ISOVORIN Side Effects

6355092-X | Dyspnoea
on Sep 09, 2009 Male patient from GREECE , 79 years of age, weighting 167.6 lb, was diagnosed with large intestine carcinoma and was treated with Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: dyspnoea. Isovorin dosage: . During the same period patient was treated with VECTIBIX (View Vectibix Review and Vectibix Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ). Patient was hospitalized.

6204548-9 | Anaphylactic Shock, Respiratory Arrest
Patient was taking Isovorin (View Usage). Patient had the following side effects: anaphylactic shock, respiratory arrest on May 15, 2009 from JAPAN Additional patient health information: Male patient , 50 years of age, . Isovorin dosage: 100 Mg/m2. During the same period patient was treated with ELPLAT (140 Mg) (View Elplat Review and Elplat Label ), FLUOROURACIL (400 Mg/m2) (View Fluorouracil Review and Fluorouracil Label ).

6016493-2 | Gastrointestinal Perforation, White Blood Cell Count Decreased
Adverse event was reported on Dec 11, 2008 by a Female patient taking Isovorin (View Usage) (Dosage: 201.3 Mg/m2) was diagnosed with colon cancer and. Location: JAPAN , weighting 130.1 lb, After Isovorin was administered, patient had the following side effects: gastrointestinal perforation, white blood cell count decreased. During the same period patient was treated with FLUOROURACIL (369.1 Mg/m2) (View Fluorouracil Review and Fluorouracil Label ), ELPLAT (83.9 Mg/m2) (View Elplat Review and Elplat Label ), AVASTIN (View Avastin Review and Avastin Label ).

5939042-3 | Ileal Perforation
on Oct 24, 2008 Male patient from JAPAN , weighting 116.8 lb, was diagnosed with rectal cancer and was treated with Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: ileal perforation. Isovorin dosage: Folfox-6. During the same period patient was treated with AVASTIN (View Avastin Review and Avastin Label ), FLUOROURACIL (Folfox-4: 608 Mg/body Bolus Then Infusion 912 Mg/body) (View Fluorouracil Review and Fluorouracil Label ), LEUCOVORIN CALCIUM (View Leucovorin Calcium Review and Leucovorin Calcium Label ), ELPLAT (View Elplat Review and Elplat Label ).


5885438-8 | Reversible Posterior Leukoencephalopathy Syndrome
on Sep 05, 2008 Female patient from JAPAN , 43 years of age, was diagnosed with colon cancer and was treated with Isovorin (View Usage). Patient had the following side effects: reversible posterior leukoencephalopathy syndrome. Isovorin dosage: Unk. During the same period patient was treated with ELPLAT (Unk) (View Elplat Review and Elplat Label ), DECADRON SRC (Unk) (View Decadron Src Review and Decadron Src Label ), FLUOROURACIL (Bolus Then Infusion Unk) (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

5872292-3 | Palmar-plantar Erythrodysaesthesia Syndrome, White Blood Cell Count Decreased
Patient was taking Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: palmar-plantar erythrodysaesthesia syndrome, white blood cell count decreased on Jul 03, 2008 from JAPAN Additional patient health information: Male patient , weighting 81.57 lb, . Isovorin dosage: . During the same period patient was treated with FLUOROURACIL (500 Mg/body=400 Mg/m2 In Bolus Then 800 Mg/body=640 Mg/m2 As Infusion) (View Fluorouracil Review and Fluorouracil Label ), BEVACIZUMAB (View Bevacizumab Review and Bevacizumab Label ), ELPLAT (View Elplat Review and Elplat Label ).

5832204-5 | Guillain-barre Syndrome
Adverse event was reported on Jul 23, 2008 by a Male patient taking Isovorin (View Usage) (Dosage: Unk) was diagnosed with rectal cancer and. Location: JAPAN , 60 years of age, Patient experienced the following unwanted or unexpected effects: guillain-barre syndrome (What is guillain-barre syndrome?). During the same period patient was treated with ELPLAT (Unk) (View Elplat Review and Elplat Label ), FLUOROURACIL (Iv Bolus Then Continuous Infusion Unk) (View Fluorouracil Review and Fluorouracil Label ).

5797051-1 | Haemorrhage
on Jun 26, 2008 Male patient from JAPAN , weighting 198.4 lb, was diagnosed with rectal cancer recurrent and was treated with Isovorin (View Usage). Patient had the following side effects: haemorrhage. Isovorin dosage: Unk. During the same period patient was treated with FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ), LEUCON (Unk) (View Leucon Review and Leucon Label ), TRAVELMIN (Unk) (View Travelmin Review and Travelmin Label ), ELPLAT (Unk) (View Elplat Review and Elplat Label ), KYTRIL (Unk) (View Kytril Review and Kytril Label ), SOLU CORTEF (Unk) (View Solu-cortef Review and Solu-cortef Label ), SHAKUYAKU KANZO TO (Unk) (View Shakuyaku-kanzo-to Review and Shakuyaku-kanzo-to Label ), URSO 250 (Unk) (View Urso 250 Review and Urso 250 Label ).

5788085-1 | Anaphylactic Shock, Myocardial Ischaemia, Neutropenia
on Jun 17, 2008 Male patient from JAPAN , weighting 149.9 lb, was diagnosed with hypertension, rectal cancer and was treated with Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: anaphylactic shock, myocardial ischaemia, neutropenia. Isovorin dosage: . During the same period patient was treated with CALBLOCK (View Calblock Review and Calblock Label ), ELPLAT (View Elplat Review and Elplat Label ), FLUOROURACIL (700 Mg/body=404.6 Mg/m2 In Bolus Followed By 4250 Mg/body=2456.6 Mg/m2) (View Fluorouracil Review and Fluorouracil Label ).

5767645-8 | Reversible Posterior Leukoencephalopathy Syndrome
Patient was taking Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: reversible posterior leukoencephalopathy syndrome on Jun 04, 2008 from JAPAN Additional patient health information: Female patient , 43 years of age, was diagnosed with colon cancer and. Isovorin dosage: Unk. During the same period patient was treated with ELPLAT (Unk) (View Elplat Review and Elplat Label ), DECADRON (Unk) (View Decadron Review and Decadron Label ), FLUOROURACIL (Bolus Then Infusion Unk) (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

5761392-4 | Shock
Adverse event was reported on Jun 03, 2008 by a Male patient taking Isovorin (View Usage) (Dosage: Unk) was diagnosed with colon cancer and. Location: JAPAN , 63 years of age, weighting 132.3 lb, Patient had the following side effects: shock. During the same period patient was treated with FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ), AVASTIN (View Avastin Review and Avastin Label ), ELPLAT (Unk) (View Elplat Review and Elplat Label ).

5716558-6 | Intestinal Perforation
on Apr 16, 2008 Male patient from JAPAN , 70 years of age, was treated with Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: intestinal perforation. Isovorin dosage: Unk. During the same period patient was treated with FLUOROURACIL (650mg/body In Bolus Then 2000mg/body As Continuous Infusion On Day 1-2) (View Fluorouracil Review and Fluorouracil Label ), ELPLAT (140mg/body In Infusion On Day 1) (View Elplat Review and Elplat Label ), AVASTIN (Unk) (View Avastin Review and Avastin Label ).

5713133-4 | Gastrointestinal Perforation
on Apr 14, 2008 Female patient from JAPAN , 48 years of age, weighting 103.6 lb, was diagnosed with colon cancer and was treated with Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: gastrointestinal perforation. Isovorin dosage: 200 Mg/m2. During the same period patient was treated with DECADRON (8 Mg) (View Decadron Review and Decadron Label ), KYTRIL (3 Mg) (View Kytril Review and Kytril Label ), AVASTIN (5mg/kg In Infusion On Day 1) (View Avastin Review and Avastin Label ), FLUOROURACIL (400 Mg/m2 In Bolus Followed By 2400 Mg/m2 As Continuous Infusion) (View Fluorouracil Review and Fluorouracil Label ), ELPLAT (85mg/m2 In Infusion On Day 1) (View Elplat Review and Elplat Label ).

5655518-0 | Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Hepatic Function Abnormal
Patient was taking Isovorin (View Usage). Patient had the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, hepatic function abnormal on Feb 29, 2008 from JAPAN Additional patient health information: Male patient , 70 years of age, was diagnosed with rectal cancer and. Isovorin dosage: Unk. During the same period patient was treated with FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ), ELPLAT (Unk) (View Elplat Review and Elplat Label ), AVASTIN (View Avastin Review and Avastin Label ). Patient was hospitalized.

5649521-4 | Disseminated Intravascular Coagulation, Leukopenia, Necrotising Fasciitis, Thrombocytopenia
Adverse event was reported on Feb 22, 2008 by a Male patient taking Isovorin (View Usage) (Dosage: 325mg/body = 203.1 Mg/m2 In Infusion On Day 1) was diagnosed with rectal cancer, prophylaxis of nausea and vomiting and. Location: JAPAN , weighting 134.5 lb, After Isovorin was administered, patient had the following side effects: disseminated intravascular coagulation, leukopenia, necrotising fasciitis, thrombocytopenia. During the same period patient was treated with ELPLAT (140mg/body=87.5mg/m2 In Infusion On Day 1) (View Elplat Review and Elplat Label ), SAWACILLIN (250 Mg) (View Sawacillin Review and Sawacillin Label ), SINSERON (8 Mg) (View Sinseron Review and Sinseron Label ), DECADRON (8 Mg) (View Decadron Review and Decadron Label ), KYTRIL (3 Mg) (View Kytril Review and Kytril Label ), FLUOROURACIL (650mg/body = 406.3mg/m2 In Bolus Then 4000mg/body = 2500mg/m2 As Continuous Infusion On Day 1-2) (View Fluorouracil Review and Fluorouracil Label ).

5602097-X | Gastrointestinal Perforation, Peritonitis, Rectal Perforation
on Jan 16, 2008 Female patient from JAPAN , 54 years of age, was diagnosed with rectal cancer metastatic and was treated with Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: gastrointestinal perforation, peritonitis, rectal perforation. Isovorin dosage: 100 Mg. During the same period patient was treated with FLUOROURACIL (500 Mg) (View Fluorouracil Review and Fluorouracil Label ), AVASTIN (View Avastin Review and Avastin Label ), ELPLAT (100 Mg) (View Elplat Review and Elplat Label ).

5573204-2 | Blood Pressure Increased, Convulsion, Heart Rate Increased, Loss Of Consciousness, Nausea
on Dec 14, 2007 Male patient from JAPAN , weighting 116.8 lb, was diagnosed with rectal cancer and was treated with Isovorin (View Usage). Patient had the following side effects: blood pressure increased, convulsion, heart rate increased, loss of consciousness, nausea (What is nausea?). Isovorin dosage: . During the same period patient was treated with ELPLAT (View Elplat Review and Elplat Label ), FLUOROURACIL (600 Mg/body=384.6 Mg/m2 In Bolus Then 3700 Mg/body=2371.8 Mg/m2 As Infusion) (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

5573192-9 | Diarrhoea, Leukopenia, Stevens-johnson Syndrome, Vomiting
Patient was taking Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: diarrhoea, leukopenia, stevens-johnson syndrome, vomiting on Dec 13, 2007 from JAPAN Additional patient health information: Female patient , 82 years of age, weighting 94.80 lb, was diagnosed with rectal cancer and. Isovorin dosage: 125 Mg/body=92.6 Mg/m2. During the same period patient was treated with ELPLAT (100 Mg/body=74.1 Mg/m2) (View Elplat Review and Elplat Label ), FLUOROURACIL (500 M/gbody=370.4 Mg/m2 Bolus Then 750 Mg/body=555.6 Mg/m2 Infusion D1-2) (View Fluorouracil Review and Fluorouracil Label ).

5558100-9 | Diarrhoea, Leukopenia, Vomiting
Adverse event was reported on Dec 06, 2007 by a Female patient taking Isovorin (View Usage) (Dosage: Unk) was diagnosed with large intestine carcinoma and. Location: JAPAN , 82 years of age, Patient experienced the following unwanted or unexpected effects: diarrhoea, leukopenia, vomiting. During the same period patient was treated with ELPLAT (100 Mg/body) (View Elplat Review and Elplat Label ), FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ).

5382160-1 | Hepatic Encephalopathy
on Jun 27, 2007 Female patient from JAPAN , 63 years of age, was diagnosed with large intestine carcinoma and was treated with Isovorin (View Usage). Patient had the following side effects: hepatic encephalopathy. Isovorin dosage: . During the same period patient was treated with ELPLAT (View Elplat Review and Elplat Label ), FLUOROURACIL (600 Mg Bolus Followed By 1800 Mg Infusion Days 1 And 2) (View Fluorouracil Review and Fluorouracil Label ).

5377223-0 | Interstitial Lung Disease
on Jun 22, 2007 Male patient from JAPAN , 74 years of age, was treated with Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: interstitial lung disease. Isovorin dosage: Unk. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ).

5336902-1 | Duodenal Ulcer Perforation, Leukopenia, Neutropenia
Patient was taking Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: duodenal ulcer perforation, leukopenia, neutropenia on May 17, 2007 from JAPAN Additional patient health information: Female patient , weighting 121.3 lb, was diagnosed with diarrhoea, rectal cancer and. Isovorin dosage: . During the same period patient was treated with SOLDEM (View Soldem Review and Soldem Label ), FLUOROURACIL (500 Mg/body=322.6 Mg/m2 In Bolus Then 3750mg/body=2419.4 Mg/m2 As Infusion, D1-2) (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ). Patient was hospitalized.

5304826-1 | Disseminated Intravascular Coagulation, Haemoglobin Decreased, Thrombocytopenia
Adverse event was reported on Apr 12, 2007 by a Female patient taking Isovorin (View Usage) (Dosage: ) was diagnosed with rectal cancer and. Location: JAPAN , weighting 70.55 lb, Patient had the following side effects: disseminated intravascular coagulation, haemoglobin decreased, thrombocytopenia. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), KYTRIL (View Kytril Review and Kytril Label ), DECADRON (View Decadron Review and Decadron Label ), FLUOROURACIL (500 Mg/body=434.8 Mg/m2 Bolus Then 1500 Mg/body=1304.3 Mg/m2 Infusion D1-2) (View Fluorouracil Review and Fluorouracil Label ).

5277600-2 | Cardiac Failure
on Mar 15, 2007 Female patient from JAPAN , weighting 99.21 lb, was diagnosed with colon cancer and was treated with Isovorin (View Usage). After Isovorin was administered, patient had the following side effects: cardiac failure. Isovorin dosage: . During the same period patient was treated with DECADRON (View Decadron Review and Decadron Label ), NASEA (View Nasea Review and Nasea Label ), FLUOROURACIL (500 Mg/body=370.4 Mg/m2 In Bolus Then 2500 Mg/body=1851.9 Mg/m2 As Infusion) (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ).

5265486-1 | Convulsion
on Mar 05, 2007 Male patient from JAPAN , 64 years of age, was diagnosed with large intestine carcinoma and was treated with Isovorin (View Usage). Patient experienced the following unwanted or unexpected effects: convulsion. Isovorin dosage: . During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

5128793-9 | Convulsion, Decubitus Ulcer, Fall, Hyperammonaemia, Loss Of Consciousness
Patient was taking Isovorin (View Usage). Patient had the following side effects: convulsion, decubitus ulcer, fall (What is fall?), hyperammonaemia, loss of consciousness on Aug 24, 2006 from JAPAN Additional patient health information: Male patient , weighting 105.8 lb, was diagnosed with large intestine carcinoma and. Isovorin dosage: . During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ).

5080440-0 | Bradycardia, Cardiac Arrest, Depressed Level Of Consciousness, Diarrhoea, Disseminated Intravascular Coagulation, Leukopenia, Metabolic Acidosis, Neutropenia
Adverse event was reported on Jul 26, 2006 by a Male patient taking Isovorin (View Usage) (Dosage: ) was diagnosed with rectal cancer and. Location: JAPAN , 60 years of age, weighting 112.4 lb, After Isovorin was administered, patient had the following side effects: bradycardia, cardiac arrest (What is cardiac arrest?), depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, leukopenia, metabolic acidosis, neutropenia. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (625mg/body=411.2mg/m2 In Bolus Then 940 Mg/body=618.4mg/m2 Infusion) (View Fluorouracil Review and Fluorouracil Label ).