From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes, said the Institute of Medicine report, released yesterday.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Metolazone Safety Reports submitted to FDA

Total Metolazone reports: 10.
Metolazone FDA safety alerts: No.
   Reported hospitalizations: 9.
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Reported Metolazone Side Effects: renal failure acute, asthenia, polyuria, vomiting, hypotension, laryngeal oedema, angioneurotic oedema, lethargy, hyponatraemia, confusional state, medical diet.
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Metolazone Side Effects Report #5242346-3
Pharmacist from UNITED STATES reported METOLAZONE problem on Feb 16, 2007. Male patient, 64 years of age, was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: hypotension. METOLAZONE dosage: 5 MG BID. During the same period patient was treated with BUMETANIDE, SPIRONOLACTONE, LACTULOSE, MG OXIDE, SENOKOT, NITROGLYCERIN. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5272133-1
METOLAZONE problem was reported by a Consumer or non-health professional from UNITED STATES on Mar 20, 2007. Male patient, 69 years of age, weighting 194.0 lb, was diagnosed with fluid retention and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: rash erythematous. METOLAZONE dosage: unknown. Patient recovered.

Metolazone Side Effects Report #5276878-9
Consumer or non-health professional from UNITED KINGDOM reported METOLAZONE problem on Dec 22, 2005. Female patient, 78 years of age, was diagnosed with oedema, blood pressure and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: hypotension, malaise, shock, syncope, vomiting. METOLAZONE dosage: unknown. During the same period patient was treated with FUROSEMIDE, DOXAZOSIN MESYLATE, ASPIRIN, ISPAGHULA HUSK, ATORVASTATIN CALCIUM, BISOPROLOL, LANSOPRAZOLE. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5305692-0
METOLAZONE problem was reported by a Pharmacist from UNITED STATES on Apr 23, 2007. Male patient, 59 years of age, was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: asthenia, hyperhidrosis, hypokalaemia, nausea, vomiting, weight decreased. METOLAZONE dosage: 5MG QAM PO. During the same period patient was treated with FUROSEMIDE. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5061187-3
Pharmacist from UNITED STATES reported METOLAZONE problem on July 19, 2006. Male patient, 83 years of age, was diagnosed with fluid retention and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: asthenia, dehydration, polyuria, renal failure acute. METOLAZONE dosage: 25 MG PO QD. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5071541-1
METOLAZONE problem was reported by a Pharmacist from UNITED STATES on Aug 03, 2006. Male patient, 85 years of age, weighting 184.1 lb, was diagnosed with oedema, hypertension and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: renal failure chronic. METOLAZONE dosage: 2.5 MG PO EVERY OTHER DAY. During the same period patient was treated with FUROSEMIDE, LISINOPRIL. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5093867-8
Pharmacist from UNITED STATES reported METOLAZONE problem on Aug 29, 2006. Male patient, weighting 249.1 lb, was diagnosed with cardiac failure congestive and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: asthenia, dyspnoea, medical diet, polyuria, renal failure acute. METOLAZONE dosage: 2.5MG MON AND FRI PO. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5120755-0
METOLAZONE problem was reported by a Pharmacist from UNITED STATES on Oct 03, 2006. Male patient, 60 years of age, was diagnosed with oedema and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: confusional state, hyponatraemia, lethargy. METOLAZONE dosage: 2.5 MG Q AM. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5139868-2
Pharmacist from UNITED STATES reported METOLAZONE problem on Oct 26, 2006. Male patient, weighting 328.5 lb, was diagnosed with cardiac failure congestive and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: renal failure acute. METOLAZONE dosage: 2.5MG DAILY PO. During the same period patient was treated with FUROSEMIDE. Patient was hospitalized. Patient recovered.

Metolazone Side Effects Report #5146692-3
METOLAZONE problem was reported by a Pharmacist from UNITED STATES on Nov 07, 2006. Male patient, weighting 222.7 lb, was diagnosed with polyuria and was treated with METOLAZONE. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, laryngeal oedema. METOLAZONE dosage: 2.5 MG EVERY 12 HOURS PO. During the same period patient was treated with FOLIC ACID, THIAMINE, PANTOPRAZOLE, DOCUSATE, OCTREOTIDE ACETATE, FERROUS SULPHATE, POTASSIUM CHLORIDE, FUROSEMIDE. Patient was hospitalized. Patient recovered.

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