LEUCOVORIN Side Effects

5706859-X | Anaphylactic Reaction, Enterocolitis, Myocardial Ischaemia, Neutropenia
on Apr 03, 2008 Male patient from JAPAN , weighting 149.9 lb, was diagnosed with rectal cancer, hypertension and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: anaphylactic reaction, enterocolitis, myocardial ischaemia, neutropenia. Leucovorin dosage: . During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), AZELNIDIPINE (View Azelnidipine Review and Azelnidipine Label ).

5591426-1 | Activities Of Daily Living Impaired, Neuropathy Peripheral
Patient was taking Leucovorin (View Usage). Patient had the following side effects: activities of daily living impaired, neuropathy peripheral on Jan 07, 2008 from UNITED STATES Additional patient health information: Female patient , 55 years of age, weighting 130.0 lb, was diagnosed with colon cancer and. Leucovorin dosage: . During the same period patient was treated with OXALIPLATIN (140 Mg Fortnightly Iv) (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), PREMPRO (View Prempro Review and Prempro Label ), PROPRANOLOL HYDROCHLORIDE (View Propranolol Hydrochloride Review and Propranolol Hydrochloride Label ), DIPHENHYDRAMINE HYDROCHLORIDE (View Diphenhydramine Hydrochloride Review and Diphenhydramine Hydrochloride Label ), DEXAMETHASONE TAB (View Dexamethasone Tab Review and Dexamethasone Tab Label ), PEGFILGRASTIM (View Pegfilgrastim Review and Pegfilgrastim Label ), DARBEPOETIN ALFA (View Darbepoetin Alfa Review and Darbepoetin Alfa Label ).

5571550-X | Activities Of Daily Living Impaired, Neuropathy, Neurotoxicity
Adverse event was reported on Dec 12, 2007 by a Female patient taking Leucovorin (View Usage) (Dosage: ) was diagnosed with colon cancer and. Location: UNITED STATES , 55 years of age, After Leucovorin was administered, patient had the following side effects: activities of daily living impaired, neuropathy, neurotoxicity. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ).

5502319-X | Pancytopenia, Pneumonia
on Oct 25, 2007 Female patient from EGYPT , weighting 143.3 lb, was diagnosed with colon cancer and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: pancytopenia, pneumonia (What is pneumonia?). Leucovorin dosage: . During the same period patient was treated with FLUOROURACIL (400 Mg/m2 Bolus Followed By 600 Mg/m2 Infusion) (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ). Patient was hospitalized.


5499636-9 | Scleroderma
on Oct 23, 2007 Male patient from KOREA, REPUBLIC OF , 72 years of age, was diagnosed with gastric cancer and was treated with Leucovorin (View Usage). Patient had the following side effects: scleroderma (What is scleroderma?). Leucovorin dosage: Unk. During the same period patient was treated with FLUOROURACIL (Unk) (View Fluorouracil Review and Fluorouracil Label ), ELOXATIN (View Eloxatin Review and Eloxatin Label ). Patient was hospitalized.

5481159-4 | Abdominal Infection, Acute Monocytic Leukaemia, Anaemia, Intestinal Obstruction, Post Procedural Haemorrhage, Post Procedural Infection, Sepsis, Wound Dehiscence
Patient was taking Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: abdominal infection, acute monocytic leukaemia, anaemia, intestinal obstruction, post procedural haemorrhage, post procedural infection, sepsis (What is sepsis?), wound dehiscence on Sep 27, 2007 from UNITED STATES Additional patient health information: Male patient , 43 years of age, was diagnosed with small intestine carcinoma and. Leucovorin dosage: 200 Mg/m2 Per _cycle. During the same period patient was treated with FLUOROURACIL (2400 Mg/m2 Per_cycle Other) (View Fluorouracil Review and Fluorouracil Label ), IRINOTECAN HCL (180 Mg/m2 Per_cycle) (View Irinotecan Hcl Review and Irinotecan Hcl Label ).

5467604-9 | Agitation, Anxiety, Haemolytic Anaemia, Pain, Recurrent Cancer
Adverse event was reported on Sep 17, 2007 by a Male patient taking Leucovorin (View Usage) (Dosage: ) was diagnosed with colon cancer and. Location: UNITED STATES , 63 years of age, Patient experienced the following unwanted or unexpected effects: agitation, anxiety (What is anxiety?), haemolytic anaemia, pain (What is pain?), recurrent cancer. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), ELOXATIN (View Eloxatin Review and Eloxatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), XELODA (View Xeloda Review and Xeloda Label ), OLANZAPINE (View Olanzapine Review and Olanzapine Label ). Patient was hospitalized.

5467276-3 |
on Sep 20, 2007 Female patient from PORTUGAL , weighting 130.1 lb, was diagnosed with neurological symptom and was treated with Leucovorin (View Usage). . Leucovorin dosage: . During the same period patient was treated with FLUOROURACIL (400 Mg/m?, Iv Bolus D1+d2 Followed By 5-fu 2400 Mg/m? Over 46-hour Continuous Infusion.) (View Fluorouracil Review and Fluorouracil Label ), OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), SR57746 (View Sr57746 Review and Sr57746 Label ).

5402210-3 | Agitation, Anxiety, Chromaturia, Haemolytic Anaemia, Pain
on Jul 19, 2007 Male patient from UNITED STATES , 63 years of age, was diagnosed with colon cancer and was treated with Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: agitation, anxiety (What is anxiety?), chromaturia, haemolytic anaemia, pain (What is pain?). Leucovorin dosage: . During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), ELOXATIN (View Eloxatin Review and Eloxatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), XELODA (View Xeloda Review and Xeloda Label ). Patient was hospitalized.

5096704-0 | Infection, Nausea, Pyrexia
Patient was taking Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: infection (What is infection?), nausea (What is nausea?), pyrexia on Aug 28, 2006 from GERMANY Additional patient health information: Male patient , 71 years of age, weighting 149.9 lb, was diagnosed with biliary neoplasm and. Leucovorin dosage: 25 Mg/m2 Daily Iv. During the same period patient was treated with FLUOROURACIL (375 Mg/m2 Daily Iv) (View Fluorouracil Review and Fluorouracil Label ), ASPIRIN (View Aspirin Review and Aspirin Label ). Patient was hospitalized.

5053112-6 | Diffuse Alveolar Damage, Dyspnoea
Adverse event was reported on Jul 11, 2006 by a Male patient taking Leucovorin (View Usage) (Dosage: ) was diagnosed with gastric cancer and. Location: KOREA, REPUBLIC OF , 75 years of age, Patient had the following side effects: diffuse alveolar damage, dyspnoea. During the same period patient was treated with OXALIPLATIN (View Oxaliplatin Review and Oxaliplatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

5033638-1 | Renal Failure
on Jun 21, 2006 Male patient from CZECH REPUBLIC , 72 years of age, weighting 191.8 lb, was diagnosed with colorectal cancer (What is colorectal cancer?) and was treated with Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: renal failure. Leucovorin dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), ELOXATIN (View Eloxatin Review and Eloxatin Label ). Patient was hospitalized.

5020739-7 | Ascites, Epistaxis, Fatigue, Haematocrit Decreased, Haemoglobin Decreased, Pallor, Petechiae, Productive Cough, Thrombocytopenia
on May 23, 2006 Female patient from GERMANY , 60 years of age, weighting 185.2 lb, was diagnosed with biliary neoplasm and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: ascites, epistaxis, fatigue, haematocrit decreased, haemoglobin decreased, pallor, petechiae, productive cough, thrombocytopenia. Leucovorin dosage: 25 Mg/m2 Daily Iv. During the same period patient was treated with FLUOROURACIL (375 Mg/m2 Daily Iv) (View Fluorouracil Review and Fluorouracil Label ), NAVOBAN (View Navoban Review and Navoban Label ). Patient was hospitalized.

5020459-9 | Hepatitis, Pancreatitis
Patient was taking Leucovorin (View Usage). Patient had the following side effects: hepatitis (What is hepatitis?), pancreatitis on May 22, 2006 from UNITED STATES Additional patient health information: Male patient , weighting 185.0 lb, was diagnosed with colon cancer and. Leucovorin dosage: . During the same period patient was treated with FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), ELOXATIN (View Eloxatin Review and Eloxatin Label ). Patient was hospitalized.

4778350-9 | Haematochezia, Haemoglobin Decreased, Haemorrhoids, Neuropathy, Platelet Count Decreased
Adverse event was reported on Sep 12, 2005 by a Female patient taking Leucovorin (View Usage) (Dosage: 400 Mg/m2 Once Iv) was diagnosed with colon cancer stage iii and. Location: UNITED STATES , 60 years of age, After Leucovorin was administered, patient had the following side effects: haematochezia, haemoglobin decreased, haemorrhoids, neuropathy, platelet count decreased. During the same period patient was treated with FLUOROURACIL (400 Mg/m2 Once Iv) (View Fluorouracil Review and Fluorouracil Label ), CETUXIMAB (400 Mg/m2 Once Iv) (View Cetuximab Review and Cetuximab Label ), OXALIPLATIN (85 Mg/m2 Once Iv) (View Oxaliplatin Review and Oxaliplatin Label ), NEURONTIN (View Neurontin Review and Neurontin Label ). Patient was hospitalized.

4750114-1 | Abdominal Distension, Abdominal Pain, Anorexia, Diarrhoea, Diverticulitis, Gallbladder Disorder, Gastrointestinal Disorder, Mucosal Inflammation, Pancytopenia
on Aug 18, 2005 Male patient from UNITED STATES , weighting 215.8 lb, was diagnosed with gastric cancer and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: abdominal distension, abdominal pain (What is abdominal pain?), anorexia, diarrhoea, diverticulitis, gallbladder disorder, gastrointestinal disorder, mucosal inflammation, pancytopenia. Leucovorin dosage: See Image. During the same period patient was treated with FLUOROURACIL (See Image) (View Fluorouracil Review and Fluorouracil Label ). Patient was hospitalized.

4714319-8 | Erythema, Flushing, Hypersensitivity, Oedema Peripheral, Pruritus, Urticaria
on May 10, 2005 Male patient from UNITED STATES , 49 years of age, weighting 187.0 lb, was diagnosed with rectal cancer stage iv and was treated with Leucovorin (View Usage). Patient had the following side effects: erythema, flushing, hypersensitivity, oedema peripheral, pruritus, urticaria. Leucovorin dosage: 350 Milligram Intravenous (nos). During the same period patient was treated with ELOXATIN (150 Milligram Intravenous (nos)) (View Eloxatin Review and Eloxatin Label ), FLUOROURACIL (View Fluorouracil Review and Fluorouracil Label ), DEXAMETHASONE (View Dexamethasone Review and Dexamethasone Label ), ZOFRAN (View Zofran Review and Zofran Label ).

4713483-4 | Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Bilirubin Increased, Diarrhoea, Hepatic Function Abnormal
Patient was taking Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, diarrhoea, hepatic function abnormal on Jun 20, 2005 from JAPAN Additional patient health information: Female patient , 37 years of age, was diagnosed with colon cancer and. Leucovorin dosage: 75 Mg Po. During the same period patient was treated with UFT (600 Mg Po) (View Uft Review and Uft Label ), METOCLOPRAMIDE (View Metoclopramide Review and Metoclopramide Label ), FAMOTIDINE (View Famotidine Review and Famotidine Label ). Patient was hospitalized.

4700470-5 | Oesophagitis
Adverse event was reported on Jun 09, 2005 by a Male patient taking Leucovorin (View Usage) (Dosage: 75 Mg, Po) was diagnosed with colon cancer, parkinson's disease (What is parkinson's disease?), hypertension and. Location: , 70 years of age, Patient experienced the following unwanted or unexpected effects: oesophagitis. During the same period patient was treated with CABERGOLINE (2 Mg, Po) (View Cabergoline Review and Cabergoline Label ), CARBIDOPA AND LEVODOPA (200 Mg, Po) (View Carbidopa And Levodopa Review and Carbidopa And Levodopa Label ), AMLODIPINE BESYLATE (5 Mg, Po) (View Amlodipine Besylate Review and Amlodipine Besylate Label ), TEGAGUR URACIL (500 Mg, Po) (View Tegagur Uracil Review and Tegagur Uracil Label ). Patient was hospitalized.

4699010-9 | Bacteria Stool Identified, Chills, Dehydration, Post Procedural Diarrhoea
on Jun 23, 2005 Male patient from , weighting 176.4 lb, was diagnosed with adenocarcinoma, gastrooesophageal cancer and was treated with Leucovorin (View Usage). Patient had the following side effects: bacteria stool identified, chills, dehydration, post procedural diarrhoea. Leucovorin dosage: 20 Mg/m2. During the same period patient was treated with FLUOROURACIL (425 Mg/m2 Cycle) (View Fluorouracil Review and Fluorouracil Label ), ZITHROMYCIN (View Zithromycin Review and Zithromycin Label ). Patient was hospitalized.

4698662-7 | Musculoskeletal Stiffness, Myalgia, Neck Pain
on Jun 06, 2005 Female patient from , 51 years of age, was diagnosed with colon cancer stage iii and was treated with Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: musculoskeletal stiffness, myalgia, neck pain. Leucovorin dosage: 400 Mg/m2 Daily Iv. During the same period patient was treated with FLUOROURACIL (2400/mg/m2 Daily Iv) (View Fluorouracil Review and Fluorouracil Label ), IRINOTECAN (180 Mg/m2 Daily Iv) (View Irinotecan Review and Irinotecan Label ). Patient was hospitalized.

4684938-6 | Decreased Appetite, Dehydration, Diarrhoea, Sepsis, Vomiting, White Blood Cell Count Decreased
Patient was taking Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: decreased appetite, dehydration, diarrhoea, sepsis (What is sepsis?), vomiting, white blood cell count decreased on May 18, 2005 from Additional patient health information: Female patient , 70 years of age, was diagnosed with colon cancer and. Leucovorin dosage: Po. During the same period patient was treated with TEGAFUR URACIL (500 Mg Po) (View Tegafur Uracil Review and Tegafur Uracil Label ), AMLODIPINE BESYLATE (View Amlodipine Besylate Review and Amlodipine Besylate Label ), ISOSORBIDE MONONITRATE (View Isosorbide Mononitrate Review and Isosorbide Mononitrate Label ).

4681208-7 | Gastric Cancer, Gastric Outlet Obstruction
Adverse event was reported on Jun 02, 2005 by a Male patient taking Leucovorin (View Usage) (Dosage: Ivp 20 Mg/m2 On Days 1 Through 5) . Location: , weighting 232.4 lb, Patient had the following side effects: gastric cancer, gastric outlet obstruction. During the same period patient was treated with COUMADIN (View Coumadin Review and Coumadin Label ), PERCOCET (View Percocet Review and Percocet Label ), REGLAN (View Reglan Review and Reglan Label ), COMPAZINE (View Compazine Review and Compazine Label ).

4677739-6 | Autoimmune Hepatitis, Condition Aggravated
on May 17, 2005 Female patient from , 58 years of age, was diagnosed with colon cancer and was treated with Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: autoimmune hepatitis, condition aggravated. Leucovorin dosage: 75 Mg. During the same period patient was treated with TEGAFUR URACIL (500 Mg) (View Tegafur Uracil Review and Tegafur Uracil Label ), PREDNISONE (View Prednisone Review and Prednisone Label ), ROXATIDINE ACETATE HCL (View Roxatidine Acetate Hcl Review and Roxatidine Acetate Hcl Label ), CALCITRIOL (View Calcitriol Review and Calcitriol Label ), URSODEOXYCHOLIC ACID (View Ursodeoxycholic Acid Review and Ursodeoxycholic Acid Label ).

4669116-9 | Abdominal Pain, Diarrhoea
on Jun 14, 2004 Female patient from , 71 years of age, was diagnosed with colon cancer and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: abdominal pain (What is abdominal pain?), diarrhoea. Leucovorin dosage: 75 Mg. During the same period patient was treated with TEGAFUR URACIL (200 Mg) (View Tegafur Uracil Review and Tegafur Uracil Label ).

4613825-4 | Neutrophil Count Decreased
Patient was taking Leucovorin (View Usage). Patient had the following side effects: neutrophil count decreased on Feb 09, 2004 from Additional patient health information: Female patient , 61 years of age, was diagnosed with neoplasm malignant and. Leucovorin dosage: 15 Mg. During the same period patient was treated with TEGAFUR URACIL (600 Mg) (View Tegafur Uracil Review and Tegafur Uracil Label ), TOPOTECAN (180 Mg) (View Topotecan Review and Topotecan Label ).

4613818-7 | Pyrexia
Adverse event was reported on Jan 12, 2004 by a Male patient taking Leucovorin (View Usage) (Dosage: 15 Mg) . Location: , 49 years of age, After Leucovorin was administered, patient had the following side effects: pyrexia. During the same period patient was treated with VITAMIN B12 (View Vitamin B12 Review and Vitamin B12 Label ), SPIRONOLACTONE (View Spironolactone Review and Spironolactone Label ). Patient was hospitalized.

4613809-6 | Granulocytopenia
on May 19, 2004 Female patient from , 32 years of age, was diagnosed with deficiency anaemia, toxoplasmosis and was treated with Leucovorin (View Usage). Patient experienced the following unwanted or unexpected effects: granulocytopenia. Leucovorin dosage: Po. During the same period patient was treated with PYRIMETHAMINE (50 M G Po) (View Pyrimethamine Review and Pyrimethamine Label ), SULFADIAZINE (4 G Po) (View Sulfadiazine Review and Sulfadiazine Label ), ZIDOVUDINE (View Zidovudine Review and Zidovudine Label ), NEVIRAPINE (View Nevirapine Review and Nevirapine Label ), LAMIVUDINE (View Lamivudine Review and Lamivudine Label ). Patient was hospitalized.

4613287-7 | Angiopathy, Pyramidal Tract Syndrome, Upper Motor Neurone Lesion, Urinary Retention
on Jun 03, 2004 Male patient from , 72 years of age, was diagnosed with colon cancer and was treated with Leucovorin (View Usage). Patient had the following side effects: angiopathy, pyramidal tract syndrome, upper motor neurone lesion, urinary retention. Leucovorin dosage: Po. During the same period patient was treated with FLUOROURACIL (Iv) (View Fluorouracil Review and Fluorouracil Label ), UFT (View Uft Review and Uft Label ), FUROSEMIDE (View Furosemide Review and Furosemide Label ), LOSARTAN POTASSIUM (View Losartan Potassium Review and Losartan Potassium Label ), RILMENIDINE (View Rilmenidine Review and Rilmenidine Label ), CYCLOSPORINE (View Cyclosporine Review and Cyclosporine Label ), SERENOA REPENS (View Serenoa Repens Review and Serenoa Repens Label ), PRAVASTATIN (View Pravastatin Review and Pravastatin Label ).

4602940-7 | Alanine Aminotransferase Increased, Anorexia, Aspartate Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Liver Disorder, Malaise
Patient was taking Leucovorin (View Usage). After Leucovorin was administered, patient had the following side effects: alanine aminotransferase increased, anorexia, aspartate aminotransferase increased, blood lactate dehydrogenase increased, liver disorder, malaise on Feb 18, 2005 from Additional patient health information: Female patient , 57 years of age, was diagnosed with rectosigmoid cancer and. Leucovorin dosage: 75 Mg Qd. During the same period patient was treated with TEGAFUR URACIL (400 Mg Qd) (View Tegafur Uracil Review and Tegafur Uracil Label ).

4597550-4 | Abdominal Pain, Anorexia, Biliary Dilatation, Dehydration, Diarrhoea, Hepatitis, Lymphopenia, Muscular Weakness, Nausea
Adverse event was reported on Feb 28, 2005 by a Female patient taking Leucovorin (View Usage) (Dosage: 500 Mg /m2 Iv Over 2 Hours On Day 1 Weekly X 6 , Every 8 Weeks For 3 Cycles) . Location: , weighting 106.0 lb, Patient experienced the following unwanted or unexpected effects: abdominal pain (What is abdominal pain?), anorexia, biliary dilatation, dehydration, diarrhoea, hepatitis (What is hepatitis?), lymphopenia, muscular weakness, nausea (What is nausea?). During the same period patient was treated with FLUOROURACIL (500 Mg/m2 Iv Bolus On Day 1 Weekly X 6, Every 8 Weeks For 3 Cycles) (View Fluorouracil Review and Fluorouracil Label ).

4546683-7 | Infective Spondylitis
on Dec 22, 2004 Female patient from , 77 years of age, was diagnosed with metastases to liver, metastases to lung, rectal cancer and was treated with Leucovorin (View Usage). Patient had the following side effects: infective spondylitis. Leucovorin dosage: 75 Mg Po. During the same period patient was treated with TEGAFUR URACIL (Po) (View Tegafur Uracil Review and Tegafur Uracil Label ), ENZYMES NOS (View Enzymes Nos Review and Enzymes Nos Label ). Patient was hospitalized.