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Metoprolol Succinate Side Effects

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Common Metoprolol Succinate Side Effects


The most commonly reported Metoprolol Succinate side effects are:
Dysphagia (2)
Flat Mood (1)
Vaginal Bleeding (1)
Fatigue (1)
Diarrhea (1)
Breast Enlargement (1)
Cold Feet (1)
Dysphagia, Cold Feet (1)

If you have experienced a side effect listed above, you can check a box to report it.


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If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Metoprolol Succinate Side Effects Reported to FDA



Metoprolol Succinate Side Effect Report#9982505
Conjunctival Ulcer, Treatment Failure, Tachycardia, Tachycardia, Myocardial Infarction
This is a report of a 70-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metoprolol Succinate - Not Given, 100 Mg (dosage: NA, start time: NS), combined with:
  • Clopidogrel
  • Lisinopril
  • Omeprazole
  • Levothyroxine
  • Simvastatin
  • Aspirin
  • Ibuprofen
  • Acyclovir
and developed a serious reaction and side effect(s): Conjunctival Ulcer, Treatment Failure, Tachycardia, Tachycardia, Myocardial Infarction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate - Not Given, 100 Mg treatment in female patients, resulting in Conjunctival Ulcer side effect. The patient was hospitalized.
Metoprolol Succinate Side Effect Report#9981469
Malaise, Hypertension, Product Quality Issue
This report suggests a potential Metoprolol Succinate 25 Mg Malaise side effect(s) that can have serious consequences. A 59-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Metoprolol Succinate 25 Mg (dosage: 25 Mg/ 1 Pill Once Daily Taken By Mouth) starting
Jan 15, 2014. After starting Metoprolol Succinate 25 Mg the patient began experiencing various side effects, including: Malaise, Hypertension, Product Quality IssueAdditional drugs used concurrently: NA. Although Metoprolol Succinate 25 Mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Malaise, may still occur.
Metoprolol Succinate Side Effect Report#9967003
Coronary Artery Occlusion, Nasopharyngitis, Cough, Off Label Use
This Coronary Artery Occlusion problem was reported by a consumer or non-health professional from US. A 63-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: heart rate increased,acute coronary syndrome,stent placement. On
Jan 13, 2014 this consumer started treatment with Metoprolol Succinate (dosage: NA). The following drugs were being taken at the same time:
  • Brilinta
  • Brilinta
  • Asprin
  • Lipitor
When using Metoprolol Succinate, the patient experienced the following unwanted symptoms/side effects: Coronary Artery Occlusion, Nasopharyngitis, Cough, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coronary Artery Occlusion, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9962828
Intentional Overdose, Completed Suicide, Convulsion, Somnolence, Hypotension, Bradycardia, Multi-organ Failure, Cardiac Arrest
This Intentional Overdose side effect was reported by a health professional from Country Not Specified. A 50-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Bupropion
  • Fenofibrate
.After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Intentional Overdose, Completed Suicide, Convulsion, Somnolence, Hypotension, Bradycardia, Multi-organ Failure, Cardiac ArrestThese side effects may potentially be related to Metoprolol Succinate. The patient was hospitalized.
Metoprolol Succinate Side Effect Report#9959215
Nausea, Glossodynia, Dyspepsia, Dysgeusia
This is a report of a 49-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: blood pressure, who was treated with Metoprolol Succinate Er (dosage: NA, start time:
Jan 14, 2014), combined with:
  • Lisinopril
  • Atorvastatin
  • Aspirin
  • Atorvastatin
and developed a serious reaction and side effect(s): Nausea, Glossodynia, Dyspepsia, Dysgeusia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate Er treatment in female patients, resulting in Nausea side effect.
Metoprolol Succinate Side Effect Report#9934958
Pyrexia, Malaise, Diarrhoea, Vomiting, Headache, Insomnia, Peripheral Coldness, Palpitations, Hyperhidrosis
This report suggests a potential Metoprolol Succinate Pyrexia side effect(s) that can have serious consequences. A 70-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: ventricular fibrillation and used Metoprolol Succinate (dosage: NA) starting
Sep 23, 2013. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Pyrexia, Malaise, Diarrhoea, Vomiting, Headache, Insomnia, Peripheral Coldness, Palpitations, HyperhidrosisAdditional drugs used concurrently: NA. Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pyrexia, may still occur.
Metoprolol Succinate Side Effect Report#9934954
Headache, Blood Pressure Increased, Tinnitus
This Headache problem was reported by a consumer or non-health professional from US. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On 201308 this consumer started treatment with Metoprolol Succinate (dosage: NA). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate, the patient experienced the following unwanted symptoms/side effects: Headache, Blood Pressure Increased, TinnitusAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Headache, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9934927
Hypersensitivity, Dyspnoea
This Hypersensitivity side effect was reported by a consumer or non-health professional from US. A 59-year-old male patient (weight:NA) experienced the following symptoms/conditions: heart rate increased,hypertension,blood cholesterol abnormal.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on 2002. Concurrently used drugs:
  • Diovan
  • Lescol
  • Benecar
.After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Hypersensitivity, DyspnoeaThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Succinate Side Effect Report#9934881
Therapeutic Response Decreased, Nausea, Heart Rate Irregular
This is a report of a 76-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Metoprolol Succinate (dosage: NA, start time: NS), combined with:
  • Aspirin (Unk)
  • Simvastatin (Unk)
and developed a serious reaction and side effect(s): Therapeutic Response Decreased, Nausea, Heart Rate Irregular after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in male patients, resulting in Therapeutic Response Decreased side effect.
Metoprolol Succinate Side Effect Report#9934694
Fall, Spinal Fracture, Stress, Photophobia, Osteoporosis, Body Height Decreased, Hypotension, Alopecia
This report suggests a potential Metoprolol Succinate Fall side effect(s) that can have serious consequences. A 82-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: hypertension and used Metoprolol Succinate (dosage: NA) starting NS. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Fall, Spinal Fracture, Stress, Photophobia, Osteoporosis, Body Height Decreased, Hypotension, AlopeciaAdditional drugs used concurrently: NA. Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Fall, may still occur.
Metoprolol Succinate Side Effect Report#9934693
Alopecia
This Alopecia problem was reported by a consumer or non-health professional from US. A 49-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: blood pressure increased. On
May 10, 2013 this consumer started treatment with Metoprolol Succinate (dosage: NA). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate, the patient experienced the following unwanted symptoms/side effects: AlopeciaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Alopecia, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9934690
Dizziness, Vertigo, Chest Discomfort, Flatulence, Panic Attack, Off Label Use
This Dizziness side effect was reported by a consumer or non-health professional from US. A 67-year-old female patient (weight:NA) experienced the following symptoms/conditions: heart rate decreased.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on
Oct 16, 2013. Concurrently used drugs: NA..After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Dizziness, Vertigo, Chest Discomfort, Flatulence, Panic Attack, Off Label UseThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Succinate Side Effect Report#9934689
Pruritus, Rash, Off Label Use
This is a report of a 41-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: ventricular extrasystoles, who was treated with Metoprolol Succinate Az (dosage: NA, start time: 2007), combined with: NA. and developed a serious reaction and side effect(s): Pruritus, Rash, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate Az treatment in female patients, resulting in Pruritus side effect.
Metoprolol Succinate Side Effect Report#9934662
Nausea, Diarrhoea, Asthenia
This report suggests a potential Metoprolol Succinate Nausea side effect(s) that can have serious consequences. A 65-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: cardiac disorder,blood pressure,multiple allergies and used Metoprolol Succinate (dosage: NA) starting NS. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Nausea, Diarrhoea, AstheniaAdditional drugs used concurrently:
  • Triamterne Hct
  • Xanax
  • Zyrtec
  • Prednisone
Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nausea, may still occur.
Metoprolol Succinate Side Effect Report#9934643
Pruritus, Burning Sensation, Off Label Use
This Pruritus problem was reported by a consumer or non-health professional from US. A 88-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: atrial fibrillation,heart rate abnormal,hypertension,thyroid disorder,blood cholesterol increased. On 2008 this consumer started treatment with Metoprolol Succinate (dosage: NA). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate, the patient experienced the following unwanted symptoms/side effects: Pruritus, Burning Sensation, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pruritus, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9934633
Cognitive Disorder, Depression, Amnesia, Insomnia, Anxiety, Insomnia
This Cognitive Disorder side effect was reported by a consumer or non-health professional from US. A 67-year-old female patient (weight:NA) experienced the following symptoms/conditions: blood pressure abnormal,heart rate abnormal,atrial fibrillation.The patient was prescribed Metoprolol Succinate (drug dosage: Watson-non Az), which was initiated on 201210. Concurrently used drugs: NA..After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: Cognitive Disorder, Depression, Amnesia, Insomnia, Anxiety, InsomniaThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Succinate Side Effect Report#9934595
Blood Pressure Inadequately Controlled
This is a report of a 75-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: hypertension,blood cholesterol,blood pressure, who was treated with Metoprolol Succinate Er (dosage: NA, start time: NS), combined with:
  • Vytorin
  • Amlodipine
  • Aspirin
  • Fosamax
  • Methenamine Mandelate
and developed a serious reaction and side effect(s): Blood Pressure Inadequately Controlled after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate Er treatment in male patients, resulting in Blood Pressure Inadequately Controlled side effect.
Metoprolol Succinate Side Effect Report#9934536
Reaction To Food Colouring, Migraine, Myalgia, Gastrooesophageal Reflux Disease, Abdominal Discomfort, Off Label Use
This report suggests a potential Metoprolol Succinate Reaction To Food Colouring side effect(s) that can have serious consequences. A 77-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: blood cholesterol abnormal,blood cholesterol increased and used Metoprolol Succinate (dosage: NA) starting 201311. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Reaction To Food Colouring, Migraine, Myalgia, Gastrooesophageal Reflux Disease, Abdominal Discomfort, Off Label UseAdditional drugs used concurrently:
  • Crestor
  • Zocor
  • Lipitor
  • Pantoprazole Sodium
Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Reaction To Food Colouring, may still occur.
Metoprolol Succinate Side Effect Report#9934517
Urticaria, Flushing
This Urticaria problem was reported by a consumer or non-health professional from US. A 62-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On 1998 this consumer started treatment with Metoprolol Succinate Er (dosage: NA). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate Er, the patient experienced the following unwanted symptoms/side effects: Urticaria, FlushingAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Urticaria, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9934512
Hypertension
This Hypertension side effect was reported by a consumer or non-health professional from US. A 76-year-old female patient (weight:NA) experienced the following symptoms/conditions: blood pressure.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Lisinopril
  • Zetia
  • Lipitor
  • Procardia
.After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: HypertensionThese side effects may potentially be related to Metoprolol Succinate.
Metoprolol Succinate Side Effect Report#9934448
Dizziness, Amnesia, Pain In Extremity, Alopecia, Dyspnoea
This is a report of a 77-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: atrial fibrillation, who was treated with Metoprolol Succinate (dosage: NA, start time: 200906), combined with: NA. and developed a serious reaction and side effect(s): Dizziness, Amnesia, Pain In Extremity, Alopecia, Dyspnoea after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in female patients, resulting in Dizziness side effect.
Metoprolol Succinate Side Effect Report#9898030
Cerebrovascular Accident, Off Label Use
This report suggests a potential Metoprolol Succinate Cerebrovascular Accident side effect(s) that can have serious consequences. A 80-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: atrial fibrillation,cerebrovascular accident and used Metoprolol Succinate (dosage: NA) starting 201209. After starting Metoprolol Succinate the patient began experiencing various side effects, including: Cerebrovascular Accident, Off Label UseAdditional drugs used concurrently: NA. Although Metoprolol Succinate demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cerebrovascular Accident, may still occur.
Metoprolol Succinate Side Effect Report#9882564
Blood Pressure Increased
This Blood Pressure Increased problem was reported by a consumer or non-health professional from US. A 74-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: hypertension. On
Jan 01, 2014 this consumer started treatment with Metoprolol Succinate (watson Laboratories) (dosage: 50 Mg, Bid). The following drugs were being taken at the same time: NA. When using Metoprolol Succinate (watson Laboratories), the patient experienced the following unwanted symptoms/side effects: Blood Pressure IncreasedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Blood Pressure Increased, may become evident only after a product is in use by the general population.
Metoprolol Succinate Side Effect Report#9858370
Angioedema
This Angioedema side effect was reported by a consumer or non-health professional from US. A 47-year-old male patient (weight:NA) experienced the following symptoms/conditions: hypertension,blood cholesterol increased.The patient was prescribed Metoprolol Succinate (drug dosage: NA), which was initiated on
Jan 24, 2014. Concurrently used drugs:
  • Simvastatin
  • Hydrochlorothiazide
  • Vitamin D
  • Baby Aspirin
.After starting to take Metoprolol Succinate the consumer reported adverse symptoms, such as: AngioedemaThese side effects may potentially be related to Metoprolol Succinate. The patient was hospitalized.
Metoprolol Succinate Side Effect Report#9856132
Ventricular Tachycardia, Pain In Extremity, Amnesia, Peripheral Coldness, Bradycardia, Palpitations
This is a report of a 45-year-old male patient (weight: NA) from NL, suffering from the following health symptoms/conditions: arrhythmia, who was treated with Metoprolol Succinate (dosage: NA, start time:
Mar 03, 2011), combined with:
  • Metoprolol Succinaat
  • Metoprolol Succinaat
  • Metoprolol Succinaat
  • Metoprolol Succinaat
  • Metoprolol Succinaat
  • Kinidine Dragee 200mg
  • Kinidine Dragee 200mg
  • Acetylsalicylzuur
and developed a serious reaction and side effect(s): Ventricular Tachycardia, Pain In Extremity, Amnesia, Peripheral Coldness, Bradycardia, Palpitations after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Metoprolol Succinate treatment in male patients, resulting in Ventricular Tachycardia side effect.


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The appearance of Metoprolol Succinate on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Metoprolol Succinate Side Effects for Women?

Women Side EffectsReports
Blood Pressure Increased 84
Dizziness 84
Fatigue 61
Palpitations 52
Nausea 48
Dyspnoea 45
Headache 43
Heart Rate Increased 37
Asthenia 32
Diarrhoea 32

What are common Metoprolol Succinate Side Effects for Men?

Men Side EffectsReports
Blood Pressure Increased 43
Bradycardia 42
Dizziness 42
Hypotension 32
Heart Rate Increased 28
Product Quality Issue 26
Syncope 26
Product Substitution Issue 25
Fatigue 24
Palpitations 24

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    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Metoprolol Succinate reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Metoprolol Succinate Safety Alerts, Active Ingredients, Usage Information

    NDC0378-4595
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameMetoprolol Succinate
    Namemetoprolol succinate
    Dosage FormTABLET, FILM COATED, EXTENDED RELEASE
    RouteORAL
    On market since20111221
    LabelerMylan Pharmaceuticals Inc.
    Active Ingredient(s)METOPROLOL SUCCINATE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassAdrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]

    More About Metoprolol succinate

    Side Effects reported to FDA: 1322

    Metoprolol Succinate safety alerts: 2005

    Reported deaths: 103

    Reported hospitalizations: 454

    Toprol-XL (metoprolol succinate)

    Audience: All healthcare professionals

    [UPDATE November 10, 2005] Letters from Novartis Pharmaceuticals Corporation added below

    [UPDATE September 30, 2005] Letters from Ortho-McNeil Neurologics, Inc. added below

    [Posted 09/26/2005] AstraZeneca and FDA notified healthcare professionals reports of medication dispensing or prescribing errors between Toprol-XL (metoprolol succinate) extended release tablets, indicated for the treatment of hypertension, long-term treatment of angina pectoris, and heart failure NYHA Class II or III, and Topamax (topiramate), a product of Ortho-McNeil Neurologics, Inc, indicated for the treatment of epilepsy and migraine prophylaxis. There have also been reports of medication errors involving confusion between Toprol-XL and Tegretol or Tegretol-XR (carbamazepine), products of Novartis Pharmaceuticals Corporation, indicated for the treatment of complex partial seizures, generalized tonic-clonic seizures, and trigeminal neuralgia. These reports include instances where Toprol-XL was incorrectly administered to patients instead of Topamax, Tegretol, or Tegretol-XR, and vice versa, some of them leading to adverse events.

    [October 2005 - Dear Healthcare Professional Letter - Novartis]
    [October 2005 - Dear Pharmacist Letter - Novartis]

    [September 2005 - Dear Healthcare Professional Letter - Ortho-McNeil Neurologics, Inc.]
    [September 2005 - Dear Pharmacist Letter - Ortho-McNeil Neurologics, Inc.]

    [September 22, 2005 - Dear Healthcare Professional Letter - AstraZeneca]
    [September 22, 2005 - Dear Pharmacist Letter - AstraZeneca]

    Latest Metoprolol Succinate clinical trials