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Metformin Side Effects

PatientsVille

Common Metformin Side Effects


The most commonly reported Metformin side effects (click to view or check a box to report):

Lactic Acidosis (2533)
Renal Failure Acute (1526)
Diarrhoea (990)
Vomiting (734)
Blood Glucose Increased (635)
Hypotension (588)
Nausea (587)
Haemodialysis (566)
Hypoglycaemia (554)
Completed Suicide (515)
Metabolic Acidosis (488)
Abdominal Pain (385)
Dehydration (375)
Renal Failure (366)
Cardiac Arrest (346)
Dyspnoea (333)
Malaise (311)
Toxicity To Various Agents (287)
Hyperkalaemia (276)
Dizziness (259)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Metformin Side Effects Reported to FDA



Metformin Side Effect Report#9883022
Completed Suicide
This is a report of a 58-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metformin (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in female patients, resulting in Completed Suicide side effect.
Metformin Side Effect Report#9883021
Poisoning, Exposure Via Ingestion, Completed Suicide
This report suggests a potential Metformin Poisoning side effect(s) that can have serious consequences. A 48-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: Df) starting NS. After starting Metformin the patient began experiencing various side effects, including: Poisoning, Exposure Via Ingestion, Completed SuicideAdditional drugs used concurrently:
  • Metoprolol (Df Oral)
  • Sitagliptin (Df Oral)
  • Furosemide (Df Oral)
Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Poisoning, may still occur.
Metformin Side Effect Report#9882842
Hypoglycaemia, Renal Failure Acute, Lactic Acidosis
This Hypoglycaemia problem was reported by a consumer or non-health professional from DE. A 81-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On NS this consumer started treatment with Metformin Hcl (dosage: NA). The following drugs were being taken at the same time:
  • Sitagliptin Phosphate
  • Ramipril
  • Torem
  • Hydrochlorothiazide
  • Folsan (Date Of Administration: 25-jan-2014)
  • Metohexal
  • Kalinor (Daily Dose: ^1 Beutel / 3x/woche^)
  • Simvastatin
When using Metformin Hcl, the patient experienced the following unwanted symptoms/side effects: Hypoglycaemia, Renal Failure Acute, Lactic AcidosisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypoglycaemia, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9882601
Suicide Attempt, Hypoglycaemic Coma
This Suicide Attempt side effect was reported by a consumer or non-health professional from DE. A 42-year-old male patient (weight:NA) experienced the following symptoms/conditions: suicide attempt.The patient was prescribed Metformin Hcl (drug dosage: NA), which was initiated on
Oct 04, 2013. Concurrently used drugs:
  • Novomix
  • Lantus (1df: 100 Iu/ml Solution For Inj?10ml/vial)
.After starting to take Metformin Hcl the consumer reported adverse symptoms, such as: Suicide Attempt, Hypoglycaemic ComaThese side effects may potentially be related to Metformin Hcl. The patient was hospitalized.
Metformin Side Effect Report#9882202
Hypersensitivity Vasculitis, Arthralgia, Rash, Pain, Swelling, Erythema, Pruritus, Pyrexia, Chills
This is a report of a 58-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metformin (dosage: NA, start time: NS), combined with:
  • Trazodone
and developed a serious reaction and side effect(s): Hypersensitivity Vasculitis, Arthralgia, Rash, Pain, Swelling, Erythema, Pruritus, Pyrexia, Chills after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in male patients, resulting in Hypersensitivity Vasculitis side effect. The patient was hospitalized.
Metformin Side Effect Report#9880693
Pallor, Haemodynamic Instability, Hyperhidrosis, Blood Pressure Decreased, Shock, Hyperglycaemia, Oliguria, Acidosis
This report suggests a potential Metformin Pallor side effect(s) that can have serious consequences. A 68-year-old male patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: NA) starting NS. After starting Metformin the patient began experiencing various side effects, including: Pallor, Haemodynamic Instability, Hyperhidrosis, Blood Pressure Decreased, Shock, Hyperglycaemia, Oliguria, AcidosisAdditional drugs used concurrently:
  • Amlodipine
  • Ethanol (Df)
  • Acetylsalicylic Acid
  • Amlodipine
  • Clonazepam
  • Glyburide
  • Irbesartan
Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pallor, may still occur.
Metformin Side Effect Report#9880427
Renal Failure, Metabolic Acidosis
This Renal Failure problem was reported by a health professional from FR. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On NS this consumer started treatment with Metformin Hydrochloride (dosage: NA). The following drugs were being taken at the same time:
  • Alendronic Acid
  • Clorazepate Dipotassium
  • Flunarizine
  • Hydrocortisone
  • Fenofibrate
  • Methotrexate
  • Pantoprazole
  • Paroxetine
When using Metformin Hydrochloride, the patient experienced the following unwanted symptoms/side effects: Renal Failure, Metabolic AcidosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9879843
Lactic Acidosis, Renal Failure Acute
This Lactic Acidosis side effect was reported by a health professional from DE. A 65-year-old female patient (weight:NA) experienced the following symptoms/conditions: diabetes mellitus.The patient was prescribed Metformin (drug dosage: 2x1000g), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metformin the consumer reported adverse symptoms, such as: Lactic Acidosis, Renal Failure AcuteThese side effects may potentially be related to Metformin. The patient was hospitalized.
Metformin Side Effect Report#9877110
Lactic Acidosis, Renal Failure Acute, Resuscitation
This is a report of a 65-year-old female patient (weight: NA) from DE, suffering from the following health symptoms/conditions: diabetes mellitus, who was treated with Metformin (dosage: 2 X 1000 G/day, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Lactic Acidosis, Renal Failure Acute, Resuscitation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in female patients, resulting in Lactic Acidosis side effect. The patient was hospitalized.
Metformin Side Effect Report#9876967
This report suggests a potential Metformin Death side effect(s) that can have serious consequences. A 57-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: NA) starting NS. After starting Metformin the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Lisinopril
  • Duloxetine
  • Atenolol
The patient was hospitalized. Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Metformin Side Effect Report#9871437
Hypoglycaemic Coma
This Hypoglycaemic Coma problem was reported by a health professional from IT. A 81-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus,hypertension,glaucoma. On
Jan 01, 2011 this consumer started treatment with Metformin (dosage: 1500 Mg, Unk). The following drugs were being taken at the same time:
  • Amlodipine (10 Mg, Unk)
  • Latanoprost
  • Humalog (22 U/l, Qd)
  • Humalog (14 U/l, Daily)
  • Lantus (22 U/l, Qd)
  • Cardirene (160 Mg, Unk)
  • Azarga
  • Atorvastatin (40 Mg, Unk)
When using Metformin, the patient experienced the following unwanted symptoms/side effects: Hypoglycaemic ComaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypoglycaemic Coma, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9870981
Toxicity To Various Agents
This Toxicity To Various Agents side effect was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformin (metformin) (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metformin (metformin) the consumer reported adverse symptoms, such as: Toxicity To Various AgentsThese side effects may potentially be related to Metformin (metformin).
Metformin Side Effect Report#9870887
Lactic Acidosis, Renal Failure Acute, Blood Potassium Increased, Resuscitation
This is a report of a 65-year-old female patient (weight: NA) from DE, suffering from the following health symptoms/conditions: diabetes mellitus, who was treated with Metformin (dosage: Oral, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Lactic Acidosis, Renal Failure Acute, Blood Potassium Increased, Resuscitation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in female patients, resulting in Lactic Acidosis side effect. The patient was hospitalized.
Metformin Side Effect Report#9870828
Poisoning, Exposure Via Ingestion
This report suggests a potential Metformin Poisoning side effect(s) that can have serious consequences. A 57-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: (df)) starting NS. After starting Metformin the patient began experiencing various side effects, including: Poisoning, Exposure Via IngestionAdditional drugs used concurrently:
  • Ethanol ((df))
  • Lisinopril ((df))
  • Duloxetine ((df))
  • Atenolol ((df))
  • Cocaine ((df))
Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Poisoning, may still occur.
Metformin Side Effect Report#9870630
Toxicity To Various Agents
This Toxicity To Various Agents problem was reported by a health professional from US. A 55-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metformin (metformin) (dosage: NA). The following drugs were being taken at the same time: NA. When using Metformin (metformin), the patient experienced the following unwanted symptoms/side effects: Toxicity To Various AgentsAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Toxicity To Various Agents, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9870602
Toxicity To Various Agents
This Toxicity To Various Agents side effect was reported by a consumer or non-health professional from US. A 53-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformine (metformin) (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metformine (metformin) the consumer reported adverse symptoms, such as: Toxicity To Various AgentsThese side effects may potentially be related to Metformine (metformin).
Metformin Side Effect Report#9870336
Completed Suicide
This is a report of a 34-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metformin Hcl (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Completed Suicide after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin Hcl treatment in male patients, resulting in Completed Suicide side effect.
Metformin Side Effect Report#9870267
Completed Suicide, Exposure Via Ingestion
This report suggests a potential Metformin Completed Suicide side effect(s) that can have serious consequences. A 60-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: NA) starting NS. After starting Metformin the patient began experiencing various side effects, including: Completed Suicide, Exposure Via IngestionAdditional drugs used concurrently:
  • Zolpidem Tartrate Tablets
  • Lisinopril And Hydrochlorothiazide
  • Ondansertron Hydrochloride
  • Pravastatin Sodium Tablets Usp
  • Atenolol
  • Digoxin
Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Metformin Side Effect Report#9869897
Eye Pruritus, Dizziness, Malaise, Heart Rate Decreased, Hyperhidrosis, Visual Acuity Reduced, Micturition Urgency
This Eye Pruritus problem was reported by a consumer or non-health professional from DK. A 44-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Metformin (dosage: NA). The following drugs were being taken at the same time:
  • Simvastatin (simvastatin)
  • Novomix
  • Victoza (liraglutide)
  • Hjertemagnyl
When using Metformin, the patient experienced the following unwanted symptoms/side effects: Eye Pruritus, Dizziness, Malaise, Heart Rate Decreased, Hyperhidrosis, Visual Acuity Reduced, Micturition UrgencyThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Pruritus, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9869703
Completed Suicide
This Completed Suicide side effect was reported by a physician from US. A 69-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformin Hcl Tablets (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Metformin Hcl Tablets the consumer reported adverse symptoms, such as: Completed SuicideThese side effects may potentially be related to Metformin Hcl Tablets.
Metformin Side Effect Report#9869653
Lactic Acidosis, Hyperlactacidaemia, Metabolic Acidosis
This is a report of a 69-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: type 2 diabetes mellitus, who was treated with Metformin (metformin) (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Lactic Acidosis, Hyperlactacidaemia, Metabolic Acidosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin (metformin) treatment in male patients, resulting in Lactic Acidosis side effect. The patient was hospitalized.
Metformin Side Effect Report#9869621
Completed Suicide
This report suggests a potential Metformin Completed Suicide side effect(s) that can have serious consequences. A 42-year-old female patient (weight: NA) from Country Not Specified was diagnosed with the following symptoms/conditions: NA and used Metformin (dosage: NA) starting NS. After starting Metformin the patient began experiencing various side effects, including: Completed SuicideAdditional drugs used concurrently:
  • Quetiapine
  • Venlafaxine
  • Haloperidol
  • Lorazepam
The patient was hospitalized. Although Metformin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Metformin Side Effect Report#9869602
Metabolic Acidosis, Renal Failure, Body Temperature Increased, Heart Rate Increased, Haemodialysis, Biopsy Kidney Abnormal, Renal Tubular Disorder, Nephritis
This Metabolic Acidosis problem was reported by a consumer or non-health professional from FR. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On NS this consumer started treatment with Metformine (metformin) (dosage: NA). The following drugs were being taken at the same time:
  • Fenofibrate
  • Flunarizine
  • Pantoprazole
  • Hydrocortisone
  • Alendronic Acid
  • Methotrexate
  • Paroxetine
  • Clorazepate
When using Metformine (metformin), the patient experienced the following unwanted symptoms/side effects: Metabolic Acidosis, Renal Failure, Body Temperature Increased, Heart Rate Increased, Haemodialysis, Biopsy Kidney Abnormal, Renal Tubular Disorder, NephritisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Metabolic Acidosis, may become evident only after a product is in use by the general population.
Metformin Side Effect Report#9868977
This Death side effect was reported by a consumer or non-health professional from Country Not Specified. A 2-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metformin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Thiazolidinediones
  • Glyburide
.After starting to take Metformin the consumer reported adverse symptoms, such as: These side effects may potentially be related to Metformin.
Metformin Side Effect Report#9868519
Lactic Acidosis, Oliguria
This is a report of a 90-year-old female patient (weight: NA) from IT, suffering from the following health symptoms/conditions: diabetes mellitus, who was treated with Metformin (dosage: 1000 Mg, Daily, start time: NS), combined with:
  • Dilatrend (Unk)
  • Enapren (Unk)
  • Lasix /00032601/ (Unk)
  • Plavix (Unk)
  • Antra /00661201/ (Unk)
  • Sivastin (Unk)
  • Keppra (Unk)
  • Zoloft (Unk)
and developed a serious reaction and side effect(s): Lactic Acidosis, Oliguria after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metformin treatment in female patients, resulting in Lactic Acidosis side effect.


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The appearance of Metformin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Metformin Side Effects for Women?

Women Side EffectsReports
Lactic Acidosis 1504
Renal Failure Acute 912
Diarrhoea 631
Vomiting 456
Nausea 395
Hypotension 353
Haemodialysis 346
Blood Glucose Increased 320
Hypoglycaemia 310
Metabolic Acidosis 309

What are common Metformin Side Effects for Men?

Men Side EffectsReports
Lactic Acidosis 1015
Renal Failure Acute 610
Diarrhoea 354
Blood Glucose Increased 311
Vomiting 277
Completed Suicide 267
Hypoglycaemia 243
Hypotension 233
Haemodialysis 215
Nausea 191

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Metformin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Metformin for You?

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    Metformin Safety Alerts, Active Ingredients, Usage Information

    NDC0093-1048
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameMetformin Hydrochloride
    NameMetformin Hydrochloride
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20020128
    LabelerTeva Pharmaceuticals USA Inc
    Active Ingredient(s)METFORMIN HYDROCHLORIDE
    Strength(s)500
    Unit(s)mg/1
    Pharma ClassBiguanide [EPC],Biguanides [Chemical/Ingredient]

    More About Metformin

    Side Effects reported to FDA: 10583

    Metformin safety alerts: 2007 2006 2005

    Reported deaths: 878

    Reported hospitalizations: 2864

    Latest Metformin clinical trials