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Total Gleevec reports: 1116.Gleevec FDA safety alerts: 2006 .
Reported deaths: 200 Reported hospitalizations: 506.
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FDA Reported Gleevec Side Effects: oedema peripheral, nausea, cardiac failure congestive, haemoglobin decreased, fatigue, malignant neoplasm progression, blood creatinine increased, pyrexia, dyspnoea exertional, dyspnoea, asthenia.
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Gleevec Side Effects Report #5305290-9Consumer or non-health professional from JAPAN reported GLEEVEC problem on Apr 11, 2007. Male patient, 76 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: metastases to central nervous system, osteomyelitis fungal. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5305291-0
GLEEVEC problem was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 63 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: lung abscess. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5305326-5
Physician from JAPAN reported GLEEVEC problem on Apr 20, 2007. Female patient, 59 years of age, was diagnosed with chloroma, myelofibrosis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, chloroma, hepatosplenomegaly, hypercalcaemia, neoplasm skin, pathological fracture, pneumonia, pyrexia. GLEEVEC dosage: 300 MG/DAY. During the same period patient was treated with PREDNISOLONE. Patient died on 08/20/2005.
Gleevec Side Effects Report #5305400-3
GLEEVEC problem was reported by a Health Professional from ITALY on Apr 19, 2007. Male patient, 82 years of age, was diagnosed with abdominal neoplasm and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest. GLEEVEC dosage: 100 MG, QID. During the same period patient was treated with MINITRAN, LASIX, LIMPIDEX. Patient died on 03/10/2007.
Gleevec Side Effects Report #5305847-5
Consumer or non-health professional from JAPAN reported GLEEVEC problem on Apr 11, 2007. Male patient, 76 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: metastases to central nervous system, osteomyelitis fungal. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5305863-3
GLEEVEC problem was reported by a Health Professional from ITALY on Apr 19, 2007. Male patient, 82 years of age, was diagnosed with abdominal neoplasm and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest. GLEEVEC dosage: 100 MG, QID. During the same period patient was treated with MINITRAN, LASIX, LIMPIDEX. Patient died on 03/10/2007.
Gleevec Side Effects Report #5305972-9
Physician from JAPAN reported GLEEVEC problem on Apr 20, 2007. Female patient, 59 years of age, was diagnosed with chloroma, myelofibrosis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: c-reactive protein increased, chloroma, hepatosplenomegaly, hypercalcaemia, neoplasm skin, pathological fracture, pneumonia, pyrexia. GLEEVEC dosage: 300 MG/DAY. During the same period patient was treated with PREDNISOLONE. Patient died on 08/20/2005.
Gleevec Side Effects Report #5306351-0
GLEEVEC problem was reported by a Consumer or non-health professional from JAPAN on Apr 11, 2007. Male patient, 63 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: lung abscess. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5306856-2
Health Professional from UNITED STATES reported GLEEVEC problem on Apr 13, 2007. Female patient, 52 years of age, was diagnosed with chronic myeloid leukaemia, depression, anaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, depression, osteosclerosis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with CELEXA, VITAMIN CAP, PROCRIT. Patient recovered.
Gleevec Side Effects Report #5306857-4
GLEEVEC problem was reported by a Physician from JAPAN on Apr 12, 2007. Male patient, 55 years of age, was diagnosed with chronic myeloid leukaemia, urticaria and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abdominal pain, blood lactate dehydrogenase increased, haemorrhagic diathesis, renal tumour excision, thrombocytopenia, white blood cell count decreased. GLEEVEC dosage: 300 MG/D. During the same period patient was treated with ALLEGRA. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5306894-X
Physician from UNITED STATES reported GLEEVEC problem on Apr 11, 2007. Female patient, 82 years of age, weighting 238.1 lb, was diagnosed with chronic myeloid leukaemia, multiple myeloma, hypertension and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dizziness, multiple myeloma, paraesthesia, tumour lysis syndrome. GLEEVEC dosage: 100 MG, QD. During the same period patient was treated with FORTEO, THALOMID, CLONIDINE, TRICOR, ACIPHEX, CARDIZEM, RYTHMOL. Patient recovered.
Gleevec Side Effects Report #5307066-5
GLEEVEC problem was reported by a Physician from BRAZIL on Apr 13, 2007. Male patient, 46 years of age, was diagnosed with chronic myeloid leukaemia, diabetes mellitus and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blood creatine phosphokinase increased, hip arthroplasty. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with ACTOS, GLUCOBAY. Patient recovered.
Gleevec Side Effects Report #5308108-3
Physician from THAILAND reported GLEEVEC problem on Apr 20, 2007. Male patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, chronic myeloid leukaemia, disease progression, febrile neutropenia. GLEEVEC dosage: 800 MG, QD. During the same period patient was treated with CYTOSAR, DOXORUBICIN. Patient died on 03/07/2007.
Gleevec Side Effects Report #5308138-1
GLEEVEC problem was reported by a Physician from CHINA on Apr 22, 2007. Female patient was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: malignant neoplasm progression. GLEEVEC dosage: 600MG. Patient died on 04/12/2007.
Gleevec Side Effects Report #5309453-8
Consumer or non-health professional from JAPAN reported GLEEVEC problem on Apr 18, 2007. Female patient, 74 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: colectomy, cyst, gastrectomy, neutropenia, tumour necrosis. GLEEVEC dosage: 400 MG/D. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5309454-X
GLEEVEC problem was reported by a Health Professional from UNITED STATES on Apr 18, 2007. Female patient, 69 years of age, weighting 181.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: diplopia, weight increased. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with BENICAR, LASIX, ZYRTEC, ZANTAC, FOLIC ACID, ACETYLSALICYLIC ACID SRT, VITAMIN CAP, PREDNISONE. Patient recovered.
Gleevec Side Effects Report #5309479-4
Physician from ITALY reported GLEEVEC problem on Apr 23, 2007. Male patient, 70 years of age, weighting 176.4 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, pneumonia, pyrexia, respiratory failure. GLEEVEC dosage: 800 MG, QD. Patient was hospitalized. Patient died on 03/09/2007.
Gleevec Side Effects Report #5311232-2
GLEEVEC problem was reported by a Physician from SPAIN on Apr 23, 2007. Male patient, 66 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac failure, cardiac flutter, ileus paralytic. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5311245-0
Health Professional from ITALY reported GLEEVEC problem on Apr 23, 2007. Male patient, 82 years of age, was diagnosed with abdominal neoplasm and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, syncope. GLEEVEC dosage: 100 MG, QID. During the same period patient was treated with MINITRAN, LASIX, LIMPIDEX, ENAPREN, DELTACORTENE. Patient died on 03/12/2007.
Gleevec Side Effects Report #5311325-X
GLEEVEC problem was reported by a Physician from FINLAND on Apr 19, 2007. Male patient, 43 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: brain oedema, c-reactive protein increased, cerebral ventricle dilatation, headache, intracranial pressure increased, neck pain, nuclear magnetic resonance imaging abnormal, pancytopenia. GLEEVEC dosage: 400 MG, BID. During the same period patient was treated with HYPER. Patient recovered.
Gleevec Side Effects Report #5311328-5
Consumer or non-health professional from FRANCE reported GLEEVEC problem on Apr 18, 2007. Male patient, 63 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: diplopia, dysphagia, dysphonia, eaton-lambert syndrome. GLEEVEC dosage: 600 MG/DAY. During the same period patient was treated with HYZAAR. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5311348-0
GLEEVEC problem was reported by a Consumer or non-health professional from JAPAN on Apr 18, 2007. Male patient, 76 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: central nervous system leukaemia, osteomyelitis fungal. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with DOXORUBICIN, VINCRISTINE, PREDNISOLONE. Patient recovered.
Gleevec Side Effects Report #5312708-4
Consumer or non-health professional from THAILAND reported GLEEVEC problem on Apr 25, 2007. Female patient, 73 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: pneumonia. GLEEVEC dosage: 600 MG. Patient died on 12/26/2006.
Gleevec Side Effects Report #5313230-1
GLEEVEC problem was reported by a Physician from ITALY on Apr 19, 2007. Female patient, 61 years of age, weighting 185.2 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, gastrointestinal haemorrhage, thrombocytopenia. GLEEVEC dosage: 800 MG, QD. During the same period patient was treated with DELTACORTENE. Patient recovered.
Gleevec Side Effects Report #5313238-6
Consumer or non-health professional from JAPAN reported GLEEVEC problem on Apr 19, 2007. Male patient, 63 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiomegaly, inflammation, lung abscess, pleural effusion, pyrexia. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5313239-8
GLEEVEC problem was reported by a Pharmacist from UNITED STATES on Apr 19, 2007. Female patient, 38 years of age, weighting 189.0 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: chest x-ray abnormal, cryptogenic organising pneumonia, pneumonitis, pyrexia. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with NEUPOGEN, VINCRISTINE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5313305-7
Physician from GREECE reported GLEEVEC problem on Apr 25, 2007. Male patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, cardiac failure, pulmonary oedema. GLEEVEC dosage: 200 MG, BID. During the same period patient was treated with ZOVIRAX, LOSEC, SPETRIN, CIPROFLOXACIN HYDROCHLORIDE, PRIMPERAN, TARGOCID. Patient died on 09/25/2006.
Gleevec Side Effects Report #5313308-2
GLEEVEC problem was reported by a Physician from POLAND on Apr 26, 2007. Female patient, 37 years of age, weighting 108.0 lb, was diagnosed with chronic myeloid leukaemia, hypertension and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, asthenia, blood phosphorus decreased, face oedema, leukopenia, metrorrhagia, thrombocytopenia, uterine haemorrhage, vaginal haemorrhage. GLEEVEC dosage: 800 MG, QD. During the same period patient was treated with PLENDIL, AMLOZEK, BETALOC. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5314550-7
Physician from VENEZUELA reported GLEEVEC problem on Apr 23, 2007. Female patient, 37 years of age, was diagnosed with chronic myeloid leukaemia, epilepsy and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: coagulopathy, hepatomegaly, hepatotoxicity, jaundice, transaminases increased, vomiting. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with DILANTIN, FENOBARBITAL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5314959-1
GLEEVEC problem was reported by a Physician from JAPAN on Apr 20, 2007. Male patient, 75 years of age, weighting 154.3 lb, was diagnosed with chronic myeloid leukaemia, hypertension, thrombosis prophylaxis, diabetes mellitus and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: face oedema, malaise, nephrotic syndrome, protein urine present, weight increased. GLEEVEC dosage: 300 MG/D. During the same period patient was treated with NORVASC, ZESTRIL, ASPIRIN, AMARYL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5315016-0
Physician from VENEZUELA reported GLEEVEC problem on Apr 23, 2007. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: fatigue, gait disturbance, palpitations, tremor. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5315529-1
GLEEVEC problem was reported by a Physician from VENEZUELA on Apr 23, 2007. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: fatigue, gait disturbance, palpitations, tremor. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5316426-8
Physician from UNITED KINGDOM reported GLEEVEC problem on Apr 23, 2007. Male patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cholelithiasis, pancreatitis. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5317467-7
GLEEVEC problem was reported by a Physician from SOUTH AFRICA on Apr 25, 2007. Female patient, 19 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, haemothorax, neutrophil count, oedema, respiratory distress, thoracic cavity drainage. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with HYDROXYUREA. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5317517-8
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on Apr 25, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abasia, deep vein thrombosis, hepatic cirrhosis, liver function test abnormal, oedema peripheral. GLEEVEC dosage: 800 MG, QD. Patient recovered.
Gleevec Side Effects Report #5317571-3
GLEEVEC problem was reported by a Pharmacist from UNITED KINGDOM on Apr 25, 2007. Male patient, 22 years of age, weighting 176.4 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: erythema nodosum, no therapeutic response. GLEEVEC dosage: 600 MG, QD. During the same period patient was treated with ACYCLOVIR, ALLOPURINOL, HYDROXYUREA, OMEPRAZOLE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5317598-1
Physician from FRANCE reported GLEEVEC problem on Apr 24, 2007. Female patient was diagnosed with autoimmune hepatitis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: autoimmune hepatitis. GLEEVEC dosage: 600 MG PER DAY. During the same period patient was treated with AZATHIOPRINE. Patient recovered.
Gleevec Side Effects Report #5317599-3
GLEEVEC problem was reported by a Physician from UNITED STATES on Apr 25, 2007. Male patient, 70 years of age, was diagnosed with chronic myeloid leukaemia, gout and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cellulitis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ALLOPURINOL. Patient recovered.
Gleevec Side Effects Report #5317638-X
Pharmacist from UNITED KINGDOM reported GLEEVEC problem on Apr 23, 2007. Female patient, 70 years of age, was diagnosed with gastrointestinal stromal tumour, malaise and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: blood prolactin increased, galactorrhoea. GLEEVEC dosage: 400MG DAILY. During the same period patient was treated with METOCLOPRAMIDE. Patient recovered.
Gleevec Side Effects Report #5317660-3
GLEEVEC problem was reported by a Physician from JAPAN on Apr 26, 2007. Male patient, 75 years of age, weighting 154.3 lb, was diagnosed with chronic myeloid leukaemia, hypertension, thrombosis prophylaxis, diabetes mellitus and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: face oedema, malaise, nephrotic syndrome, protein urine present, weight increased. GLEEVEC dosage: 300 MG/D. During the same period patient was treated with NORVASC, ZESTRIL, ASPIRIN, AMARYL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5317676-7
Physician from ITALY reported GLEEVEC problem on Apr 30, 2007. Male patient, 82 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, diarrhoea, syncope. GLEEVEC dosage: 100 MG, QID. During the same period patient was treated with MINITRAN, LASIX, LIMPIDEX, ENAPREN, DELTACORTENE. Patient died on 03/12/2007.
Gleevec Side Effects Report #5317677-9
GLEEVEC problem was reported by a Physician from JAPAN on Apr 26, 2007. Male patient, 25 years of age, was diagnosed with acute lymphocytic leukaemia recurrent, infection, disseminated intravascular coagulation, hypertension and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, disseminated intravascular coagulation, encephalitis, hypertension, rhabdomyolysis. GLEEVEC dosage: 600 MG/DAY. During the same period patient was treated with DORMICUM, DIPRIVAN, BAKTAR, ANCOTIL, PROBITOR, CLARUTE, ACIROVEC. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5317682-2
Physician from UNITED STATES reported GLEEVEC problem on Apr 26, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: thrombocythaemia, white blood cell count decreased. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5317691-3
GLEEVEC problem was reported by a Physician from ITALY on Apr 30, 2007. Male patient, 82 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, diarrhoea, syncope. GLEEVEC dosage: 100 MG, QID. During the same period patient was treated with MINITRAN, LASIX, LIMPIDEX, ENAPREN, DELTACORTENE. Patient died on 03/12/2007.
Gleevec Side Effects Report #5318255-8
Physician from GERMANY reported GLEEVEC problem on Apr 27, 2007. Male patient, weighting 178.6 lb, was diagnosed with chronic myeloid leukaemia, hyperlipidaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: muscle spasms, thyroid operation. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with SIMVASTATIN, ALLOPURINOL, BLOPRESS, BISOPROLOL, ACETYLSALICYLIC ACID SRT, TRIAMTERENE AND HYDROCHLOROTHIAZIDE, EUTHYROX. Patient recovered.
Gleevec Side Effects Report #5318661-1
GLEEVEC problem was reported by a Consumer or non-health professional from FRANCE on May 03, 2007. Male patient, 78 years of age, weighting 189.6 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. GLEEVEC dosage: 400 MG DAILY. During the same period patient was treated with ELISOR, PREVISCAN, ALDACTONE, HEMIGOXINE NATIVELLE, LASIX, TRIATEC, KREDEX, RISPERDAL. Patient died on 03/30/2007.
Gleevec Side Effects Report #5318665-9
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on May 03, 2007. Male patient, 65 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: angiogram, blood count abnormal, chest pain, myocardial infarction, platelet count decreased, vascular bypass graft, white blood cell count increased. GLEEVEC dosage: unknown. Patient was hospitalized. Patient died on 09/10/2006.
Gleevec Side Effects Report #5319270-0
GLEEVEC problem was reported by a Pharmacist from UNITED STATES on Apr 27, 2007. Female patient, 38 years of age, weighting 189.0 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bronchiolitis, cerebrovascular accident, chest x-ray abnormal, dyspnoea, hypoxia, lung infiltration, neutropenia, pleural effusion, pleural fibrosis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with FUROSEMIDE, NEUPOGEN, VINCRISTINE, ELSPAR, METHOTREXATE, FRAGMIN. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5319830-7
Pharmacist from UNITED STATES reported GLEEVEC problem on Apr 27, 2007. Female patient, 38 years of age, weighting 189.0 lb, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bronchiolitis, cerebrovascular accident, chest x-ray abnormal, dyspnoea, hypoxia, lung infiltration, neutropenia, pleural effusion, pleural fibrosis. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with FUROSEMIDE, NEUPOGEN, VINCRISTINE, ELSPAR, METHOTREXATE, FRAGMIN. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5321951-X
GLEEVEC problem was reported by a Physician from GERMANY on Apr 30, 2007. Female patient, 85 years of age, weighting 158.7 lb, was diagnosed with chronic myeloid leukaemia, hypertension and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: gastrointestinal haemorrhage, rash, skin lesion, swelling face, thrombocythaemia. GLEEVEC dosage: 200 MG/DAY. During the same period patient was treated with RAMIPRIL, BLOPRESS PLUS. Patient recovered.
Gleevec Side Effects Report #5323359-X
Physician from SOUTH AFRICA reported GLEEVEC problem on May 08, 2007. Female patient, 72 years of age, weighting 114.6 lb, was diagnosed with gastrointestinal stromal tumour, hypertension, diabetes mellitus non-insulin-dependent and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dermatitis exfoliative, oedema, renal failure, skin exfoliation, urinary tract infection. GLEEVEC dosage: 400MG. During the same period patient was treated with HYDROCHLOROTHIAZIDE, ENALAPRIL, METFORMIN. Patient was hospitalized. Patient died on 04/28/2007.
Gleevec Side Effects Report #5323378-3
GLEEVEC problem was reported by a Physician from SPAIN on May 07, 2007. Male patient, 66 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: atrial flutter, cardiac failure, ileus paralytic. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5323453-3
Physician from AUSTRALIA reported GLEEVEC problem on May 04, 2007. Female patient, 69 years of age, was diagnosed with metastases to liver and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, biopsy bone marrow abnormal, blood immunoglobulin m increased, diarrhoea, protein total increased, reflux oesophagitis, rouleaux formation, tumour necrosis, waldenstrom's macroglobulinaemia. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with VITAMINS. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5323454-5
GLEEVEC problem was reported by a Physician from JAPAN on May 09, 2007. Male patient, 79 years of age, weighting 77.16 lb, was diagnosed with chronic myeloid leukaemia, cardiac failure, atrial fibrillation, prophylaxis against gastrointestinal ulcer and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: activities of daily living impaired, anorexia, blood pressure decreased, carbon dioxide increased, cardiac failure, cardio-respiratory arrest, dyspnoea exertional, fluid retention, hypercapnia. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ALDACTONE, LASIX, WARFARIN, SUNRYTHM, GASTER. Patient died on 02/22/2006.
Gleevec Side Effects Report #5323469-7
Consumer or non-health professional from TAIWAN, PROVINCE OF CHINA reported GLEEVEC problem on May 04, 2007. Female patient, 68 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cyst. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5323479-X
GLEEVEC problem was reported by a Physician from GERMANY on May 08, 2007. Male patient, 51 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: biopsy colon abnormal, blood creatinine increased, colitis ulcerative, colonoscopy abnormal, dehydration, diarrhoea, enterocolitis bacterial, faeces discoloured, hepatic cyst. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ACETYLSALICYLIC ACID SRT, PLAVIX, PANTOZOL, SIMVAHEXAL, RAMIPRIL, BISOPROLOL FUMARATE. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5323990-1
Pharmacist from UNITED STATES reported GLEEVEC problem on May 09, 2007. Male patient, 51 years of age, weighting 240.3 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: hypoxia, lung infiltration, pyrexia. GLEEVEC dosage: unknown. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5324906-4
GLEEVEC problem was reported by a Physician from COLOMBIA on May 08, 2007. Female patient, child 10 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: hepatitis a, jaundice, transaminases increased. GLEEVEC dosage: 300 MG/D. Patient recovered.
Gleevec Side Effects Report #5326479-9
Physician from SOUTH AFRICA reported GLEEVEC problem on May 10, 2007. Female patient, 19 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, haemothorax, neutrophil count, oedema, respiratory distress, thoracic cavity drainage. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with CONTRACEPTIVES NOS. Patient was hospitalized. Patient died on 05/01/2007.
Gleevec Side Effects Report #5327038-4
GLEEVEC problem was reported by a Physician from FRANCE on May 09, 2007. Male patient, weighting 143.3 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: laryngeal cancer. GLEEVEC dosage: 600 MG DAILY. Patient recovered.
Gleevec Side Effects Report #5327058-X
Physician from FRANCE reported GLEEVEC problem on May 09, 2007. Male patient, weighting 48.50 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: growth retardation. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5327066-9
GLEEVEC problem was reported by a Pharmacist from FRANCE on May 09, 2007. Male patient, weighting 143.3 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: aphonia, laryngeal cancer. GLEEVEC dosage: 600 MG DAILY. Patient recovered.
Gleevec Side Effects Report #5327068-2
Pharmacist from JAPAN reported GLEEVEC problem on May 09, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: eosinophil count increased. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5327070-0
GLEEVEC problem was reported by a Physician from JAPAN on May 10, 2007. Male patient, 75 years of age, weighting 154.3 lb, was diagnosed with chronic myeloid leukaemia, hypertension, thrombosis prophylaxis, diabetes mellitus and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: face oedema, malaise, nephrotic syndrome, protein urine present, weight increased. GLEEVEC dosage: 300 MG/D. During the same period patient was treated with NORVASC, ZESTRIL, ASPIRIN, AMARYL. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5327150-X
Physician from SWITZERLAND reported GLEEVEC problem on May 10, 2007. Female patient, 73 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bone formation decreased, device failure, knee arthroplasty. GLEEVEC dosage: 400 MG/D. Patient recovered.
Gleevec Side Effects Report #5327773-8
GLEEVEC problem was reported by a Physician from UNITED STATES on May 14, 2007. Male patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bone marrow failure, lymphoma, nausea. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5328606-6
Consumer or non-health professional from UNITED STATES reported GLEEVEC problem on May 15, 2007. Male patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abdominal distension, abdominal pain, chills, diarrhoea, dizziness, flatulence, headache, oedema peripheral, pancreatic carcinoma. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with DIOVAN, LIPITOR, LASIX, ATENOLOL, HYDROCODONE BITARTRATE. Patient recovered.
Gleevec Side Effects Report #5328610-8
GLEEVEC problem was reported by a Consumer or non-health professional from JAPAN on May 08, 2007. Female patient, 65 years of age, weighting 110.2 lb, was diagnosed with chronic myeloid leukaemia, arthralgia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, eosinophilia, erythema, herpes zoster, interstitial lung disease, pain, photophobia, photosensitivity reaction, toxic skin eruption. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with MS CONTIN, CODEINE PHOSPHATE, PREDONINE, MUCOSTA, GLORIAMIN. Patient was hospitalized and became disabled. Patient recovered.
Gleevec Side Effects Report #5328611-X
Consumer or non-health professional from JAPAN reported GLEEVEC problem on May 08, 2007. Female patient, 65 years of age, weighting 110.2 lb, was diagnosed with chronic myeloid leukaemia, arthralgia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, eosinophilia, erythema, herpes zoster, interstitial lung disease, pain, photophobia, photosensitivity reaction, toxic skin eruption. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with MS CONTIN, CODEINE PHOSPHATE, PREDONINE, MUCOSTA, GLORIAMIN. Patient was hospitalized and became disabled. Patient recovered.
Gleevec Side Effects Report #5330679-1
GLEEVEC problem was reported by a Physician from UNITED KINGDOM on May 08, 2007. Female patient, 65 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: facial palsy, periorbital oedema. GLEEVEC dosage: 400MG/DAY. Patient recovered.
Gleevec Side Effects Report #5330702-4
Consumer or non-health professional from JAPAN reported GLEEVEC problem on May 18, 2007. Male patient, 71 years of age, was diagnosed with gastrointestinal stromal tumour, aortic valve stenosis and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: aortic valve stenosis, cardio-respiratory arrest, face oedema, stomach discomfort, vomiting. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with MEXITIL, DIGOXIN, GASTROM, LASIX. Patient died on 12/12/2005.
Gleevec Side Effects Report #5330739-5
GLEEVEC problem was reported by a Physician from TAIWAN, PROVINCE OF CHINA on May 16, 2007. Male patient, 70 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: pneumonia, tendonitis. GLEEVEC dosage: 400 MG/DAY. Patient was hospitalized. Patient died on 05/01/2007.
Gleevec Side Effects Report #5331846-3
Consumer or non-health professional from JAPAN reported GLEEVEC problem on May 09, 2007. Female patient, 61 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: hepatectomy, metastases to liver. GLEEVEC dosage: 400 MG/DAY. Patient recovered.
Gleevec Side Effects Report #5331994-8
GLEEVEC problem was reported by a Physician from on May 14, 2007. Female patient, 75 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: eyelid disorder, lacrimation increased, visual acuity reduced, white blood cell count decreased. GLEEVEC dosage: 200 MG/D. During the same period patient was treated with LEVOTHYROXINE, SOTALOL, LIPITOR. Patient recovered.
Gleevec Side Effects Report #5332524-7
Consumer or non-health professional from JAPAN reported GLEEVEC problem on May 11, 2007. Male patient, 61 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: arthralgia, blast crisis in myelogenous leukaemia, blood alkaline phosphatase increased, blood bilirubin increased, blood lactate dehydrogenase increased, bone cancer metastatic, bone marrow failure, c-reactive protein increased, dyspnoea. GLEEVEC dosage: 300 MG/DAY. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5333160-9
GLEEVEC problem was reported by a Consumer or non-health professional from UNITED STATES on May 15, 2007. Female patient, 82 years of age, weighting 116.0 lb, was diagnosed with sarcoma and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: angioplasty, anxiety, intermittent claudication, nasal congestion, panic reaction, peripheral arterial occlusive disease, platelet count increased, urticaria. GLEEVEC dosage: 200 MG, QD. Patient recovered.
Gleevec Side Effects Report #5333166-X
Pharmacist from JAPAN reported GLEEVEC problem on May 15, 2007. Female patient, 70 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: hyperglycaemia. GLEEVEC dosage: 200 MG/D. During the same period patient was treated with CELESTONE. Patient recovered.
Gleevec Side Effects Report #5333178-6
GLEEVEC problem was reported by a Physician from SWEDEN on May 15, 2007. Male patient, 43 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: visual acuity reduced. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with PREDNISOLONE, KALCIPOS, LANZOPRAZOL, ENALAPRIL, TRIOBE, NASONEX. Patient recovered.
Gleevec Side Effects Report #5333206-8
Physician from JAPAN reported GLEEVEC problem on May 15, 2007. Male patient, 87 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: bronchiolitis, dyspnoea, haematocrit decreased, haemoglobin decreased, platelet count decreased, pyrexia, red blood cell count decreased, white blood cell count decreased. GLEEVEC dosage: 400 MG/D. During the same period patient was treated with FAMOTIDINE, MUCOSTA, ASPIRIN, LASIX, CLEANAL, URALYT. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5333208-1
GLEEVEC problem was reported by a Physician from JAPAN on May 11, 2007. Male patient, 55 years of age, was diagnosed with chronic myeloid leukaemia, urticaria and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abdominal pain, blood lactate dehydrogenase increased, haemorrhagic diathesis, renal tumour excision, thrombocytopenia, white blood cell count decreased. GLEEVEC dosage: 300 MG/D. During the same period patient was treated with ALLEGRA. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5334282-9
Physician from JAPAN reported GLEEVEC problem on May 16, 2007. Female patient, 36 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: caesarean section, disease progression, metastases to lymph nodes, neutrophil count decreased, normal newborn, pancytopenia, white blood cell count decreased. GLEEVEC dosage: 200 MG PER 3 DAYS. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5334312-4
GLEEVEC problem was reported by a Physician from TURKEY on May 16, 2007. Male patient, 57 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: angioedema, excoriation, pigmentation disorder, rash papular, skin exfoliation, skin lesion, skin maceration, xerosis. GLEEVEC dosage: 400 MG/DAY. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5334391-4
Consumer or non-health professional from TAIWAN, PROVINCE OF CHINA reported GLEEVEC problem on May 16, 2007. Female patient, 68 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: cyst, pyrexia, surgery. GLEEVEC dosage: 400 MG/D. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5334398-7
GLEEVEC problem was reported by a Physician from FINLAND on May 14, 2007. Female patient was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: neutropenia, thrombocytopenia, uterine cancer. GLEEVEC dosage: 200MG. Patient recovered.
Gleevec Side Effects Report #5334786-9
Physician from TURKEY reported GLEEVEC problem on May 16, 2007. Male patient, 57 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: angioedema, excoriation, no therapeutic response, pigmentation disorder, rash papular, skin exfoliation, skin lesion, skin maceration. GLEEVEC dosage: 400 MG/DAY. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5336731-9
GLEEVEC problem was reported by a Physician from ARGENTINA on May 16, 2007. Female patient, 52 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: alopecia, hyperkeratosis, skin exfoliation. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5336999-9
Physician from TURKEY reported GLEEVEC problem on Apr 03, 2007. Female patient, 68 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaphylactoid reaction, burning sensation, chest pain, erythema, hypersensitivity, hypotension, oedema, pruritus. GLEEVEC dosage: 400 MG/D. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5338098-9
GLEEVEC problem was reported by a Physician from VENEZUELA on May 18, 2007. Male patient, 33 years of age, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: splenomegaly, white blood cell count increased. GLEEVEC dosage: 800MG/DAY. Patient recovered.
Gleevec Side Effects Report #5338802-X
Physician from JAPAN reported GLEEVEC problem on May 26, 2007. Male patient, 70 years of age, weighting 143.3 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, basophilia, blood alkaline phosphatase increased, blood bilirubin increased, blood creatinine increased, blood lactate dehydrogenase increased, blood urea decreased, blood urea increased. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with ALLOPURINOL, ULCERMIN, SIGMART, GASTER D, EUGLUCON, GLYBURIDE. Patient died on 02/27/2005.
Gleevec Side Effects Report #5341456-X
GLEEVEC problem was reported by a Physician from UNITED STATES on May 23, 2007. Male patient, 71 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: anaemia, lymphoma, nausea, thrombocytopenia. GLEEVEC dosage: 400 MG, QD. Patient recovered.
Gleevec Side Effects Report #5341474-1
Physician from UNITED KINGDOM reported GLEEVEC problem on May 24, 2007. Male patient, 24 years of age, weighting 227.1 lb, was diagnosed with chronic myeloid leukaemia, pain and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: breast discomfort, ejaculation failure, erectile dysfunction, gynaecomastia, hypogonadism male, testicular disorder. GLEEVEC dosage: 400 MG/DAY. During the same period patient was treated with CODEINE PHOSPHATE AND ACETAMINOPHEN. Patient recovered.
Gleevec Side Effects Report #5341553-9
GLEEVEC problem was reported by a Consumer or non-health professional from CHINA on May 30, 2007. Male patient was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. GLEEVEC dosage: unknown. Patient died on 02/01/2007.
Gleevec Side Effects Report #5343495-1
Consumer or non-health professional from FRANCE reported GLEEVEC problem on May 22, 2007. Male patient, 68 years of age, weighting 152.1 lb, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: prostatic adenoma. GLEEVEC dosage: 400 MG, QD. During the same period patient was treated with METOPROLOL TARTRATE, KARDEGIC, COVERSYL, ESOMEPRAZOLE MAGNESIUM, PLAVIX. Patient was hospitalized. Patient recovered.
Gleevec Side Effects Report #5343496-3
GLEEVEC problem was reported by a Physician from TAIWAN, PROVINCE OF CHINA on May 31, 2007. Male patient, 64 years of age, weighting 143.3 lb, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: abdominal mass, ascites, bronchiectasis, disease progression, duodenal ulcer, gastritis, gastrointestinal stromal tumour, malignant neoplasm progression, metastases to liver. GLEEVEC dosage: 400 MG/DAY. Patient was hospitalized. Patient died on 05/01/2007.
Gleevec Side Effects Report #5343534-8
Consumer or non-health professional from SWEDEN reported GLEEVEC problem on May 22, 2007. Male patient, 60 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: squamous cell carcinoma of skin. GLEEVEC dosage: unknown. Patient recovered.
Gleevec Side Effects Report #5345211-6
GLEEVEC problem was reported by a Physician from GERMANY on May 29, 2007. Male patient, weighting 3.62 lb, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: apgar score low, ascites, atrial septal defect, cerebellar hypoplasia, heart disease congenital, hydrocephalus, muscle spasticity, neonatal respiratory failure. GLEEVEC dosage: MATERNAL DOSE: 400 MG/DAY. Patient died on 04/09/2006.
Gleevec Side Effects Report #5345213-X
Health Professional from UNITED STATES reported GLEEVEC problem on May 22, 2007. Male patient, 56 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: lichenoid keratosis, rash papular, rash pruritic, skin exfoliation. GLEEVEC dosage: 600 MG/DAY. During the same period patient was treated with PROMETHAZINE, LANSOPRAZOLE. Patient recovered.
Gleevec Side Effects Report #5345220-7
GLEEVEC problem was reported by a Physician from GERMANY on May 29, 2007. Male patient, weighting 3.62 lb, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: apgar score low, congenital hydrocephalus, heart disease congenital, neonatal respiratory failure, premature baby, ultrasound doppler abnormal. GLEEVEC dosage: unknown. Patient died on 04/09/2006.
Gleevec Side Effects Report #5345221-9
Physician from GERMANY reported GLEEVEC problem on May 29, 2007. Male patient, weighting 3.62 lb, was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: apgar score low, ascites, atrial septal defect, cerebellar hypoplasia, heart disease congenital, hydrocephalus, muscle spasticity, neonatal respiratory failure. GLEEVEC dosage: MATERNAL DOSE: 400 MG/DAY. Patient died on 04/09/2006.
Gleevec Side Effects Report #5345223-2
GLEEVEC problem was reported by a Physician from GERMANY on May 29, 2007. Female patient, 25 years of age, was diagnosed with chronic myeloid leukaemia and was treated with GLEEVEC. After drug was administered, patient experienced the following problems/side effects: amniocentesis abnormal, amniorrhexis, episiotomy, local anaesthesia, placental disorder, premature baby, premature labour, premature rupture of membranes. GLEEVEC dosage: 400 MG, QD. Patient was hospitalized. Patient recovered.
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Drug Information: Imatinib
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a606018.html
(i mat' in ib)Why is this medication prescribed?
Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers of the blood cells. Imatinib is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Imatinib is also used to treat dermatofibrosarcoma protuberans (a tumor that forms under the top layer of skin) when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery. Imatinib is in a class of medications called protein-tyrosine kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
How should this medicine be used?
Imatinib comes as a tablet to take by mouth. It is usually taken with a meal and a large glass of water once or twice a day. Take imatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take imatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are unable to swallow imatinib tablets, you may place all of the tablets that you need for one dose into a glass of water or apple juice. Use 50 mL (a little less than 2 ounces) of liquid for each 100 mg tablet and 100 mL (a little less than 4 ounces) of liquid for each 400 mg tablet. Stir with a spoon until the tablets crumble completely and drink the mixture immediately.
If your doctor has told you to take 800 mg of imatinib, you should take two of the 400 mg tablets. Do not take 8 of the 100 mg tablets. The tablet coating contains iron, and you will receive too much iron if you take 8 of the 100 mg tablets.
Your doctor may increase or decrease your dose of imatinib during your treatment. This depends on how well the medication works for you and on the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take imatinib even if you feel well. Do not stop taking imatinib without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking imatinib,
- tell your doctor and pharmacist if you are allergic to imatinib or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acetaminophen (Tylenol); certain antibiotics including erythromycin (E.E.S., E-Mycin, Erythrocin), clarithromycin (Biaxin), and rifampin (Rifadin, in Rifamate); anticoagulants ('blood thinners') such as warfarin (Coumadin); antifungals such as ketoconazole (Nizoral) and itraconazole (Sporanox); calcium channel blockers such as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem, Tiazac), felodipine (Plendil), isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia, others), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); cyclosporine (Neoral, Sandimmune); dexamethasone; hormonal contraceptives (birth control pills, patches, rings, injections or implants); pimozide (Orap); medications for anxiety; medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); sedatives; sleeping pills; and tranquilizers. Other medications may also interact with imatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had high blood pressure a heart attack; an irregular heartbeat; diabetes; or heart, lung, thyroid, or liver disease. Also tell your doctor if you smoke, if you use street drugs, and if you drink or have ever drunk large amounts of alcohol.
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking imatinib. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking imatinib, call your doctor. Imatinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed while you are taking imatinib.
- talk to your doctor about what you should do if you develop diarrhea during your treatment. Do not take any medications to treat diarrhea without talking to your doctor.
What special dietary instructions should I follow?
Talk to your doctor about drinking grapefruit juice or eating grapefruit while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Imatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- diarrhea
- constipation
- gas
- nausea
- vomiting
- loss of appetite
- indigestion
- joint pain
- muscle cramps
- depression
- anxiety
- night sweats
- teary eyes
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
- puffiness under the eyes
- swelling of the hands, feet, ankles, or lower legs
- weight gain
- shortness of breath
- fast, irregular, or pounding heartbeat
- difficulty falling asleep or staying asleep
- fainting
- coughing up pink or bloody mucus
- increased urination, especially at night
- chest pain
- fever
- rash or blisters
- yellowing of the skin or eyes
- blood in the stool
- unusual bruising or bleeding
- sore throat, fever, chills, and other signs of infection
- excessive tiredness or weakness
- headache
- dizziness
Imatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- muscle cramps
- swollen or bloated stomach
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to imatinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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