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Nucynta Side Effects

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Common Nucynta Side Effects


The most commonly reported Nucynta side effects (click to view or check a box to report):

Dizziness (51)
Nausea (49)
Hallucination (44)
Confusional State (44)
Dyspnoea (40)
Headache (35)
Loss Of Consciousness (34)
Depression (30)
Serotonin Syndrome (30)
Palpitations (28)
Tremor (27)
Vomiting (26)
Hypotension (26)
Overdose (26)
Feeling Abnormal (25)
Toxicity To Various Agents (24)
Insomnia (23)
Hypertension (22)
Convulsion (22)
Blood Pressure Increased (21)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Nucynta Side Effects Reported to FDA



Nucynta Side Effect Report#9995479
Dizziness, Hangover, Movement Disorder, Activities Of Daily Living Impaired
This is a report of a 44-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: procedural pain, who was treated with Nucynta (dosage: NA, start time:
Feb 14, 2014), combined with: NA. and developed a serious reaction and side effect(s): Dizziness, Hangover, Movement Disorder, Activities Of Daily Living Impaired after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta treatment in female patients, resulting in Dizziness side effect.
Nucynta Side Effect Report#9983592
Joint Arthroplasty, Immobile, Muscle Spasticity, Muscular Weakness, Feeling Abnormal
This report suggests a potential Nucynta Ir Joint Arthroplasty side effect(s) that can have serious consequences. A 33-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: back injury and used Nucynta Ir (dosage: NA) starting 2010. After starting Nucynta Ir the patient began experiencing various side effects, including: Joint Arthroplasty, Immobile, Muscle Spasticity, Muscular Weakness, Feeling AbnormalAdditional drugs used concurrently: NA. Although Nucynta Ir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Joint Arthroplasty, may still occur.
Nucynta Side Effect Report#9929426
Livedo Reticularis, Blood Magnesium Decreased, Dyspnoea, Pain, Road Traffic Accident
This Livedo Reticularis problem was reported by a consumer or non-health professional from US. A 33-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pain. On 201304 this consumer started treatment with Nucynta Ir (dosage: NA). The following drugs were being taken at the same time: NA. When using Nucynta Ir, the patient experienced the following unwanted symptoms/side effects: Livedo Reticularis, Blood Magnesium Decreased, Dyspnoea, Pain, Road Traffic AccidentThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Livedo Reticularis, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9928205
Hospitalisation, Migraine, Cellulitis, Suicidal Ideation, Screaming, Crying, Weight Decreased, Skin Ulcer
This Hospitalisation side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: pain.The patient was prescribed Nucynta (drug dosage: NA), which was initiated on 2004. Concurrently used drugs:
  • Actiq
  • Valium
  • Levothyroxine
.After starting to take Nucynta the consumer reported adverse symptoms, such as: Hospitalisation, Migraine, Cellulitis, Suicidal Ideation, Screaming, Crying, Weight Decreased, Skin UlcerThese side effects may potentially be related to Nucynta. The patient was hospitalized.
Nucynta Side Effect Report#9893893
Rhabdomyolysis
This is a report of a male patient (weight: NA) from US, suffering from the following health symptoms/conditions: neuropathy peripheral, who was treated with Nucynta Er (dosage: NA, start time:
Jan 30, 2014), combined with: NA. and developed a serious reaction and side effect(s): Rhabdomyolysis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta Er treatment in male patients, resulting in Rhabdomyolysis side effect.
Nucynta Side Effect Report#9890813
Pancreatitis, Pancreatitis Chronic, Tooth Loss, Tooth Disorder
This report suggests a potential Nucynta Pancreatitis side effect(s) that can have serious consequences. A 29-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nucynta (dosage: NA) starting NS. After starting Nucynta the patient began experiencing various side effects, including: Pancreatitis, Pancreatitis Chronic, Tooth Loss, Tooth DisorderAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nucynta demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pancreatitis, may still occur.
Nucynta Side Effect Report#9885072
Investigation, Pain
This Investigation problem was reported by a health professional from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: cancer pain. On 201312 this consumer started treatment with Nucynta Ir (dosage: 1- 2 Tablet Every 4 Hours As Needed). The following drugs were being taken at the same time: NA. When using Nucynta Ir, the patient experienced the following unwanted symptoms/side effects: Investigation, PainThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Investigation, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9822394
Akathisia, Torticollis, Grimacing, Dyskinesia, Dystonia, Fibromyalgia, Serotonin Syndrome, Hyperthermia, Hypertension
This Akathisia side effect was reported by a health professional from US. A 59-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain.The patient was prescribed Nucynta (drug dosage: NA), which was initiated on
Sep 22, 2013. Concurrently used drugs:
  • Sertraline
  • Duloxetine
  • Doxepin
  • Cyclobenzaprine
.After starting to take Nucynta the consumer reported adverse symptoms, such as: Akathisia, Torticollis, Grimacing, Dyskinesia, Dystonia, Fibromyalgia, Serotonin Syndrome, Hyperthermia, HypertensionThese side effects may potentially be related to Nucynta. The patient was hospitalized.
Nucynta Side Effect Report#9822390
Completed Suicide, Hypotension, Heart Rate Decreased, Somnolence
This is a report of a 28-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nucynta (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Completed Suicide, Hypotension, Heart Rate Decreased, Somnolence after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta treatment in female patients, resulting in Completed Suicide side effect.
Nucynta Side Effect Report#9822389
Hospitalisation
This report suggests a potential Nucynta Ir Hospitalisation side effect(s) that can have serious consequences. A female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nucynta Ir (dosage: NA) starting NS. After starting Nucynta Ir the patient began experiencing various side effects, including: HospitalisationAdditional drugs used concurrently:
  • Methadone
The patient was hospitalized. Although Nucynta Ir demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hospitalisation, may still occur.
Nucynta Side Effect Report#9822388
Aspiration, Loss Of Consciousness, Hypotension, Productive Cough
This Aspiration problem was reported by a health professional from US. A 45-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Nucynta Er (dosage: 90 Tablets). The following drugs were being taken at the same time:
  • Cocaine
  • Alcohol
When using Nucynta Er, the patient experienced the following unwanted symptoms/side effects: Aspiration, Loss Of Consciousness, Hypotension, Productive CoughAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Aspiration, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9815536
Toxicity To Various Agents, Depressed Level Of Consciousness, Respiratory Depression, Electrocardiogram Qrs Complex Prolonged, Liver Function Test Abnormal, Electrocardiogram Qt Prolonged, Blood Glucose Abnormal
This Toxicity To Various Agents side effect was reported by a health professional from US. A 53-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nucynta Er (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Acetaminophen
  • Acetaminophen
  • Caffeine
  • Butalbital
  • Cannabis
.After starting to take Nucynta Er the consumer reported adverse symptoms, such as: Toxicity To Various Agents, Depressed Level Of Consciousness, Respiratory Depression, Electrocardiogram Qrs Complex Prolonged, Liver Function Test Abnormal, Electrocardiogram Qt Prolonged, Blood Glucose AbnormalThese side effects may potentially be related to Nucynta Er. The patient was hospitalized.
Nucynta Side Effect Report#9815530
Intentional Overdose, Respiratory Depression, Tachycardia, Electroencephalogram Abnormal, Bradycardia, Hypotension, Restlessness, Hypertension, Acidosis
This is a report of a 30-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nucynta Er (dosage: NA, start time: NS), combined with:
  • Tramadol
  • Baclofen
  • Ethanol
and developed a serious reaction and side effect(s): Intentional Overdose, Respiratory Depression, Tachycardia, Electroencephalogram Abnormal, Bradycardia, Hypotension, Restlessness, Hypertension, Acidosis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta Er treatment in male patients, resulting in Intentional Overdose side effect. The patient was hospitalized.
Nucynta Side Effect Report#9813159
Overdose, Blood Thyroid Stimulating Hormone Increased, Tachycardia, Somnolence, Blood Pressure Decreased
This report suggests a potential Nucynta Er Overdose side effect(s) that can have serious consequences. A 19-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nucynta Er (dosage: 50 Of 50mg Tablets) starting NS. After starting Nucynta Er the patient began experiencing various side effects, including: Overdose, Blood Thyroid Stimulating Hormone Increased, Tachycardia, Somnolence, Blood Pressure DecreasedAdditional drugs used concurrently: NA.The patient was hospitalized. Although Nucynta Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Overdose, may still occur.
Nucynta Side Effect Report#9812672
Restless Legs Syndrome, Tachycardia, Hypertension, Toxicity To Various Agents, Anxiety, Tremor, Muscle Spasms, Flushing
This Restless Legs Syndrome problem was reported by a health professional from US. A 31-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: back pain. On NS this consumer started treatment with Nucynta Er (dosage: 2 Weeks Ago). The following drugs were being taken at the same time: NA. When using Nucynta Er, the patient experienced the following unwanted symptoms/side effects: Restless Legs Syndrome, Tachycardia, Hypertension, Toxicity To Various Agents, Anxiety, Tremor, Muscle Spasms, FlushingThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Restless Legs Syndrome, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9812192
Suicide Attempt, Sinus Bradycardia, Unresponsive To Stimuli, Aspiration, Vomiting
This Suicide Attempt side effect was reported by a physician from US. A 42-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nucynta (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Acetaminophen
  • Acetaminophen
  • Baclofen
  • Benzodiazepine Nos
  • Pregabalin
  • Buprenorphine
  • Clonidine
  • Ondansetron
.After starting to take Nucynta the consumer reported adverse symptoms, such as: Suicide Attempt, Sinus Bradycardia, Unresponsive To Stimuli, Aspiration, VomitingThese side effects may potentially be related to Nucynta. The patient was hospitalized.
Nucynta Side Effect Report#9782423
Spinal Rod Insertion
This is a report of a 57-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: pain, who was treated with Nucynta Er (dosage: Strength: 200 Mg, start time: 201305), combined with: NA. and developed a serious reaction and side effect(s): Spinal Rod Insertion after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta Er treatment in female patients, resulting in Spinal Rod Insertion side effect.
Nucynta Side Effect Report#9753008
Hypertension, Tremor, Transient Ischaemic Attack, Vision Blurred, Fall, Psychomotor Hyperactivity, Hypotension, Chest Pain, Heart Rate Increased
This report suggests a potential Nucynta Er Hypertension side effect(s) that can have serious consequences. A 55-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: pain and used Nucynta Er (dosage: NA) starting
Nov 29, 2013. After starting Nucynta Er the patient began experiencing various side effects, including: Hypertension, Tremor, Transient Ischaemic Attack, Vision Blurred, Fall, Psychomotor Hyperactivity, Hypotension, Chest Pain, Heart Rate IncreasedAdditional drugs used concurrently: NA. Although Nucynta Er demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypertension, may still occur.
Nucynta Side Effect Report#9749391
Gastrointestinal Motility Disorder, Pancreatitis
This Gastrointestinal Motility Disorder problem was reported by a consumer or non-health professional from US. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: procedural pain. On 2011 this consumer started treatment with Nucynta Ir (dosage: NA). The following drugs were being taken at the same time: NA. When using Nucynta Ir, the patient experienced the following unwanted symptoms/side effects: Gastrointestinal Motility Disorder, PancreatitisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Gastrointestinal Motility Disorder, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9733438
Thinking Abnormal, Tremor
This Thinking Abnormal side effect was reported by a consumer or non-health professional from US. A 51-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Nucynta (drug dosage: 1-2 Tbs Po Q 6hrs.), which was initiated on
Nov 22, 2013. Concurrently used drugs: NA..After starting to take Nucynta the consumer reported adverse symptoms, such as: Thinking Abnormal, TremorThese side effects may potentially be related to Nucynta.
Nucynta Side Effect Report#9697423
Asthma, Gait Disturbance, Tooth Disorder
This is a report of a female patient (weight: NA) from US, suffering from the following health symptoms/conditions: back pain, who was treated with Nucynta Er (dosage: NA, start time: 1986), combined with:
  • Tegretol
  • Baclofen
  • Baclofen
  • Thyroid
  • Ventolin Hfa
  • Cytomel
  • Multivitamins
  • Prednisone (Daily)
and developed a serious reaction and side effect(s): Asthma, Gait Disturbance, Tooth Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta Er treatment in female patients, resulting in Asthma side effect.
Nucynta Side Effect Report#9674600
Swelling Face, Local Swelling, Feeling Hot, Dyspnoea, Pruritus
This report suggests a potential Nucynta Swelling Face side effect(s) that can have serious consequences. A 64-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Nucynta (dosage: NA) starting
Oct 03, 2013. After starting Nucynta the patient began experiencing various side effects, including: Swelling Face, Local Swelling, Feeling Hot, Dyspnoea, PruritusAdditional drugs used concurrently:
  • Vitamin B Complex
  • Vitamin C
  • Vitamin D
  • Vitamin E
  • Osteo-bi Flex
  • Calcium
  • Fish Oil
  • Coq10
Although Nucynta demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Swelling Face, may still occur.
Nucynta Side Effect Report#9630966
Suicide Attempt, Toxicity To Various Agents, Intentional Overdose, Bradycardia, Hypotension, Depressed Level Of Consciousness, Respiratory Depression, Oxygen Saturation Decreased, Miosis
This Suicide Attempt problem was reported by a health professional from US. A 73-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Nucynta (dosage: 20 Mg 4 Doses). The following drugs were being taken at the same time: NA. When using Nucynta, the patient experienced the following unwanted symptoms/side effects: Suicide Attempt, Toxicity To Various Agents, Intentional Overdose, Bradycardia, Hypotension, Depressed Level Of Consciousness, Respiratory Depression, Oxygen Saturation Decreased, MiosisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Suicide Attempt, may become evident only after a product is in use by the general population.
Nucynta Side Effect Report#9629528
Convulsion, Headache, Confusional State, Nasopharyngitis, Oropharyngeal Pain
This Convulsion side effect was reported by a consumer or non-health professional from US. A female patient (weight:NA) experienced the following symptoms/conditions: neurofibromatosis,tachycardia,pain.The patient was prescribed Nucynta Er (drug dosage: 2 Doses Per Day), which was initiated on 2013. Concurrently used drugs:
  • Lopressor
  • Neurontin
  • Hydromorphone
  • Morphine
.After starting to take Nucynta Er the consumer reported adverse symptoms, such as: Convulsion, Headache, Confusional State, Nasopharyngitis, Oropharyngeal PainThese side effects may potentially be related to Nucynta Er.
Nucynta Side Effect Report#9628883
Toxicity To Various Agents, Hypertension, Tachycardia, Intentional Overdose, Blood Potassium Decreased
This is a report of a 22-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Nucynta (dosage: 675 Mg (9 Tablets Of 75 Mg) A Day, start time:
May 24, 2013), combined with: NA. and developed a serious reaction and side effect(s): Toxicity To Various Agents, Hypertension, Tachycardia, Intentional Overdose, Blood Potassium Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Nucynta treatment in female patients, resulting in Toxicity To Various Agents side effect.


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The appearance of Nucynta on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Nucynta Side Effects for Women?

Women Side EffectsReports
Dizziness 42
Nausea 40
Dyspnoea 30
Confusional State 25
Hallucination 25
Headache 25
Loss Of Consciousness 22
Depression 20
Palpitations 20
Blood Pressure Increased 18

What are common Nucynta Side Effects for Men?

Men Side EffectsReports
Confusional State 19
Hallucination 19
Serotonin Syndrome 17
Disorientation 14
Loss Of Consciousness 12
Vomiting 12
Dysarthria 11
Aggression 10
Depression 10
Dyspnoea 10

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Nucynta reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

    Discuss Nucynta Side Effects

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    How Effective is Nucynta for You?

    Exceeded Expectations
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    Nucynta Safety Alerts, Active Ingredients, Usage Information

    NDC16590-289
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameNUCYNTA
    Nametapentadol hydrochloride
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20090601
    LabelerStat Rx USA
    Active Ingredient(s)TAPENTADOL HYDROCHLORIDE
    Strength(s)100
    Unit(s)mg/1
    Pharma ClassOpioid Agonist [EPC],Opioid Agonists [MoA]

    More About Nucynta

    Side Effects reported to FDA: 535

    Nucynta safety alerts: No

    Reported deaths: 29

    Reported hospitalizations: 143

    Latest Nucynta clinical trials