaemia and after a treatment with Dextrose (dosage: NA) experienced the following side effect(s):
  • Ventricular Arrhythmia
  • Electrolyte Imbalance
The treatment was started on NS. Dextrose was used in combination with the following drugs: NA.This report could alert potential Dextrose consumers.

Cardiac Arrest
In this report, a 84-year-old male patient from US (weight: NA) was affected by a possible Dextrose side effect.The patient was diagnosed with blood glucose decreased. After a treatment with Dextrose (dosage: 50 Ml, Once, Injection, start date: May 19, 2013), the patient experienced the following side effect(s):
  • Cardiac Arrest
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Dextrose treatment.

Ascites, Sinus Bradycardia, Dyspnoea, Abdominal Distension, Condition Aggravated, Malignant Neoplasm Progression, Pulmonary Mass
This is a report of a 61-year-old male patient from US (weight: NA), who used Dextrose (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Ascites
  • Sinus Bradycardia
  • Dyspnoea
  • Abdominal Distension
  • Condition Aggravated
  • Malignant Neoplasm Progression
  • Pulmonary Mass
The following drugs could possibly have interacted with the Dextrose treatment
  • Vicodin
  • Flomax
  • Tamsulosin
  • Cisplatin
The patient was hospitalized.Taken together, these observations suggest that a Dextrose treatment could be related to side effect(s), such as Ascites, Sinus Bradycardia, Dyspnoea, Abdominal Distension, Condition Aggravated, Malignant Neoplasm Progression, Pulmonary Mass.

Glycosuria, Hyperglycaemia, Urine Output Increased
This glycosuria side effect was reported by a health professional from US. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: prophylaxis,ileus. The patient was prescribed Dextrose (dosage: NA), which was started on NS. Concurrently used drugs:
  • Tpn
  • (vasopressin)
When starting to take Dextrose the consumer reported the following symptoms:
  • Glycosuria
  • Hyperglycaemia
  • Urine Output Increased
These side effects may potentially be related to Dextrose.

Heparin-induced Thrombocytopenia
This is a Dextrose/heparin side effect report of a 66-year-old male patient (weight:NA) from US, suffering from the following symptoms/conditions: atrial fibrillation, who was treated with Dextrose/heparin (dosage:25000 Units Ud Iv, start time: Jan 08, 2013), combined with: NA., and developed a serious reaction and a heparin-induced thrombocytopenia side effect. The patient presented with:
  • Heparin-induced Thrombocytopenia
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Dextrose/heparin treatment in male patients suffering from atrial fibrillation, resulting in heparin-induced thrombocytopenia.

Throat Tightness, Sneezing, Chest Discomfort, Pruritus
This report suggests a potential Dextrose 5% Injection (dextrose) throat tightness side effect(s) that can have serious consequences. A 70-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): NA and used Dextrose 5% Injection (dextrose) (dosage: NA) starting Jan 16, 2012. Soon after starting Dextrose 5% Injection (dextrose) the patient began experiencing various side effects, including:
  • Throat Tightness
  • Sneezing
  • Chest Discomfort
  • Pruritus
Drugs used concurrently:
  • Calcium Leuvocorin (calcium Folinate)
  • Oxaliplatin
Although Dextrose 5% Injection (dextrose) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as throat tightness, may still occur.

Erythema, Infusion Related Reaction
This erythema problem was reported by a consumer or non-health professional from US. A 70-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): colon cancer.On Feb 06, 2012 a consumer started treatment with Dextrose (dosage: NA). The following drugs/medications were being taken at the same time:
  • Leucovorin
  • (oxaliplatin)
When commencing Dextrose, the patient experienced the following unwanted symptoms /side effects:
  • Erythema
  • Infusion Related Reaction
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as erythema, may become evident only after a product is in use by the general population.

Gastric Haemorrhage, International Normalised Ratio Increased, Haemoglobin Decreased, Haematocrit Decreased
This is a Dextrose\heparin side effect report of a 78-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: pulmonary embolism and was treated with Dextrose\heparin (dosage: NA) starting Jul 07, 2012. Concurrently used drugs:
  • Warfarin
Soon after that, the consumer experienced the following of symptoms:
  • Gastric Haemorrhage
  • International Normalised Ratio Increased
  • Haemoglobin Decreased
  • Haematocrit Decreased
The patient was hospitalized. This opens a possibility that Dextrose\heparin could cause gastric haemorrhage and that some male patients may be more susceptible.

Haemorrhage, Hypotension, Tachycardia
A 81-year-old male patient (weight: NA) from US with the following symptoms: atrial fibrillation,vascular operation started Dextrose\heparin treatment (dosage: NA) on Dec 07, 2012. Soon after starting Dextrose\heparin treatment, the consumer experienced several side effects, including:
  • Haemorrhage
  • Hypotension
  • Tachycardia
. Concurrently used drugs:
  • Clopidogrel
This finding indicates that some patients can be more vulnerable to developing Dextrose\heparin side effects, such as haemorrhage.

Product Quality Issue, Feeling Cold, Pyrexia, Decreased Appetite, Cough, Vomiting, Neck Pain, Restlessness, Insomnia
This product quality issue side effect was reported by a consumer or non-health professional from US. A 67-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Dextrose (dosage: NA), which was started on Jul 24, 2012. Concurrently used drugs:
  • Bacitracin
  • Heparin
.When starting to take Dextrose the consumer reported symptoms, such as:
  • Product Quality Issue
  • Feeling Cold
  • Pyrexia
  • Decreased Appetite
  • Cough
  • Vomiting
  • Neck Pain
  • Restlessness
  • Insomnia
These side effects may potentially be related to Dextrose.

Encephalopathy, Large Intestinal Ulcer, Bacteraemia, Haemoglobin Decreased, Colitis, Angiodysplasia, Vascular Neoplasm, Haemorrhage
This is a report of a 12-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Dextrose (dosage: NA, start time: Dec 24, 2012), combined with:
  • Hydromorphone
  • Vincristine
  • Daunorubicin
  • Dasatinib
  • Doxorubicin
  • Cyclophosphamide
  • Cytarabine
  • Etoposide (Intravenous (not Otherwise Specified))
and developed a serious reaction and side effect(s). The consumer presented with:
  • Encephalopathy
  • Large Intestinal Ulcer
  • Bacteraemia
  • Haemoglobin Decreased
  • Colitis
  • Angiodysplasia
  • Vascular Neoplasm
  • Haemorrhage
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Dextrose treatment in female patients, resulting in encephalopathy side effect. The patient was hospitalized.

Ascites
This report suggests a potential Dextrose Ascites side effect(s) that can have serious consequences. A 61-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Dextrose (dosage: NA) starting NS. Soon after starting Dextrose the patient began experiencing various side effects, including:
  • Ascites
Drugs used concurrently:
  • Vicodin
  • Flomax
  • Tamsulosin
  • Cysplatin
The patient was hospitalized. Although Dextrose demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as ascites, may still occur.

Nuchal Rigidity, Headache, Pyrexia, Device Infusion Issue
This Nuchal Rigidity, Headache, Pyrexia, Device Infusion Issue problem was reported by a health professional from PR. A 10-year-old patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Dextrose Solution\sodium Chloride (dosage: NA). The following drugs were being taken at the same time:
  • Cytarabine
When commencing Dextrose Solution\sodium Chloride, the patient experienced the following unwanted symptoms/side effects:
  • Nuchal Rigidity
  • Headache
  • Pyrexia
  • Device Infusion Issue
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as nuchal rigidity, may become evident only after a product is in use by the general population.

Hyponatraemia, No Therapeutic Response
This is a report of a 60-year-old male patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: hypoglycaemia and was treated with Dextrose 10% (dosage: 40 Ml/hr Routine Iv Drip) starting Mar 28, 2012. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Hyponatraemia
  • No Therapeutic Response
This opens a possibility that Dextrose 10% treatment could cause the above reactions, including hyponatraemia, and some male subjects may be more susceptible.

Chills, Hyperpyrexia, Convulsion
A 2-year-old male patient (weight: NA) from INDIA with the following symptoms/conditions: NA started Dextrose 5% And Electrolyte No.48 In Plastic Container treatment (dosage: NA) on NS. Soon after starting Dextrose 5% And Electrolyte No.48 In Plastic Container treatment, the subject experienced various side effects, including:
  • Chills
  • Hyperpyrexia
  • Convulsion
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Dextrose 5% And Electrolyte No.48 In Plastic Container.

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Top 10 Dextrose Side Effects for Women

Women Side EffectsReports
Pyrexia 13
Tremor 12
Dizziness 7
Death 6
Back Pain 5
Blood Glucose Decreased 5
Grand Mal Convulsion 5
Infusion Related Reaction 5
Nausea 5
Chest Pain 4

Top 10 Dextrose Side Effects for Men

Men Side EffectsReports
Chills 16
Pyrexia 16
Hypotension 12
Thrombocytopenia 9
Anaphylactic Reaction 7
Death 7
Convulsion 6
Dyspnoea 6
Hyponatraemia 6
Tremor 6

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Dextrose Side Effects

    Did You Have a Dextrose Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Dextrose for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Dextrose Safety Alerts, Active Ingredients, Usage Information

    NDC0069-0700
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameOndansetron hydrochloride and dextrose
    Nameondansetron hydrochloride and dextrose
    Dosage FormINJECTION, SOLUTION
    RouteINTRAVENOUS
    On market since20090501
    LabelerPfizer Labs, Division of Pfizer Inc.
    Active Ingredient(s)ONDANSETRON HYDROCHLORIDE
    Strength(s)32
    Unit(s)mg/50mL
    Pharma ClassSerotonin 3 Receptor Antagonists [MoA],Serotonin-3 Receptor Antagonist [EPC]

    Dextrose Dosage, Warnings, Usage.

    Side Effects reported to FDA: 189

    Dextrose safety alerts: 2014 2013 2012 2008

    Reported deaths: 9

    Reported hospitalizations: 50

    Lactated Ringers and 5 Percent Dextrose Injection, USP, 1000 ML, Flexible Containers: Recall - Due to Non-Sterility

    [Posted 01/28/2013]

    AUDIENCE: Pharmacy, Patient, Health Professional

    ISSUE: Hospira, Inc. is initiating a voluntary nationwide user-level recall of one lot of Lactated Ringers and 5% Dextrose Injection, USP, 1000 mL, Flexible Container, NDC 0409-7929-09. This action is due to one confirmed customer report where a spore-like structured particulate, consistent with mold, was noted in the solution. Hospira has not received reports of any adverse events associated with this issue for this lot, and has not identified any quality issues with retention samples for this lot. If contaminated solution is used on a patient, this may cause thrombosis, phlebitis, bacteremia, sepsis, septic shock and/or endocarditis, or result in a fatal infection in a broad array of patients.

    BACKGROUND: The product is used as a source of water, electrolytes and calories or as an alkalizing agent and is packaged in a 1000 mL flexible container, lot number 05-019-JT, with an expiration date of May 1, 2013. The affected lot was distributed nationwide between June 2011 and January 2012 to wholesalers/distributors, hospitals and pharmacies.

    RECOMMENDATION: Anyone with an existing inventory should stop use and distribution, quarantine the product immediately, and call Stericycle at 1-888-965-5798 between the hours of 8am to 5pm EST, Monday through Friday, to arrange for the return of the product. Replacement product from other lots is available. For medical inquiries, please contact Hospira Medical Communications at 1-800-615-0187.

    Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

    • Complete and submit the report Online: www.fda.gov/MedWatch/report.htm
    • Download form or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178

    [01/25/2013 - Firm Press Release - Hospira, Inc]

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