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Nortriptyline Side Effects

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Common Nortriptyline Side Effects


The most commonly reported Nortriptyline side effects (click to view or check a box to report):

Completed Suicide (19)
Dizziness (16)
Fall (15)
Toxicity To Various Agents (14)
Headache (13)
Confusional State (11)
Electrocardiogram Qrs Complex Prolonged (11)
Convulsion (11)
Insomnia (10)
Hypotension (10)
Dry Mouth (9)
Cardiac Arrest (9)
Depression (9)
Feeling Abnormal (9)
Weight Increased (9)
Nausea (9)
Syncope (9)
Overdose (9)
Hyperhidrosis (8)
Suicidal Ideation (8)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Nortriptyline Side Effects Reported to FDA



Nortriptyline Side Effect Report#9931785
Panic Attack, Confusional State, Nightmare, Nervousness, Dry Mouth, Constipation
This is a report of a 46-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: depression, who was treated with Nortriptyline (dosage: 1 Capsule At Bedtime Taken By Mouth, start time:
Dec 26, 2013), combined with: NA. and developed a serious reaction and side effect(s): Panic Attack, Confusional State, Nightmare, Nervousness, Dry Mouth, Constipation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in male patients, resulting in Panic Attack side effect.
Nortriptyline Side Effect Report#9681928
Cardiotoxicity, Tachycardia, Hypotension, Electrocardiogram Qrs Complex Prolonged, Toxicity To Various Agents
This report suggests a potential Nortriptyline Cardiotoxicity side effect(s) that can have serious consequences. A 12-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nortriptyline (dosage: NA) starting NS. After starting Nortriptyline the patient began experiencing various side effects, including: Cardiotoxicity, Tachycardia, Hypotension, Electrocardiogram Qrs Complex Prolonged, Toxicity To Various AgentsAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Cardiotoxicity, may still occur.
Nortriptyline Side Effect Report#9681083
Palpitations, Blister, Pruritus, Product Substitution Issue, Skin Discolouration
This Palpitations problem was reported by a consumer or non-health professional from CA. A 45-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: migraine. On NS this consumer started treatment with Nortriptyline (dosage: NA). The following drugs were being taken at the same time: NA. When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Palpitations, Blister, Pruritus, Product Substitution Issue, Skin DiscolourationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Palpitations, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9675907
Toxicity To Various Agents, Electrocardiogram Qrs Complex Prolonged, Tachycardia, Hypotension
This Toxicity To Various Agents side effect was reported by a health professional from US. A 12-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nortriptyline (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Nortriptyline the consumer reported adverse symptoms, such as: Toxicity To Various Agents, Electrocardiogram Qrs Complex Prolonged, Tachycardia, HypotensionThese side effects may potentially be related to Nortriptyline.
Nortriptyline Side Effect Report#9674671
Electrocardiogram Qrs Complex Prolonged, Tachycardia, Hypotension, Toxicity To Various Agents
This is a report of a 12-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nortriptyline (dosage: Unk, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Electrocardiogram Qrs Complex Prolonged, Tachycardia, Hypotension, Toxicity To Various Agents after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in female patients, resulting in Electrocardiogram Qrs Complex Prolonged side effect.
Nortriptyline Side Effect Report#9617100
Alopecia
This report suggests a potential Nortriptyline Alopecia side effect(s) that can have serious consequences. A 22-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: depression,headache,prophylaxis and used Nortriptyline (dosage: NA) starting
Sep 10, 2013. After starting Nortriptyline the patient began experiencing various side effects, including: AlopeciaAdditional drugs used concurrently: NA. Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Alopecia, may still occur.
Nortriptyline Side Effect Report#9552288
Lethargy, Mental Status Changes, Overdose, Confusional State
This Lethargy problem was reported by a pharmacist from US. A 80-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression,insomnia. On
Sep 03, 2013 this consumer started treatment with Nortriptyline (dosage: At Bedtime, By Mouth). The following drugs were being taken at the same time: NA. When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Lethargy, Mental Status Changes, Overdose, Confusional StateThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Lethargy, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9535622
Electrocardiogram Qrs Complex Prolonged
This Electrocardiogram Qrs Complex Prolonged side effect was reported by a health professional from NL. A 35-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Nortriptyline (drug dosage: 150 Mg, Qd), which was initiated on NS. Concurrently used drugs: NA..After starting to take Nortriptyline the consumer reported adverse symptoms, such as: Electrocardiogram Qrs Complex ProlongedThese side effects may potentially be related to Nortriptyline.
Nortriptyline Side Effect Report#9535117
Electrocardiogram Qrs Complex Prolonged
This is a report of a 35-year-old male patient (weight: NA) from NL, suffering from the following health symptoms/conditions: depression, who was treated with Nortriptyline (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Electrocardiogram Qrs Complex Prolonged after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in male patients, resulting in Electrocardiogram Qrs Complex Prolonged side effect.
Nortriptyline Side Effect Report#9526912
Sinus Tachycardia, Electrocardiogram Qrs Complex Prolonged, Ventricular Tachycardia, Syncope
This report suggests a potential Nortriptyline Sinus Tachycardia side effect(s) that can have serious consequences. A 35-year-old male patient (weight: NA) from NL was diagnosed with the following symptoms/conditions: depression and used Nortriptyline (dosage: 150 Mg, Qd For 1 Year) starting NS. After starting Nortriptyline the patient began experiencing various side effects, including: Sinus Tachycardia, Electrocardiogram Qrs Complex Prolonged, Ventricular Tachycardia, SyncopeAdditional drugs used concurrently: NA. Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Sinus Tachycardia, may still occur.
Nortriptyline Side Effect Report#9499542
Cardiac Arrest, Haemodynamic Instability, Toxicity To Various Agents, Suicide Attempt
This Cardiac Arrest problem was reported by a health professional from DK. A 40-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Nortriptyline (dosage: Unk). The following drugs were being taken at the same time:
  • Lithium (Unk)
When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Cardiac Arrest, Haemodynamic Instability, Toxicity To Various Agents, Suicide AttemptThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cardiac Arrest, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9492314
Haemodynamic Instability, Cardiac Arrest, Toxicity To Various Agents, Loss Of Consciousness, Suicide Attempt
This Haemodynamic Instability side effect was reported by a health professional from DK. A 40-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Nortriptyline (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Lithium
.After starting to take Nortriptyline the consumer reported adverse symptoms, such as: Haemodynamic Instability, Cardiac Arrest, Toxicity To Various Agents, Loss Of Consciousness, Suicide AttemptThese side effects may potentially be related to Nortriptyline. The patient was hospitalized.
Nortriptyline Side Effect Report#9472633
Muscular Weakness, Myoclonus
This is a report of a 67-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: neuropathy peripheral, who was treated with Nortriptyline (dosage: NA, start time:
Jun 18, 2009), combined with:
  • Gabapentin
and developed a serious reaction and side effect(s): Muscular Weakness, Myoclonus after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in male patients, resulting in Muscular Weakness side effect. The patient was hospitalized.
Nortriptyline Side Effect Report#9469928
Dry Mouth, Vision Blurred, Dizziness, Toxicity To Various Agents, Hyperhidrosis, Qrs Axis Abnormal, Hypotension
This report suggests a potential Nortriptyline Dry Mouth side effect(s) that can have serious consequences. A 56-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: neuralgia and used Nortriptyline (dosage: NA) starting
Jul 26, 2013. After starting Nortriptyline the patient began experiencing various side effects, including: Dry Mouth, Vision Blurred, Dizziness, Toxicity To Various Agents, Hyperhidrosis, Qrs Axis Abnormal, HypotensionAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dry Mouth, may still occur.
Nortriptyline Side Effect Report#9457403
Hypersensitivity, Dry Mouth, Oral Pruritus, Chest Pain, Eye Irritation
This Hypersensitivity problem was reported by a consumer or non-health professional from BR. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Jul 01, 2013 this consumer started treatment with Nortriptyline (dosage: 50 Mg, Qd). The following drugs were being taken at the same time: NA. When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Hypersensitivity, Dry Mouth, Oral Pruritus, Chest Pain, Eye IrritationAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypersensitivity, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9422282
Dyskinesia
This Dyskinesia side effect was reported by a pharmacist from US. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: depression.The patient was prescribed Nortriptyline (drug dosage: NA), which was initiated on
Apr 20, 2013. Concurrently used drugs: NA..After starting to take Nortriptyline the consumer reported adverse symptoms, such as: DyskinesiaThese side effects may potentially be related to Nortriptyline. The patient was hospitalized.
Nortriptyline Side Effect Report#9419944
Fatigue, Dry Mouth, Atrial Fibrillation
This is a report of a 35-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nortriptyline (dosage: 25mg Three Times Daily Po, start time:
Jun 17, 2013), combined with: NA. and developed a serious reaction and side effect(s): Fatigue, Dry Mouth, Atrial Fibrillation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in female patients, resulting in Fatigue side effect.
Nortriptyline Side Effect Report#9382759
Dizziness, Balance Disorder, Amnesia, Off Label Use
This report suggests a potential Nortriptyline Dizziness side effect(s) that can have serious consequences. A 52-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: neuropathy peripheral and used Nortriptyline (dosage: 150 Milligram Daily;) starting 201201. After starting Nortriptyline the patient began experiencing various side effects, including: Dizziness, Balance Disorder, Amnesia, Off Label UseAdditional drugs used concurrently:
  • Lyrica (450 Milligram Daily;)
  • Benadryl (75 Milligram Daily;)
  • Potassium
  • Effexor-xr (150 Milligram Daily;)
  • Baclofen (30 Milligram Daily;)
  • Ropinirole
Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Dizziness, may still occur.
Nortriptyline Side Effect Report#9350382
Hypoaesthesia, Hypoaesthesia, Dizziness, Saliva Altered, Peripheral Coldness, Headache, Pyrexia, Pharyngeal Oedema
This Hypoaesthesia problem was reported by a consumer or non-health professional from BR. A 60-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On
Jun 03, 2013 this consumer started treatment with Nortriptyline (dosage: 25 Mg, Qd). The following drugs were being taken at the same time: NA. When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Hypoaesthesia, Hypoaesthesia, Dizziness, Saliva Altered, Peripheral Coldness, Headache, Pyrexia, Pharyngeal OedemaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypoaesthesia, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9341290
Headache, Product Substitution Issue, Product Quality Issue
This Headache side effect was reported by a consumer or non-health professional from US. A 35-year-old male patient (weight:NA) experienced the following symptoms/conditions: tension,migraine.The patient was prescribed Nortriptyline (drug dosage: 3 Capsules (30 Mg) At Bedtime By Mouth), which was initiated on
Jun 03, 2013. Concurrently used drugs: NA..After starting to take Nortriptyline the consumer reported adverse symptoms, such as: Headache, Product Substitution Issue, Product Quality IssueThese side effects may potentially be related to Nortriptyline.
Nortriptyline Side Effect Report#9320673
Psychotic Disorder, Abnormal Behaviour, Hallucination, Auditory, Disorientation, Dizziness, Delusion, Amnesia
This is a report of a 40-year-old female patient (weight: NA) from AU, suffering from the following health symptoms/conditions: depression, who was treated with Nortriptyline (dosage: 10 Mg, Qid, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Psychotic Disorder, Abnormal Behaviour, Hallucination, Auditory, Disorientation, Dizziness, Delusion, Amnesia after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in female patients, resulting in Psychotic Disorder side effect.
Nortriptyline Side Effect Report#9320507
Psychotic Disorder
This report suggests a potential Nortriptyline Psychotic Disorder side effect(s) that can have serious consequences. A 40-year-old female patient (weight: NA) from AU was diagnosed with the following symptoms/conditions: depression and used Nortriptyline (dosage: NA) starting NS. After starting Nortriptyline the patient began experiencing various side effects, including: Psychotic DisorderAdditional drugs used concurrently: NA. Although Nortriptyline demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Psychotic Disorder, may still occur.
Nortriptyline Side Effect Report#9320505
Psychotic Disorder
This Psychotic Disorder problem was reported by a health professional from AU. A 17-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: depression. On NS this consumer started treatment with Nortriptyline (dosage: NA). The following drugs were being taken at the same time: NA. When using Nortriptyline, the patient experienced the following unwanted symptoms/side effects: Psychotic DisorderThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Psychotic Disorder, may become evident only after a product is in use by the general population.
Nortriptyline Side Effect Report#9310829
Feeling Abnormal
This Feeling Abnormal side effect was reported by a physician from US. A 53-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nortriptyline (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Wellbutrin
.After starting to take Nortriptyline the consumer reported adverse symptoms, such as: Feeling AbnormalThese side effects may potentially be related to Nortriptyline.
Nortriptyline Side Effect Report#9280436
Pityriasis Rosea, Papule, Rash Pruritic, Skin Plaque, Rash, Erythema, Vulvovaginal Mycotic Infection, Vulvovaginal Discomfort
This is a report of a 20-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nortriptyline (dosage: 10 Mg, Daily With A Plan To Increase By 10 Mg Every 5 Days To As High As 100 To 150 Mg Daily, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Pityriasis Rosea, Papule, Rash Pruritic, Skin Plaque, Rash, Erythema, Vulvovaginal Mycotic Infection, Vulvovaginal Discomfort after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nortriptyline treatment in female patients, resulting in Pityriasis Rosea side effect.


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The appearance of Nortriptyline on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Nortriptyline Side Effects for Women?

Women Side EffectsReports
Completed Suicide 11
Dizziness 9
Fall 9
Headache 9
Electrocardiogram Qrs Complex Prolonged 7
Insomnia 7
Overdose 7
Weight Increased 7
Abnormal Behaviour 6
Cardiac Arrest 6

What are common Nortriptyline Side Effects for Men?

Men Side EffectsReports
Completed Suicide 7
Convulsion 7
Dizziness 7
Syncope 7
Confusional State 6
Fall 6
Toxicity To Various Agents 6
Dyspnoea 5
Hyperhidrosis 5
Agitation 4

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Nortriptyline reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Nortriptyline Side Effects

    Did You Have a Nortriptyline Side Effect?

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    How Effective is Nortriptyline for You?

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    Nortriptyline Safety Alerts, Active Ingredients, Usage Information

    NDC0093-0810
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameNortriptyline Hydrochloride
    NameNortriptyline Hydrochloride
    Dosage FormCAPSULE
    RouteORAL
    On market since19950405
    LabelerTeva Pharmaceuticals USA Inc
    Active Ingredient(s)NORTRIPTYLINE HYDROCHLORIDE
    Strength(s)10
    Unit(s)mg/1
    Pharma ClassTricyclic Antidepressant [EPC]

    More About Nortriptyline

    Side Effects reported to FDA: 268

    Nortriptyline safety alerts: No

    Reported deaths: 24

    Reported hospitalizations: 56

    Latest Nortriptyline clinical trials