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Leponex Side Effects

Common Leponex Side Effects


The most commonly reported Leponex side effects (click to view or check a box to report):

Pyrexia (104)
C-reactive Protein Increased (65)
White Blood Cell Count Increased (50)
White Blood Cell Count Decreased (49)
Somnolence (49)
Fall (46)
Neutropenia (45)
Leukopenia (43)
Salivary Hypersecretion (41)
Agranulocytosis (40)
Neutrophil Count Decreased (39)
Fatigue (36)
Infection (35)
Agitation (35)
Tachycardia (34)
Confusional State (32)
Alanine Aminotransferase Increased (31)
Constipation (31)
Haemoglobin Decreased (31)
Heart Rate Increased (29)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Leponex Side Effects Reported to FDA

The following Leponex reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Leponex on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Kidney Fibrosis, Renal Tubular Atrophy, Nephrogenic Diabetes Insipidus, Gait Disturbance, Fall, Dysarthria, Aphasia
This is a report of a 39-year-old male patient (weight: NA) from CH, suffering from the following symptoms/conditions: NA, who was treated with Leponex (dosage: 3 Df, Qd, start time: 2003), combined with:
  • Priadel (1 Df, Qd)
  • Bilol (Unk)
  • Temesta (Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Kidney Fibrosis
  • Renal Tubular Atrophy
  • Nephrogenic Diabetes Insipidus
  • Gait Disturbance
  • Fall
  • Dysarthria
  • Aphasia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in kidney fibrosis side effect. The patient was hospitalized.

Pyelonephritis, C-reactive Protein Increased, Pyrexia, White Blood Cell Count Increased, Urinary Tract Infection, Eosinophilia, Sinus Tachycardia, Palpitations, Heart Rate Increased
This report suggests a potential Leponex Pyelonephritis, C-reactive Protein Increased, Pyrexia, White Blood Cell Count Increased, Urinary Tract Infection, Eosinophilia, Sinus Tachycardia, Palpitations, Heart Rate Increased side effect(s) that can have serious consequences. A 69-year-old female patient (weight: NA) from COUNTRY NOT SPECIFIED was diagnosed with the following symptoms/conditions: NA and used Leponex (dosage: 75 Mg, Qd) starting Jan 24, 2014. Soon after starting Leponex the patient began experiencing various side effects, including:
  • Pyelonephritis
  • C-reactive Protein Increased
  • Pyrexia
  • White Blood Cell Count Increased
  • Urinary Tract Infection
  • Eosinophilia
  • Sinus Tachycardia
  • Palpitations
  • Heart Rate Increased
Drugs used concurrently: NA. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pyelonephritis, may still occur.

Viral Infection, C-reactive Protein Decreased, Nasopharyngitis, White Blood Cell Count Decreased, Neutrophil Count Decreased
This Viral Infection, C-reactive Protein Decreased, Nasopharyngitis, White Blood Cell Count Decreased, Neutrophil Count Decreased problem was reported by a consumer or non-health professional from COUNTRY NOT SPECIFIED. A 23-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: schizophrenia. On 201310 this consumer started treatment with Leponex (dosage: Unk). The following drugs were being taken at the same time: NA. When commencing Leponex, the patient experienced the following unwanted symptoms/side effects:
  • Viral Infection
  • C-reactive Protein Decreased
  • Nasopharyngitis
  • White Blood Cell Count Decreased
  • Neutrophil Count Decreased
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as viral infection, may become evident only after a product is in use by the general population.

Schizophrenia
This is a report of a 38-year-old female patient (weight: NA) from JP. The patient developed the following symptoms/conditions: NA and was treated with Leponex / Clozaril (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Schizophrenia
This opens a possibility that Leponex / Clozaril treatment could cause the above reactions, including schizophrenia, and some female subjects may be more susceptible.


Suicide Attempt, Intentional Overdose
A 60-year-old male patient (weight: NA) from LT with the following symptoms/conditions: suicide attempt started Leponex treatment (dosage: Unk) on Dec 14, 2013. Soon after starting Leponex treatment, the subject experienced various side effects, including:
  • Suicide Attempt
  • Intentional Overdose
Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Leponex.

Depression, Contusion, Malaise, Psychiatric Symptom, Tension, Headache
A 53-year-old female patient from CL (weight: NA) experienced symptoms, such as: bipolar disorder,off label use,depression and was treated with Leponex(dosage: 50 Mg, Qd (at Night)). The treatment was initiated on 1998. After that a consumer reported the following side effect(s):
  • Depression
  • Contusion
  • Malaise
  • Psychiatric Symptom
  • Tension
  • Headache
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Leponex efficacy: NA.

Urosepsis
In this report, Leponex was administered for the following condition: schizophrenia, disorganised type.A 58-year-old male consumer from FI (weight: NA) started Leponex treatment (dosage: Unk) on 1991.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Urosepsis
A possible interaction with other drugs could have contributed to this reaction: NA.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Leponex treatment could be related to the listed above side effect(s).

Apparent Life Threatening Event, Haemorrhage, Pneumothorax, Hepatic Rupture, Hip Fracture, Abnormal Behaviour, Confusional State, Anxiety, Nerve Injury
This is a report of the following Leponex side effect(s):
  • Apparent Life Threatening Event
  • Haemorrhage
  • Pneumothorax
  • Hepatic Rupture
  • Hip Fracture
  • Abnormal Behaviour
  • Confusional State
  • Anxiety
  • Nerve Injury
A 40-year-old male patient from COUNTRY NOT SPECIFIED (weight: NA) presented with the following condition: schizophrenia and received a treatment with Leponex (dosage: 550 Mg Per Day) starting: 201402.The following concurrently used drugs could have generated interactions: NA.The patient was hospitalized.This report suggests that a Leponex treatment could be associated with the listed above side effect(s).

Gastroenteritis, Diarrhoea, Dehydration, Hypovolaemia, Rhabdomyolysis, Renal Failure, Hepatitis, Somnolence, Myocarditis
This Leponex report was submitted by a 60-year-old male consumer from FR (weight: NA). The patient was diagnosed with: schizophrenia and Leponex was administered (dosage: 450 Mg, Daily) starting: NS. The consumer developed a set of symptoms:
  • Gastroenteritis
  • Diarrhoea
  • Dehydration
  • Hypovolaemia
  • Rhabdomyolysis
  • Renal Failure
  • Hepatitis
  • Somnolence
  • Myocarditis
Other drugs used simultaneously:
  • Loxapac (12.5 Mg, In The Evening)
The patient was hospitalized.Those unexpected symptoms could be linked to a Leponex treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Chronic Sinusitis
This is a report of a possible correlation between Leponex / Clozaril use and the following symptoms/side effect(s):
  • Chronic Sinusitis
which could contribute to an assessment of Leponex / Clozaril risk profile.A 37-year-old male consumer from JP (weight: NA) was suffering from schizophrenia and was treated with Leponex / Clozaril (dosage: Unk) starting Jan 21, 2014.Other concurrent medications: NA.

Delusion, Foreign Body, Suicide Attempt
A 40-year-old male patient from JP (weight: NA) presented with the following symptoms: schizophrenia, paranoid type and after a treatment with Leponex / Clozaril (dosage: 12.5 Mg, Daily) experienced the following side effect(s):
  • Delusion
  • Foreign Body
  • Suicide Attempt
The treatment was started on Aug 01, 2013. Leponex / Clozaril was used in combination with the following drugs: NA.This report could alert potential Leponex / Clozaril consumers.

Convulsion, Heart Rate Increased, Body Temperature Decreased
In this report, a 39-year-old female patient from JP (weight: NA) was affected by a possible Leponex / Clozaril side effect.The patient was diagnosed with schizophrenia, paranoid type. After a treatment with Leponex / Clozaril (dosage: 12.5 Mg, Daily, start date: Jan 11, 2011), the patient experienced the following side effect(s):
  • Convulsion
  • Heart Rate Increased
  • Body Temperature Decreased
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Leponex / Clozaril treatment.

Extrapyramidal Disorder
This is a report of a 75-year-old female patient from FR (weight: NA), who used Leponex (dosage: Unk) for a treatment of bipolar disorder. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Extrapyramidal Disorder
The following drugs could possibly have interacted with the Leponex treatment
  • Tazocilline (Unk)
  • Atrovent (Unk)
  • Doliprane (Unk)
  • Ventoline (Unk)
  • Inexium (Unk)
  • Aspegic (Unk)
The patient was hospitalized.Taken together, these observations suggest that a Leponex treatment could be related to side effect(s), such as Extrapyramidal Disorder.

Papule, Erythema, Erythema Annulare
This papule side effect was reported by a physician from JP. A 35-year-old female patient (weight:NA) experienced the following symptoms/conditions: schizophrenia. The patient was prescribed Leponex / Clozaril (dosage: 125 Mg, Daily), which was started on Sep 02, 2010. Concurrently used drugs: NA. When starting to take Leponex / Clozaril the consumer reported the following symptoms:
  • Papule
  • Erythema
  • Erythema Annulare
These side effects may potentially be related to Leponex / Clozaril.

Embolism, Psychotic Disorder, Aggression
This is a Leponex side effect report of a female patient (weight:NA) from DE, suffering from the following symptoms/conditions: psychotic disorder, who was treated with Leponex (dosage:Unk, start time: Dec 17, 2013), combined with:
  • Lorazepam (4 Mg, 1 Df Qd)
, and developed a serious reaction and a embolism side effect. The patient presented with:
  • Embolism
  • Psychotic Disorder
  • Aggression
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Leponex treatment in female patients suffering from psychotic disorder, resulting in embolism.

Acute Myeloid Leukaemia
This report suggests a potential Leponex acute myeloid leukaemia side effect(s) that can have serious consequences. A 48-year-old male patient from SY (weight:NA) was diagnosed with the following health condition(s): NA and used Leponex (dosage: 100 Mg, Qd) starting NS. Soon after starting Leponex the patient began experiencing various side effects, including:
  • Acute Myeloid Leukaemia
Drugs used concurrently:NA. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as acute myeloid leukaemia, may still occur.

Pyelonephritis, Neutropenia, Leukopenia, Pyrexia, Dysphonia, Tearfulness, Emotional Distress, Panic Disorder, Hiatus Hernia
This pyelonephritis problem was reported by a health professional from FI. A 64-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): schizophrenia.On NS a consumer started treatment with Leponex (dosage: 700 Mg, Daily (3 X100 Mg + 4 X100 Mg)). The following drugs/medications were being taken at the same time: NA. When commencing Leponex, the patient experienced the following unwanted symptoms /side effects:
  • Pyelonephritis
  • Neutropenia
  • Leukopenia
  • Pyrexia
  • Dysphonia
  • Tearfulness
  • Emotional Distress
  • Panic Disorder
  • Hiatus Hernia
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as pyelonephritis, may become evident only after a product is in use by the general population.

Coma
This is a Leponex side effect report of a 58-year-old male patient (weight: NA) from CH. The patient developed the following symptoms/conditions: bipolar i disorder and was treated with Leponex (dosage: NA) starting Nov 09, 2013. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Coma
The patient was hospitalized. This opens a possibility that Leponex could cause coma and that some male patients may be more susceptible.

Appendicitis
A 42-year-old female patient (weight: NA) from JP with the following symptoms: schizophrenia started Leponex / Clozaril treatment (dosage: 12.5 Mg, Daily) on Jan 11, 2014. Soon after starting Leponex / Clozaril treatment, the consumer experienced several side effects, including:
  • Appendicitis
. Concurrently used drugs: NA.The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Leponex / Clozaril side effects, such as appendicitis.

Appendicitis
This appendicitis side effect was reported by a physician from JP. A 42-year-old female patient (weight:NA) experienced the following symptoms/conditions: schizophrenia.The patient was prescribed Leponex / Clozaril (dosage: Unk Ukn, Unk), which was started on Jan 11, 2014. Concurrently used drugs: NA..When starting to take Leponex / Clozaril the consumer reported symptoms, such as:
  • Appendicitis
These side effects may potentially be related to Leponex / Clozaril. The patient was hospitalized.

Extrapyramidal Disorder, Agitation
This is a report of a 66-year-old male patient (weight: NA) from FR, suffering from the following symptoms/conditions: abnormal behaviour, who was treated with Leponex (dosage: 50 Mg, Qd (progressive Dose Increase Starting With Of 50 Mg Once A Day ), start time: Jan 23, 2013), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Extrapyramidal Disorder
  • Agitation
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Leponex treatment in male patients, resulting in extrapyramidal disorder side effect. The patient was hospitalized.

Pericarditis, Myocarditis
This report suggests a potential Leponex Pericarditis, Myocarditis side effect(s) that can have serious consequences. A 60-year-old male patient (weight: NA) from DE was diagnosed with the following symptoms/conditions: NA and used Leponex (dosage: 25- 200 Mg, Qd) starting Jan 08, 2013. Soon after starting Leponex the patient began experiencing various side effects, including:
  • Pericarditis
  • Myocarditis
Drugs used concurrently:
  • Falithrom (Unk Ukn, Unk)
  • Valproic Acid (900 Mg, Unk)
  • Vitamin B Complex /00003501/ (1 Df, Unk)
  • Folsan (5 Mg, Unk)
The patient was hospitalized. Although Leponex demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pericarditis, may still occur.

Dementia With Lewy Bodies, Extrapyramidal Disorder, Libido Increased, Hot Flush, Libido Decreased, Sensory Disturbance
This Dementia With Lewy Bodies, Extrapyramidal Disorder, Libido Increased, Hot Flush, Libido Decreased, Sensory Disturbance problem was reported by a consumer or non-health professional from FR. A 63-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: dementia. On Aug 27, 2013 this consumer started treatment with Leponex (dosage: 50 Mg, Qd). The following drugs were being taken at the same time: NA. When commencing Leponex, the patient experienced the following unwanted symptoms/side effects:
  • Dementia With Lewy Bodies
  • Extrapyramidal Disorder
  • Libido Increased
  • Hot Flush
  • Libido Decreased
  • Sensory Disturbance
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as dementia with lewy bodies, may become evident only after a product is in use by the general population.

Renal Disorder, Epididymitis, Scrotal Swelling, Balanoposthitis, Renal Impairment, Pneumonia, Pyrexia, Haemoglobin Decreased, Haematocrit Decreased
This is a report of a 53-year-old male patient (weight: NA) from JP. The patient developed the following symptoms/conditions: schizophrenia and was treated with Leponex / Clozaril (dosage: 12.5 Mg, Daily) starting Mar 11, 2013. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Renal Disorder
  • Epididymitis
  • Scrotal Swelling
  • Balanoposthitis
  • Renal Impairment
  • Pneumonia
  • Pyrexia
  • Haemoglobin Decreased
  • Haematocrit Decreased
The patient was hospitalized. This opens a possibility that Leponex / Clozaril treatment could cause the above reactions, including renal disorder, and some male subjects may be more susceptible.

Urinary Tract Infection, C-reactive Protein Increased, White Blood Cell Count Increased, Pneumonia Aspiration, Blood Creatine Phosphokinase Increased, Myoclonus, Asthenia, Constipation
A 46-year-old female patient (weight: NA) from JP with the following symptoms/conditions: schizophrenia, paranoid type started Leponex / Clozaril treatment (dosage: 12.5 Mg, Daily) on Mar 01, 2013. Soon after starting Leponex / Clozaril treatment, the subject experienced various side effects, including:
  • Urinary Tract Infection
  • C-reactive Protein Increased
  • White Blood Cell Count Increased
  • Pneumonia Aspiration
  • Blood Creatine Phosphokinase Increased
  • Myoclonus
  • Asthenia
  • Constipation
Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Leponex / Clozaril.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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