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Hydrochlorothiazid Side Effects

Common Hydrochlorothiazid Side Effects


The most commonly reported Hydrochlorothiazid side effects (click to view or check a box to report):

Hyponatraemia (213)
Dizziness (178)
Nausea (126)
Hypotension (121)
Hypokalaemia (119)
Renal Failure Acute (106)
Dyspnoea (103)
Fatigue (102)
Dehydration (102)
Asthenia (100)
Diarrhoea (90)
Pain (86)
Angioedema (83)
Vomiting (82)
Syncope (82)
Blood Pressure Increased (81)
Hypertension (79)
Headache (70)
Fall (69)
Rash (69)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Hydrochlorothiazid Side Effects Reported to FDA

The following Hydrochlorothiazid reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Hydrochlorothiazid on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Inappropriate Antidiuretic Hormone Secretion
This is a report of a 75-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: hypertension, who was treated with Hydrochlorothiazide (dosage: NA, start time: Apr 13, 2011), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Inappropriate Antidiuretic Hormone Secretion
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydrochlorothiazide treatment in male patients, resulting in inappropriate antidiuretic hormone secretion side effect. The patient was hospitalized.

Angioedema
This report suggests a potential Hydrochlorothiazide/lisinopril Angioedema side effect(s) that can have serious consequences. A 67-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Hydrochlorothiazide/lisinopril (dosage: Mg) starting May 10, 2010. Soon after starting Hydrochlorothiazide/lisinopril the patient began experiencing various side effects, including:
  • Angioedema
Drugs used concurrently: NA.The patient was hospitalized. Although Hydrochlorothiazide/lisinopril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as angioedema, may still occur.

Mycosis Fungoides
This Mycosis Fungoides problem was reported by a physician from US. A 77-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On NS this consumer started treatment with Hydrochlorothiazide (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Hydrochlorothiazide, the patient experienced the following unwanted symptoms/side effects:
  • Mycosis Fungoides
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as mycosis fungoides, may become evident only after a product is in use by the general population.

Mycosis Fungoides
This is a report of a 61-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: hypertension and was treated with Hydrochlorothiazide (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Mycosis Fungoides
This opens a possibility that Hydrochlorothiazide treatment could cause the above reactions, including mycosis fungoides, and some female subjects may be more susceptible.


Mycosis Fungoides
A 71-year-old male patient (weight: NA) from US with the following symptoms/conditions: hypertension started Hydrochlorothiazide treatment (dosage: NA) on NS. Soon after starting Hydrochlorothiazide treatment, the subject experienced various side effects, including:
  • Mycosis Fungoides
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Hydrochlorothiazide.

Mycosis Fungoides
A 75-year-old male patient from US (weight: NA) experienced symptoms, such as: hypertension and was treated with Hydrochlorothiazide(dosage: NA). The treatment was initiated on 2004. After that a consumer reported the following side effect(s):
  • Mycosis Fungoides
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Hydrochlorothiazide efficacy: NA.

Blood Urea Increased, Blood Creatinine Increased, Renal Failure Acute, Hyperkalaemia
In this report, Hydrochlorothiazide/lisinopril was administered for the following condition: hypertension.A 54-year-old male consumer from US (weight: NA) started Hydrochlorothiazide/lisinopril treatment (dosage: NA) on Jun 10, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Blood Urea Increased
  • Blood Creatinine Increased
  • Renal Failure Acute
  • Hyperkalaemia
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Hydrochlorothiazide/lisinopril treatment could be related to the listed above side effect(s).

Toxic Epidermal Necrolysis
This is a report of the following Hydrochlorothiazide/irbesartan side effect(s):
  • Toxic Epidermal Necrolysis
A 58-year-old male patient from FR (weight: NA) presented with the following condition: hypertension and received a treatment with Hydrochlorothiazide/irbesartan (dosage: NA) starting: Aug 03, 2013.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Hydrochlorothiazide/irbesartan treatment could be associated with the listed above side effect(s).

Mycosis Fungoides
This Hydrochlorothiazide report was submitted by a 75-year-old male consumer from US (weight: NA). The patient was diagnosed with: hypertension and Hydrochlorothiazide was administered (dosage: NA) starting: 2004. The consumer developed a set of symptoms:
  • Mycosis Fungoides
Other drugs used simultaneously: NA.Those unexpected symptoms could be linked to a Hydrochlorothiazide treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Mycosis Fungoides
This is a report of a possible correlation between Hydrochlorothiazide use and the following symptoms/side effect(s):
  • Mycosis Fungoides
which could contribute to an assessment of Hydrochlorothiazide risk profile.A 61-year-old female consumer from US (weight: NA) was suffering from hypertension and was treated with Hydrochlorothiazide (dosage: NA) starting NS.Other concurrent medications: NA.

Mycosis Fungoides
A 71-year-old male patient from US (weight: NA) presented with the following symptoms: hypertension and after a treatment with Hydrochlorothiazide (dosage: NA) experienced the following side effect(s):
  • Mycosis Fungoides
The treatment was started on NS. Hydrochlorothiazide was used in combination with the following drugs: NA.This report could alert potential Hydrochlorothiazide consumers.

Mycosis Fungoides
In this report, a 77-year-old female patient from US (weight: NA) was affected by a possible Hydrochlorothiazide side effect.The patient was diagnosed with hypertension. After a treatment with Hydrochlorothiazide (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Mycosis Fungoides
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Hydrochlorothiazide treatment.

Hypokalaemia, Hypomagnesaemia
This is a report of a 67-year-old female patient from US (weight: NA), who used Hydrochlorothiazide (dosage: NA) for a treatment of hypertension. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Hypokalaemia
  • Hypomagnesaemia
The following drugs could possibly have interacted with the Hydrochlorothiazide treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Hydrochlorothiazide treatment could be related to side effect(s), such as Hypokalaemia, Hypomagnesaemia.

Abdominal Pain, Dyspnoea Exertional, Polyuria, Weight Increased, Blood Pressure Increased, Renal Tubular Necrosis, Renal Failure
This abdominal pain side effect was reported by a health professional from US. A 42-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Hydrochlorothiazide (hydrochlorothiazide) (dosage: NA), which was started on NS. Concurrently used drugs:
  • Lisinopril (lisinopril)
  • Ibuprofen (ibuprofen)
When starting to take Hydrochlorothiazide (hydrochlorothiazide) the consumer reported the following symptoms:
  • Abdominal Pain
  • Dyspnoea Exertional
  • Polyuria
  • Weight Increased
  • Blood Pressure Increased
  • Renal Tubular Necrosis
  • Renal Failure
These side effects may potentially be related to Hydrochlorothiazide (hydrochlorothiazide).

Blood Creatinine Increased, Renal Artery Stenosis, Renal Impairment
This is a Hydrochlorothiazide side effect report of a 63-year-old female patient (weight:NA) from CA, suffering from the following symptoms/conditions: NA, who was treated with Hydrochlorothiazide (dosage:25 Milligram Daily;, start time: NS), combined with:
  • Irbesartan (150 Milligram Daily;)
  • Amlodipine
  • Captopril
  • Lipidil Ez
  • Synthroid
, and developed a serious reaction and a blood creatinine increased side effect. The patient presented with:
  • Blood Creatinine Increased
  • Renal Artery Stenosis
  • Renal Impairment
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Hydrochlorothiazide treatment in female patients suffering from NA, resulting in blood creatinine increased.

Angioedema
This report suggests a potential Hydrochlorothiazide/lisinopril angioedema side effect(s) that can have serious consequences. A 58-year-old male patient from US (weight:NA) was diagnosed with the following health condition(s): hypertension and used Hydrochlorothiazide/lisinopril (dosage: NA) starting Mar 05, 2013. Soon after starting Hydrochlorothiazide/lisinopril the patient began experiencing various side effects, including:
  • Angioedema
Drugs used concurrently:NA. The patient was hospitalized. Although Hydrochlorothiazide/lisinopril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as angioedema, may still occur.

Renal Failure Acute, Dehydration
This renal failure acute problem was reported by a pharmacist from US. A 88-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): hypertension.On Dec 12, 2013 a consumer started treatment with Hydrochlorothiazide/lisinopril (dosage: 1/2 Tab?every Day ?po). The following drugs/medications were being taken at the same time: NA. When commencing Hydrochlorothiazide/lisinopril, the patient experienced the following unwanted symptoms /side effects:
  • Renal Failure Acute
  • Dehydration
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as renal failure acute, may become evident only after a product is in use by the general population.

Dysphagia, Angioedema
This is a Hydrochlorothiazide/lisinopril side effect report of a 53-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: hypertension and was treated with Hydrochlorothiazide/lisinopril (dosage: NA) starting Aug 29, 2013. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Dysphagia
  • Angioedema
The patient was hospitalized. This opens a possibility that Hydrochlorothiazide/lisinopril could cause dysphagia and that some male patients may be more susceptible.

Abdominal Pain, Fatigue, Lacrimation Increased
A 83-year-old female patient (weight: NA) from US with the following symptoms: oedema,blood pressure increased started Hydrochlorothiazide Capsules treatment (dosage: NA) on May 24, 2013. Soon after starting Hydrochlorothiazide Capsules treatment, the consumer experienced several side effects, including:
  • Abdominal Pain
  • Fatigue
  • Lacrimation Increased
. Concurrently used drugs:
  • Lisinopril
  • Taztia
This finding indicates that some patients can be more vulnerable to developing Hydrochlorothiazide Capsules side effects, such as abdominal pain.

Myopia
This myopia side effect was reported by a consumer or non-health professional from US. A 60-year-old female patient (weight:NA) experienced the following symptoms/conditions: blood pressure increased.The patient was prescribed Hydrochlorothiazide Capsules (dosage: NA), which was started on 201304. Concurrently used drugs:
  • Amlodipine Besylate Tablets
  • Vitamins
.When starting to take Hydrochlorothiazide Capsules the consumer reported symptoms, such as:
  • Myopia
These side effects may potentially be related to Hydrochlorothiazide Capsules.

Dyspnoea, Hypotension, Fatigue, Tinnitus, Pruritus, Rash, Alopecia, Trichorrhexis, Onychoclasis
This is a report of a 76-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: blood pressure increased, who was treated with Hydrochlorothiazide Capsules (dosage: NA, start time: 201302), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Dyspnoea
  • Hypotension
  • Fatigue
  • Tinnitus
  • Pruritus
  • Rash
  • Alopecia
  • Trichorrhexis
  • Onychoclasis
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydrochlorothiazide Capsules treatment in female patients, resulting in dyspnoea side effect.

Rash Erythematous, Rash Pruritic
This report suggests a potential Hydrochlorothiazide Capsules Rash Erythematous, Rash Pruritic side effect(s) that can have serious consequences. A 49-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: blood pressure increased,insomnia,gastrooesophageal reflux disease and used Hydrochlorothiazide Capsules (dosage: NA) starting 201211. Soon after starting Hydrochlorothiazide Capsules the patient began experiencing various side effects, including:
  • Rash Erythematous
  • Rash Pruritic
Drugs used concurrently:
  • Trazodone Tablets, Usp
  • Pepcid
  • Multivitamin
  • Colace
  • Metamucil
Although Hydrochlorothiazide Capsules demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as rash erythematous, may still occur.

Confusional State, Hyponatraemia
This Confusional State, Hyponatraemia problem was reported by a pharmacist from US. A 65-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On Jun 19, 2013 this consumer started treatment with Hydrochlorothiazide (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Hydrochlorothiazide, the patient experienced the following unwanted symptoms/side effects:
  • Confusional State
  • Hyponatraemia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as confusional state, may become evident only after a product is in use by the general population.

Angioedema
This is a report of a 59-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: hypertension and was treated with Hydrochlorothiazide/lisinopril (dosage: NA) starting Jan 24, 2014. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Angioedema
The patient was hospitalized. This opens a possibility that Hydrochlorothiazide/lisinopril treatment could cause the above reactions, including angioedema, and some male subjects may be more susceptible.

Pemphigus, Herpes Simplex Serology Positive, Nausea
A 64-year-old female patient (weight: NA) from US with the following symptoms/conditions: NA started Hydrochlorothiazide treatment (dosage: NA) on NS. Soon after starting Hydrochlorothiazide treatment, the subject experienced various side effects, including:
  • Pemphigus
  • Herpes Simplex Serology Positive
  • Nausea
Concurrently used drugs:
  • Amlodipine (amlodipine) (amlodipine)
  • Hydrocodone - Acetaminophen
  • Ibuprofen
  • Insulin (insulin)
  • Metformin (metformin) (metformin)
  • Gabapentin (gabapentin) (gabapentin)
  • Lisinopril (lisinopril) (lisinopril)
  • Metoprolol (metoprolol) (metoprolol)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Hydrochlorothiazide.

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Top 10 Hydrochlorothiazid Side Effects for Women

Women Side EffectsReports
Dizziness 97
Hyponatraemia 88
Nausea 85
Dyspnoea 68
Fatigue 65
Asthenia 62
Pain 62
Hypokalaemia 61
Blood Pressure Increased 60
Diarrhoea 60

Top 10 Hydrochlorothiazid Side Effects for Men

Men Side EffectsReports
Hyponatraemia 123
Dizziness 79
Hypotension 79
Renal Failure Acute 67
Angioedema 62
Hypokalaemia 57
Dehydration 51
Syncope 51
Nausea 41
Asthenia 38

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Hydrochlorothiazid Safety Alerts, Active Ingredients, Usage Information

    NDC0054-0126
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameLosartan Potassium and Hydrochlorothiazide
    NameLosartan Potassium and Hydrochlorothiazide
    Dosage FormTABLET
    RouteORAL
    On market since20101006
    LabelerRoxane Laboratories, Inc.
    Active Ingredient(s)HYDROCHLOROTHIAZIDE; LOSARTAN POTASSIUM
    Strength(s)12.5; 50
    Unit(s)mg/1; mg/1
    Pharma ClassAngiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Increased Diuresis [PE

    More About Hydrochlorothiazid

    Side Effects reported to FDA: 2564

    Hydrochlorothiazid safety alerts: No

    Reported deaths: 152

    Reported hospitalizations: 1164

    Latest Hydrochlorothiazid clinical trials