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Kadian Side Effects

Common Kadian Side Effects


The most commonly reported Kadian side effects (click to view or check a box to report):

Death (34)
Completed Suicide (32)
Overdose (23)
Cardiac Arrest (13)
Respiratory Depression (12)
Somnolence (11)
Cardio-respiratory Arrest (10)
Cardiomegaly (9)
Coma (9)
Depressed Level Of Consciousness (8)
Hypotension (8)
Headache (8)
Respiratory Arrest (8)
Pulmonary Congestion (7)
Aspiration (7)
Fall (7)
Accidental Death (7)
Contusion (7)
Loss Of Consciousness (7)
Nausea (7)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Kadian Side Effects Reported to FDA

The following Kadian reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Kadian on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Hallucination, Auditory, Aggression, Feeling Abnormal, Lethargy, Anger, Violence-related Symptom
This is a report of a 48-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: pain management, who was treated with Kadian (watson Laboratories) (dosage: 1 Df, Bid, start time: 2007), combined with:
  • Oxycodone / Acetaminophen (1 Df, Tid)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Hallucination, Auditory
  • Aggression
  • Feeling Abnormal
  • Lethargy
  • Anger
  • Violence-related Symptom
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Kadian (watson Laboratories) treatment in female patients, resulting in hallucination, auditory side effect.

Rheumatoid Arthritis, Skin Exfoliation, Dry Skin, Erythema, Pruritus
This report suggests a potential Kadian (watson Laboratories) Rheumatoid Arthritis, Skin Exfoliation, Dry Skin, Erythema, Pruritus side effect(s) that can have serious consequences. A 63-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: arthritis,rheumatoid arthritis,blood pressure,hypersensitivity and used Kadian (watson Laboratories) (dosage: 1-2 Tablets Daily) starting NS. Soon after starting Kadian (watson Laboratories) the patient began experiencing various side effects, including:
  • Rheumatoid Arthritis
  • Skin Exfoliation
  • Dry Skin
  • Erythema
  • Pruritus
Drugs used concurrently:
  • Humira (40 Mg, Solution For Injection)
  • Benicar (40/25 Mg Daily)
  • Allegra (1-2 Tablets Daily)
Although Kadian (watson Laboratories) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as rheumatoid arthritis, may still occur.

Hypersensitivity, Pharyngeal Oedema
This Hypersensitivity, Pharyngeal Oedema problem was reported by a pharmacist from US. A 61-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: psoriatic arthropathy. On Jan 28, 2013 this consumer started treatment with Kadian (watson Laboratories) (dosage: 100 Mg, Bid). The following drugs were being taken at the same time: NA. When commencing Kadian (watson Laboratories), the patient experienced the following unwanted symptoms/side effects:
  • Hypersensitivity
  • Pharyngeal Oedema
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hypersensitivity, may become evident only after a product is in use by the general population.

Completed Suicide
This is a report of a 29-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Kadian (dosage: NA) starting NS. Concurrently used drugs:
  • Amitriptyline
  • Trazodone
Soon after that, the consumer experienced the following side effects:
  • Completed Suicide
This opens a possibility that Kadian treatment could cause the above reactions, including completed suicide, and some male subjects may be more susceptible.



A 54-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Kadian treatment (dosage: NA) on NS. Soon after starting Kadian treatment, the subject experienced various side effects, including:
    Concurrently used drugs:
    • Heroin
    • Ethanol
    • Laxative (stimulant)
    • Quetiapine
    This finding indicates that some male patients could be more vulnerable to Kadian.


    A 33-year-old female patient from US (weight: NA) experienced symptoms, such as: NA and was treated with Kadian(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
      Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Kadian efficacy:
      • Lorazepam


      Completed Suicide
      In this report, Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) was administered for the following condition: NA.A 19-year-old male consumer from US (weight: NA) started Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) treatment (dosage: Par) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
      • Completed Suicide
      A possible interaction with other drugs could have contributed to this reaction:
      • Heroin (Par)
      • Lorazepam (Par)
      • Diazepam (Par)
      • Diphenhydramine (Par)
      Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) treatment could be related to the listed above side effect(s).

      Aspiration
      This is a report of the following Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) side effect(s):
      • Aspiration
      A 27-year-old female patient from US (weight: NA) presented with the following condition: NA and received a treatment with Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) treatment could be associated with the listed above side effect(s).


      This Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) report was submitted by a 28-year-old male consumer from US (weight: NA). The patient was diagnosed with: NA and Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
        Other drugs used simultaneously:
        • Clonazepam
        • Clomipramine
        Those unexpected symptoms could be linked to a Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.


        This is a report of a possible correlation between Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) use and the following symptoms/side effect(s):
          which could contribute to an assessment of Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) risk profile.A 27-year-old male consumer from US (weight: NA) was suffering from NA and was treated with Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) (dosage: NA) starting NS.Other concurrent medications:
          • Hydromorphone
          • Oxazepam
          • Temazepam
          • Alprazolam Tablets Usp, 2 Mg (purepac) (alprazolam)
          • Cannabis Sativa Subsp. Indica Top



          A 40-year-old female patient from US (weight: NA) presented with the following symptoms: NA and after a treatment with Kadian (dosage: NA) experienced the following side effect(s):
            The treatment was started on NS. Kadian was used in combination with the following drugs: NA.This report could alert potential Kadian consumers.

            Completed Suicide
            In this report, a 47-year-old female patient from US (weight: NA) was affected by a possible Kadian side effect.The patient was diagnosed with NA. After a treatment with Kadian (dosage: NA, start date: NS), the patient experienced the following side effect(s):
            • Completed Suicide
            The following simultaneously used drugs could have led to this reaction:
            • Diazepam Tablets Usp, 10 Mg (purepac) (diazepam)
            The findings here stress that side effects should be taken into consideration when evaluating a Kadian treatment.


            This is a report of a 36-year-old female patient from US (weight: NA), who used Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc) (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
              The following drugs could possibly have interacted with the Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc) treatment
              • Acetaminophen + Codeine Phosphate
              • Oxycodone Hcl
              Taken together, these observations suggest that a Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc) treatment could be related to side effect(s), such as .


              This death side effect was reported by a physician from US. A 36-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Kadian (dosage: NA), which was started on NS. Concurrently used drugs:
              • Tramadol Hydrochloride
              • Risperidone
              • Quetiapine
              • Skeletal Muscle Relaxant
              • Alprazolam Tablets Usp, 2 Mg (purepac) (alprazolam)
              • Hydromorphone
              When starting to take Kadian the consumer reported the following symptoms:
                These side effects may potentially be related to Kadian.


                This is a Kadian side effect report of a 34-year-old male patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Kadian (dosage:NA, start time: NS), combined with:
                • Oxycodone Hcl
                • Alprazolam
                , and developed a serious reaction and a death side effect. The patient presented with:
                  which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Kadian treatment in male patients suffering from NA, resulting in death.


                  This report suggests a potential Kadian death side effect(s) that can have serious consequences. A 31-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): NA and used Kadian (dosage: NA) starting NS. Soon after starting Kadian the patient began experiencing various side effects, including:
                    Drugs used concurrently:
                    • Methadone
                    • Benzodiazepine
                    Although Kadian demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as death, may still occur.


                    This death problem was reported by a physician from US. A 39-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Kadian (dosage: NA). The following drugs/medications were being taken at the same time:
                    • Alprazolam Tablets Usp, 2 Mg (purepac) (alprazolam)
                    • Paroxetine
                    When commencing Kadian, the patient experienced the following unwanted symptoms /side effects:
                      Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as death, may become evident only after a product is in use by the general population.

                      Completed Suicide
                      This is a Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) side effect report of a 37-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) (dosage: NA) starting NS. Concurrently used drugs:
                      • Oxycodone Hcl Tablets, Usp, 30 Mg (amide)
                      Soon after that, the consumer experienced the following of symptoms:
                      • Completed Suicide
                      This opens a possibility that Kadian (morphine Sulfate Extended-release) Capsules 80mg (aellc) could cause completed suicide and that some male patients may be more susceptible.

                      Abdominal Pain, Throat Irritation, Haemoglobin Increased, Haematocrit Increased, International Normalised Ratio Increased, Cardiac Arrest, Tracheal Injury, Gastrointestinal Injury
                      A 53-year-old female patient (weight: NA) from US with the following symptoms: NA started Kadian treatment (dosage: ; Unk; Unk) on NS. Soon after starting Kadian treatment, the consumer experienced several side effects, including:
                      • Abdominal Pain
                      • Throat Irritation
                      • Haemoglobin Increased
                      • Haematocrit Increased
                      • International Normalised Ratio Increased
                      • Cardiac Arrest
                      • Tracheal Injury
                      • Gastrointestinal Injury
                      . Concurrently used drugs:
                      • Clonazepam (; Unk; Unk)
                      • Compound Containing Nitric Acid, Selenium And Copper Compounds (; 6-7 Ounces;)
                      • Cocaine (; Unk; Unk)
                      The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Kadian side effects, such as abdominal pain.

                      Agitation, Delirium, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Blood Creatine Phosphokinase Increased, International Normalised Ratio Increased, Platelet Count Decreased, Blood Alcohol Increased
                      This agitation side effect was reported by a physician from US. A 34-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc) (dosage: ; Unk; Unk), which was started on NS. Concurrently used drugs:
                      • Amphetamines (synthetic Stimulant) (; Unk; Unk)
                      • Oxycodone (; Unk; Unk)
                      • Lorazepam (; Unk; Unk)
                      .When starting to take Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc) the consumer reported symptoms, such as:
                      • Agitation
                      • Delirium
                      • Aspartate Aminotransferase Increased
                      • Alanine Aminotransferase Increased
                      • Blood Creatine Phosphokinase Increased
                      • International Normalised Ratio Increased
                      • Platelet Count Decreased
                      • Blood Alcohol Increased
                      These side effects may potentially be related to Kadian (morphine Sulfate Extended-release) Capsules 80 Mg (aellc). The patient was hospitalized.

                      Completed Suicide
                      This is a report of a 51-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Kadian (dosage: NA, start time: NS), combined with:
                      • Tramadol Hydrochloride Tablets
                      • Quetiapine
                      • Etodolac
                      • Lipozene
                      and developed a serious reaction and side effect(s). The consumer presented with:
                      • Completed Suicide
                      which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Kadian treatment in female patients, resulting in completed suicide side effect.


                      This report suggests a potential Kadian side effect(s) that can have serious consequences. A 49-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Kadian (dosage: ; Unk; Unk) starting NS. Soon after starting Kadian the patient began experiencing various side effects, including:
                        Drugs used concurrently:
                        • Ethanol (; Unk; Po)
                        • Heroin (; Unk; Unk)
                        Although Kadian demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as death, may still occur.


                        This problem was reported by a physician from US. A 2-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Kadian (dosage: ; Unk; Unk). The following drugs were being taken at the same time: NA. When commencing Kadian, the patient experienced the following unwanted symptoms/side effects:
                          Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as death, may become evident only after a product is in use by the general population.

                          Completed Suicide
                          This is a report of a 33-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Kadian (dosage: NA) starting NS. Concurrently used drugs:
                          • Beta Blocker
                          • Lorazepam
                          • Acetaminophen\hydrocodone
                          • Clonazepam Tablets, Usp
                          • Raloxifene
                          Soon after that, the consumer experienced the following side effects:
                          • Completed Suicide
                          This opens a possibility that Kadian treatment could cause the above reactions, including completed suicide, and some male subjects may be more susceptible.

                          Completed Suicide
                          A 71-year-old male patient (weight: NA) from US with the following symptoms/conditions: NA started Kadian treatment (dosage: NA) on NS. Soon after starting Kadian treatment, the subject experienced various side effects, including:
                          • Completed Suicide
                          Concurrently used drugs:
                          • Lisinopril
                          This finding indicates that some male patients could be more vulnerable to Kadian.

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                          Keep Track of Side Effects

                          Note Your Observations

                          It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

                          Why Your Notes are Important

                          Your notes could be helpful in several ways:

                        • You can use them to remind you of details that may alert your health care professional(s) to a problem
                        • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

                        • Log Form

                          You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

                          Medicine Name and Dosage:
                          Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
                          Scale: 1 = very mild to 10 = very bad

                          You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


                          Discuss Kadian Side Effects

                          Did You Have a Kadian Side Effect?

                          Yes, Severe
                          Yes, Moderate
                          Yes, Minor
                          No

                          How Effective is Kadian for You?

                          Exceeded Expectations
                          Effective
                          Somewhat Effective
                          Not Effective

                          Kadian Safety Alerts, Active Ingredients, Usage Information

                          NDC16590-598
                          TypeHUMAN PRESCRIPTION DRUG
                          Proprietary NameKADIAN
                          NameMORPHINE SULFATE
                          Dosage FormCAPSULE, EXTENDED RELEASE
                          RouteORAL
                          On market since20090407
                          LabelerSTAT RX USA LLC
                          Active Ingredient(s)MORPHINE SULFATE
                          Strength(s)60
                          Unit(s)mg/1
                          Pharma ClassFull Opioid Agonists [MoA],Opioid Agonist [EPC]

                          Kadian Dosage, Warnings, Usage.

                          Side Effects reported to FDA: 208

                          Kadian safety alerts: No

                          Reported deaths: 109

                          Reported hospitalizations: 80

                          Latest Kadian clinical trials