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Metformin Side Effects

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Common Metformin Side Effects


The most commonly reported Metformin side effects (click to view or check a box to report):

Lactic Acidosis (2533)
Renal Failure Acute (1526)
Diarrhoea (990)
Vomiting (734)
Blood Glucose Increased (635)
Hypotension (588)
Nausea (587)
Haemodialysis (566)
Hypoglycaemia (554)
Completed Suicide (515)
Metabolic Acidosis (488)
Abdominal Pain (385)
Dehydration (375)
Renal Failure (366)
Cardiac Arrest (346)
Dyspnoea (333)
Malaise (311)
Toxicity To Various Agents (287)
Hyperkalaemia (276)
Dizziness (259)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Metformin Side Effects Reported to FDA



Metformin Side Effect Report#9970102
Abdominal Pain, Gastrointestinal Angiodysplasia, Gastritis, Aphthous Stomatitis, Weight Decreased, Decreased Appetite
This is a report of a 69-year-old male patient (weight: NA) from IL, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Metformin (dosage: 1700 Daily;, start time:
Mar 31, 2010), combined with:
  • Aspirin (100 Milligram Daily;)
  • Omepradex (20 Milligram Daily;)
  • Atenolol (50 Milligram Daily;)
  • Simvastatin (40 Milligram Daily;)
  • Allopurinol (300 Milligram Daily;)
  • Losartan (100 Milligram Daily;)
  • Hydrochlorothiazide (25 Milligram Daily;)
and developed a serious reaction and side effect(s): Abdominal Pain, Gastrointestinal Angiodysplasia, Gastritis, Aphthous Stomatitis, Weight Decreased, Decreased Appetite after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in male patients, resulting in Abdominal Pain side effect. The patient was hospitalized.
Metformin Side Effect Report#9964473
Lactic Acidosis, Renal Failure
This report suggests a potential Metformine Tablet 850mg Lactic Acidosis side effect(s) that can have serious consequences. A 78-year-old male patient (weight: NA) from NL was diagnosed with the following symptoms/conditions: diabetes mellitus and used Metformine Tablet 850mg (dosage: Extra Info: Has Recently Been Increased From 2 Times Daily 1000 Mg To 3 Times Daily 850 Mg..) starting
Feb 10, 2014. After starting Metformine Tablet 850mg the patient began experiencing various side effects, including: Lactic Acidosis, Renal FailureAdditional drugs used concurrently:
  • Lisinopril Tablet 10mg (10 Milligram Daily;)
  • Spironolacton Tablet 25mg (25 Milligram Daily;)
  • Furabid Capsule Mga 100mg (200 Milligram Daily; Prolonged-release Capsule)
  • Glimepiride Tablet 2mg (2 Milligram Daily;)
  • Xatral Xr Tablet Mva 10mg (10 Milligram Daily;)
  • Escitalopram Tablet 10mg (10 Milligram Daily;)
The patient was hospitalized. Although Metformine Tablet 850mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lactic Acidosis, may still occur.
Metformin Side Effect Report#9964469
Renal Failure Acute
This Renal Failure Acute problem was reported by a physician from IL. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On
Jul 08, 2011 this consumer started treatment with Metformin (dosage: 2550 Milligram Daily;). The following drugs were being taken at the same time: NA. When using Metformin, the patient experienced the following unwanted symptoms/side effects: Renal Failure AcuteAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9961168
Gastroenteritis, Colitis
This Gastroenteritis side effect was reported by a physician from IL. A 44-year-old male patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Metformin (drug dosage: 2250 Milligram Daily;), which was initiated on 2009. Concurrently used drugs:
  • Tritace (5 Milligram Daily;)
  • Cardiloc (5 Milligram Daily;)
  • Cartia (100 Milligram Daily;)
  • Losec (20 Milligram Daily;)
  • Glucoprace Retard (2550 Milligram Daily;)
  • Lipitor (20 Milligram Daily;)
  • Ramipril
  • Bisoprolol Fumarate
.After starting to take Metformin the consumer reported adverse symptoms, such as: Gastroenteritis, ColitisThese side effects may potentially be related to Metformin. The patient was hospitalized.
Metformin Side Effect Report#9960720
Chest Pain
This is a report of a 58-year-old male patient (weight: NA) from IL, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Metformin (dosage: 1700 Milligram Daily;, start time: 200801), combined with: NA. and developed a serious reaction and side effect(s): Chest Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in male patients, resulting in Chest Pain side effect. The patient was hospitalized.
Metformin Side Effect Report#9960393
Lactic Acidosis
This report suggests a potential Metformin Lactic Acidosis side effect(s) that can have serious consequences. A 82-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: NA) starting
Sep 16, 2013. After starting Metformin the patient began experiencing various side effects, including: Lactic AcidosisAdditional drugs used concurrently:
  • Amlodipine
  • Alprazolam
  • Ascorbic Acid
  • Ibuprofen
  • Insulin
  • Metoprolol
  • Ondansetron
  • Simvastatin
Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lactic Acidosis, may still occur.
Metformin Side Effect Report#9960295
Lactic Acidosis
This Lactic Acidosis problem was reported by a physician from US. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metformin (dosage: NA). The following drugs were being taken at the same time: NA. When using Metformin, the patient experienced the following unwanted symptoms/side effects: Lactic AcidosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Lactic Acidosis, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9958754
Gastrointestinal Disorder, Decreased Appetite, Asthenia, Diarrhoea, Vomiting, Disorientation, Dyspnoea, Metabolic Acidosis, Blood Potassium Increased
This Gastrointestinal Disorder side effect was reported by a health professional from IT. A 73-year-old female patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Metformin (drug dosage: 1 D), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metformin the consumer reported adverse symptoms, such as: Gastrointestinal Disorder, Decreased Appetite, Asthenia, Diarrhoea, Vomiting, Disorientation, Dyspnoea, Metabolic Acidosis, Blood Potassium IncreasedThese side effects may potentially be related to Metformin. The patient was hospitalized.
Metformin Side Effect Report#9958611
Hypoglycaemia
This is a report of a 58-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Metformin Hcl Tablets (dosage: NA, start time: NS), combined with:
  • Glipizide Tablets
  • Rosuvastatin
  • Fenofibrate
  • Acetylsalicylic Acid
  • Lisinopril
  • Gabapentin
  • Tramadol
  • Nabumetone
and developed a serious reaction and side effect(s): Hypoglycaemia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin Hcl Tablets treatment in male patients, resulting in Hypoglycaemia side effect.
Metformin Side Effect Report#9958610
Lactic Acidosis, Overdose
This report suggests a potential Metformin Hcl Tablets Lactic Acidosis side effect(s) that can have serious consequences. A 27-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: polycystic ovaries and used Metformin Hcl Tablets (dosage: NA) starting NS. After starting Metformin Hcl Tablets the patient began experiencing various side effects, including: Lactic Acidosis, OverdoseAdditional drugs used concurrently: NA.The patient was hospitalized. Although Metformin Hcl Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lactic Acidosis, may still occur.
Metformin Side Effect Report#9958607
Lactic Acidosis
This Lactic Acidosis problem was reported by a physician from US. A 62-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On NS this consumer started treatment with Metformin Hcl Tablets (dosage: NA). The following drugs were being taken at the same time: NA. When using Metformin Hcl Tablets, the patient experienced the following unwanted symptoms/side effects: Lactic AcidosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Lactic Acidosis, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9958514
Suicide Attempt, Renal Failure Acute, Intentional Overdose, Lactic Acidosis
This Suicide Attempt side effect was reported by a pharmacist from US. A 59-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Amlodipine
  • Lisinopril
  • Simvastatin
.After starting to take Metformin the consumer reported adverse symptoms, such as: Suicide Attempt, Renal Failure Acute, Intentional Overdose, Lactic AcidosisThese side effects may potentially be related to Metformin. The patient was hospitalized.
Metformin Side Effect Report#9955363
Lactic Acidosis, Anuria, Circulatory Collapse
This is a report of a 50-year-old female patient (weight: NA) from FI, suffering from the following health symptoms/conditions: diabetes mellitus,urinary tract infection,insomnia, who was treated with Metformin (dosage: NA, start time:
Dec 11, 2013), combined with:
  • Ciproxin
  • Surmontil
  • Mirtazapine
  • Lantus
  • Primaspan
  • Pantoprazole
  • Flixotide
  • Bisoprolol
and developed a serious reaction and side effect(s): Lactic Acidosis, Anuria, Circulatory Collapse after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in female patients, resulting in Lactic Acidosis side effect.
Metformin Side Effect Report#9949148
Gastrointestinal Disorder, Hereditary Angioedema
This report suggests a potential Metformin Hcl 500mg Tablets Gastrointestinal Disorder side effect(s) that can have serious consequences. A 24-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: polycystic ovaries and used Metformin Hcl 500mg Tablets (dosage: NA) starting NS. After starting Metformin Hcl 500mg Tablets the patient began experiencing various side effects, including: Gastrointestinal Disorder, Hereditary AngioedemaAdditional drugs used concurrently:
  • Ethinylestradiol
Although Metformin Hcl 500mg Tablets demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Gastrointestinal Disorder, may still occur.
Metformin Side Effect Report#9948947
Incorrect Dose Administered, Hypoglycaemic Coma, Pyrexia
This Incorrect Dose Administered problem was reported by a pharmacist from FR. A 63-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hyperglycaemia. On
Nov 16, 2013 this consumer started treatment with Metformine (dosage: NA). The following drugs were being taken at the same time:
  • Amarel
  • Onglyza
When using Metformine, the patient experienced the following unwanted symptoms/side effects: Incorrect Dose Administered, Hypoglycaemic Coma, PyrexiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Incorrect Dose Administered, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9945881
Erythema Multiforme
This Erythema Multiforme side effect was reported by a health professional from GB. A 73-year-old male patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus,urinary tract disorder,cardiac disorder,hypercholesterolaemia,hypertension.The patient was prescribed Metformin (drug dosage: 500 Mg, Bid), which was initiated on
Jan 20, 2014. Concurrently used drugs:
  • Tamsulosin (400 Ug, Unk)
  • Bisoprolol (5 Mg, Unk)
  • Simvastatin (40 Mg, Unk)
  • Ramipril (5 Mg, Unk)
  • Aspirin (75 Mg, Unk)
.After starting to take Metformin the consumer reported adverse symptoms, such as: Erythema MultiformeThese side effects may potentially be related to Metformin. The patient was hospitalized.
Metformin Side Effect Report#9940956
Erythema Multiforme
This is a report of a 73-year-old male patient (weight: NA) from DE, suffering from the following health symptoms/conditions: NA, who was treated with Metformin Hcl (dosage: NA, start time:
Jan 20, 2014), combined with:
  • Aspirin
  • Bisoprolol
  • Ramipril
  • Simvastatin
  • Tamsulosin
and developed a serious reaction and side effect(s): Erythema Multiforme after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin Hcl treatment in male patients, resulting in Erythema Multiforme side effect. The patient was hospitalized.
Metformin Side Effect Report#9940768
Lactic Acidosis, Renal Failure Acute, Cardiac Failure, Respiratory Disorder, Pancreatitis Acute
This report suggests a potential Metformin Hydrochloride (watson Laboratories) Lactic Acidosis side effect(s) that can have serious consequences. A 54-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: diabetes mellitus and used Metformin Hydrochloride (watson Laboratories) (dosage: Unk) starting NS. After starting Metformin Hydrochloride (watson Laboratories) the patient began experiencing various side effects, including: Lactic Acidosis, Renal Failure Acute, Cardiac Failure, Respiratory Disorder, Pancreatitis AcuteAdditional drugs used concurrently:
  • Enalapril (watson Laboratories) (Unk)
  • Acetylsalicylic Acid (Unk)
  • Ibuprofen (amallc) (Unk)
The patient was hospitalized. Although Metformin Hydrochloride (watson Laboratories) demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lactic Acidosis, may still occur.
Metformin Side Effect Report#9940745
Lactic Acidosis, Cardiac Arrest, Renal Failure, Acute Respiratory Distress Syndrome, Intentional Overdose, Transaminases Increased
This Lactic Acidosis problem was reported by a health professional from US. A 39-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: intentional overdose. On NS this consumer started treatment with Metformin Hydrochloride Extended Release (watson Laboratories) (dosage: 50000 Mg, Single( 50 Tablets Of 1000 Mg Each)). The following drugs were being taken at the same time: NA. When using Metformin Hydrochloride Extended Release (watson Laboratories), the patient experienced the following unwanted symptoms/side effects: Lactic Acidosis, Cardiac Arrest, Renal Failure, Acute Respiratory Distress Syndrome, Intentional Overdose, Transaminases IncreasedThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Lactic Acidosis, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9940588
Jaundice Hepatocellular, Hypertension
This Jaundice Hepatocellular side effect was reported by a consumer or non-health professional from DE. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformin Hcl (drug dosage: For Last 7 Years-ongoing), which was initiated on NS. Concurrently used drugs:
  • Levothyroxine (For Last 10 Years-ongoing)
  • Calcium (For Last 5 Years-ongoing)
  • Atenolol (For Last 3 Weeks-stopped)
.After starting to take Metformin Hcl the consumer reported adverse symptoms, such as: Jaundice Hepatocellular, HypertensionThese side effects may potentially be related to Metformin Hcl.
Metformin Side Effect Report#9934063
Blood Glucose Increased, Malaise, Tinnitus
This is a report of a 51-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: insulin-requiring type 2 diabetes mellitus, who was treated with Metformin Hydrochloride Tablets Usp (dosage: NA, start time: 201210), combined with: NA. and developed a serious reaction and side effect(s): Blood Glucose Increased, Malaise, Tinnitus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin Hydrochloride Tablets Usp treatment in male patients, resulting in Blood Glucose Increased side effect.
Metformin Side Effect Report#9934062
Diarrhoea
This report suggests a potential Metformin Hydrochloride Tablets Usp Diarrhoea side effect(s) that can have serious consequences. A 70-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: diabetes mellitus and used Metformin Hydrochloride Tablets Usp (dosage: NA) starting 2013. After starting Metformin Hydrochloride Tablets Usp the patient began experiencing various side effects, including: DiarrhoeaAdditional drugs used concurrently:
  • Insulin (Taken For Years)
Although Metformin Hydrochloride Tablets Usp demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Diarrhoea, may still occur.
Metformin Side Effect Report#9934060
Myalgia, Somnolence
This Myalgia problem was reported by a consumer or non-health professional from US. A 61-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: diabetes mellitus,blood pressure increased. On 2010 this consumer started treatment with Metformin Hydrochloride Tablets Usp (dosage: NA). The following drugs were being taken at the same time:
  • Felodipine
  • Lasix
When using Metformin Hydrochloride Tablets Usp, the patient experienced the following unwanted symptoms/side effects: Myalgia, SomnolenceAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Myalgia, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9934059
Blood Glucose Increased, Abdominal Distension, Furuncle, Incorrect Product Storage
This Blood Glucose Increased side effect was reported by a consumer or non-health professional from US. A 68-year-old female patient (weight:NA) experienced the following symptoms/conditions: diabetes mellitus.The patient was prescribed Metformin Hydrochloride Tablets Usp (drug dosage: NA), which was initiated on 201304. Concurrently used drugs: NA..After starting to take Metformin Hydrochloride Tablets Usp the consumer reported adverse symptoms, such as: Blood Glucose Increased, Abdominal Distension, Furuncle, Incorrect Product StorageThese side effects may potentially be related to Metformin Hydrochloride Tablets Usp.
Metformin Side Effect Report#9934053
Chest Pain, Dizziness, Headache
This is a report of a 69-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metformin Hydrochloride Tablets Usp (dosage: NA, start time: 201211), combined with: NA. and developed a serious reaction and side effect(s): Chest Pain, Dizziness, Headache after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin Hydrochloride Tablets Usp treatment in male patients, resulting in Chest Pain side effect.


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The appearance of Metformin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Metformin Side Effects for Women?

Women Side EffectsReports
Lactic Acidosis 1504
Renal Failure Acute 912
Diarrhoea 631
Vomiting 456
Nausea 395
Hypotension 353
Haemodialysis 346
Blood Glucose Increased 320
Hypoglycaemia 310
Metabolic Acidosis 309

What are common Metformin Side Effects for Men?

Men Side EffectsReports
Lactic Acidosis 1015
Renal Failure Acute 610
Diarrhoea 354
Blood Glucose Increased 311
Vomiting 277
Completed Suicide 267
Hypoglycaemia 243
Hypotension 233
Haemodialysis 215
Nausea 191

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Metformin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Metformin Safety Alerts, Active Ingredients, Usage Information

    NDC0093-1048
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameMetformin Hydrochloride
    NameMetformin Hydrochloride
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20020128
    LabelerTeva Pharmaceuticals USA Inc
    Active Ingredient(s)METFORMIN HYDROCHLORIDE
    Strength(s)500
    Unit(s)mg/1
    Pharma ClassBiguanide [EPC],Biguanides [Chemical/Ingredient]

    More About Metformin

    Side Effects reported to FDA: 10583

    Metformin safety alerts: 2007 2006 2005

    Reported deaths: 878

    Reported hospitalizations: 2864

    Latest Metformin clinical trials