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Loxonin Side Effects

Common Loxonin Side Effects


The most commonly reported Loxonin side effects (click to view or check a box to report):

Hepatic Function Abnormal (15)
Pyrexia (14)
Interstitial Lung Disease (13)
Renal Failure Acute (12)
Aspartate Aminotransferase Increased (11)
Nausea (10)
Blood Creatinine Increased (10)
Blood Urea Increased (9)
Decreased Appetite (9)
Dizziness (9)
Rash (9)
Renal Impairment (8)
Blood Creatine Phosphokinase Increased (8)
Blood Lactate Dehydrogenase Increased (8)
Blood Alkaline Phosphatase Increased (7)
Somnolence (7)
Pneumonia (7)
Gait Disturbance (6)
Platelet Count Decreased (6)
Malaise (6)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Loxonin Side Effects Reported to FDA

The following Loxonin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Loxonin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Rash
This is a report of a 48-year-old male patient (weight: NA) from JP, suffering from the following symptoms/conditions: prophylaxis, who was treated with Loxonin (dosage: Unk Unk, Prn, start time: Mar 16, 2012), combined with:
  • Mucosta (Unk Unk, Prn)
  • Zyloric (200 Mg, Qd)
  • Evamyl (As Needed)
  • Zyloric (100 Mg, Qd)
  • Peginterferon Alfa-2b (1.05 ?g/kg/week)
  • Rebetol (600 Mg, Qd)
  • Telavic (2250 Mg, Qd)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Rash
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Loxonin treatment in male patients, resulting in rash side effect.

White Blood Cell Count Decreased, Haemoglobin Decreased
This report suggests a potential Loxonin White Blood Cell Count Decreased, Haemoglobin Decreased side effect(s) that can have serious consequences. A 66-year-old female patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: NA and used Loxonin (dosage: 60 Mg, Prn) starting Feb 22, 2012. Soon after starting Loxonin the patient began experiencing various side effects, including:
  • White Blood Cell Count Decreased
  • Haemoglobin Decreased
Drugs used concurrently:
  • Vx-950 (telaprevir) (2250 Mg, Qd)
  • Vx-950 (telaprevir) (1500 Mg, Qd)
  • Rebetol (600 Mg, Qd)
  • Rebetol (400 Mg, Qd)
  • Rebetol (200 Mg, Qd)
  • Pegintron /01543001/ (1.5 ?g/kg, Qw)
Although Loxonin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as white blood cell count decreased, may still occur.

Respiratory Arrest, Heart Rate Decreased, Somnolence
This Respiratory Arrest, Heart Rate Decreased, Somnolence problem was reported by a physician from JAPAN. A 80-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Sep 01, 2008 this consumer started treatment with Loxonin (dosage: Unk). The following drugs were being taken at the same time:
  • Hypen /00613801/ (Unk)
  • Risedronate Sodium (Unk)
  • Tizanidine Hydrochloride (Unk)
  • Buprenorphine (5 Mcg, Q1h)
  • Rebamipide (Unk)
  • Arofuto (Unk)
When commencing Loxonin, the patient experienced the following unwanted symptoms/side effects:
  • Respiratory Arrest
  • Heart Rate Decreased
  • Somnolence
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as respiratory arrest, may become evident only after a product is in use by the general population.

Face Oedema, Renal Impairment
This is a report of a 58-year-old male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: pain and was treated with Loxonin (dosage: Unk) starting May 02, 2012. Concurrently used drugs:
  • Lyrica (75 Mg, 2x/day)
  • Cymbalta (Unk)
  • Fentanyl
  • Betamethasone (Unk)
Soon after that, the consumer experienced the following side effects:
  • Face Oedema
  • Renal Impairment
This opens a possibility that Loxonin treatment could cause the above reactions, including face oedema, and some male subjects may be more susceptible.


Gait Disturbance, Loss Of Control Of Legs
A 74-year-old female patient (weight: NA) from JAPAN with the following symptoms/conditions: NA started Loxonin treatment (dosage: 60 Mg, 3x/day) on May 05, 2012. Soon after starting Loxonin treatment, the subject experienced various side effects, including:
  • Gait Disturbance
  • Loss Of Control Of Legs
Concurrently used drugs:
  • Celoop (50 Mg, 2x/day)
  • Celebrex (100 Mg, 2x/day)
  • Rize (5 Mg, 3x/day)
  • Lyrica (75 Mg, 2x/day)
This finding indicates that some female patients could be more vulnerable to Loxonin.

Pyelonephritis, International Normalised Ratio Increased, Epistaxis, Haematuria
A male patient from JAPAN (weight: NA) experienced symptoms, such as: NA and was treated with Loxonin(dosage: NA). The treatment was initiated on May 15, 2012. After that a consumer reported the following side effect(s):
  • Pyelonephritis
  • International Normalised Ratio Increased
  • Epistaxis
  • Haematuria
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Loxonin efficacy:
  • Rocephin
  • Selbex
  • Rabeprazole Sodium
  • Miconazole
  • Selbex
  • Miconazole (2%)
  • Warfarin Sodium
  • Warfarin Sodium
The patient was hospitalized.

Osteomyelitis
In this report, Loxonin was administered for the following condition: NA.A 75-year-old female consumer from JAPAN (weight: NA) started Loxonin treatment (dosage: NA) on Feb 28, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Osteomyelitis
A possible interaction with other drugs could have contributed to this reaction:
  • Evista
  • Prednisolone
  • Methotrexate
  • Fosamax
  • Foliamin
  • Fosamax
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Loxonin treatment could be related to the listed above side effect(s).

Lung Disorder
This is a report of the following Loxonin side effect(s):
  • Lung Disorder
A male patient from JAPAN (weight: NA) presented with the following condition: NA and received a treatment with Loxonin (dosage: Unk) starting: Sep 18, 2010.The following concurrently used drugs could have generated interactions:
  • Vitamin B12 (Unk)
  • Vitamin B12 (Unk)
  • Amoban (Unk)
  • Oxinorm /00045603/ (Unk)
  • Amlodipine (Unk)
  • Panvitan (Unk)
  • Kinedak (Unk)
  • Morphine Sulfate (Unk)
The patient was hospitalized.This report suggests that a Loxonin treatment could be associated with the listed above side effect(s).

Gastric Ulcer
This Loxonin report was submitted by a 70-year-old male consumer from JAPAN (weight: NA). The patient was diagnosed with: pyrexia,hepatic neoplasm malignant and Loxonin was administered (dosage: Unk) starting: Dec 02, 2011. The consumer developed a set of symptoms:
  • Gastric Ulcer
Other drugs used simultaneously:
  • Nexavar (400 Mg, Qd)
  • Nsaid's
Those unexpected symptoms could be linked to a Loxonin treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Papule, Blister, Mouth Ulceration, Pruritus, Conjunctival Hyperaemia, Oral Mucosa Erosion
This is a report of a possible correlation between Loxonin use and the following symptoms/side effect(s):
  • Papule
  • Blister
  • Mouth Ulceration
  • Pruritus
  • Conjunctival Hyperaemia
  • Oral Mucosa Erosion
which could contribute to an assessment of Loxonin risk profile.A 45-year-old male consumer from JAPAN (weight: NA) was suffering from NA and was treated with Loxonin (dosage: NA) starting Mar 08, 2012.Other concurrent medications:
  • Zolpidem
  • Allegra
  • Gasmotin
  • Peg-intron (1.5 Mcg/kg;qw;sc)
  • Telavic (antivirals Nos) (2250 Mg;qd;po)
  • Prednisolone
  • Rebetol (800 Mg;qd;po)
  • Allopurinol
The patient was hospitalized.

Anuria, Renal Failure Acute, Dysarthria, Nervous System Disorder
A male patient from JAPAN (weight: NA) presented with the following symptoms: herpes zoster,hypertension,gastric ulcer and after a treatment with Loxonin (dosage: 180mg Per Day) experienced the following side effect(s):
  • Anuria
  • Renal Failure Acute
  • Dysarthria
  • Nervous System Disorder
The treatment was started on Apr 24, 2012. Loxonin was used in combination with the following drugs:
  • Doxazosin Mesylate (2mg Per Day)
  • Mucosta (300mg Per Day)
  • Amlodipine (2.5g Per Day)
  • Valtrex (3000mg Per Day)
  • Allopurinol (100mg Per Day)
The patient was hospitalized.This report could alert potential Loxonin consumers.

Subarachnoid Haemorrhage
In this report, a female patient from JAPAN (weight: NA) was affected by a possible Loxonin side effect.The patient was diagnosed with rheumatoid arthritis. After a treatment with Loxonin (dosage: NA, start date: Jan 01, 2011), the patient experienced the following side effect(s):
  • Subarachnoid Haemorrhage
The following simultaneously used drugs could have led to this reaction:
  • Rheumatrex
  • Lipitor
  • Vitamin B12
  • Raloxifene Hcl
  • Actemra
  • Rabeprazole Sodium
  • Foliamin
  • Selbex
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Loxonin treatment.

Rash
This is a report of a 53-year-old male patient from JAPAN (weight: NA), who used Loxonin (dosage: NA) for a treatment of NA. After starting a treatment on Apr 23, 2012, the patient experienced the following side effect(s):
  • Rash
The following drugs could possibly have interacted with the Loxonin treatment
  • Peginterferon Alfa-2b
  • Ribavirin
  • Telavic (telaprevir)
  • Ribavirin
  • Peginterferon Alfa-2b
The patient was hospitalized.Taken together, these observations suggest that a Loxonin treatment could be related to side effect(s), such as Rash.

Pyrexia, Gamma-glutamyltransferase Increased, Hepatic Function Abnormal, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased
This pyrexia side effect was reported by a physician from JAPAN. A 63-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Loxonin (dosage: 60 Mg, Daily), which was started on Nov 29, 2011. Concurrently used drugs:
  • Zometa (4 Mg, Unk)
  • Femara (2.5 Mg, Daily)
When starting to take Loxonin the consumer reported the following symptoms:
  • Pyrexia
  • Gamma-glutamyltransferase Increased
  • Hepatic Function Abnormal
  • Aspartate Aminotransferase Increased
  • Blood Alkaline Phosphatase Increased
  • Alanine Aminotransferase Increased
These side effects may potentially be related to Loxonin.

Pancytopenia, Leukaemia
This is a Loxonin side effect report of a 44-year-old male patient (weight:NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Loxonin (dosage:NA, start time: May 01, 2012), combined with:
  • Stelara
  • Lorfenamin
  • Oxarol
  • Mucosta
  • Pravastan
  • Clobetasol Propionate
, and developed a serious reaction and a pancytopenia side effect. The patient presented with:
  • Pancytopenia
  • Leukaemia
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Loxonin treatment in male patients suffering from NA, resulting in pancytopenia.

White Blood Cell Count Increased, Haematocrit Decreased, Blood Albumin Decreased, Haemoglobin Decreased, Depressed Level Of Consciousness, Pneumonia, Blood Chloride Decreased
This report suggests a potential Loxonin (loxoprofen Sodium) white blood cell count increased side effect(s) that can have serious consequences. A 96-year-old male patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): NA and used Loxonin (loxoprofen Sodium) (dosage: NA) starting Feb 21, 2004. Soon after starting Loxonin (loxoprofen Sodium) the patient began experiencing various side effects, including:
  • White Blood Cell Count Increased
  • Haematocrit Decreased
  • Blood Albumin Decreased
  • Haemoglobin Decreased
  • Depressed Level Of Consciousness
  • Pneumonia
  • Blood Chloride Decreased
Drugs used concurrently:
  • Pletal (100 Mg, Bid, Oral)
  • Cerocral (ifenprodil Tartrate)
  • Bufferin
The patient was hospitalized. Although Loxonin (loxoprofen Sodium) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as white blood cell count increased, may still occur.

Peripheral Arterial Occlusive Disease, Gastrointestinal Haemorrhage, Nephrogenic Anaemia, Hypotension, Skin Ulcer, Renal Failure Chronic
This peripheral arterial occlusive disease problem was reported by a physician from JAPAN. A 69-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): back pain.On Sep 29, 2005 a consumer started treatment with Loxonin (loxoprofen Sodium) (dosage: 60 Mg, Tid, Oral). The following drugs/medications were being taken at the same time:
  • Vencoll (casantrhranol, Docusate Sodium)
  • Basen (voglibose)
  • Novolin N (insulin Human (genetical Recombination)
  • Heparin
  • Lasix
  • Mucosta (rebamipide)
  • Lendorm
  • Renagel
When commencing Loxonin (loxoprofen Sodium), the patient experienced the following unwanted symptoms /side effects:
  • Peripheral Arterial Occlusive Disease
  • Gastrointestinal Haemorrhage
  • Nephrogenic Anaemia
  • Hypotension
  • Skin Ulcer
  • Renal Failure Chronic
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as peripheral arterial occlusive disease, may become evident only after a product is in use by the general population.

Pyrexia, Hepatic Function Abnormal
This is a Loxonin side effect report of a 63-year-old female patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: NA and was treated with Loxonin (dosage: 60 Mg, Daily) starting Nov 29, 2011. Concurrently used drugs:
  • Zometa (4 Mg, Unk)
  • Femara (2.5 Mg, Daily)
Soon after that, the consumer experienced the following of symptoms:
  • Pyrexia
  • Hepatic Function Abnormal
This opens a possibility that Loxonin could cause pyrexia and that some female patients may be more susceptible.

Pneumonia
A female patient (weight: NA) from JAPAN with the following symptoms: NA started Loxonin treatment (dosage: NA) on Feb 14, 2012. Soon after starting Loxonin treatment, the consumer experienced several side effects, including:
  • Pneumonia
. Concurrently used drugs:
  • Mucosta
  • Rheumatrex
  • Prednisolone
  • Simponi
  • Cytotec
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Loxonin side effects, such as pneumonia.

Breast Cancer
This breast cancer side effect was reported by a physician from JAPAN. A female patient (weight:NA) experienced the following symptoms/conditions: rheumatoid arthritis.The patient was prescribed Loxonin (dosage: NA), which was started on Dec 22, 2008. Concurrently used drugs:
  • Rheumatrex
  • Alosenn
  • Boric Acid
  • Foliamin
  • Mucosta
  • Ketoprofen
  • Golimumab
  • Lansoprazole
.When starting to take Loxonin the consumer reported symptoms, such as:
  • Breast Cancer
These side effects may potentially be related to Loxonin.

Pulmonary Embolism
This is a report of a 81-year-old female patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Loxonin (dosage: NA, start time: Apr 16, 2012), combined with:
  • Buprenorphine (5 Mcg, Q1h)
  • Lyrica
and developed a serious reaction and side effect(s). The consumer presented with:
  • Pulmonary Embolism
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Loxonin treatment in female patients, resulting in pulmonary embolism side effect.

Pneumonia Bacterial, Cardiac Failure
This report suggests a potential Loxonin Pneumonia Bacterial, Cardiac Failure side effect(s) that can have serious consequences. A 83-year-old male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: rheumatoid arthritis,angina pectoris,hyperuricaemia and used Loxonin (dosage: 60 Mg, 1x/day) starting Nov 21, 2008. Soon after starting Loxonin the patient began experiencing various side effects, including:
  • Pneumonia Bacterial
  • Cardiac Failure
Drugs used concurrently:
  • Sigmart (5 Mg, 3x/day)
  • Allopurinol (100 Mg, 1x/day)
  • Enbrel (25 Mg, Weekly)
  • Enbrel (25 Mg, Weekly)
  • Pletal (100 Mg, 2x/day)
  • Enbrel (25 Mg, Weekly)
  • Epinastine Hydrochloride (20 Mg, 1x/day)
  • Metoprolol Tartrate (20 Mg, 2x/day)
The patient was hospitalized. Although Loxonin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pneumonia bacterial, may still occur.

Communication Disorder, Blood Urea Increased, Listless, Hypokinesia, Altered State Of Consciousness, Renal Failure, Pneumonia Aspiration, Decreased Appetite, Hypoglycaemia
This Communication Disorder, Blood Urea Increased, Listless, Hypokinesia, Altered State Of Consciousness, Renal Failure, Pneumonia Aspiration, Decreased Appetite, Hypoglycaemia problem was reported by a pharmacist from JAPAN. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jul 30, 2010 this consumer started treatment with Loxonin (dosage: NA). The following drugs were being taken at the same time:
  • Selbex
  • Aspara-ca
  • Valtrex (3000mg Per Day)
  • Candesartan Cilexetil
  • Depas
  • Frandol S
  • Adalat Cc
  • Chinese Medicine
When commencing Loxonin, the patient experienced the following unwanted symptoms/side effects:
  • Communication Disorder
  • Blood Urea Increased
  • Listless
  • Hypokinesia
  • Altered State Of Consciousness
  • Renal Failure
  • Pneumonia Aspiration
  • Decreased Appetite
  • Hypoglycaemia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as communication disorder, may become evident only after a product is in use by the general population.

Overdose, Product Quality Issue, Condition Aggravated, Delirium, Treatment Noncompliance
This is a report of a 64-year-old male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: pain,insomnia,oedema and was treated with Loxonin (dosage: NA) starting Apr 24, 2012. Concurrently used drugs:
  • Zolpidem
  • Lasix
  • Fentanyl-100 (Reported As 2.5 Ug/hr)
  • Fentanyl-100 (Two 75 Ug/hr Patches)
  • Morphine (As Needed)
  • Fentanyl-100
  • Fentanyl-100
  • Lendem
Soon after that, the consumer experienced the following side effects:
  • Overdose
  • Product Quality Issue
  • Condition Aggravated
  • Delirium
  • Treatment Noncompliance
This opens a possibility that Loxonin treatment could cause the above reactions, including overdose, and some male subjects may be more susceptible.

Injection Site Ulcer
A 73-year-old female patient (weight: NA) from JAPAN with the following symptoms/conditions: pain,breast cancer,metastases to bone,hepatic function abnormal,constipation started Loxonin treatment (dosage: NA) on Nov 21, 2011. Soon after starting Loxonin treatment, the subject experienced various side effects, including:
  • Injection Site Ulcer
Concurrently used drugs:
  • Faslodex (500 Mg)
  • Zometa
  • Urso 250
  • Pursennid
  • Magmitt
This finding indicates that some female patients could be more vulnerable to Loxonin.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    More About Loxonin

    Side Effects reported to FDA: 219

    Loxonin safety alerts: No

    Reported deaths: 30

    Reported hospitalizations: 120

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