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Hydroxyzine Hcl Side Effects

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Common Hydroxyzine Hcl Side Effects


The most commonly reported Hydroxyzine Hcl side effects are:
Numb Hands Feet (4)
Feet (4)
Tingling (3)
Restless Legs (1)
Depression (1)
Swolen Hand (1)
Swolen Hand And Feet (1)

If you have experienced a side effect listed above, you can check a box to report it.


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If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Hydroxyzine Hcl Side Effects Reported to FDA



Hydroxyzine Hcl Side Effect Report#9971833
Injection Site Mass, Injection Site Erythema, Injection Site Pruritus
This is a report of a 55-year-old female patient (weight: NA) from Country Not Specified, suffering from the following health symptoms/conditions: NA, who was treated with Hydroxyzine Hcl (dosage: NA, start time:
Aug 02, 2013), combined with:
  • Pravastatin (Bedtime)
  • Gemfibrozil
  • Imipramine Hydrochloride (2 Tablets At Bedtime)
  • Amlodipine Besylate (Beditime)
  • Lantus Insulin Per Sliding Scale
  • Humalog Insulin (Bedtime)
  • Ciprofloxacin
  • Calcium Acetate (With Meals)
and developed a serious reaction and side effect(s): Injection Site Mass, Injection Site Erythema, Injection Site Pruritus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Injection Site Mass side effect.
Hydroxyzine Hcl Side Effect Report#9779980
Anaphylactic Reaction, Dyspnoea, Bronchospasm, Cough, Eosinophilia, Eczema, Nasal Oedema
This report suggests a potential Hydroxyzine Hcl Anaphylactic Reaction side effect(s) that can have serious consequences. A 47-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Hydroxyzine Hcl (dosage: 25 Mg) starting NS. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Anaphylactic Reaction, Dyspnoea, Bronchospasm, Cough, Eosinophilia, Eczema, Nasal OedemaAdditional drugs used concurrently: NA. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Anaphylactic Reaction, may still occur.
Hydroxyzine Hcl Side Effect Report#9461371
Headache, Pruritus
This Headache problem was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pruritus. On
Jul 17, 2013 this consumer started treatment with Hydroxyzine Hcl (dosage: 25 Mg 1-2 Tabs Every 6 Hours E2 Every 6 Hours By Mouth). The following drugs were being taken at the same time: NA. When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: Headache, PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Headache, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#9275070
Paraesthesia
This Paraesthesia side effect was reported by a consumer or non-health professional from US. A 34-year-old female patient (weight:NA) experienced the following symptoms/conditions: insomnia,panic attack.The patient was prescribed Hydroxyzine Hcl (drug dosage: 50 Mg Nightly Before Bed Po), which was initiated on
Apr 01, 2012. Concurrently used drugs: NA..After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: ParaesthesiaThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#9258346
Somnolence, Product Odour Abnormal, Product Taste Abnormal
This is a report of a 70-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: pruritus,dermatitis allergic, who was treated with Hydroxyzine Hcl (dosage: 1 A Bedtime, 3 Nignts, start time: 201303), combined with: NA. and developed a serious reaction and side effect(s): Somnolence, Product Odour Abnormal, Product Taste Abnormal after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Somnolence side effect.
Hydroxyzine Hcl Side Effect Report#9153658
Hallucination, Heart Rate Increased, Respiratory Arrest
This report suggests a potential Hydroxyzine Hcl Hallucination side effect(s) that can have serious consequences. A 45-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: anxiety,sinus disorder and used Hydroxyzine Hcl (dosage: 50 Mg Every 8 Hourrs) starting
Jan 23, 2013. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Hallucination, Heart Rate Increased, Respiratory ArrestAdditional drugs used concurrently: NA. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hallucination, may still occur.
Hydroxyzine Hcl Side Effect Report#9146595
Nausea, Headache, Unresponsive To Stimuli, Drooling, Respiratory Distress, Abdominal Distension, Cerebrovascular Accident, Injection Site Pain, Burning Sensation
This Nausea problem was reported by a consumer or non-health professional from US. A 37-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: anxiety. On 201103 this consumer started treatment with Hydroxyzine Hcl (dosage: NA). The following drugs were being taken at the same time:
  • Zometa (zoledronic Acid) (zoledronic Acid)
When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: Nausea, Headache, Unresponsive To Stimuli, Drooling, Respiratory Distress, Abdominal Distension, Cerebrovascular Accident, Injection Site Pain, Burning SensationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Nausea, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#9033143
Chemical Submission
This Chemical Submission side effect was reported by a physician from FR. A 11-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Hydroxyzine Hcl (drug dosage: Unk), which was initiated on NS. Concurrently used drugs:
  • Lidocaine Hcl (Unk)
  • Tramadol Hydrochloride Aurobindo (Unk)
  • Cetirizine Hydrochloride (Unk)
.After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: Chemical SubmissionThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#8942944
Completed Suicide, Poisoning
This is a report of a 42-year-old female patient (weight: NA) from SE, suffering from the following health symptoms/conditions: NA, who was treated with Hydroxyzine Hcl (dosage: Unk, start time: NS), combined with:
  • Pregabalin (Unk)
  • Herceptin (Unk)
  • Diazepam (Unk)
  • Mirtazapine (Unk)
  • Codeine Phosphate (Unk)
and developed a serious reaction and side effect(s): Completed Suicide, Poisoning after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Completed Suicide side effect.
Hydroxyzine Hcl Side Effect Report#8816705
Mental Status Changes, Asthenia, Somnolence, Confusional State, Muscular Weakness, Dizziness, Overdose
This report suggests a potential Hydroxyzine Hcl Mental Status Changes side effect(s) that can have serious consequences. A 53-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: urticaria and used Hydroxyzine Hcl (dosage: NA) starting NS. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Mental Status Changes, Asthenia, Somnolence, Confusional State, Muscular Weakness, Dizziness, OverdoseAdditional drugs used concurrently:
  • Paroxetine
  • Hydrocodone
The patient was hospitalized. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Mental Status Changes, may still occur.
Hydroxyzine Hcl Side Effect Report#8453464-0
Pruritus
This Pruritus problem was reported by a consumer or non-health professional from . A male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
May 08, 2012 this consumer started treatment with Hydroxyzine Hcl (dosage: NA). The following drugs were being taken at the same time:
  • Incivek
  • Ribavirin
  • Prevacid
  • Pegasys
  • Hydrochlorothiazide
When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pruritus, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#8230779-2
Pain, Vein Disorder, Balance Disorder, Paraesthesia, Hypoaesthesia, Skin Discolouration, Injection Site Pain, Joint Contracture, Feeling Abnormal
This Pain side effect was reported by a consumer or non-health professional from United States. A 37-year-old male patient (weight:NA) experienced the following symptoms/conditions: anxiety.The patient was prescribed Hydroxyzine Hcl (drug dosage: Dose Once), which was initiated on
Mar 01, 2011. Concurrently used drugs: NA..After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: Pain, Vein Disorder, Balance Disorder, Paraesthesia, Hypoaesthesia, Skin Discolouration, Injection Site Pain, Joint Contracture, Feeling AbnormalThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#8144721-6
Febrile Neutropenia
This is a report of a 57-year-old male patient (weight: NA) from Poland, suffering from the following health symptoms/conditions: eczema,hypertension,prophylaxis,mantle cell lymphoma, who was treated with Hydroxyzine Hcl (dosage: Unk, start time:
Nov 07, 2011), combined with:
  • Lozap (Unk)
  • Heviran (Unk)
  • Temsirolimus (Once Weekly (scheduled 175 Mg Weekly For First 3 Weeks, Then 75 Mg Weekly))
  • Advantan (Unk)
  • Imovane (Unk)
  • Desipramine Hcl (50 Mg, Weekly For 2 Weeks)
  • Atorvastatin
  • Fexofenadine Hcl (180 Unk, Unk)
and developed a serious reaction and side effect(s): Febrile Neutropenia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in male patients, resulting in Febrile Neutropenia side effect. The patient was hospitalized.
Hydroxyzine Hcl Side Effect Report#8114806-9
Pruritus, Condition Aggravated
This report suggests a potential Hydroxyzine Hcl Pruritus side effect(s) that can have serious consequences. A 67-year-old female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: herpes zoster,pruritus and used Hydroxyzine Hcl (dosage: 25 Mg. Suppose To Be 3 Times A Day Oral Tablet) starting
Jan 12, 2012. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Pruritus, Condition AggravatedAdditional drugs used concurrently: NA. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pruritus, may still occur.
Hydroxyzine Hcl Side Effect Report#8101492-7
Inflammation, Sinusitis, Rash, Pruritus
This Inflammation problem was reported by a consumer or non-health professional from United States. A 62-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: hypersensitivity,blood pressure increased,asthma,rheumatoid arthritis. On
Aug 18, 2011 this consumer started treatment with Hydroxyzine Hcl (dosage: NA). The following drugs were being taken at the same time:
  • Benicar
When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: Inflammation, Sinusitis, Rash, PruritusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Inflammation, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#8083754-5
Dizziness
This Dizziness side effect was reported by a consumer or non-health professional from United States. A 54-year-old female patient (weight:NA) experienced the following symptoms/conditions: pruritus.The patient was prescribed Hydroxyzine Hcl (drug dosage: 1-3 Every 4-6 Hours), which was initiated on
Jan 07, 2011. Concurrently used drugs:
  • Anaproxyn (1 Tab 3 Times A Day)
  • Humira
  • Simvastatin
.After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: DizzinessThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#8044170-5
Tachycardia, Lower Gastrointestinal Haemorrhage, Dyspnoea, Neoplasm Malignant
This is a report of a 69-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Hydroxyzine Hcl (dosage: NA, start time:
Nov 14, 2011), combined with:
  • Ipilimumab (Frequncy:q3m. Last Dose On29dec2011)
  • Prilosec
  • Bevacizumab (Last Dose On 29dec2011)
  • Ativan
  • Multi-vitamins
  • Ciprofloxacin
and developed a serious reaction and side effect(s): Tachycardia, Lower Gastrointestinal Haemorrhage, Dyspnoea, Neoplasm Malignant after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Tachycardia side effect. The patient was hospitalized.
Hydroxyzine Hcl Side Effect Report#8032605-3
Dizziness, Fall, Atelectasis, Platelet Count Decreased, Muscle Spasms, Head Injury, Fatigue, Asthenia, Syncope
This report suggests a potential Hydroxyzine Hcl Dizziness side effect(s) that can have serious consequences. A 65-year-old male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Hydroxyzine Hcl (dosage: NA) starting
Sep 27, 2011. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Dizziness, Fall, Atelectasis, Platelet Count Decreased, Muscle Spasms, Head Injury, Fatigue, Asthenia, SyncopeAdditional drugs used concurrently:
  • Acetaminophen
  • Hydrocodone Bitartrate
  • Glucosamine
  • Esomeprazole Magnesium
  • Acetaminophen
  • Fish Oil
  • Keppra
  • Nexium
The patient was hospitalized. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Hydroxyzine Hcl Side Effect Report#8015985-4
Diarrhoea, Decreased Appetite, Dizziness, Vomiting, Insomnia, Malaise, Anxiety
This Diarrhoea problem was reported by a consumer or non-health professional from United States. A 35-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Hydroxyzine Hcl (dosage: 1 To 2). The following drugs were being taken at the same time: NA. When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: Diarrhoea, Decreased Appetite, Dizziness, Vomiting, Insomnia, Malaise, AnxietyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Diarrhoea, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#8002024-4
Balance Disorder, Off Label Use, Hypoaesthesia, Skin Discolouration, Joint Contracture, Pain In Extremity, Vein Disorder, Infusion Site Pain, Paraesthesia
This Balance Disorder side effect was reported by a consumer or non-health professional from United States. A 37-year-old male patient (weight:NA) experienced the following symptoms/conditions: anxiety.The patient was prescribed Hydroxyzine Hcl (drug dosage: Unk Dose Once, Intravenous Bolus), which was initiated on
Mar 01, 2011. Concurrently used drugs: NA..After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: Balance Disorder, Off Label Use, Hypoaesthesia, Skin Discolouration, Joint Contracture, Pain In Extremity, Vein Disorder, Infusion Site Pain, ParaesthesiaThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#7954253-3
Chest Pain, Burning Sensation, Venous Stenosis
This is a report of a 30-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: nausea, who was treated with Hydroxyzine Hcl (dosage: Intravenous, start time:
Sep 21, 2011), combined with:
  • Hydrocodone
  • Xanax
and developed a serious reaction and side effect(s): Chest Pain, Burning Sensation, Venous Stenosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Chest Pain side effect.
Hydroxyzine Hcl Side Effect Report#7932651-1
Neoplasm Malignant, Dyspnoea, Neoplasm Progression
This report suggests a potential Hydroxyzine Hcl Neoplasm Malignant side effect(s) that can have serious consequences. A 69-year-old female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Hydroxyzine Hcl (dosage: NA) starting
Oct 31, 2011. After starting Hydroxyzine Hcl the patient began experiencing various side effects, including: Neoplasm Malignant, Dyspnoea, Neoplasm ProgressionAdditional drugs used concurrently:
  • Ipilimumab (Frequncy:q3m.)
  • Ativan
  • Prilosec
  • Bevacizumab
  • Multi-vitamins
The patient was hospitalized. Although Hydroxyzine Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Neoplasm Malignant, may still occur.
Hydroxyzine Hcl Side Effect Report#7923680-2
Joint Stiffness, Musculoskeletal Stiffness, Pain In Extremity, Joint Swelling, Oedema Peripheral, Skin Exfoliation, Arthralgia, Musculoskeletal Pain, Blister
This Joint Stiffness problem was reported by a physician from United States. A 52-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Nov 11, 2010 this consumer started treatment with Hydroxyzine Hcl (dosage: 25 Mg, Q6h). The following drugs were being taken at the same time:
  • Enbrel
  • Enbrel (50 Mg, 2 Times/wk)
When using Hydroxyzine Hcl, the patient experienced the following unwanted symptoms/side effects: Joint Stiffness, Musculoskeletal Stiffness, Pain In Extremity, Joint Swelling, Oedema Peripheral, Skin Exfoliation, Arthralgia, Musculoskeletal Pain, BlisterAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Joint Stiffness, may become evident only after a product is in use by the general population.
Hydroxyzine Hcl Side Effect Report#7903442-2
Pain In Extremity, Burning Sensation, Vein Disorder, Hypoaesthesia, Discomfort, Paraesthesia, Infusion Site Pain, Balance Disorder, Joint Contracture
This Pain In Extremity side effect was reported by a consumer or non-health professional from United States. A 37-year-old male patient (weight:NA) experienced the following symptoms/conditions: anxiety.The patient was prescribed Hydroxyzine Hcl (drug dosage: Unk Dose Once), which was initiated on NS. Concurrently used drugs: NA..After starting to take Hydroxyzine Hcl the consumer reported adverse symptoms, such as: Pain In Extremity, Burning Sensation, Vein Disorder, Hypoaesthesia, Discomfort, Paraesthesia, Infusion Site Pain, Balance Disorder, Joint ContractureThese side effects may potentially be related to Hydroxyzine Hcl.
Hydroxyzine Hcl Side Effect Report#7901176-1
Syncope, Torsade De Pointes, Electrocardiogram Qt Prolonged
This is a report of a 34-year-old female patient (weight: NA) from Japan, suffering from the following health symptoms/conditions: prurigo, who was treated with Hydroxyzine Hcl (dosage: 75 Mg, 1x/day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Syncope, Torsade De Pointes, Electrocardiogram Qt Prolonged after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Hydroxyzine Hcl treatment in female patients, resulting in Syncope side effect. The patient was hospitalized.


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The appearance of Hydroxyzine Hcl on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Hydroxyzine Hcl Side Effects for Women?

Women Side EffectsReports
Death 8
Completed Suicide 5
Pleural Effusion 5
Pruritus 5
Acute Respiratory Distress Syndrome 4
Anuria 4
Anxiety 4
Dyspnoea 4
Electrocardiogram Qt Prolonged 4
Restless Legs Syndrome 4

What are common Hydroxyzine Hcl Side Effects for Men?

Men Side EffectsReports
Death 6
Confusional State 5
Balance Disorder 4
Tremor 4
Amnesia 3
Anxiety 3
Aphasia 3
Brain Scan Abnormal 3
Completed Suicide 3
Disorientation 3

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    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Hydroxyzine Hcl reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Hydroxyzine Hcl Safety Alerts, Active Ingredients, Usage Information

    NDC54879-006
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameHydroxyzine HCl
    NameHydroxyzine HCl
    Dosage FormSOLUTION
    RouteORAL
    On market since19820101
    LabelerSTI Pharma LLC
    Active Ingredient(s)HYDROXYZINE HYDROCHLORIDE
    Strength(s)10
    Unit(s)mg/5mL
    Pharma ClassAntihistamine [EPC],Histamine Receptor Antagonists [MoA]

    More About Hydroxyzine hcl

    Side Effects reported to FDA: 147

    Hydroxyzine Hcl safety alerts: No

    Reported deaths: 34

    Reported hospitalizations: 59

    Latest Hydroxyzine Hcl clinical trials