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Mannitol Side Effects

Common Mannitol Side Effects


The most commonly reported Mannitol side effects (click to view or check a box to report):

Maculopathy (14)
Pain (14)
Renal Failure (12)
Renal Failure Acute (11)
Injury (10)
Unevaluable Event (9)
Stress (9)
Death (8)
Anxiety (8)
Multi-organ Failure (8)
Emotional Distress (7)
Fear (7)
Renal Impairment (7)
Renal Injury (7)
Anhedonia (6)
Hyperkalaemia (5)
Brain Oedema (3)
Dyspnoea (3)
Hyponatraemia (3)
Hypotension (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Mannitol Side Effects Reported to FDA

The following Mannitol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Mannitol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Extravasation, Compartment Syndrome
This is a report of a 17-year-old female patient (weight: NA) from TR, suffering from the following symptoms/conditions: NA, who was treated with Mannitol (dosage: NA, start time: NS), combined with:
  • Atropine
  • Atropine
  • Saline
and developed a serious reaction and side effect(s). The consumer presented with:
  • Extravasation
  • Compartment Syndrome
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in female patients, resulting in extravasation side effect.

Multi-organ Failure
This report suggests a potential Mannitol 20% Baxter Multi-organ Failure side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: NA and used Mannitol 20% Baxter (dosage: NA) starting NS. Soon after starting Mannitol 20% Baxter the patient began experiencing various side effects, including:
  • Multi-organ Failure
Drugs used concurrently:
  • Ceftriaxone
  • Vancomycin
  • Rifampicin
  • Pefloxacin
  • Dexamethasone
The patient was hospitalized. Although Mannitol 20% Baxter demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as multi-organ failure, may still occur.

Anaphylactic Reaction
This Anaphylactic Reaction problem was reported by a physician from US. A 19-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: polyuria,atypical teratoid/rhabdoid tumour of cns. On NS this consumer started treatment with Mannitol (dosage: 8 G/m^2 Bolus). The following drugs were being taken at the same time: NA. When commencing Mannitol, the patient experienced the following unwanted symptoms/side effects:
  • Anaphylactic Reaction
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as anaphylactic reaction, may become evident only after a product is in use by the general population.

Cerebral Infarction
This is a report of a 16-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: medulloblastoma and was treated with Mannitol (dosage: 12 G, Once, Ia) starting Oct 28, 2013. Concurrently used drugs:
  • Hydrocortisone Sodium Succinate
  • Sodium Thiosulfate
  • Dexamethasone
  • Ondansetron
  • Lorazepam
  • Phenobarbital
  • Diphenhydramine
  • Ranitidine
Soon after that, the consumer experienced the following side effects:
  • Cerebral Infarction
The patient was hospitalized. This opens a possibility that Mannitol treatment could cause the above reactions, including cerebral infarction, and some male subjects may be more susceptible.


Renal Failure Acute, Hyperthermia, Altered State Of Consciousness
A 77-year-old male patient (weight: NA) from FR with the following symptoms/conditions: cerebral infarction started Mannitol 20 % Viaflo, Solution Pour Perfusion treatment (dosage: NA) on NS. Soon after starting Mannitol 20 % Viaflo, Solution Pour Perfusion treatment, the subject experienced various side effects, including:
  • Renal Failure Acute
  • Hyperthermia
  • Altered State Of Consciousness
Concurrently used drugs:
  • Furosemide
This finding indicates that some male patients could be more vulnerable to Mannitol 20 % Viaflo, Solution Pour Perfusion.

Renal Failure Acute, Gastroduodenitis Haemorrhagic
A 57-year-old patient from FR (weight: NA) experienced symptoms, such as: hyponatraemia and was treated with Mannitol(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Renal Failure Acute
  • Gastroduodenitis Haemorrhagic
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Mannitol efficacy:
  • Furosemide


Gastroduodenitis Haemorrhagic, Renal Failure Acute
In this report, Mannitol was administered for the following condition: cerebral infarction.A 71-year-old consumer from FR (weight: NA) started Mannitol treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Gastroduodenitis Haemorrhagic
  • Renal Failure Acute
A possible interaction with other drugs could have contributed to this reaction:
  • Furosemide
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Mannitol treatment could be related to the listed above side effect(s).

Toxicity To Various Agents, Renal Failure Acute
This is a report of the following Mannitol side effect(s):
  • Toxicity To Various Agents
  • Renal Failure Acute
A 71-year-old male patient from IT (weight: NA) presented with the following condition: transient ischaemic attack,hypertension and received a treatment with Mannitol (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions:
  • Clonidine
The patient was hospitalized.This report suggests that a Mannitol treatment could be associated with the listed above side effect(s).

Pulmonary Oedema, Oliguria
This Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l report was submitted by a 46-year-old male consumer from GB (weight: NA). The patient was diagnosed with: polyuria and Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Pulmonary Oedema
  • Oliguria
Other drugs used simultaneously: NA.Those unexpected symptoms could be linked to a Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Consciousness Fluctuating, Respiratory Disorder, Listeriosis
This is a report of a possible correlation between Mannitol 20% Baxter use and the following symptoms/side effect(s):
  • Consciousness Fluctuating
  • Respiratory Disorder
  • Listeriosis
which could contribute to an assessment of Mannitol 20% Baxter risk profile.A 61-year-old consumer from PL (weight: NA) was suffering from NA and was treated with Mannitol 20% Baxter (dosage: NA) starting NS.Other concurrent medications:
  • Acyclovir
  • Dexamethasone


Renal Failure Acute, Cardiomegaly, Angina Pectoris, Pulmonary Congestion, Dyspnoea, Nausea
A 71-year-old female patient from NL (weight: NA) presented with the following symptoms: complex regional pain syndrome and after a treatment with Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l (dosage: NA) experienced the following side effect(s):
  • Renal Failure Acute
  • Cardiomegaly
  • Angina Pectoris
  • Pulmonary Congestion
  • Dyspnoea
  • Nausea
The treatment was started on NS. Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l was used in combination with the following drugs: NA.This report could alert potential Mannitol 10%, Oplossing Voor Intraveneuze Infusie 100 G/l consumers.

Grand Mal Convulsion, Blood Sodium Decreased
In this report, a 40-year-old male patient from PL (weight: NA) was affected by a possible Mannitol 20% Baxter side effect.The patient was diagnosed with NA. After a treatment with Mannitol 20% Baxter (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Grand Mal Convulsion
  • Blood Sodium Decreased
The following simultaneously used drugs could have led to this reaction:
  • Acyclovir
The findings here stress that side effects should be taken into consideration when evaluating a Mannitol 20% Baxter treatment.

Electrolyte Imbalance, Blood Sodium Increased, Blood Potassium Decreased, Hyperkalaemia, Ventricular Tachycardia, Hypotension, Stress Cardiomyopathy
This is a report of a 19-year-old male patient from IE (weight: NA), who used Mannitol (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Electrolyte Imbalance
  • Blood Sodium Increased
  • Blood Potassium Decreased
  • Hyperkalaemia
  • Ventricular Tachycardia
  • Hypotension
  • Stress Cardiomyopathy
The following drugs could possibly have interacted with the Mannitol treatment
  • Potassium (potassium)
  • Norepinephrine (norepinephrine)
  • Sedatives
  • Analgesics (analgesics)
Taken together, these observations suggest that a Mannitol treatment could be related to side effect(s), such as Electrolyte Imbalance, Blood Sodium Increased, Blood Potassium Decreased, Hyperkalaemia, Ventricular Tachycardia, Hypotension, Stress Cardiomyopathy.

Renal Failure Acute, Lung Infection
This renal failure acute side effect was reported by a health professional from CN. A 77-year-old male patient (weight:NA) experienced the following symptoms/conditions: intracranial pressure increased. The patient was prescribed Mannitol (dosage: NA), which was started on NS. Concurrently used drugs: NA. When starting to take Mannitol the consumer reported the following symptoms:
  • Renal Failure Acute
  • Lung Infection
These side effects may potentially be related to Mannitol.

Dyspnoea, Rash Erythematous
This is a Mannitol side effect report of a 42-year-old female patient (weight:NA) from GB, suffering from the following symptoms/conditions: NA, who was treated with Mannitol (dosage:NA, start time: Jan 16, 2013), combined with:
  • Buscopan (buscopan Comp.)
  • Carobel
  • Dotarem (meglumine Gadoterate)
  • Metoclopramide (metoclopramide)
, and developed a serious reaction and a dyspnoea side effect. The patient presented with:
  • Dyspnoea
  • Rash Erythematous
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Mannitol treatment in female patients suffering from NA, resulting in dyspnoea.

Pollakiuria, Product Formulation Issue
This report suggests a potential Mannitol pollakiuria side effect(s) that can have serious consequences. A 50-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): NA and used Mannitol (dosage: Po Daily) starting NS. Soon after starting Mannitol the patient began experiencing various side effects, including:
  • Pollakiuria
  • Product Formulation Issue
Drugs used concurrently:
  • Levothyroxine
Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as pollakiuria, may still occur.

Dyspnoea, Rash Erythematous
This dyspnoea problem was reported by a health professional from GB. A 42-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Jan 16, 2013 a consumer started treatment with Mannitol (dosage: NA). The following drugs/medications were being taken at the same time:
  • Buscopan
  • Dotarem
  • Metoclopramide
When commencing Mannitol, the patient experienced the following unwanted symptoms /side effects:
  • Dyspnoea
  • Rash Erythematous
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as dyspnoea, may become evident only after a product is in use by the general population.

Renal Failure Acute
This is a Mannitol side effect report of a 77-year-old male patient (weight: NA) from CN. The patient developed the following symptoms/conditions: cerebral infarction,intracranial pressure increased and was treated with Mannitol (dosage: NA) starting Feb 05, 2011. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Renal Failure Acute
This opens a possibility that Mannitol could cause renal failure acute and that some male patients may be more susceptible.

Renal Failure Acute
A 56-year-old male patient (weight: NA) from US with the following symptoms: intracranial pressure increased started Mannitol treatment (dosage: 90 Mg Q6hrs Iv Drip) on Sep 06, 2012. Soon after starting Mannitol treatment, the consumer experienced several side effects, including:
  • Renal Failure Acute
. Concurrently used drugs:
  • Pantoprazole
  • Amlodipine
  • Nicardipine
  • Lorazepam
  • Labetalol
This finding indicates that some patients can be more vulnerable to developing Mannitol side effects, such as renal failure acute.

Brain Neoplasm Malignant, Product Label Confusion, Polyuria, Condition Aggravated
This brain neoplasm malignant side effect was reported by a physician from SE. A 4-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mannitol (dosage: NA), which was started on Aug 28, 2012. Concurrently used drugs: NA..When starting to take Mannitol the consumer reported symptoms, such as:
  • Brain Neoplasm Malignant
  • Product Label Confusion
  • Polyuria
  • Condition Aggravated
These side effects may potentially be related to Mannitol.

Small Bowel Angioedema, Anaphylactic Reaction
This is a report of a 46-year-old male patient (weight: NA) from CHINA, suffering from the following symptoms/conditions: scan with contrast, who was treated with Mannitol (dosage: 1000 Ml, Scan Preparation, Oral, start time: NS), combined with:
  • Iohexol (iohexol) (370 Mg, Per Ml, Intravenous (not Otherwise Specified))
and developed a serious reaction and side effect(s). The consumer presented with:
  • Small Bowel Angioedema
  • Anaphylactic Reaction
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mannitol treatment in male patients, resulting in small bowel angioedema side effect.

Anaphylactic Reaction, Diarrhoea, Small Bowel Angioedema
This report suggests a potential Mannitol Anaphylactic Reaction, Diarrhoea, Small Bowel Angioedema side effect(s) that can have serious consequences. A 55-year-old male patient (weight: NA) from CHINA was diagnosed with the following symptoms/conditions: scan with contrast and used Mannitol (dosage: 400 Ml, Oral) starting NS. Soon after starting Mannitol the patient began experiencing various side effects, including:
  • Anaphylactic Reaction
  • Diarrhoea
  • Small Bowel Angioedema
Drugs used concurrently:
  • Ultravist 150 (90 Ml)
  • Iopamidol
Although Mannitol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as anaphylactic reaction, may still occur.

Encephalopathy
This Encephalopathy problem was reported by a physician from UNITED STATES. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Apr 26, 2012 this consumer started treatment with Mannitol (dosage: 200mg/ml). The following drugs were being taken at the same time:
  • Mycophenolate Mofetil (Bid)
  • Lisinopril
  • Ergocalciferol
  • Desflurane (1df)
  • Morphine (10mg/ml)
  • Atorvastatin Calcium
  • Propofol (10mg/ml)
  • Rocuronium Bromide (10mg/ml)
When commencing Mannitol, the patient experienced the following unwanted symptoms/side effects:
  • Encephalopathy
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as encephalopathy, may become evident only after a product is in use by the general population.

Chest Discomfort, Panic Attack
This is a report of a 55-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: NA and was treated with Mannitol (dosage: NA) starting NS. Concurrently used drugs:
  • Copaxone (One Syringe)
Soon after that, the consumer experienced the following side effects:
  • Chest Discomfort
  • Panic Attack
This opens a possibility that Mannitol treatment could cause the above reactions, including chest discomfort, and some female subjects may be more susceptible.

Brain Oedema, Brain Stem Microhaemorrhage, Nervous System Disorder
A 57-year-old male patient (weight: NA) from UNITED STATES with the following symptoms/conditions: NA started Mannitol 25% treatment (dosage: 10 Ml Over 2 Minutes Ia) on Dec 08, 2011. Soon after starting Mannitol 25% treatment, the subject experienced various side effects, including:
  • Brain Oedema
  • Brain Stem Microhaemorrhage
  • Nervous System Disorder
Concurrently used drugs:
  • Temodar (100 Mg/m2 X 1 Ia)
This finding indicates that some male patients could be more vulnerable to Mannitol 25%.

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Top 10 Mannitol Side Effects for Women

Women Side EffectsReports
Pain 6
Renal Failure 6
Fear 5
Stress 5
Anhedonia 4
Anxiety 4
Injury 4
Multi-organ Failure 4
Renal Impairment 4
Renal Injury 4

Top 10 Mannitol Side Effects for Men

Men Side EffectsReports
Pain 8
Renal Failure Acute 7
Injury 6
Renal Failure 6
Unevaluable Event 5
Anxiety 4
Death 4
Emotional Distress 4
Hyperkalaemia 4
Multi-organ Failure 4

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Mannitol Side Effects

    Did You Have a Mannitol Side Effect?

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    How Effective is Mannitol for You?

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    Mannitol Safety Alerts, Active Ingredients, Usage Information

    NDC0264-2303
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameMannitol
    NameMannitol
    Dosage FormIRRIGANT
    RouteIRRIGATION
    On market since19780210
    LabelerB. Braun Medical Inc.
    Active Ingredient(s)MANNITOL
    Strength(s)5
    Unit(s)g/100mL
    Pharma ClassIncreased Diuresis [PE],Osmotic Activity [MoA],Osmotic Diuretic [EPC]

    Mannitol Dosage, Warnings, Usage.

    Side Effects reported to FDA: 75

    Mannitol safety alerts: No

    Reported deaths: 18

    Reported hospitalizations: 18

    Latest Mannitol clinical trials