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From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Review Epinephrine Safety Reports submitted to FDA

Total Epinephrine reports: 41.
Epinephrine FDA safety alerts: 2004 2005 2006 .
   Reported hospitalizations: 9.
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FDA Reported Epinephrine Side Effects: device failure, device malfunction, hypertension, anaphylactic reaction, incorrect dose administered, ventricular tachycardia, loss of consciousness, transplant failure, shock, ocular vascular disorder, corneal transplant.
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Epinephrine Side Effects Report #5677200-6
Physician from UNITED STATES reported EPINEPHRINE problem on Mar 11, 2008. Female patient, child 12 years of age, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: hypotension, long qt syndrome, tachycardia. EPINEPHRINE dosage: 0.3 MG, SINGLE, INTRAMUSCULAR. During the same period patient was treated with ASPRIN. Patient recovered.

Epinephrine Side Effects Report #5679094-1
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 24, 2008. Male patient, 33 years of age, was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anxiety, chest pain, disturbance in attention, electrocardiogram abnormal, overdose. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5616305-2
Consumer or non-health professional from UNITED STATES reported EPINEPHRINE problem on Jan 22, 2008. Male patient, child 10 years of age, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure, medical device complication. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR. Patient recovered.

Epinephrine Side Effects Report #5626417-5
EPINEPHRINE problem was reported by a Pharmacist from CANADA on Jan 25, 2008. Male patient, weighting 155.0 lb, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction, incorrect dose administered, injection site haemorrhage. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5630325-3
Physician from UNITED STATES reported EPINEPHRINE problem on Jan 28, 2008. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: contusion, device failure, medical device complication. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5631529-6
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 30, 2008. Female patient, weighting 150.0 lb, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR. During the same period patient was treated with XOPENEX, GUAIFENESIN, ALLEGRA, PREVACID, FLAXSEED OIL, SENNA, ASCORBIC ACID. Patient recovered.

Epinephrine Side Effects Report #5639709-0
Consumer or non-health professional from UNITED STATES reported EPINEPHRINE problem on Feb 06, 2008. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5584208-8
EPINEPHRINE problem was reported by a Physician from UNITED STATES on Dec 18, 2007. Male patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: 0.3 MG, INTRAMUSCULAR. During the same period patient was treated with ALBUTEROL, ALLEGRA, ASMANEX TWISTHALER, SINGULAIR, XOLAIR. Patient recovered.

Epinephrine Side Effects Report #5593271-X
Consumer or non-health professional from UNITED STATES reported EPINEPHRINE problem on Dec 28, 2007. Female patient, weighting 113.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure, heart rate increased, tremor. EPINEPHRINE dosage: (0.3 MG, SUBCUTANEOUS). During the same period patient was treated with XOPENEX, ADVAIR DISKUS, ATROVENT, ASTELIN, TOPIRAMATE, RELPAX. Patient recovered.

Epinephrine Side Effects Report #5605464-3
EPINEPHRINE problem was reported by a Pharmacist from CANADA on Jan 08, 2008. Male patient, weighting 43.00 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: hypertension. EPINEPHRINE dosage: 0.15 MG INTRAMUSCULAR/SUBCUTANEOUS. Patient recovered.

Epinephrine Side Effects Report #5610458-8
Physician from UNITED STATES reported EPINEPHRINE problem on Jan 20, 2008. Female patient was diagnosed with heart rate decreased and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: false positive laboratory result, medical device complication. EPINEPHRINE dosage: 0.1 MG, NOT REPORTED, ENDOTRACHEAL, NOT REPORTED, NOT REPORTED, VIA ENDOTRACHEAL TUBE. Patient recovered.

Epinephrine Side Effects Report #5610659-9
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 31, 2008. Female patient, 30 years of age, was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anxiety, dyspnoea. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5613317-X
Consumer or non-health professional from CANADA reported EPINEPHRINE problem on Jan 10, 2008. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction, dyspnoea, obstructive airways disorder. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5565774-5
EPINEPHRINE problem was reported by a Health Professional from UNITED STATES on Nov 28, 2007. Female patient, weighting 240.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactoid reaction, device malfunction. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5567397-0
Health Professional from CANADA reported EPINEPHRINE problem on Nov 28, 2007. Female patient, 52 years of age, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: accidental needle stick, device malfunction, genital swelling, hypersensitivity, injection site pallor, no therapeutic response, oedema peripheral, pain in extremity. EPINEPHRINE dosage: (0.3 MG INTRAMUSCULAR). During the same period patient was treated with EPIPEN. Patient recovered.

Epinephrine Side Effects Report #5568024-9
EPINEPHRINE problem was reported by a Physician from UNITED STATES on Dec 05, 2007. Male patient was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR. Patient recovered.

Epinephrine Side Effects Report #5578139-7
Consumer or non-health professional from CANADA reported EPINEPHRINE problem on Dec 11, 2007. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure, dyspnoea, obstructive airways disorder. EPINEPHRINE dosage: (0.3 MG INTRAMUSCULAR). Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5505275-3
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Oct 31, 2007. Female patient was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: injection site anaesthesia, injection site coldness, injection site pallor, nerve injury, pain. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5517713-0
Health Professional from UNITED STATES reported EPINEPHRINE problem on Oct 25, 2007. Female patient, weighting 240.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5478773-9
EPINEPHRINE problem was reported by a Pharmacist from UNITED STATES on Sept 17, 2007. Male patient was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction, musculoskeletal chest pain. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. During the same period patient was treated with ETHANOL. Patient recovered.

Epinephrine Side Effects Report #5484869-8
Health Professional from CANADA reported EPINEPHRINE problem on Sept 25, 2007. Male patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: accidental needle stick, device malfunction, iatrogenic injury, scratch, traumatic haemorrhage. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. Patient recovered.

Epinephrine Side Effects Report #5491347-9
EPINEPHRINE problem was reported by a Consumer or non-health professional from CANADA on Oct 04, 2007. Male patient, weighting 25.00 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: application site bruising, device malfunction, hypoxia. EPINEPHRINE dosage: 0.15 MG INTRAMUSCULAR/ SUBCUTANEOUS. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5495400-5
Pharmacist from UNITED STATES reported EPINEPHRINE problem on Sept 10, 2007. Male patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: 0.3 MG PRN INTRAMUSCULAR. Patient recovered.

Epinephrine Side Effects Report #5503081-7
EPINEPHRINE problem was reported by a Pharmacist from UNITED STATES on Oct 11, 2007. Male patient, weighting 405.7 lb, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure, nausea. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. During the same period patient was treated with LIPITOR, FLOMAX, OMEPRAZOLE. Patient recovered.

Epinephrine Side Effects Report #5449428-1
Physician from CANADA reported EPINEPHRINE problem on Aug 24, 2007. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. During the same period patient was treated with MOGADON. Patient recovered.

Epinephrine Side Effects Report #5450654-6
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 27, 2007. Male patient, weighting 118.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device malfunction. EPINEPHRINE dosage: (0.3 MG INTRAMUSCULAR/SUBCUTANEOUS). During the same period patient was treated with ANTIHISTAMINES. Patient recovered.

Epinephrine Side Effects Report #5456464-8
Physician from UNITED STATES reported EPINEPHRINE problem on Sept 06, 2007. Female patient was diagnosed with local anaesthesia and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: hypertension, paralysis, respiratory arrest, respiratory depression, tachycardia. EPINEPHRINE dosage: 5 ML, SINGLE. During the same period patient was treated with LIDOCAINE, RADIOACTIVE MATERIAL, MIDAZOLAM, FENTANYL, PROPOFOL, SEVOFLURANE, CEPHALOZOLIN, METOCLOPRAMIDE. Patient recovered.

Epinephrine Side Effects Report #5472196-4
EPINEPHRINE problem was reported by a Health Professional from UNITED STATES on Sept 13, 2007. Female patient, weighting 240.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: medical device complication. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5472198-8
Pharmacist from UNITED STATES reported EPINEPHRINE problem on Sept 10, 2007. Male patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: (0.3 MG INTRAMUSCULAR). Patient recovered.

Epinephrine Side Effects Report #5410350-8
EPINEPHRINE problem was reported by a Consumer or non-health professional from CANADA on July 23, 2007. Female patient, weighting 125.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: (0.3 MG INTRAMUSCULAR/SUBCUTANEOUS). During the same period patient was treated with VENTOLIN, PULMICORT. Patient recovered.

Epinephrine Side Effects Report #5415032-4
Health Professional from UNITED STATES reported EPINEPHRINE problem on Aug 14, 2007. Female patient, 40 years of age, weighting 220.0 lb, was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: angioedema, chest pain, dysphagia, dyspnoea, electrocardiogram abnormal, electrocardiogram st segment elevation, ventricular tachycardia. EPINEPHRINE dosage: 1MG IV. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5419749-7
EPINEPHRINE problem was reported by a Pharmacist from CANADA on July 30, 2007. Female patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, device failure. EPINEPHRINE dosage: 0.03 MG INATRAMUSCULAR/SUBCUTANEOUS. During the same period patient was treated with SINGULAIR, ADVAIR DISKUS, BRICANYL. Patient recovered.

Epinephrine Side Effects Report #5421888-1
Pharmacist from CANADA reported EPINEPHRINE problem on Aug 09, 2007. Male patient was diagnosed with anaphylactic reaction and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, device breakage. EPINEPHRINE dosage: 0.3 MG INTRAMUSCULAR/SUBCUTANEOUS. During the same period patient was treated with VENTOLIN. Patient recovered.

Epinephrine Side Effects Report #5427086-X
EPINEPHRINE problem was reported by a Pharmacist from UNITED STATES on Aug 24, 2007. Female patient, 37 years of age, was diagnosed with overdose and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: convulsion, headache, hypertension, incorrect dose administered, loss of consciousness, muscular weakness, ventricular tachycardia. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5427462-5
Pharmacist from UNITED STATES reported EPINEPHRINE problem on Aug 24, 2007. Female patient, 28 years of age, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: cardiac enzymes increased, vasospasm. EPINEPHRINE dosage: 0.5ML ONE TIME IV BOLUS. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5431690-2
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 20, 2007. Female patient was diagnosed with local anaesthesia, scan lymph nodes and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: paralysis, respiratory arrest. EPINEPHRINE dosage: unknown. During the same period patient was treated with LIDOCAINE, MIDAZOLAM, FENTANYL, PROPOFOL, SEVOFLURANE, CEPHALOZOLIN, METOCLOPRAMIDE, LYMPHAZURIN. Patient recovered.

Epinephrine Side Effects Report #5444084-0
Physician from UNITED STATES reported EPINEPHRINE problem on Aug 16, 2007. Female patient, weighting 138.0 lb, was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, device malfunction. EPINEPHRINE dosage: unknown. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5382772-5
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on June 18, 2007. Female patient, weighting 130.0 lb, was diagnosed with lip swelling, swollen tongue and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5392962-3
Health Professional from UNITED STATES reported EPINEPHRINE problem on July 03, 2007. Female patient was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, hypersensitivity, incorrect dose administered. EPINEPHRINE dosage: unknown. Patient was hospitalized. Patient recovered.

Epinephrine Side Effects Report #5382772-5
EPINEPHRINE problem was reported by a Consumer or non-health professional from UNITED STATES on June 18, 2007. Female patient, weighting 130.0 lb, was diagnosed with lip swelling, swollen tongue and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: device failure. EPINEPHRINE dosage: unknown. Patient recovered.

Epinephrine Side Effects Report #5392962-3
Health Professional from UNITED STATES reported EPINEPHRINE problem on July 03, 2007. Female patient was diagnosed with hypersensitivity and was treated with EPINEPHRINE. After drug was administered, patient experienced the following problems/side effects: anaphylactic reaction, hypersensitivity, incorrect dose administered. EPINEPHRINE dosage: unknown. Patient was hospitalized. Patient recovered.


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