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Metamizol Side Effects

Common Metamizol Side Effects


The most commonly reported Metamizol side effects (click to view or check a box to report):

Diarrhoea (7)
Pleural Effusion (7)
Left Ventricular Failure (6)
Anaemia (6)
Aplasia Pure Red Cell (5)
Hyponatraemia (5)
Agranulocytosis (5)
Nausea (5)
Right Ventricular Failure (5)
Pain (5)
Fatigue (4)
Anal Fissure (4)
Hepatic Enzyme Increased (4)
Dyspnoea (4)
Hypopnoea (4)
Muscle Twitching (4)
Vomiting (4)
Pyrexia (4)
Varicose Vein (3)
Weight Decreased (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Metamizol Side Effects Reported to FDA

The following Metamizol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Metamizol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Pancytopenia
This is a report of a 87-year-old female patient (weight: NA) from DE, suffering from the following symptoms/conditions: back pain,confusional state,gastrointestinal angiodysplasia,hypertension, who was treated with Metamizol (dosage: 20 Gtt, Tid, start time: May 07, 2012), combined with:
  • Risperidon (0.5 Mg, Unk)
  • Pantoprazol (20 Mg, Unk)
  • Amlodipin (5 Mg, 0-0-1)
  • Lorazepam (0.5 Mg, Unk)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Pancytopenia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in female patients, resulting in pancytopenia side effect. The patient was hospitalized.

Human Herpes Virus 6 Serology Positive, Rash Erythematous, Lymphadenopathy, Rash Maculo-papular, Lymphocyte Transformation Test Positive, Dermatitis, Hepatic Enzyme Increased, Pruritus
This report suggests a potential Metamizole Human Herpes Virus 6 Serology Positive, Rash Erythematous, Lymphadenopathy, Rash Maculo-papular, Lymphocyte Transformation Test Positive, Dermatitis, Hepatic Enzyme Increased, Pruritus side effect(s) that can have serious consequences. A 43-year-old female patient (weight: NA) from SPAIN was diagnosed with the following symptoms/conditions: colitis ulcerative and used Metamizole (dosage: 2 G, Q6h) starting NS. Soon after starting Metamizole the patient began experiencing various side effects, including:
  • Human Herpes Virus 6 Serology Positive
  • Rash Erythematous
  • Lymphadenopathy
  • Rash Maculo-papular
  • Lymphocyte Transformation Test Positive
  • Dermatitis
  • Hepatic Enzyme Increased
  • Pruritus
Drugs used concurrently:
  • Piperacillin/tazobactam (4/0.5 G Every 12 Hour)
  • Acetaminophen (1 G, Q6h)
Although Metamizole demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as human herpes virus 6 serology positive, may still occur.

Eye Swelling, Oedema Peripheral, Antinuclear Antibody Increased, Arthralgia, Erythema, Myalgia, Abscess, Cutaneous Tuberculosis
This Eye Swelling, Oedema Peripheral, Antinuclear Antibody Increased, Arthralgia, Erythema, Myalgia, Abscess, Cutaneous Tuberculosis problem was reported by a physician from GERMANY. A 46-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jan 01, 2011 this consumer started treatment with Metamizole (dosage: Three Times A Day). The following drugs were being taken at the same time:
  • Remicade
  • Remicade
  • Remicade
  • Prednisolone
  • Allopurinol
  • Ibuprofen (Twice Daily)
  • Cefuroxime Axetil
  • Pantoprazole
When commencing Metamizole, the patient experienced the following unwanted symptoms/side effects:
  • Eye Swelling
  • Oedema Peripheral
  • Antinuclear Antibody Increased
  • Arthralgia
  • Erythema
  • Myalgia
  • Abscess
  • Cutaneous Tuberculosis
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as eye swelling, may become evident only after a product is in use by the general population.

Tumour Pain
This is a report of a 62-year-old male patient (weight: NA) from SPAIN. The patient developed the following symptoms/conditions: NA and was treated with Metamizol (dosage: NA) starting Nov 25, 2011. Concurrently used drugs:
  • Micardis
  • Dexamethasone
  • Oxycodone Hcl
  • Ipilimumab
  • Zoladex
  • Metoclopramide Hydrochloride
  • Enoxaparin
  • Furosemide
Soon after that, the consumer experienced the following side effects:
  • Tumour Pain
The patient was hospitalized. This opens a possibility that Metamizol treatment could cause the above reactions, including death, and some male subjects may be more susceptible.


Diarrhoea, Vomiting, Weight Decreased, Dyspepsia, Nausea
A 54-year-old female patient (weight: NA) from UNITED STATES with the following symptoms/conditions: NA started Metamizol treatment (dosage: NA) on Mar 30, 2011. Soon after starting Metamizol treatment, the subject experienced various side effects, including:
  • Diarrhoea
  • Vomiting
  • Weight Decreased
  • Dyspepsia
  • Nausea
Concurrently used drugs:
  • Oxycodone Hcl
  • Bupropion Hcl
  • Zofran
  • Xeloda
  • Protonix
  • Xgeva
  • Tykerb (1250mg Per Day)
  • Citalopram Hydrobromide
This finding indicates that some female patients could be more vulnerable to Metamizol.

Faecaloma, Hyperglycaemia, Perineal Pain
A 83-year-old male patient from UNITED STATES (weight: NA) experienced symptoms, such as: NA and was treated with Metamizole (metamizole)(dosage: NA). The treatment was initiated on Feb 06, 2008. After that a consumer reported the following side effect(s):
  • Faecaloma
  • Hyperglycaemia
  • Perineal Pain
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Metamizole (metamizole) efficacy:
  • Ibuprofen
  • Tamsulosin Hcl
  • Cp-751, 871 (1280 Milligram) ((1280 Mg, 1 In 3 Wk), Intravenous)
  • Prednisone ((123.9 Mg, 1 In 3 Wk), Intravenous)
  • Actiq
  • Decapepyl
  • Magnesium Hydroxide Tab
  • Docetaxel (1in 3 Weeks , Intravenous)
The patient was hospitalized.

Intervertebral Disc Protrusion, Nerve Root Lesion, Osteoarthritis
In this report, Metamizol was administered for the following condition: NA.A 70-year-old female consumer from GERMANY (weight: NA) started Metamizol treatment (dosage: NA) on Jan 03, 2012.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Intervertebral Disc Protrusion
  • Nerve Root Lesion
  • Osteoarthritis
A possible interaction with other drugs could have contributed to this reaction:
  • Actemra (Last Dose Prior To Sae:15/mar/2012)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Metamizol treatment could be related to the listed above side effect(s).

Maternal Exposure During Pregnancy, Oligohydramnios, Syncope, Premature Delivery
This is a report of the following Metamizole side effect(s):
  • Maternal Exposure During Pregnancy
  • Oligohydramnios
  • Syncope
  • Premature Delivery
A 23-year-old female patient from SPAIN (weight: NA) presented with the following condition: pyelonephritis acute and received a treatment with Metamizole (dosage: 2 G, Q8h) starting: NS.The following concurrently used drugs could have generated interactions:
  • Amoxicillin And Clavulanate Potassium
This report suggests that a Metamizole treatment could be associated with the listed above side effect(s).

Toxic Epidermal Necrolysis
This Metamizole report was submitted by a 59-year-old female consumer from GERMANY (weight: NA). The patient was diagnosed with: NA and Metamizole was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Toxic Epidermal Necrolysis
Other drugs used simultaneously:
  • Piperacillin And Tazobactam
Those unexpected symptoms could be linked to a Metamizole treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Disease Progression, Eastern Cooperative Oncology Group Performance Status Worsened
This is a report of a possible correlation between Metamizol use and the following symptoms/side effect(s):
  • Disease Progression
  • Eastern Cooperative Oncology Group Performance Status Worsened
which could contribute to an assessment of Metamizol risk profile.A male consumer from GERMANY (weight: NA) was suffering from bone pain and was treated with Metamizol (dosage: Dose = 130.0 Units Not Specified) starting May 27, 2009.Other concurrent medications:
  • Leuprolide Acetate (Dose = 130.0 Units Not Specified)
  • Utk Uno (Dose = 130.0 Units Not Specified)
  • Calcium-sandoz D Osteo (Dose = 130.0 Units Not Specified)
  • Abiraterone Acetate
  • Prednisolone
  • Ciprofloxacin (Dose = 130.0 Units Not Specified)
  • Fentanyl (Start Date = 08-nov-2010)
The patient was hospitalized and became disabled.

Gastroenteritis
A female patient from GERMANY (weight: NA) presented with the following symptoms: post herpetic neuralgia and after a treatment with Metamizole (dosage: NA) experienced the following side effect(s):
  • Gastroenteritis
The treatment was started on Oct 07, 2011. Metamizole was used in combination with the following drugs:
  • Nsaid's
  • Metoprolol Succinate
  • Tapentadol Hydrochloride (Twice A Day)
This report could alert potential Metamizole consumers.

Pain, Pyrexia
In this report, a female patient from POLAND (weight: NA) was affected by a possible Metamizol side effect.The patient was diagnosed with NA. After a treatment with Metamizol (dosage: 500mg Three Times Per Day, start date: Aug 30, 2011), the patient experienced the following side effect(s):
  • Pain
  • Pyrexia
The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Metamizol treatment.

Hydrocephalus, Anaemia
This is a report of a 54-year-old male patient from GERMANY (weight: NA), who used Metamizol (dosage: NA) for a treatment of NA. After starting a treatment on Oct 25, 2011, the patient experienced the following side effect(s):
  • Hydrocephalus
  • Anaemia
The following drugs could possibly have interacted with the Metamizol treatment
  • Dexamethasone Sodium Phosphate
  • Restex (100/25 Mg)
  • Fentanyl (12 Mg/hour)
  • Pantoprazole
  • Vemurafenib (Last Dos Eprior To Sae 21 Nov 2011)
  • Ibuprofen
  • Moviprep
  • Zoledronic Acid
The patient was hospitalized.Taken together, these observations suggest that a Metamizol treatment could be related to side effect(s), such as Hydrocephalus, Anaemia.

Deep Vein Thrombosis
This deep vein thrombosis side effect was reported by a physician from RUSSIAN FEDERATION. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain. The patient was prescribed Metamizol Natrii (dosage: 2 Ml), which was started on Jul 21, 2011. Concurrently used drugs:
  • Ketoprofen (300 Mg)
  • Indapamidum
  • Pradaxa (220 Mg)
  • Tramadol Hydrochloride And Acetaminophen (225 Mg/1950 Mg)
  • Omeprazole (20 Mg)
  • Cefazolin (2000 Mg)
  • Diphenhydraminum (1 Mg)
  • Midazolam (5 Mg)
When starting to take Metamizol Natrii the consumer reported the following symptoms:
  • Deep Vein Thrombosis
The patient was hospitalized. These side effects may potentially be related to Metamizol Natrii.

Pyrexia, Pain
This is a Metamizol side effect report of a female patient (weight:NA) from POLAND, suffering from the following symptoms/conditions: NA, who was treated with Metamizol (dosage:500mg Three Times Per Day, start time: Aug 30, 2011), combined with:
  • Vinorelbine Tartrate (20mgm2 Cyclic)
, and developed a serious reaction and a pyrexia side effect. The patient presented with:
  • Pyrexia
  • Pain
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Metamizol treatment in female patients suffering from NA, resulting in pyrexia.

Neoplasm Malignant, Dehydration, Hyponatraemia, Diarrhoea
This report suggests a potential Metamizole neoplasm malignant side effect(s) that can have serious consequences. A 32-year-old female patient from ROMANIA (weight:NA) was diagnosed with the following health condition(s): NA and used Metamizole (dosage: 1df=1 Vial) starting Jan 09, 2012. Soon after starting Metamizole the patient began experiencing various side effects, including:
  • Neoplasm Malignant
  • Dehydration
  • Hyponatraemia
  • Diarrhoea
Drugs used concurrently:
  • Zometa
  • Yervoy
  • Morphine Sulfate
The patient was hospitalized. Although Metamizole demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as neoplasm malignant, may still occur.

Oedema Peripheral, Pulmonary Oedema, Cough, Cardiac Failure Congestive, Hypertension, Dilatation Ventricular, Dyspnoea
This oedema peripheral problem was reported by a physician from GERMANY. A female patient (weight: NA) was diagnosed with the following medical condition(s): pain,renal cell carcinoma.On Jun 10, 2011 a consumer started treatment with Metamizole (dosage: NA). The following drugs/medications were being taken at the same time:
  • Afinitor (10 Mg, Per Day)
  • Steroids Nos (1333 Mg, Prednisolone Equivalent)
  • Proton Pump Inhibitors
  • Omeprazole (40 Mg, Daily)
When commencing Metamizole, the patient experienced the following unwanted symptoms /side effects:
  • Oedema Peripheral
  • Pulmonary Oedema
  • Cough
  • Cardiac Failure Congestive
  • Hypertension
  • Dilatation Ventricular
  • Dyspnoea
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as oedema peripheral, may become evident only after a product is in use by the general population.

Cholecystectomy
This is a Metamizole side effect report of a female patient (weight: NA) from SPAIN. The patient developed the following symptoms/conditions: back pain,osteoporosis prophylaxis,rheumatoid arthritis,hypertension and was treated with Metamizole (dosage: NA) starting Feb 18, 2009. Concurrently used drugs:
  • Calcium With Vitamin D
  • Celecoxib
  • Nebivolol Hcl
  • Alendronate Sodium
  • Prednisone Tab
  • Folic Acid
  • Omeprazole
  • Omeprazole
Soon after that, the consumer experienced the following of symptoms:
  • Cholecystectomy
The patient was hospitalized. This opens a possibility that Metamizole could cause cholecystectomy and that some female patients may be more susceptible.

Acute Coronary Syndrome
A 78-year-old male patient (weight: NA) from SPAIN with the following symptoms: musculoskeletal chest pain,prostate cancer started Metamizole treatment (dosage: 375 Mg, As Needed) on Feb 10, 2010. Soon after starting Metamizole treatment, the consumer experienced several side effects, including:
  • Acute Coronary Syndrome
. Concurrently used drugs:
  • Cyclophosphamide (50 Mg, 1x/day)
  • Prednisone Tab (Tdd 10 Mg)
  • Sunitinib Malate (25 Mg, 1x/day)
  • Enalapril (5 Mg, 1x/day)
  • Metoclopramide (Unk)
  • Metoclopramide
  • Amiloride Hcl And Hydrochlorothiazide (5 Mg/ 50 Mg 1x/day)
  • Omeprazole (10 Mg, 1x/day)
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Metamizole side effects, such as acute coronary syndrome.

Agranulocytosis
This agranulocytosis side effect was reported by a physician from DENMARK. A 26-year-old male patient (weight:NA) experienced the following symptoms/conditions: phantom pain.The patient was prescribed Metamizole (metamizole) (dosage: 500 Mg; ; Po), which was started on Apr 01, 2011. Concurrently used drugs:
  • Tramadol Hydrochloride (100 Mg; ; Po)
  • Ibuprofen (600 Mg; ; Po)
  • Pregabalin (300 Mg; ; Po)
  • Amoxicillin
.When starting to take Metamizole (metamizole) the consumer reported symptoms, such as:
  • Agranulocytosis
These side effects may potentially be related to Metamizole (metamizole). The patient was hospitalized.

Pain In Extremity, Nausea, Dyspnoea, Angina Pectoris, Hyponatraemia, Restlessness, Productive Cough, Agitation
This is a report of a 69-year-old female patient (weight: NA) from GERMANY, suffering from the following symptoms/conditions: pain,korsakoff's syndrome,hypertension, who was treated with Metamizol (dosage: 1000 Mg, Unk, start time: Mar 15, 2009), combined with:
  • Dipiperon (120 Mg, 1x/day)
  • Altace (7.5 Mg, 1x/day)
  • Haloperidol (10 Mg, 1x/day)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Pain In Extremity
  • Nausea
  • Dyspnoea
  • Angina Pectoris
  • Hyponatraemia
  • Restlessness
  • Productive Cough
  • Agitation
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metamizol treatment in female patients, resulting in pain in extremity side effect. The patient was hospitalized.

Electrolyte Depletion, Hyponatraemia, Hypokalaemia, Syncope, Prothrombin Time Prolonged
This report suggests a potential Metamizol Natrium Electrolyte Depletion, Hyponatraemia, Hypokalaemia, Syncope, Prothrombin Time Prolonged side effect(s) that can have serious consequences. A 79-year-old male patient (weight: NA) from GERMANY was diagnosed with the following symptoms/conditions: pain,hypertension,duodenal ulcer,dementia,coronary artery disease and used Metamizol Natrium (dosage: 500 Mg, Unk) starting Jan 01, 2000. Soon after starting Metamizol Natrium the patient began experiencing various side effects, including:
  • Electrolyte Depletion
  • Hyponatraemia
  • Hypokalaemia
  • Syncope
  • Prothrombin Time Prolonged
Drugs used concurrently:
  • Ramipril (1.25 Mg, Qd)
  • Pantoprazole (40 Mg, Qd)
  • Risperidone (0.5 Mg, Qd)
  • Simvastatin (40 Mg, Qd)
  • Torsemide (10 Mg, Qd)
  • Aldactone (25 Mg, Qd)
  • Falithrom ^hexal^ (Unk)
  • Metoclopramide (20 Gtt, Tid)
The patient was hospitalized. Although Metamizol Natrium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as electrolyte depletion, may still occur.

Sinus Bradycardia, Blood Pressure Decreased
This Sinus Bradycardia, Blood Pressure Decreased problem was reported by a health professional from SWITZERLAND. A 48-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Dec 01, 2010 this consumer started treatment with Metamizole (metamizole) (dosage: NA). The following drugs were being taken at the same time:
  • Citalopram Hydrobromide (20 Mg Per Day,oral)
  • Tizanidine Hydrochloride (12 Mg (2 X 6 Mg Per Day) Oral; 06 Mg Daily; Oral)
  • Tranxilium (clorazepate Dispotassium)
  • Acetaminophen
  • Lyrica (300 Mg (2 X 150 Mg Per Day), Oral)
  • Bulboid (glycerol)
  • Importal (lactitol)
  • Oxycodone Hcl (10 Mg (2 X 5 Mg Per Day) Oral)
When commencing Metamizole (metamizole), the patient experienced the following unwanted symptoms/side effects:
  • Sinus Bradycardia
  • Blood Pressure Decreased
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as sinus bradycardia, may become evident only after a product is in use by the general population.

Constipation, Colonic Stenosis
This is a report of a female patient (weight: NA) from GERMANY. The patient developed the following symptoms/conditions: crohn's disease and was treated with Metamizol (dosage: 4x/die) starting Nov 18, 2010. Concurrently used drugs:
  • Pantoprazole Sodium (Bid)
  • Humira (80 Mg In Week 0; 40 Mg In Week 2; 40 Mg Eow)
  • Fraxiparin (Od)
Soon after that, the consumer experienced the following side effects:
  • Constipation
  • Colonic Stenosis
The patient was hospitalized. This opens a possibility that Metamizol treatment could cause the above reactions, including constipation, and some female subjects may be more susceptible.

Agranulocytosis
A 26-year-old male patient (weight: NA) from GERMANY with the following symptoms/conditions: phantom pain started Metamizol treatment (dosage: NA) on Apr 01, 2011. Soon after starting Metamizol treatment, the subject experienced various side effects, including:
  • Agranulocytosis
Concurrently used drugs:
  • Ibuprofen
  • Ibuprofen
  • Amoxicillin
  • Tramadol Hcl
  • Pregabalin
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Metamizol.

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Why Your Notes are Important

Your notes could be helpful in several ways:

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    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

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