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Domperidone Side Effects

Common Domperidone Side Effects


The most commonly reported Domperidone side effects (click to view or check a box to report):

Dyspnoea (16)
Nausea (13)
Pyrexia (12)
Fatigue (12)
Diarrhoea (10)
Abdominal Pain (9)
Electrocardiogram Qt Prolonged (8)
Chest Discomfort (7)
Cough (7)
Paraesthesia (7)
Weight Decreased (7)
Malaise (6)
Chest Pain (6)
Depressed Level Of Consciousness (6)
Pneumonia (6)
Restlessness (6)
Vomiting (6)
Torsade De Pointes (6)
Hypokalaemia (5)
Pain (5)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Domperidone Side Effects Reported to FDA

The following Domperidone reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Domperidone on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Skin Discolouration, Decreased Appetite, Serotonin Syndrome, Pallor, Paralysis, Hypoaesthesia Oral, Neuroleptic Malignant Syndrome, Schizophrenia
This is a report of a 30-year-old female patient (weight: NA) from GB, suffering from the following symptoms/conditions: NA, who was treated with Domperidone (dosage: NA, start time: NS), combined with:
  • Clonazepam (clonazepam) (clonazepam)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Skin Discolouration
  • Decreased Appetite
  • Serotonin Syndrome
  • Pallor
  • Paralysis
  • Hypoaesthesia Oral
  • Neuroleptic Malignant Syndrome
  • Schizophrenia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Domperidone treatment in female patients, resulting in skin discolouration side effect. The patient was hospitalized and became disabled.

Chest Pain, Palpitations, Pain In Extremity, Arrhythmia, Coronary Artery Disease, Torsade De Pointes, Muscular Weakness, Arteriosclerosis Coronary Artery
This report suggests a potential Domperidone Chest Pain, Palpitations, Pain In Extremity, Arrhythmia, Coronary Artery Disease, Torsade De Pointes, Muscular Weakness, Arteriosclerosis Coronary Artery side effect(s) that can have serious consequences. A 46-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease and used Domperidone (dosage: 10 Mg Bid Po) starting Feb 08, 2010. Soon after starting Domperidone the patient began experiencing various side effects, including:
  • Chest Pain
  • Palpitations
  • Pain In Extremity
  • Arrhythmia
  • Coronary Artery Disease
  • Torsade De Pointes
  • Muscular Weakness
  • Arteriosclerosis Coronary Artery
Drugs used concurrently:
  • Kapidex
Although Domperidone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as chest pain, may still occur.

Weight Decreased, Off Label Use
This Weight Decreased, Off Label Use problem was reported by a physician from CL. A 58-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: sleep apnoea syndrome,snoring. On NS this consumer started treatment with Domperidone (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Domperidone, the patient experienced the following unwanted symptoms/side effects:
  • Weight Decreased
  • Off Label Use
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as weight decreased, may become evident only after a product is in use by the general population.

Atrioventricular Block
This is a report of a 34-year-old female patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Domperidone (dosage: 10 Mg, Tid) starting Dec 03, 2012. Concurrently used drugs:
  • Ondansetron (8 Mg, Tid)
  • Pregabalin (150 Mg, Bid)
  • Sertraline (50 Mg, Bid)
  • Sumatriptan (6 Mg, Bid)
  • Baclofen (10 Mg,5/1 Days)
  • Dihydroergotamine (Unk)
  • Lamotrigine (25 Mg, Bid)
  • Loratadine (10 Mg, Qd)
Soon after that, the consumer experienced the following side effects:
  • Atrioventricular Block
The patient was hospitalized. This opens a possibility that Domperidone treatment could cause the above reactions, including atrioventricular block, and some female subjects may be more susceptible.


Cerebrovascular Accident
A 68-year-old male patient (weight: NA) from GB with the following symptoms/conditions: nausea started Domperidone treatment (dosage: NA) on Oct 22, 2012. Soon after starting Domperidone treatment, the subject experienced various side effects, including:
  • Cerebrovascular Accident
Concurrently used drugs:
  • Dexamethasone
  • Scopolamine Hydrobromide
  • Ondansetron
  • Irinotecan Hydrochloride
  • Xeloda
This finding indicates that some male patients could be more vulnerable to Domperidone.

Dyspnoea, Respiratory Depth Decreased, Chest Discomfort, Chest Pain, Fatigue
A 48-year-old female patient from UNITED KINGDOM (weight: NA) experienced symptoms, such as: NA and was treated with Domperidone (domperidone)(dosage: 20 Mg, Po). The treatment was initiated on May 24, 2011. After that a consumer reported the following side effect(s):
  • Dyspnoea
  • Respiratory Depth Decreased
  • Chest Discomfort
  • Chest Pain
  • Fatigue
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Domperidone (domperidone) efficacy:
  • Dexamethasone (20 Mg, Iv)
  • Biotene
  • Dexamethasone (4 Mg, Bid, Po)
  • Doxorubicin Hcl
  • Cyclophosphamide
  • Paclitaxel (315;300 Mg, Qow, Iv)
  • Paclitaxel (315;300 Mg, Qow, Iv)
  • Chlorpheniramine Tab (10 Mg, Unk, Iv)


Basal Cell Carcinoma, Injection Site Pain, Limb Crushing Injury, Night Sweats, Fall
In this report, Domperidone was administered for the following condition: NA.A female consumer from UNITED STATES (weight: NA) started Domperidone treatment (dosage: NA) on Mar 03, 2012.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Basal Cell Carcinoma
  • Injection Site Pain
  • Limb Crushing Injury
  • Night Sweats
  • Fall
A possible interaction with other drugs could have contributed to this reaction:
  • Bentyl
  • Lamictal (150 Mg Every Morning)
  • Emsam (6 Mg - 24 Hr Patch Which Is An Maoi)
  • Multi-vitamin
  • Lasix
  • Flexeril (10 To 20mg As Needed)
  • Excedrin Aspirin Free
  • Zofran
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Domperidone treatment could be related to the listed above side effect(s).

Convulsion, Steatorrhoea, Incorrect Dose Administered
This is a report of the following Domperidone side effect(s):
  • Convulsion
  • Steatorrhoea
  • Incorrect Dose Administered
A male patient from BRAZIL (weight: NA) presented with the following condition: vomiting,dyspepsia,convulsion,vitamin supplementation and received a treatment with Domperidone (dosage: In The Morning, At Noon And At Night, Form Strength 1 Milligram) starting: Aug 01, 2011.The following concurrently used drugs could have generated interactions:
  • Creon (6:00 Am, 9:00 Am, 12:00 Am, 3:00 Pm, 6:00 Pm)
  • Phenobarbital Tab (Form Strength 40 Milligram)
This report suggests that a Domperidone treatment could be associated with the listed above side effect(s).

Lung Disorder
This Domperidone report was submitted by a 80-year-old female consumer from FRANCE (weight: NA). The patient was diagnosed with: NA and Domperidone was administered (dosage: Unk) starting: Mar 29, 2012. The consumer developed a set of symptoms:
  • Lung Disorder
Other drugs used simultaneously:
  • Arixtra
  • Nexium
  • Losartan /01121602/
  • Medrol
  • Spasfon-lyoc (Unk)
  • Tarceva (1 Df, Uid/qd)
  • Duragesic-100
  • Aspirin (75 Mg, Uid/qd)
Those unexpected symptoms could be linked to a Domperidone treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Herpes Zoster
This is a report of a possible correlation between Domperidone use and the following symptoms/side effect(s):
  • Herpes Zoster
which could contribute to an assessment of Domperidone risk profile.A female consumer from CANADA (weight: NA) was suffering from NA and was treated with Domperidone (dosage: NA) starting NS.Other concurrent medications:
  • Risperidone
  • Levothyroxine Sodium
  • Micro-k
  • Ranitidine
  • Alendronate Sodium
  • Citalopram
  • Azathioprine
  • Remicade (Had 40 Infusions)


Hepatocellular Injury
A 28-year-old female patient from FRANCE (weight: NA) presented with the following symptoms: NA and after a treatment with Domperidone (dosage: NA) experienced the following side effect(s):
  • Hepatocellular Injury
The treatment was started on Apr 22, 2012. Domperidone was used in combination with the following drugs:
  • Clindamycin
  • Ceftriaxone
  • Acetaminophen (In The Evening)
  • Acetaminophen
  • Orbenin Cap
  • Lovenox
  • Morphine Sulfate
  • Ceftriaxone
The patient was hospitalized.This report could alert potential Domperidone consumers.

Gastric Cancer
In this report, a female patient from JAPAN (weight: NA) was affected by a possible Domperidone side effect.The patient was diagnosed with NA. After a treatment with Domperidone (dosage: NA, start date: Jan 13, 2012), the patient experienced the following side effect(s):
  • Gastric Cancer
The following simultaneously used drugs could have led to this reaction:
  • Diovan
  • Cytotec
  • Methotrexate
  • Foliamin
  • Lipitor
  • Simponi
  • Urso 250
  • Clarithromycin
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Domperidone treatment.

Fatigue, Dyspnoea, Chest Pain, Chest Discomfort, Respiratory Depth Decreased
This is a report of a 48-year-old female patient from UNITED KINGDOM (weight: NA), who used Domperidone (dosage: NA) for a treatment of NA. After starting a treatment on May 24, 2011, the patient experienced the following side effect(s):
  • Fatigue
  • Dyspnoea
  • Chest Pain
  • Chest Discomfort
  • Respiratory Depth Decreased
The following drugs could possibly have interacted with the Domperidone treatment
  • Ranitidine
  • Decadron Phosphate
  • Docusate Sodium
  • Paclitaxel
  • Pegfilgrastim
  • Granisetron
  • Decadron
  • Chlorpheniramine Maleate
Taken together, these observations suggest that a Domperidone treatment could be related to side effect(s), such as Fatigue, Dyspnoea, Chest Pain, Chest Discomfort, Respiratory Depth Decreased.

Cardiac Perforation, Delusional Disorder, Persecutory Type, Persecutory Delusion, Cardiogenic Shock, Completed Suicide
This cardiac perforation side effect was reported by a health professional from GERMANY. A female patient (weight:NA) experienced the following symptoms/conditions: dyspepsia. The patient was prescribed Domperidone (dosage: NA), which was started on Aug 28, 2008. Concurrently used drugs:
  • Gilenya (0.5 Mg, Qd)
  • Amitriptyline Hcl
  • Rabeprazole Sodium
  • Gilenya
When starting to take Domperidone the consumer reported the following symptoms:
  • Cardiac Perforation
  • Delusional Disorder, Persecutory Type
  • Persecutory Delusion
  • Cardiogenic Shock
  • Completed Suicide
These side effects may potentially be related to Domperidone.

Dyspnoea, Chest Discomfort, Fatigue, Chest Pain, Respiratory Depth Decreased
This is a Domperidone side effect report of a 48-year-old female patient (weight:NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: NA, who was treated with Domperidone (dosage:NA, start time: May 24, 2011), combined with:
  • Docusate
  • Pegfilgrastim
  • Chlorpheniramine Tab
  • Dexamethasone
  • Ranitidine
  • Biotene Dry Mouth
  • Granisetron
  • Dexamethasone
, and developed a serious reaction and a dyspnoea side effect. The patient presented with:
  • Dyspnoea
  • Chest Discomfort
  • Fatigue
  • Chest Pain
  • Respiratory Depth Decreased
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Domperidone treatment in female patients suffering from NA, resulting in dyspnoea.

Loss Of Consciousness, Pulseless Electrical Activity, Toxicity To Various Agents, Ventricular Fibrillation, Ventricular Tachycardia, Intentional Overdose
This report suggests a potential Domperidone loss of consciousness side effect(s) that can have serious consequences. A 24-year-old male patient from BELGIUM (weight:NA) was diagnosed with the following health condition(s): intentional overdose and used Domperidone (dosage: 5 Tablets Of Domperidone 10mg) starting NS. Soon after starting Domperidone the patient began experiencing various side effects, including:
  • Loss Of Consciousness
  • Pulseless Electrical Activity
  • Toxicity To Various Agents
  • Ventricular Fibrillation
  • Ventricular Tachycardia
  • Intentional Overdose
Drugs used concurrently:
  • Chloroquine Phosphate (58 Tablets Of Chloroquine 250mg)
  • Midazolam (20 Tablets Of Midazolam 7.5mg)
  • Ondansetron (10 Tablets Of Ondansetron 4mg)
The patient was hospitalized. Although Domperidone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as loss of consciousness, may still occur.

Ventricular Fibrillation, Pulseless Electrical Activity, Intentional Overdose, Ventricular Tachycardia, Loss Of Consciousness, Nodal Rhythm
This ventricular fibrillation problem was reported by a health professional from BELGIUM. A 24-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Domperidone (dosage: 5 Df, Once/single). The following drugs/medications were being taken at the same time:
  • Midazolam (20 Df, Once/single)
  • Ondansetron (10 Df, Once/single)
  • Chloroquine Phosphate (58 Df, Once/single)
When commencing Domperidone, the patient experienced the following unwanted symptoms /side effects:
  • Ventricular Fibrillation
  • Pulseless Electrical Activity
  • Intentional Overdose
  • Ventricular Tachycardia
  • Loss Of Consciousness
  • Nodal Rhythm
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as ventricular fibrillation, may become evident only after a product is in use by the general population.

Circulatory Collapse, Neck Pain, Feeling Hot, Resuscitation, Tachycardia, Bradycardia
This is a Domperidone (domperidone) side effect report of a 57-year-old male patient (weight: NA) from UNITED KINGDOM. The patient developed the following symptoms/conditions: NA and was treated with Domperidone (domperidone) (dosage: NA) starting Sep 17, 2011. Concurrently used drugs:
  • Cyclizine (cyclizine)
  • Zopiclone (zopiclone)
  • Ondansetron (8 Mg, Intramuscular)
  • Oxycodone Hcl
  • Fentanyl
Soon after that, the consumer experienced the following of symptoms:
  • Circulatory Collapse
  • Neck Pain
  • Feeling Hot
  • Resuscitation
  • Tachycardia
  • Bradycardia
This opens a possibility that Domperidone (domperidone) could cause sudden death and that some male patients may be more susceptible.

Pulseless Electrical Activity, Ventricular Fibrillation, Intentional Overdose, Toxicity To Various Agents, Loss Of Consciousness, Nodal Rhythm, Ventricular Tachycardia
A 24-year-old male patient (weight: NA) from BELGIUM with the following symptoms: NA started Domperidone treatment (dosage: 5 Df, Once/single) on NS. Soon after starting Domperidone treatment, the consumer experienced several side effects, including:
  • Pulseless Electrical Activity
  • Ventricular Fibrillation
  • Intentional Overdose
  • Toxicity To Various Agents
  • Loss Of Consciousness
  • Nodal Rhythm
  • Ventricular Tachycardia
. Concurrently used drugs:
  • Midazolam (20 Df, Once/single)
  • Chloroquine Phosphate (58 Df, Once/single)
  • Ondansetron (10 Df, Once/single)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Domperidone side effects, such as pulseless electrical activity.

Sensory Loss, Hypoaesthesia, Muscular Weakness, Dyskinesia, Muscle Twitching
This sensory loss side effect was reported by a consumer or non-health professional from UNITED STATES. A 35-year-old female patient (weight:NA) experienced the following symptoms/conditions: lactation disorder.The patient was prescribed Domperidone 90 Mg (dosage: 30 Mg 3 Times A Day Po), which was started on Feb 02, 2012. Concurrently used drugs: NA..When starting to take Domperidone 90 Mg the consumer reported symptoms, such as:
  • Sensory Loss
  • Hypoaesthesia
  • Muscular Weakness
  • Dyskinesia
  • Muscle Twitching
These side effects may potentially be related to Domperidone 90 Mg. The patient was hospitalized and became disabled.

Chest Discomfort, Fatigue, Dyspnoea
This is a report of a 48-year-old female patient (weight: NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: NA, who was treated with Domperidone (dosage: NA, start time: May 24, 2011), combined with:
  • Chlorpheniramine Tab
  • Pegfilgrastim
  • Dexamethasone (4 Mg, Bid)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Chest Discomfort
  • Fatigue
  • Dyspnoea
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Domperidone treatment in female patients, resulting in chest discomfort side effect.

Vision Blurred, Visual Acuity Reduced, Visual Impairment, Papilloedema, Optic Atrophy, Retinal Haemorrhage
This report suggests a potential Domperidone Vision Blurred, Visual Acuity Reduced, Visual Impairment, Papilloedema, Optic Atrophy, Retinal Haemorrhage side effect(s) that can have serious consequences. A 48-year-old female patient (weight: NA) from UNITED KINGDOM was diagnosed with the following symptoms/conditions: NA and used Domperidone (dosage: NA) starting Aug 01, 2011. Soon after starting Domperidone the patient began experiencing various side effects, including:
  • Vision Blurred
  • Visual Acuity Reduced
  • Visual Impairment
  • Papilloedema
  • Optic Atrophy
  • Retinal Haemorrhage
Drugs used concurrently:
  • Dexamethasone
  • Codeine Phosphate
  • Omeprazole
  • Paclitaxel
  • Acetaminophen
  • Carboplatin (740mg Q21d (5 Cycles))
  • Ondansetron
  • Ranitidine
Although Domperidone demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as vision blurred, may still occur.

Tachycardia, Bradycardia, Oesophageal Adenocarcinoma Metastatic, Feeling Hot, Neck Pain
This Tachycardia, Bradycardia, Oesophageal Adenocarcinoma Metastatic, Feeling Hot, Neck Pain problem was reported by a physician from UNITED KINGDOM. A 57-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: vomiting. On Jan 01, 2011 this consumer started treatment with Domperidone (dosage: 30-60mg). The following drugs were being taken at the same time:
  • Cyclizine
When commencing Domperidone, the patient experienced the following unwanted symptoms/side effects:
  • Tachycardia
  • Bradycardia
  • Oesophageal Adenocarcinoma Metastatic
  • Feeling Hot
  • Neck Pain
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as tachycardia, may become evident only after a product is in use by the general population.

Pancreatitis
This is a report of a 80-year-old female patient (weight: NA) from SWITZERLAND. The patient developed the following symptoms/conditions: NA and was treated with Domperidone (dosage: NA) starting Nov 01, 2011. Concurrently used drugs:
  • Pantoprazole
  • Electrolytes Nos And Polyethylene Glycol
  • Benorilate
  • Aspirin
  • Vemurafenib (Date Of Last Dose Prior To Sae: 04/apr/2012)
  • Levothyroxine Sodium
  • Sodium Picosulfate
Soon after that, the consumer experienced the following side effects:
  • Pancreatitis
The patient was hospitalized. This opens a possibility that Domperidone treatment could cause the above reactions, including pancreatitis, and some female subjects may be more susceptible.

Limb Crushing Injury, Basal Cell Carcinoma, Fall, Injection Site Pain, Night Sweats
A 58-year-old female patient (weight: NA) from UNITED STATES with the following symptoms/conditions: NA started Domperidone treatment (dosage: NA) on Mar 03, 2012. Soon after starting Domperidone treatment, the subject experienced various side effects, including:
  • Limb Crushing Injury
  • Basal Cell Carcinoma
  • Fall
  • Injection Site Pain
  • Night Sweats
Concurrently used drugs:
  • Emsam (6 Mg - 24 Hr Patch Which Is An Maoi)
  • Baclofen
  • Vicodin (1 To 2 Tablets As Needed)
  • Flexeril (10 To 20mg As Needed)
  • Lamictal (150 Mg Every Morning)
  • Synthroid (0.025 Mg 5/week, Skips Sunday And Thursday)
  • Clonazepam (1 To 1.5 Of 2 Mg Tabs As Needed)
  • Erythromycin
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Domperidone.

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Top 10 Domperidone Side Effects for Men

Men Side EffectsReports
Pyrexia 10
Nausea 8
Diarrhoea 6
Dyspnoea 6
Restlessness 6
Apnoea 5
Blood Pressure Decreased 5
Cough 5
Depressed Level Of Consciousness 5
Pneumonia 5

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Domperidone Safety Alerts, Active Ingredients, Usage Information

    More About Domperidone

    Side Effects reported to FDA: 163

    Domperidone safety alerts: 2004

    Reported deaths: 30

    Reported hospitalizations: 74

    Domperidone

    Audience: Consumers and healthcare professionals

    FDA warned healthcare professionals and breastfeeding women not to use an unapproved drug, domperidone, to increase milk production (lactation). The agency is concerned with the potential public health risks associated with domperidone. FDA took these actions because it has become aware that some women are purchasing this drug from compounding pharmacies and from foreign sources. Although domperidone is approved in several countries outside the U.S. to treat certain gastric disorders, it is not approved in any country, including the U.S., for enhancing breast milk production in lactating women and is also not approved in the U.S. for any indication.

    Latest Domperidone clinical trials