IRINOTECAN Side Effects

6724120-1 | Pneumocystis Jiroveci Pneumonia
on May 10, 2010 Female patient from GERMANY , weighting 125.7 lb, was diagnosed with colorectal cancer metastatic and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: pneumocystis jiroveci pneumonia. Irinotecan dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), FOLINIC ACID (View Folinic Acid Review and Folinic Acid Label ), CETUXIMAB (View Cetuximab Review and Cetuximab Label ), ONDANSETRON HYDROCHLORIDE (View Ondansetron Hydrochloride Review and Ondansetron Hydrochloride Label ), APREPITANT (View Aprepitant Review and Aprepitant Label ), DEXAMETHASONE PHOSPHATE (View Dexamethasone Phosphate Review and Dexamethasone Phosphate Label ). Patient was hospitalized.

6722882-0 | Cough, Hypophagia, Pyrexia, Rash Erythematous, Rhinorrhoea, Vomiting
Patient was taking Irinotecan (View Usage). Patient had the following side effects: cough, hypophagia, pyrexia, rash erythematous, rhinorrhoea, vomiting on May 12, 2010 from UNITED STATES Additional patient health information: Female patient , weighting 29.10 lb, was diagnosed with neuroblastoma (What is neuroblastoma?) and. Irinotecan dosage: 40mg/m2 Day 1-5; Iv. During the same period patient was treated with VELCADE (1.2mg/m2 Day1,4,6,11; Iv) (View Velcade Review and Velcade Label ), PENTAMIDINE ISETHIONATE (View Pentamidine Isethionate Review and Pentamidine Isethionate Label ). Patient was hospitalized.

6716141-X | Cough, Hypophagia, Leukocytosis, Pyrexia, Rash Erythematous, Rhinorrhoea, Skin Warm, Vomiting
Adverse event was reported on May 06, 2010 by a Female patient taking Irinotecan (View Usage) (Dosage: 40mg/m2 Day 1-5; Iv) was diagnosed with neuroblastoma (What is neuroblastoma?) and. Location: UNITED STATES , weighting 29.10 lb, After Irinotecan was administered, patient had the following side effects: cough, hypophagia, leukocytosis, pyrexia, rash erythematous, rhinorrhoea, skin warm, vomiting. During the same period patient was treated with VELCADE (1.2mg/m2 Day1,4,6,11: Iv) (View Velcade Review and Velcade Label ), PENTAMIDINE ISETHIONATE (View Pentamidine Isethionate Review and Pentamidine Isethionate Label ). Patient was hospitalized.

6303799-2 | Abdominal Distension, Asthenia, Dyspnoea, Hypophagia, Pleural Effusion, Vomiting
on Aug 07, 2009 Female patient from UNITED STATES , 63 years of age, weighting 145.0 lb, was diagnosed with ovarian cancer and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: abdominal distension, asthenia, dyspnoea, hypophagia, pleural effusion, vomiting. Irinotecan dosage: 605mg Weekly X3 :. During the same period patient was treated with SORAFENIB (400mg Daily :) (View Sorafenib Review and Sorafenib Label ). Patient was hospitalized.


6028049-6 | Diffuse Alveolar Damage, Interstitial Lung Disease, Left Ventricular Hypertrophy, Respiratory Distress, Respiratory Failure
on Dec 15, 2008 Male patient from SPAIN , 68 years of age, was diagnosed with colon cancer stage iv and was treated with Irinotecan (View Usage). Patient had the following side effects: diffuse alveolar damage, interstitial lung disease, left ventricular hypertrophy, respiratory distress, respiratory failure. Irinotecan dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), LEUCOVORIN CALCIUM (View Leucovorin Calcium Review and Leucovorin Calcium Label ).

5778138-6 | Bacillus Infection, Blood Culture Positive, Pyrexia
Patient was taking Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: bacillus infection, blood culture positive, pyrexia on Jun 18, 2008 from UNITED STATES Additional patient health information: Male patient , weighting 110.9 lb, was diagnosed with neuroblastoma (What is neuroblastoma?) and. Irinotecan dosage: 1.04 Mg D1, 4,8,11 Iv. During the same period patient was treated with BORTEZOMIB (30 Mg D1-5 Of 21d Cycl Iv) (View Bortezomib Review and Bortezomib Label ). Patient was hospitalized.

5611468-7 | Diarrhoea, Gastric Haemorrhage, Gastric Perforation, Impaired Healing, Malnutrition, Respiratory Failure, Vomiting
Adverse event was reported on Jan 25, 2008 by a Female patient taking Irinotecan (View Usage) (Dosage: Unk) was diagnosed with colon cancer and. Location: TAIWAN, PROVINCE OF CHINA , 82 years of age, Patient experienced the following unwanted or unexpected effects: diarrhoea, gastric haemorrhage, gastric perforation, impaired healing, malnutrition, respiratory failure, vomiting. During the same period patient was treated with FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ), FOLINIC ACID (Unk) (View Folinic Acid Review and Folinic Acid Label ), OXALIPLATIN (Unk) (View Oxaliplatin Review and Oxaliplatin Label ), AVASTIN (View Avastin Review and Avastin Label ). Patient was hospitalized.

5051201-3 | Diarrhoea, Febrile Neutropenia
on Jun 30, 2006 Male patient from UNITED STATES , 59 years of age, was treated with Irinotecan (View Usage). Patient had the following side effects: diarrhoea, febrile neutropenia. Irinotecan dosage: . During the same period patient was treated with ERBITUX (View Erbitux Review and Erbitux Label ), TEGAFUR (View Tegafur Review and Tegafur Label ), CPT 11 (View Cpt-11 Review and Cpt-11 Label ). Patient was hospitalized.

5049588-0 | Diarrhoea, Febrile Neutropenia
on Jun 30, 2006 Male patient from UNITED STATES , 59 years of age, was treated with Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: diarrhoea, febrile neutropenia. Irinotecan dosage: . During the same period patient was treated with ERBITUX (View Erbitux Review and Erbitux Label ), TEGAFUR (View Tegafur Review and Tegafur Label ), CPT 11 (View Cpt-11 Review and Cpt-11 Label ). Patient was hospitalized.

5017894-1 | Aphasia, Brain Herniation, Computerised Tomogram Abnormal, Condition Aggravated, Depressed Level Of Consciousness, Fatigue, Pyrexia, Respiratory Arrest, Somnolence
Patient was taking Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: aphasia (What is aphasia?), brain herniation, computerised tomogram abnormal, condition aggravated, depressed level of consciousness, fatigue, pyrexia, respiratory arrest, somnolence on Jun 02, 2006 from UNITED STATES Additional patient health information: Female patient , weighting 125.9 lb, was diagnosed with glioblastoma multiforme and. Irinotecan dosage: 325mg/m2 Day 1, 8, 22, 29 Iv. During the same period patient was treated with TEMODAR (200mg/m2 Days 1-5 Po) (View Temodar Review and Temodar Label ), DILANTIN (View Dilantin Review and Dilantin Label ), PEPCID (View Pepcid Review and Pepcid Label ), DECADRON (View Decadron Review and Decadron Label ), FLORINEF (View Florinef Review and Florinef Label ), MICARDIS (View Micardis Review and Micardis Label ), HUMALOG (View Humalog Review and Humalog Label ), LANTUS (View Lantus Review and Lantus Label ).

5011283-1 | Convulsion, Fatigue, Laboratory Test Abnormal, Somnolence
Adverse event was reported on May 23, 2006 by a Male patient taking Irinotecan (View Usage) (Dosage: 125 Mg/m2 Day 1, 8, 22, 29 Iv) was diagnosed with glioblastoma multiforme and. Location: UNITED STATES , weighting 233.7 lb, Patient had the following side effects: convulsion, fatigue, laboratory test abnormal, somnolence. During the same period patient was treated with TEMODAR (200 Mg/m2 Days 1-5 Po) (View Temodar Review and Temodar Label ), WELLBUTRIN (View Wellbutrin Review and Wellbutrin Label ), DECADRON SRC (View Decadron Src Review and Decadron Src Label ), PROVIGIL (View Provigil Review and Provigil Label ), XANAX (View Xanax Review and Xanax Label ), PROTONIX (View Protonix Review and Protonix Label ). Patient was hospitalized.

5006886-4 | Abnormal Faeces, Anorexia, Ascites, Blood Pressure Immeasurable, Cancer Pain, Cardiac Arrest, Diarrhoea, Incoherent, Interstitial Lung Disease
on Apr 28, 2006 Male patient from JAPAN , 77 years of age, was diagnosed with colon cancer and was treated with Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: abnormal faeces, anorexia, ascites, blood pressure immeasurable, cancer pain, cardiac arrest (What is cardiac arrest?), diarrhoea, incoherent, interstitial lung disease. Irinotecan dosage: 100 Mg (100 Mg, Daily), Intravenous. During the same period patient was treated with TEGAFUR/GIMERACIL/OTERACIL POTASSIUM (80 Mg (40 Mg, 2 In 1 D), Oral) (View Tegafur/gimeracil/oteracil Potassium Review and Tegafur/gimeracil/oteracil Potassium Label ), MUCOSTA (REBAMIPIDE) (View Mucosta (rebamipide) Review and Mucosta (rebamipide) Label ), MAGNESIUM OXIDE (MAGNESIUM OXIDE) (View Magnesium Oxide (magnesium Oxide) Review and Magnesium Oxide (magnesium Oxide) Label ), MORPHINE (View Morphine Review and Morphine Label ), FENTANYL (View Fentanyl Review and Fentanyl Label ), MOBIC (View Mobic Review and Mobic Label ), PRIMPERAN TAB (View Primperan Tab Review and Primperan Tab Label ), DOGMATYL (SULPIRIDE) (View Dogmatyl (sulpiride) Review and Dogmatyl (sulpiride) Label ).

4990216-8 | Body Temperature Increased, Neutrophil Count Decreased
on May 01, 2006 Male patient from UNITED STATES , 67 years of age, weighting 149.7 lb, was diagnosed with non-small cell lung cancer and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: body temperature increased, neutrophil count decreased. Irinotecan dosage: 700 Mg Q 3 Weeks Iv Drip. Patient was hospitalized.

4832439-4 | Blood Culture Positive, Cholera, Enterococcal Infection, Escherichia Infection, Hypotension, Neutrophil Count Decreased, Pseudomonas Infection
Patient was taking Irinotecan (View Usage). Patient had the following side effects: blood culture positive, cholera, enterococcal infection, escherichia infection, hypotension, neutrophil count decreased, pseudomonas infection on Nov 17, 2005 from UNITED STATES Additional patient health information: Male patient , weighting 173.1 lb, . Irinotecan dosage: See Image. During the same period patient was treated with CISPLATIN (See Image) (View Cisplatin Review and Cisplatin Label ), ETOPOSIDE (See Image) (View Etoposide Review and Etoposide Label ). Patient was hospitalized.

4758746-1 | Hypotension, Nausea, Pyrexia
Adverse event was reported on Aug 31, 2005 by a Female patient taking Irinotecan (View Usage) (Dosage: 100 Mg , Over 30-90 Min Iv Day 1 + 8 X 4 Cycles) . Location: UNITED STATES , 52 years of age, weighting 223.0 lb, After Irinotecan was administered, patient had the following side effects: hypotension, nausea (What is nausea?), pyrexia. During the same period patient was treated with CARBOPLATIN (735 Mg Iv Day 1 X 4 Cycles) (View Carboplatin Review and Carboplatin Label ), ATIVAN (View Ativan Review and Ativan Label ), DECADRON (View Decadron Review and Decadron Label ), ZOFRAN (View Zofran Review and Zofran Label ), PHENERAGAN (View Pheneragan Review and Pheneragan Label ). Patient was hospitalized.

4754885-X | Abnormal Faeces, Blood Creatinine Increased, Coagulopathy, Condition Aggravated, Diarrhoea, Haematoma, Nausea, Renal Failure
on Aug 26, 2005 Male patient from GERMANY , 65 years of age, weighting 163.1 lb, was diagnosed with colon cancer and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: abnormal faeces, blood creatinine increased, coagulopathy, condition aggravated, diarrhoea, haematoma, nausea (What is nausea?), renal failure. Irinotecan dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), FOLINIC ACID (300 Mg) (View Folinic Acid Review and Folinic Acid Label ), ATROPINE SULFATE (View Atropine Sulfate Review and Atropine Sulfate Label ), OPIUM TINCTURE (View Opium Tincture Review and Opium Tincture Label ), MCP (METOCLOPRAMIDE HYDROCHLORIDE) (View Mcp (metoclopramide Hydrochloride) Review and Mcp (metoclopramide Hydrochloride) Label ), KALITRANS (POTASSIUM BICARBONATE) (View Kalitrans (potassium Bicarbonate) Review and Kalitrans (potassium Bicarbonate) Label ). Patient was hospitalized.

4752193-4 | Cellulitis, Difficulty In Walking, Erythema, Fall, Infection, Joint Swelling, Skin Injury
on Aug 24, 2005 Male patient from UNITED STATES , weighting 169.8 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan (View Usage). Patient had the following side effects: cellulitis (What is cellulitis?), difficulty in walking, erythema, fall (What is fall?), infection (What is infection?), joint swelling, skin injury. Irinotecan dosage: See Image. During the same period patient was treated with TEMOZOLOMIDE (See Image) (View Temozolomide Review and Temozolomide Label ), COUMADIN (View Coumadin Review and Coumadin Label ), KEPPRA (View Keppra Review and Keppra Label ), NEURONTIN (View Neurontin Review and Neurontin Label ). Patient was hospitalized.

4751622-X | Arthritis Infective, Cellulitis, Difficulty In Walking, Erythema, Excoriation, Joint Effusion, Joint Injury, Joint Swelling
Patient was taking Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: arthritis infective, cellulitis (What is cellulitis?), difficulty in walking, erythema, excoriation, joint effusion, joint injury, joint swelling on Aug 23, 2005 from UNITED STATES Additional patient health information: Male patient , weighting 169.8 lb, was diagnosed with glioblastoma multiforme and. Irinotecan dosage: See Image. During the same period patient was treated with TEMOZOLOMIDE (See Image) (View Temozolomide Review and Temozolomide Label ), COUMADIN (View Coumadin Review and Coumadin Label ), KEPPRA (View Keppra Review and Keppra Label ), NEURONTIN (View Neurontin Review and Neurontin Label ). Patient was hospitalized.

4727231-5 | Neutropenia
Adverse event was reported on Jul 27, 2005 by a Male patient taking Irinotecan (View Usage) (Dosage: Intraven) was diagnosed with adenocarcinoma and. Location: UNITED STATES , 82 years of age, weighting 205.0 lb, Patient experienced the following unwanted or unexpected effects: neutropenia. During the same period patient was treated with BEVACIZUMAB (View Bevacizumab Review and Bevacizumab Label ), FLUTICASONE PROP (View Fluticasone Prop Review and Fluticasone Prop Label ), GLIPIZIDE (View Glipizide Review and Glipizide Label ), LISINOPRIL (View Lisinopril Review and Lisinopril Label ), AZITHROMYCIN (View Azithromycin Review and Azithromycin Label ), LOPERAMIDE HCL (View Loperamide Hcl Review and Loperamide Hcl Label ), MULTI VITAMIN (View Multi-vitamin Review and Multi-vitamin Label ), ASPIRIN (View Aspirin Review and Aspirin Label ). Patient was hospitalized.

4725994-6 | Eye Pain, Infusion Related Reaction, Oedema Peripheral
on Jul 22, 2005 Female patient from UNITED STATES , 68 years of age, weighting 112.0 lb, was diagnosed with pancreatic carcinoma and was treated with Irinotecan (View Usage). Patient had the following side effects: eye pain, infusion related reaction, oedema peripheral. Irinotecan dosage: 103 Mg Iv Weekly. During the same period patient was treated with MS CONTIN (View Ms Contin Review and Ms Contin Label ), ATIVAN (View Ativan Review and Ativan Label ), PHENERGAN (View Phenergan Review and Phenergan Label ).

4714613-0 | Cough, Hyperhidrosis, Hypoxia, Tachycardia, Tachypnoea
on Jul 13, 2005 Male patient from UNITED STATES , 28 years of age, was treated with Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: cough, hyperhidrosis, hypoxia, tachycardia, tachypnoea. Irinotecan dosage: . Patient was hospitalized.

4697875-8 | Chest Pain, Dyspnoea, Nausea
Patient was taking Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: chest pain (What is chest pain?), dyspnoea, nausea (What is nausea?) on Jun 21, 2005 from Additional patient health information: Male patient , weighting 236.6 lb, was diagnosed with rectal cancer and. Irinotecan dosage: 180 Mg/m2 Iv (day 1 Every 14 Days. During the same period patient was treated with LEUCOVORIN (400 Mg/m2 Iv (day 1 Every 14 Days)) (View Leucovorin Review and Leucovorin Label ), FLUOROURACIL (Bolus 400 Mg/m2 Iv Push (day 1 Every 14 Days)) (View Fluorouracil Review and Fluorouracil Label ).

4692067-0 | Anorexia, Bone Pain, Constipation, Dehydration, Diarrhoea, Flat Affect, International Normalised Ratio Increased, Malaise, Nausea
Adverse event was reported on Jun 16, 2005 by a Male patient taking Irinotecan (View Usage) (Dosage: 60 Mg/m2 Iv Over 90 Min On Days 1, 8 + 15 Q 4 Wks.) . Location: , weighting 168.4 lb, Patient had the following side effects: anorexia, bone pain, constipation (What is constipation?), dehydration, diarrhoea, flat affect, international normalised ratio increased, malaise, nausea (What is nausea?). During the same period patient was treated with CISPLATIN (60 Mg/m2 Iv Over 30-60 Min On Day 1 Q 4 Wks.) (View Cisplatin Review and Cisplatin Label ).

4687468-0 | Abdominal Pain, Neoplasm Progression, Obstructive Uropathy, Pelvic Mass
on Jun 09, 2005 Male patient from , weighting 172.0 lb, was diagnosed with colorectal cancer (What is colorectal cancer?) and was treated with Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: abdominal pain (What is abdominal pain?), neoplasm progression, obstructive uropathy, pelvic mass. Irinotecan dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), CETUXIMAB (View Cetuximab Review and Cetuximab Label ).

4677649-4 | Musculoskeletal Stiffness, Neck Pain
on May 27, 2005 Female patient from , weighting 230.4 lb, was diagnosed with colon cancer and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: musculoskeletal stiffness, neck pain. Irinotecan dosage: 180 Mg/m2 Iv Over 120 Minutes On Day 1, Every 2 Weeks X 12 Cycles. During the same period patient was treated with LEUCOVORIN (400 Mg/m2 Iv Over 120 Minutes On Day 1, Every 2 Weeks X 12 Cycles) (View Leucovorin Review and Leucovorin Label ), FLUOROURACIL (400 Mg/m2 Iv Push On Day 1 Followed By 2400 Mg/m2 Civ Over 46-48 Hours, Every 2 Weeks) (View Fluorouracil Review and Fluorouracil Label ).

4675917-3 | Blood Culture Positive, Dyspnoea Exertional, Fatigue, Haemoglobin Decreased, Neutrophil Count Decreased, Oxygen Saturation Decreased, Pulmonary Embolism, Pyrexia, Red Blood Cell Count Decreased
Patient was taking Irinotecan (View Usage). Patient had the following side effects: blood culture positive, dyspnoea exertional, fatigue, haemoglobin decreased, neutrophil count decreased, oxygen saturation decreased, pulmonary embolism (What is pulmonary embolism?), pyrexia, red blood cell count decreased on May 26, 2005 from Additional patient health information: Male patient , weighting 200.2 lb, . Irinotecan dosage: 50 Mg/m2 Iv Days 1 + 8, Over 90 Mins. During the same period patient was treated with CISPLATIN (20mg/m2 Iv Over 60 Mins Days 1 + 8 Of Each 3 Week Cycle) (View Cisplatin Review and Cisplatin Label ), ETOPOSIDE (85 Mg/m2 Po Divided In 2 Doses Q 12 Hr. Days 3 + 10 Of Each Cycle) (View Etoposide Review and Etoposide Label ). Patient was hospitalized.

4658845-9 | Abdominal Pain, Constipation, Diarrhoea, Duodenal Perforation, Leukopenia, Malaise, Peritonitis, Stress
Adverse event was reported on Apr 25, 2005 by a Male patient taking Irinotecan (View Usage) (Dosage: Intravenous) was diagnosed with ill-defined disorder, nausea (What is nausea?), abdominal pain (What is abdominal pain?), diarrhoea and. Location: , 71 years of age, After Irinotecan was administered, patient had the following side effects: abdominal pain (What is abdominal pain?), constipation (What is constipation?), diarrhoea, duodenal perforation, leukopenia, malaise, peritonitis, stress (What is stress?). During the same period patient was treated with DICLOFENAC SODUM (DICLOFENAC SODIUM) (75 Mg (daily), Oral) (View Diclofenac Sodum (diclofenac Sodium) Review and Diclofenac Sodum (diclofenac Sodium) Label ), MORPHINE (See Image) (View Morphine Review and Morphine Label ), BETAMETHASONE (See Image) (View Betamethasone Review and Betamethasone Label ), LOPERAMIDE (2 Mg (daily), Oral) (View Loperamide Review and Loperamide Label ), CISPLATIN (View Cisplatin Review and Cisplatin Label ), PREPARATION (HERBAL PREPARATION) (View Preparation (herbal Preparation) Review and Preparation (herbal Preparation) Label ).

4647227-1 | Catheter Related Complication, Jugular Vein Thrombosis, Pyrexia, Venous Thrombosis Limb
on Apr 26, 2005 Female patient from , 61 years of age, weighting 169.8 lb, was diagnosed with colorectal cancer (What is colorectal cancer?) and was treated with Irinotecan (View Usage). Patient experienced the following unwanted or unexpected effects: catheter related complication, jugular vein thrombosis, pyrexia, venous thrombosis limb. Irinotecan dosage: 290 Mg Other. During the same period patient was treated with LEUCOVCORIN (FOLINIC ACID) (385 Mg Other) (View Leucovcorin (folinic Acid) Review and Leucovcorin (folinic Acid) Label ), FLUOROURACIL (1540 Mg Other) (View Fluorouracil Review and Fluorouracil Label ), DEXAMETHASONE (View Dexamethasone Review and Dexamethasone Label ), TEMAZEPAM (View Temazepam Review and Temazepam Label ), ESOMEPRAZOLE MAGNESIUM (View Esomeprazole Magnesium Review and Esomeprazole Magnesium Label ), OXAZEPAM (View Oxazepam Review and Oxazepam Label ), WARFARIN SODIUM (View Warfarin Sodium Review and Warfarin Sodium Label ). Patient was hospitalized.

4560793-X | Blood Lactate Dehydrogenase Increased, Haemodialysis, Hyperphosphataemia, Hyperuricaemia, Hypocalcaemia, Hypochromasia, Metabolic Acidosis, Ph Urine Decreased, Red Blood Cell Anisocytes Present
on Jan 14, 2005 Male patient from , 66 years of age, was treated with Irinotecan (View Usage). Patient had the following side effects: blood lactate dehydrogenase increased, haemodialysis, hyperphosphataemia, hyperuricaemia, hypocalcaemia, hypochromasia, metabolic acidosis, ph urine decreased, red blood cell anisocytes present. Irinotecan dosage: 180 Mg/m2 Fortnightly Inj. During the same period patient was treated with FLUOROURCIL (600 Mg/m2 Fortnightly Inj) (View Fluorourcil Review and Fluorourcil Label ), LEUCOVORIN (200 Mg/m2 Fortnightly) (View Leucovorin Review and Leucovorin Label ). Patient was hospitalized.

4551288-8 | Blood Creatinine Increased, Coagulopathy, International Normalised Ratio Increased, Prothrombin Time Prolonged
Patient was taking Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: blood creatinine increased, coagulopathy, international normalised ratio increased, prothrombin time prolonged on Jan 10, 2005 from Additional patient health information: Male patient , 65 years of age, weighting 163.1 lb, was diagnosed with colon cancer and. Irinotecan dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), FOLINIC ACID (380 Mg) (View Folinic Acid Review and Folinic Acid Label ), ATROPINE (View Atropine Review and Atropine Label ), MARCUMAR (View Marcumar Review and Marcumar Label ). Patient was hospitalized.

4549457-6 | Coma, Pulse Absent
Adverse event was reported on Jan 07, 2005 by a Female patient taking Irinotecan (View Usage) (Dosage: 100 Mg/m2; 2x3wks; Iv) was diagnosed with cervix carcinoma and. Location: , 49 years of age, weighting 144.0 lb, Patient experienced the following unwanted or unexpected effects: coma, pulse absent. During the same period patient was treated with CAPECITABINE (1750 Mg/m2; 1-14 Days; Iv) (View Capecitabine Review and Capecitabine Label ).

4548191-6 | Anaemia, Diarrhoea, Electrolyte Imbalance, Hypovolaemia, Neutropenia, Rectal Haemorrhage, Thrombocytopenia
on Jan 05, 2005 Male patient from , 80 years of age, weighting 130.1 lb, was treated with Irinotecan (View Usage). Patient had the following side effects: anaemia, diarrhoea, electrolyte imbalance, hypovolaemia, neutropenia, rectal haemorrhage, thrombocytopenia. Irinotecan dosage: . During the same period patient was treated with CISPLATIN (View Cisplatin Review and Cisplatin Label ). Patient was hospitalized.

4546684-9 | Convulsion, Gastrointestinal Haemorrhage, Multi-organ Failure
on Dec 21, 2004 Male patient from , 62 years of age, was diagnosed with colorectal cancer metastatic and was treated with Irinotecan (View Usage). After Irinotecan was administered, patient had the following side effects: convulsion, gastrointestinal haemorrhage, multi-organ failure. Irinotecan dosage: Iv. During the same period patient was treated with FLUOROURACIL (2400 Mg/m2 Total Iv) (View Fluorouracil Review and Fluorouracil Label ), FOLINIC ACID (Iv) (View Folinic Acid Review and Folinic Acid Label ), SERTRALINE HCL (View Sertraline Hcl Review and Sertraline Hcl Label ), IRBESARTAN (View Irbesartan Review and Irbesartan Label ), MORPHINE (View Morphine Review and Morphine Label ). Patient was hospitalized.