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From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes, said the Institute of Medicine report, released yesterday.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Metamizole Safety Reports submitted to FDA

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Total Metamizole reports: 10.
Metamizole FDA safety alerts: No.
Reported deaths: 3    Reported hospitalizations: 6.
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FDA Reported Metamizole Side Effects: inappropriate antidiuretic hormone secretion, hyponatraemia, coma, respiratory failure, pneumonia, agranulocytosis, mucosal haemorrhage, haemorrhagic diathesis, gastritis haemorrhagic, ecchymosis, rhabdomyolysis.
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Metamizole Side Effects Report #5212261-X
Consumer or non-health professional from reported METAMIZOLE problem on Jan 12, 2007. Female patient, 64 years of age, was diagnosed with pneumonia and was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: granulocytopenia, hepatic enzyme decreased, pyrexia. METAMIZOLE dosage: unknown. During the same period patient was treated with CLARITHROMYCIN, AMOXICILLIN, DESIPRAMINE, PREDNISOLONE. Patient recovered.

Metamizole Side Effects Report #5212270-0
METAMIZOLE problem was reported by a Consumer or non-health professional from on Jan 12, 2007. Male patient, 37 years of age, was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis. METAMIZOLE dosage: unknown. During the same period patient was treated with CLARITHROMYCIN, CEFIXIME CHEWABLE, CODEINE SUL, ACETYLCYSTEINE. Patient died.

Metamizole Side Effects Report #5236960-9
Consumer or non-health professional from COLOMBIA reported METAMIZOLE problem on Feb 07, 2007. Female patient, 18 years of age, was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: anaphylactic shock. METAMIZOLE dosage: unknown. During the same period patient was treated with DICLOFENAC. Patient died.

Metamizole Side Effects Report #5354671-6
METAMIZOLE problem was reported by a Consumer or non-health professional from on June 08, 2007. Female patient, 76 years of age, was diagnosed with pain, rheumatoid arthritis and was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: bicytopenia, candidiasis, circulatory collapse, mouth ulceration, myelodysplastic syndrome, pharyngeal ulceration, pharyngolaryngeal pain, pneumonia, staphylococcal sepsis. METAMIZOLE dosage: unknown. During the same period patient was treated with METHOTREXATE, STEROIDS. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5425385-9
Consumer or non-health professional from reported METAMIZOLE problem on Aug 24, 2007. Female patient, 78 years of age, was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: respiratory failure. METAMIZOLE dosage: unknown. During the same period patient was treated with MIDAZOLAM, DICLOFENAC, DOXYLAMINE, TRAMADOL, PENTOBARBITAL CAP, METOPROLOL SUCCINATE. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5425386-0
METAMIZOLE problem was reported by a Consumer or non-health professional from on Aug 24, 2007. Male patient, 29 years of age, was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: coma, respiratory failure. METAMIZOLE dosage: unknown. During the same period patient was treated with MORPHINE, ETILEFRINE, COCAINE, CODEINE SUL, METOCLOPRAMIDE, HEROIN. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5425387-2
Consumer or non-health professional from reported METAMIZOLE problem on Aug 24, 2007. Female patient, 77 years of age, was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: confusional state, reflexes abnormal, somnolence. METAMIZOLE dosage: unknown. During the same period patient was treated with ASPIRIN, LACTULOSE, BARBITURATE, DOXEPIN, ENALAPRIL, FLUNITRAZEPAM, NIFEDIPINE, OMEPRAZOLE. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5442684-5
METAMIZOLE problem was reported by a Consumer or non-health professional from on Sept 04, 2007. Female patient, 30 years of age, was diagnosed with hypertension and was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: hyponatraemia, inappropriate antidiuretic hormone secretion. METAMIZOLE dosage: unknown. During the same period patient was treated with DIAZEPAM, METOCLOPRAMIDE, PARACETAMOL, HYOSCINE N BUTYLBROMIDE, DICLOFENAC, HYDRALAZINE. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5464514-8
Consumer or non-health professional from reported METAMIZOLE problem on Sept 14, 2007. Female patient, 30 years of age, was diagnosed with abdominal pain, grand mal convulsion, nausea, vomiting and was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: coma, grand mal convulsion, hypertension, hyponatraemia, inappropriate antidiuretic hormone secretion, porphyria, rhabdomyolysis. METAMIZOLE dosage: unknown. During the same period patient was treated with PARACETAMOL, DIAZEPAM, HYOSCINE N BUTYLBROMIDE, DICLOFENAC, METOCLOPRAMIDE. Patient was hospitalized. Patient recovered.

Metamizole Side Effects Report #5465967-1
METAMIZOLE problem was reported by a Consumer or non-health professional from on Sept 21, 2007. Female patient, 81 years of age, was diagnosed with arthritis and was treated with METAMIZOLE. After drug was administered, patient experienced the following problems/side effects: agranulocytosis, ecchymosis, gastritis haemorrhagic, haemorrhagic diathesis, mucosal haemorrhage, pneumonia. METAMIZOLE dosage: unknown. During the same period patient was treated with METHOTREXATE, DICLOFENAC. Patient died.


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granulocytopenia, hepatic enzyme decreased, pyrexia agranulocytosis anaphylactic shock bicytopenia, candidiasis, circulatory collapse, mouth ulceration, myelodysplastic syndrome, pharyngeal ulceration, pharyngolaryngeal pain, pneumonia, staphylococcal sepsis, was diagnosed with pneumonia and was diagnosed with pain, rheumatoid arthritis and was diagnosed with hypertension and