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Mecobalamin Side Effects

Common Mecobalamin Side Effects


The most commonly reported Mecobalamin side effects (click to view or check a box to report):

Blood Glucose Decreased (3)
Myelodysplastic Syndrome (3)
Cardiac Failure (3)
Blood Lactate Dehydrogenase Increased (2)
Decreased Appetite (2)
Blood Pressure Diastolic Decreased (2)
Alanine Aminotransferase Increased (2)
Aspartate Aminotransferase Increased (2)
Blood Alkaline Phosphatase Increased (2)
Pyrexia (2)
Hypoglycaemia (2)
Disseminated Intravascular Coagulation (2)
Dermatitis Exfoliative (2)
Dizziness (2)
Hepatic Function Abnormal (2)
Heart Rate Decreased (1)
Vomiting (1)
Haemorrhoids (1)
Headache (1)
Haematemesis (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Mecobalamin Side Effects Reported to FDA

The following Mecobalamin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Mecobalamin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Flushing
This is a report of a 81-year-old female patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Mecobalamin (dosage: NA, start time: Jun 16, 2012), combined with:
  • Atorvastatin
  • Metformin Hcl
  • Omeprazole
  • Zetia
  • Micamlo
  • Opaprosmon
and developed a serious reaction and side effect(s). The consumer presented with:
  • Flushing
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mecobalamin treatment in female patients, resulting in flushing side effect.

Disseminated Intravascular Coagulation, Dermatitis Exfoliative
This report suggests a potential Mecobalamin Disseminated Intravascular Coagulation, Dermatitis Exfoliative side effect(s) that can have serious consequences. A male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: prophylaxis and used Mecobalamin (dosage: 500 Milligram) starting Sep 16, 2011. Soon after starting Mecobalamin the patient began experiencing various side effects, including:
  • Disseminated Intravascular Coagulation
  • Dermatitis Exfoliative
Drugs used concurrently:
  • Allopurinol (100 Milligram)
  • Betamethasone (5 Milligram)
  • Lenalidomide (25 Milligram)
  • Rabeprazole Sodium (10 Milligram)
  • Sulfamethoxazole (80 Milligram)
  • Betamethasone Valerate (Adequate Dose)
  • Fluconazole (100 Milligram)
The patient was hospitalized. Although Mecobalamin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as disseminated intravascular coagulation, may still occur.

Disseminated Intravascular Coagulation, Dermatitis Exfoliative
This Disseminated Intravascular Coagulation, Dermatitis Exfoliative problem was reported by a health professional from JAPAN. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: prophylaxis. On Apr 30, 2012 this consumer started treatment with Mecobalamin (dosage: 500 Milligram). The following drugs were being taken at the same time:
  • Allopurinol (100 Milligram)
  • Lenalidomide (25 Milligram)
  • Corticosteroids
  • Fluid
  • Fluconazole (100 Milligram)
  • Rabeprazole Sodium (10 Milligram)
  • Betamethasone (5 Milligram)
  • Sulfamethoxazole (80 Milligram)
When commencing Mecobalamin, the patient experienced the following unwanted symptoms/side effects:
  • Disseminated Intravascular Coagulation
  • Dermatitis Exfoliative
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as disseminated intravascular coagulation, may become evident only after a product is in use by the general population.

Inadequate Analgesia, Gastric Ulcer
This is a report of a male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: pain and was treated with Mecobalamin (dosage: 500 Mg X 1 Per 1 Day) starting Nov 24, 2009. Concurrently used drugs:
  • Tramadol Hydrochloride And Acetaminophen
  • Amlodipine Besilate (5 Mg X 1 Per 1 Day)
  • Tramadol Hydrochloride And Acetaminophen
  • Maibastan (5 Mg X 1 Per 1 Day)
Soon after that, the consumer experienced the following side effects:
  • Inadequate Analgesia
  • Gastric Ulcer
This opens a possibility that Mecobalamin treatment could cause the above reactions, including inadequate analgesia, and some male subjects may be more susceptible.


Cardiac Failure, Myelodysplastic Syndrome
A 85-year-old female patient (weight: NA) from JAPAN with the following symptoms/conditions: NA started Mecobalamin treatment (dosage: NA) on Feb 26, 2011. Soon after starting Mecobalamin treatment, the subject experienced various side effects, including:
  • Cardiac Failure
  • Myelodysplastic Syndrome
Concurrently used drugs:
  • Rantac
  • Ferrous Citrate
  • Ceftriaxone Sodium
  • Azulfidine
  • Orencia (500 Mg, Ivd)
  • Prednisolone (Unk)
  • Candesartan Cilexetil
  • Epogin
This finding indicates that some female patients could be more vulnerable to Mecobalamin.

Myocardial Infarction
A 62-year-old female patient from CHINA (weight: NA) experienced symptoms, such as: diabetic neuropathy and was treated with Mecobalamin(dosage: NA). The treatment was initiated on Jan 01, 2009. After that a consumer reported the following side effect(s):
  • Myocardial Infarction
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Mecobalamin efficacy:
  • Humalog (Dose:21 Unit(s))
  • Insulin Glargine (Dose:20 Unit(s))
  • Solostar
  • Metformin Hcl
The patient was hospitalized.

Cholangitis Acute
In this report, Mecobalamin was administered for the following condition: pain.A male consumer from JAPAN (weight: NA) started Mecobalamin treatment (dosage: NA) on Dec 14, 2011.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Cholangitis Acute
A possible interaction with other drugs could have contributed to this reaction:
  • Mucosta
  • Zolpidem
  • Sunbazon
  • Rebamipide
  • Gabexate Mesilate
  • Dextrose
  • Midazolam
  • Amlodin Od
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Mecobalamin treatment could be related to the listed above side effect(s).

Rheumatoid Arthritis, Dementia
This is a report of the following Mecobalamin side effect(s):
  • Rheumatoid Arthritis
  • Dementia
A 70-year-old female patient from JAPAN (weight: NA) presented with the following condition: arteriosclerosis and received a treatment with Mecobalamin (dosage: NA) starting: Feb 24, 2011.The following concurrently used drugs could have generated interactions:
  • Atorvastatin Calcium
  • Ketoprofen (Qs)
  • Quazepam
  • Sulpiride
  • Carbamazepine
  • Lansoprazole
  • Folic Acid
  • Ketoprofen (Qs)
The patient was hospitalized.This report suggests that a Mecobalamin treatment could be associated with the listed above side effect(s).

Vomiting, Haemorrhoids, Ingrowing Nail, Hyperkeratosis, Conjunctivitis
This Mecobalamin report was submitted by a 50-year-old male consumer from JAPAN (weight: NA). The patient was diagnosed with: NA and Mecobalamin was administered (dosage: Unk) starting: Sep 17, 2010. The consumer developed a set of symptoms:
  • Vomiting
  • Haemorrhoids
  • Ingrowing Nail
  • Hyperkeratosis
  • Conjunctivitis
Other drugs used simultaneously:
  • Dexamethasone Sodium Phosphate (Unk)
  • Motilium (Unk)
  • Panitumumab (6 Mg/kg, Q2wk)
  • Panitumumab (6 Mg/kg, Q2wk)
  • Topotecan (150 Mg/m2, Q2wk)
  • Antebate (Unk)
  • Emend (Unk)
  • Posterisan (Unk)
Those unexpected symptoms could be linked to a Mecobalamin treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Gastrooesophageal Reflux Disease, Headache, Haematemesis
This is a report of a possible correlation between Mecobalamin use and the following symptoms/side effect(s):
  • Gastrooesophageal Reflux Disease
  • Headache
  • Haematemesis
which could contribute to an assessment of Mecobalamin risk profile.A 57-year-old female consumer from JAPAN (weight: NA) was suffering from diabetic neuropathy and was treated with Mecobalamin (dosage: 500 Ug, 3x/day) starting Jun 27, 2007.Other concurrent medications:
  • Mexitil (50 Mg, 2x/day)
  • Amitriptyline Hcl (10 Mg, 1x/day)
  • Glyburide (2.5 Mg, 1x/day)
  • Lyrica (75 Mg, 2x/day)
  • Glyburide (1.25 Mg, 1x/day)
  • Clonazepam (0.5 Mg, 1x/day)
  • Voglibose (0.3 Mg, 3x/day)
The patient was hospitalized.

Diabetes Mellitus Inadequate Control, Blood Glucose Decreased
A 55-year-old female patient from CHINA (weight: NA) presented with the following symptoms: NA and after a treatment with Mecobalamin (dosage: Unk) experienced the following side effect(s):
  • Diabetes Mellitus Inadequate Control
  • Blood Glucose Decreased
The treatment was started on Dec 24, 2010. Mecobalamin was used in combination with the following drugs:
  • Novorapid (1u+1u+1u Bolus)
  • Estazolam (Unk)
  • Aspirin (Unk)
  • Novolog (30 U, Bid)
  • Levemir (12u At Bed Time)
  • Novorapid (6u+6u+5.2u Bolus, 38.9u Basal (maximum))
  • Simvastatin (Unk)
  • Novorapid (6u+6u+7u Bolus)
The patient was hospitalized.This report could alert potential Mecobalamin consumers.

Cardiac Failure, Myelodysplastic Syndrome
In this report, a 85-year-old female patient from JAPAN (weight: NA) was affected by a possible Mecobalamin side effect.The patient was diagnosed with NA. After a treatment with Mecobalamin (dosage: NA, start date: Feb 26, 2011), the patient experienced the following side effect(s):
  • Cardiac Failure
  • Myelodysplastic Syndrome
The following simultaneously used drugs could have led to this reaction:
  • Lasix
  • Prednisolone (Unk)
  • Mobic
  • Folic Acid
  • Rantac
  • Rheumatrex (2 Mg, 1 Week)
  • Cerocral
  • Amlodipine
The findings here stress that side effects should be taken into consideration when evaluating a Mecobalamin treatment.

Liver Carcinoma Ruptured, Blood Pressure Diastolic Decreased
This is a report of a male patient from JAPAN (weight: NA), who used Mecobalamin (dosage: 0.5 Mg, Unk) for a treatment of NA. After starting a treatment on Jul 31, 2007, the patient experienced the following side effect(s):
  • Liver Carcinoma Ruptured
  • Blood Pressure Diastolic Decreased
The following drugs could possibly have interacted with the Mecobalamin treatment
  • Promac (150 Mg, Unk)
  • Candesartan Cilexetil (4 Mg, Unk)
  • Sigmart (15 Mg, Unk)
  • Lansoprazole (15 Mg, Unk)
  • Valsartan (40 Mg, Qd)
  • Gasmotin (15 Mg, Unk)
The patient was hospitalized.Taken together, these observations suggest that a Mecobalamin treatment could be related to side effect(s), such as Liver Carcinoma Ruptured, Blood Pressure Diastolic Decreased.

Liver Disorder, Melaena, C-reactive Protein Increased, Gastrointestinal Haemorrhage, Rectal Ulcer Haemorrhage, Blood Albumin Decreased, Ascites
This liver disorder side effect was reported by a physician from JAPAN. A female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Mecobalamin (dosage: 1500 Mcg Daily), which was started on Mar 14, 2011. Concurrently used drugs: NA. When starting to take Mecobalamin the consumer reported the following symptoms:
  • Liver Disorder
  • Melaena
  • C-reactive Protein Increased
  • Gastrointestinal Haemorrhage
  • Rectal Ulcer Haemorrhage
  • Blood Albumin Decreased
  • Ascites
The patient was hospitalized. These side effects may potentially be related to Mecobalamin.

Cardiac Failure, Myelodysplastic Syndrome
This is a Mecobalamin side effect report of a 85-year-old female patient (weight:NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Mecobalamin (dosage:NA, start time: Feb 26, 2011), combined with:
  • Mucodyne
  • Ceftriaxone Sodium
  • Rantac
  • Cerocral
  • Candesartan Cilexetil
  • Rheumatrex (2 Mg, 1 Week)
  • Folic Acid
  • Prednisolone (Unk)
, and developed a serious reaction and a cardiac failure side effect. The patient presented with:
  • Cardiac Failure
  • Myelodysplastic Syndrome
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Mecobalamin treatment in female patients suffering from NA, resulting in cardiac failure.

Hypotension, Blood Pressure Decreased, Renal Impairment, Hyperkalaemia, Dehydration, Decreased Appetite, Dizziness, Metabolic Acidosis, Heart Rate Decreased
This report suggests a potential Mecobalamin hypotension side effect(s) that can have serious consequences. A 68-year-old male patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): NA and used Mecobalamin (dosage: NA) starting Mar 10, 2010. Soon after starting Mecobalamin the patient began experiencing various side effects, including:
  • Hypotension
  • Blood Pressure Decreased
  • Renal Impairment
  • Hyperkalaemia
  • Dehydration
  • Decreased Appetite
  • Dizziness
  • Metabolic Acidosis
  • Heart Rate Decreased
Drugs used concurrently:
  • Ternelin (tizanidine Hydrochloride)
  • Juvela (tocopheryl Acetate)
  • Celecoxib
  • Olmesartan Medoxomil (20 Mg (20 Mg, 1 In 1 D), Per Oral; 10 Mg (10 Mg, 1 In 1 D), Per Oral)
  • Olmesartan Medoxomil (20 Mg (20 Mg, 1 In 1 D), Per Oral; 10 Mg (10 Mg, 1 In 1 D), Per Oral)
  • Amaryl
  • Prorenal (limaprost)
  • Metformin Hydrochloride
The patient was hospitalized. Although Mecobalamin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hypotension, may still occur.

Blood Pressure Diastolic Decreased
This blood pressure diastolic decreased problem was reported by a physician from JAPAN. A male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On May 27, 2008 a consumer started treatment with Mecobalamin (dosage: 0.5 Mg, Unk). The following drugs/medications were being taken at the same time:
  • Promac (150 Mg, Unk)
  • Candesartan Cilexetil (4 Mg, Unk)
  • Sigmart (15 Mg, Unk)
  • Takepron (15 Mg, Unk)
  • Gasmotin (15 Mg, Unk)
  • Valsartan (40 Mg, Qd)
When commencing Mecobalamin, the patient experienced the following unwanted symptoms /side effects:
  • Blood Pressure Diastolic Decreased
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as blood pressure diastolic decreased, may become evident only after a product is in use by the general population.

Malaise, Dizziness, Decreased Appetite
This is a Mecobalamin side effect report of a 74-year-old male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: NA and was treated with Mecobalamin (dosage: Unk) starting Dec 10, 2007. Concurrently used drugs:
  • Troxipide (Unk)
  • Pioglitazone Hydrochloride (Unk)
  • Metoclopramide Hcl (Unk)
  • Pilsicainide Hydrochloride (Unk)
  • Sulpiride (Unk)
  • Candesartan Cilexetil (Unk)
  • Warfarin Potassium (Unk)
  • Famvir (1500 Mg Daily)
Soon after that, the consumer experienced the following of symptoms:
  • Malaise
  • Dizziness
  • Decreased Appetite
The patient was hospitalized. This opens a possibility that Mecobalamin could cause malaise and that some male patients may be more susceptible.

Paronychia, Tremor, Chills, Vertigo, Dermatitis
A 74-year-old male patient (weight: NA) from JAPAN with the following symptoms: NA started Mecobalamin treatment (dosage: Unk Unk, Unk) on Jul 29, 2010. Soon after starting Mecobalamin treatment, the consumer experienced several side effects, including:
  • Paronychia
  • Tremor
  • Chills
  • Vertigo
  • Dermatitis
. Concurrently used drugs:
  • Livalo
  • Gasmotin
  • Aspirin
  • Lasix
  • Gaster D
  • Norvasc
  • Plavix
  • Lasix
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Mecobalamin side effects, such as paronychia.

Muscular Weakness, Stem Cell Transplant, Diffuse Large B-cell Lymphoma, Memory Impairment, Neoplasm Malignant, Metastases To Central Nervous System, Disorientation
This muscular weakness side effect was reported by a physician from JAPAN. A 52-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Mecobalamin (mecobalamin) (dosage: NA), which was started on Feb 19, 2009. Concurrently used drugs:
  • Etoposide
  • Thymoglobulin (50 Mg, Qd, Intravenous)
  • Itraconazole
  • Cytarabine
  • Lansoprazole
  • Platelets, Concentrated (platelets, Concentrated)
  • Melphalan Hydrochloride
  • Rebamipide (rebamipide)
.When starting to take Mecobalamin (mecobalamin) the consumer reported symptoms, such as:
  • Muscular Weakness
  • Stem Cell Transplant
  • Diffuse Large B-cell Lymphoma
  • Memory Impairment
  • Neoplasm Malignant
  • Metastases To Central Nervous System
  • Disorientation
These side effects may potentially be related to Mecobalamin (mecobalamin). The patient was hospitalized.

Epilepsy
This is a report of a 74-year-old patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Mecobalamin (dosage: Unk, start time: Oct 02, 2008), combined with:
  • Plavix (75 Mg)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Epilepsy
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Mecobalamin treatment in patients, resulting in epilepsy side effect.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia
This report suggests a potential Mecobalamin Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia side effect(s) that can have serious consequences. A 24-year-old male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: hypoaesthesia and used Mecobalamin (dosage: Unk, Unk) starting Jul 19, 1997. Soon after starting Mecobalamin the patient began experiencing various side effects, including:
  • Alanine Aminotransferase Increased
  • Aspartate Aminotransferase Increased
  • Blood Alkaline Phosphatase Increased
  • Blood Glucose Decreased
  • Blood Lactate Dehydrogenase Increased
  • Hepatic Function Abnormal
  • Hypoglycaemia
  • Pyrexia
Drugs used concurrently:
  • Goshajinkigan (Unk, Unk)
  • Insulin
  • Troglitazone (Unk, Unk)
  • Tegretol
The patient was hospitalized. Although Mecobalamin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as alanine aminotransferase increased, may still occur.

Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia
This Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Blood Alkaline Phosphatase Increased, Blood Glucose Decreased, Blood Lactate Dehydrogenase Increased, Hepatic Function Abnormal, Hypoglycaemia, Pyrexia problem was reported by a health professional from JAPAN. A 24-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hypoaesthesia. On Jul 19, 1997 this consumer started treatment with Mecobalamin (dosage: NA). The following drugs were being taken at the same time:
  • Goshajinkigan
  • Insulin
  • Troglitazone
  • Carbamazepine
When commencing Mecobalamin, the patient experienced the following unwanted symptoms/side effects:
  • Alanine Aminotransferase Increased
  • Aspartate Aminotransferase Increased
  • Blood Alkaline Phosphatase Increased
  • Blood Glucose Decreased
  • Blood Lactate Dehydrogenase Increased
  • Hepatic Function Abnormal
  • Hypoglycaemia
  • Pyrexia
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as alanine aminotransferase increased, may become evident only after a product is in use by the general population.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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