Common Nexium Side Effects


The most commonly reported Nexium side effects (click to view or check a box to report):

Gastrooesophageal Reflux Disease (3970)
Malaise (2729)
Dyspepsia (2294)
Pain (1309)
Vomiting (1209)
Osteoporosis (1201)
Abdominal Pain Upper (1180)
Abdominal Discomfort (946)
Off Label Use (839)
Fall (820)
Gastric Disorder (817)
Chest Pain (787)
Nausea (778)
Diarrhoea (704)
Aphagia (702)
Diabetes Mellitus (634)
Cerebrovascular Accident (610)
Headache (579)
Adverse Event (578)
Dyspnoea (575)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Nexium Side Effects Reported to FDA



Nexium Side Effect Report#9999715
Dysphagia, Abdominal Discomfort, Flatulence, Off Label Use
This is a report of a 76-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: gastrooesophageal reflux disease,ulcer,abdominal discomfort, who was treated with Nexium (dosage: NA, start time: 2011), combined with: NA. and developed a serious reaction and side effect(s): Dysphagia, Abdominal Discomfort, Flatulence, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in female patients, resulting in Dysphagia side effect.
Nexium Side Effect Report#9999714
Dyspepsia, Gastrooesophageal Reflux Disease, Oropharyngeal Pain, Neck Pain, Gastrointestinal Disorder, Chest Pain, Activities Of Daily Living Impaired, Feeling Abnormal, Malaise
This report suggests a potential Nexium Dyspepsia side effect(s) that can have serious consequences. A 37-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease and used Nexium (dosage: NA) starting 201310. After starting Nexium the patient began experiencing various side effects, including: Dyspepsia, Gastrooesophageal Reflux Disease, Oropharyngeal Pain, Neck Pain, Gastrointestinal Disorder, Chest Pain, Activities Of Daily Living Impaired, Feeling Abnormal, MalaiseAdditional drugs used concurrently: NA. Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dyspepsia, may still occur.
Nexium Side Effect Report#9999471
Coma, Myocardial Infarction, Respiratory Arrest, Gait Disturbance, Asthenia
This Coma problem was reported by a consumer or non-health professional from BR. A 54-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: barrett^s oesophagus,myocardial infarction. On 201402 this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time:
  • Brilinta
When using Nexium, the patient experienced the following unwanted symptoms/side effects: Coma, Myocardial Infarction, Respiratory Arrest, Gait Disturbance, AstheniaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Coma, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9999353
Nervousness
This Nervousness side effect was reported by a pharmacist from US. A 80-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nexium (drug dosage: NA), which was initiated on
Oct 31, 2013. Concurrently used drugs:
  • Metoprolol
  • Diltiazem
  • Urosiol
  • Warfarin
  • Lisinopril
  • Oxybutynin
  • Atorvastatin
.After starting to take Nexium the consumer reported adverse symptoms, such as: NervousnessThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9998064
Blood Thyroid Stimulating Hormone Increased, Blood Iron Decreased, Haemoglobin Decreased, Red Blood Cell Count Decreased, Haematocrit Decreased, Lymphocyte Count Decreased, Monocyte Count Increased, Duodenal Ulcer, Weight Increased
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: duodenal ulcer, who was treated with Nexium (dosage: NA, start time: 1993), combined with:
  • Prilosec
  • Synthroid
  • Synthroid
  • Norvasc
  • Celexa
  • Maxide
  • Cozaar
  • Ropinerole
and developed a serious reaction and side effect(s): Blood Thyroid Stimulating Hormone Increased, Blood Iron Decreased, Haemoglobin Decreased, Red Blood Cell Count Decreased, Haematocrit Decreased, Lymphocyte Count Decreased, Monocyte Count Increased, Duodenal Ulcer, Weight Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in female patients, resulting in Blood Thyroid Stimulating Hormone Increased side effect.
Nexium Side Effect Report#9998062
Rash, Pruritus
This report suggests a potential Nexium Rash side effect(s) that can have serious consequences. A 66-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nexium (dosage: NA) starting NS. After starting Nexium the patient began experiencing various side effects, including: Rash, PruritusAdditional drugs used concurrently: NA. Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rash, may still occur.
Nexium Side Effect Report#9997957
Dyspepsia
This Dyspepsia problem was reported by a consumer or non-health professional from US. A 59-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On 2007 this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexium, the patient experienced the following unwanted symptoms/side effects: DyspepsiaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Dyspepsia, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9997956
Hepatomegaly, Muscle Spasms, Blood Magnesium Decreased, Abdominal Pain, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This Hepatomegaly side effect was reported by a consumer or non-health professional from US. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease,blood pressure abnormal.The patient was prescribed Nexium (drug dosage: NA), which was initiated on 201401. Concurrently used drugs:
  • Lisinopril/hctz
  • Lisinopril/hctz
  • Amlodipine
  • Over The Counter Supplements
.After starting to take Nexium the consumer reported adverse symptoms, such as: Hepatomegaly, Muscle Spasms, Blood Magnesium Decreased, Abdominal Pain, Aspartate Aminotransferase Increased, Alanine Aminotransferase IncreasedThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9997939
Vitamin D Decreased, Barrett^s Oesophagus, Off Label Use
This is a report of a 49-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: barrett^s oesophagus,gastrooesophageal reflux disease, who was treated with Nexium (dosage: NA, start time: 1987), combined with: NA. and developed a serious reaction and side effect(s): Vitamin D Decreased, Barrett^s Oesophagus, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in female patients, resulting in Vitamin D Decreased side effect.
Nexium Side Effect Report#9997937
Affective Disorder, Depression, Abdominal Discomfort
This report suggests a potential Nexium Affective Disorder side effect(s) that can have serious consequences. A 15-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: eosinophilic oesophagitis,gastric disorder and used Nexium (dosage: NA) starting 201302. After starting Nexium the patient began experiencing various side effects, including: Affective Disorder, Depression, Abdominal DiscomfortAdditional drugs used concurrently: NA. Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Affective Disorder, may still occur.
Nexium Side Effect Report#9997720
Interstitial Lung Disease
This Interstitial Lung Disease problem was reported by a pharmacist from JP. A 57-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Feb 11, 2014 this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time:
  • Bayaspirin
  • Plavix
  • Lansoprazole
  • Lipitor
  • Coniel
  • Zetia
  • Nitroderm Tts
  • Miya Bm
When using Nexium, the patient experienced the following unwanted symptoms/side effects: Interstitial Lung DiseaseThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Interstitial Lung Disease, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9996465
Hypoaesthesia, Paraesthesia, Arthralgia, Neuralgia
This Hypoaesthesia side effect was reported by a pharmacist from US. A 70-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nexium (drug dosage: NA), which was initiated on
Mar 02, 2004. Concurrently used drugs: NA..After starting to take Nexium the consumer reported adverse symptoms, such as: Hypoaesthesia, Paraesthesia, Arthralgia, NeuralgiaThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9995679
Visual Impairment, Dyspepsia, Diabetes Mellitus, Cardiac Disorder, Dysuria, Cardiac Failure Congestive, Gait Disturbance, Pollakiuria, Dysphagia
This is a report of a 56-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: dyspepsia,gastrooesophageal reflux disease, who was treated with Nexium (dosage: NA, start time: 2008), combined with: NA. and developed a serious reaction and side effect(s): Visual Impairment, Dyspepsia, Diabetes Mellitus, Cardiac Disorder, Dysuria, Cardiac Failure Congestive, Gait Disturbance, Pollakiuria, Dysphagia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in male patients, resulting in Visual Impairment side effect.
Nexium Side Effect Report#9993237
Condition Aggravated, Hypophagia, Parosmia, Paranoia, Sinus Disorder, Vitreous Floaters, Weight Decreased, Overweight, Ageusia
This report suggests a potential Nexium Condition Aggravated side effect(s) that can have serious consequences. A 48-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: dyspepsia,gastrooesophageal reflux disease and used Nexium (dosage: NA) starting 201309. After starting Nexium the patient began experiencing various side effects, including: Condition Aggravated, Hypophagia, Parosmia, Paranoia, Sinus Disorder, Vitreous Floaters, Weight Decreased, Overweight, AgeusiaAdditional drugs used concurrently: NA. Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Condition Aggravated, may still occur.
Nexium Side Effect Report#9992810
Asthma, Off Label Use
This Asthma problem was reported by a consumer or non-health professional from US. A 61-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On
Jan 22, 2014 this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexium, the patient experienced the following unwanted symptoms/side effects: Asthma, Off Label UseAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Asthma, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9992732
Asthma, Malaise
This Asthma side effect was reported by a consumer or non-health professional from US. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease.The patient was prescribed Nexium (drug dosage: NA), which was initiated on 2009. Concurrently used drugs: NA..After starting to take Nexium the consumer reported adverse symptoms, such as: Asthma, MalaiseThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9991672
Diarrhoea, Cough, Off Label Use
This is a report of a 72-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: cough,bronchiolitis, who was treated with Nexium (dosage: NA, start time: 200108), combined with:
  • Pulmicort Flexhaler (180mcg, Two Puffs Bid)
  • Hyzaar
  • Zocor
  • Hycomine Syrup With Codeine
and developed a serious reaction and side effect(s): Diarrhoea, Cough, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in female patients, resulting in Diarrhoea side effect.
Nexium Side Effect Report#9988085
Rhabdomyolysis, Spinal Compression Fracture, Hepatic Function Abnormal
This report suggests a potential Nexium Rhabdomyolysis side effect(s) that can have serious consequences. A 70-year-old male patient (weight: NA) from JP was diagnosed with the following symptoms/conditions: NA and used Nexium (dosage: NA) starting NS. After starting Nexium the patient began experiencing various side effects, including: Rhabdomyolysis, Spinal Compression Fracture, Hepatic Function AbnormalAdditional drugs used concurrently: NA. Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Rhabdomyolysis, may still occur.
Nexium Side Effect Report#9986575
Adverse Event
This Adverse Event problem was reported by a consumer or non-health professional from US. A 71-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time:
  • Tagamet
  • Tums
  • Pepcid
When using Nexium, the patient experienced the following unwanted symptoms/side effects: Adverse EventAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Adverse Event, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9986533
Adverse Event, Schizophrenia, Decreased Appetite, Gastrooesophageal Reflux Disease, Amnesia, Disturbance In Attention, Depression, Agitation
This Adverse Event side effect was reported by a consumer or non-health professional from US. A 20-year-old male patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease.The patient was prescribed Nexium (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Omeprazole Rx
  • Celexa
  • Topamax
  • Geodon
.After starting to take Nexium the consumer reported adverse symptoms, such as: Adverse Event, Schizophrenia, Decreased Appetite, Gastrooesophageal Reflux Disease, Amnesia, Disturbance In Attention, Depression, AgitationThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9986454
Hypertension, Gastrooesophageal Reflux Disease, Eructation
This is a report of a 64-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: gastrooesophageal reflux disease, who was treated with Nexium (dosage: NA, start time: 201401), combined with:
  • Prilosec Delayed-release Capsules
  • Sulcralfate
and developed a serious reaction and side effect(s): Hypertension, Gastrooesophageal Reflux Disease, Eructation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in male patients, resulting in Hypertension side effect.
Nexium Side Effect Report#9986431
Gastrooesophageal Reflux Disease, Gastritis
This report suggests a potential Nexium Gastrooesophageal Reflux Disease side effect(s) that can have serious consequences. A 38-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease and used Nexium (dosage: NA) starting 2011. After starting Nexium the patient began experiencing various side effects, including: Gastrooesophageal Reflux Disease, GastritisAdditional drugs used concurrently:
  • Prilosec
  • Prilosec
  • Prilosec (Omeprazole, 20 Mg, Two Times A Day)
  • Prilosec Otc
  • Zyrtec
  • Zyrtec
  • Centrum Multivitamin (1 Tab/cap Daily)
  • Zantac
Although Nexium demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Gastrooesophageal Reflux Disease, may still occur.
Nexium Side Effect Report#9986408
Burning Sensation
This Burning Sensation problem was reported by a consumer or non-health professional from US. A 56-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On 2012 this consumer started treatment with Nexium (dosage: NA). The following drugs were being taken at the same time: NA. When using Nexium, the patient experienced the following unwanted symptoms/side effects: Burning SensationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Burning Sensation, may become evident only after a product is in use by the general population.
Nexium Side Effect Report#9986372
Muscle Spasms, Cough, Gastrooesophageal Reflux Disease, Weight Increased, Weight Decreased
This Muscle Spasms side effect was reported by a consumer or non-health professional from US. A 69-year-old male patient (weight:NA) experienced the following symptoms/conditions: gastrooesophageal reflux disease.The patient was prescribed Nexium (drug dosage: NA), which was initiated on 201306. Concurrently used drugs: NA..After starting to take Nexium the consumer reported adverse symptoms, such as: Muscle Spasms, Cough, Gastrooesophageal Reflux Disease, Weight Increased, Weight DecreasedThese side effects may potentially be related to Nexium.
Nexium Side Effect Report#9986318
Gastrooesophageal Reflux Disease, Aphagia, Nausea, Abdominal Discomfort, Off Label Use
This is a report of a 41-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: gastrooesophageal reflux disease, who was treated with Nexium (dosage: NA, start time: 2013), combined with: NA. and developed a serious reaction and side effect(s): Gastrooesophageal Reflux Disease, Aphagia, Nausea, Abdominal Discomfort, Off Label Use after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nexium treatment in male patients, resulting in Gastrooesophageal Reflux Disease side effect.


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The appearance of Nexium on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Nexium Side Effects for Women?

Women Side Effects Reports
Gastrooesophageal Reflux Disease 2955
Malaise 2199
Dyspepsia 1697
Pain 1006
Osteoporosis 922
Vomiting 917
Abdominal Pain Upper 909
Abdominal Discomfort 721
Fall 675
Gastric Disorder 624

What are common Nexium Side Effects for Men?

Men Side Effects Reports
Gastrooesophageal Reflux Disease 1013
Dyspepsia 595
Malaise 528
Pain 302
Vomiting 291
Abdominal Pain Upper 270
Off Label Use 269
Osteoporosis 259
Myocardial Infarction 232
Abdominal Discomfort 225

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Nexium reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Nexium Side Effects

    Did You Have a Nexium Side Effect?

    Yes, Severe
    Yes, Moderate
    Yes, Minor
    No

    How Effective is Nexium for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Nexium Safety Alerts, Active Ingredients, Usage Information

    NDC 0186-4010
    Type HUMAN PRESCRIPTION DRUG
    Proprietary Name NEXIUM
    Name Esomeprazole magnesium
    Dosage Form GRANULE, DELAYED RELEASE
    Route ORAL
    On market since 20080707
    Labeler AstraZeneca LP
    Active Ingredient(s) ESOMEPRAZOLE MAGNESIUM
    Strength(s) 10
    Unit(s) mg/1
    Pharma Class Proton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA],Cytochrome P450 2C19 Inhibitors [MoA]

    Nexium Dosage, Warnings, Usage.

    Side Effects reported to FDA: 23376

    Nexium safety alerts: 2007

    Reported deaths: 730

    Reported hospitalizations: 5053

    Nexium (esomeprazole)

    Audience: Gastroenterologists, other healthcare professionals, consumers

    [UPDATE 12/11/2007] FDA informed healthcare professionals of the issuance of the Agency's follow-up communication regarding its review of safety data for the drugs omeprazole and esomeprazole that raised concerns about a potential increased risk of heart problems for patients treated with these drugs. The Agency conducted a comprehensive review of the data from two studies that were submitted to FDA. FDA continues to believe that long-term use of omeprazole or esomeprazole is not likely to be associated with an increased risk of heart problems and recommends that healthcare providers continue to prescribe and patients continue to use these products in the manner described in the labeling for the two products. See the "Update of Safety Review" for information regarding the two studies that were reviewed.

    [Posted August 09, 2007] FDA issued an early communication about the ongoing review of new safety data for the proton pump inhibitors, Prilosec and Nexium. The new safety data was from two small long-term clinical studies in patients with severe gastroesophageal reflux disease (GERD). In both studies, patients were randomly assigned to receive treatment with a drug (either omeprazole or esomeprazole) or to have surgery to control their GERD.

    The results from the study of Prilosec and analyses from an ongoing study of Nexium raised concerns that long-term use of Prilosec or Nexium may have increased the risk of heart attacks, heart failure, and heart-related sudden death in those patients taking either one of the drugs compared to patients who received surgery. After reviewing these and other data submitted by the company, FDA's preliminary conclusion at this time, is that collectively, these data do not suggest an increased risk of heart problems for patients treated with omeprazole or esomeprazole. Healthcare providers should not change their prescribing practices and patients should not change their use of these products at this time.

    Both drugs are used for the treatment of GERD, esophageal erosions and for maintenance of healing erosions of the esophagus. They are also used for the treatment of ulcers. Prilosec is also sold over the counter for frequent heartburn.

    [December 10, 2007 - Update of Safety Review - Omeprazole and Esomeprazole - FDA]
    [August 09, 2007 - Early Communication About an Ongoing Safety Review - Omeprazole and Esomeprazole - FDA]

    Latest Nexium clinical trials