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Penfill Side Effects

Common Penfill Side Effects


The most commonly reported Penfill side effects (click to view or check a box to report):

Hypoglycaemia (35)
Intentional Overdose (13)
Suicide Attempt (13)
Blood Glucose Fluctuation (11)
Anti-insulin Antibody Increased (8)
Blood Glucose Increased (7)
Hypoglycaemic Coma (7)
Anti-insulin Antibody (6)
Hepatic Function Abnormal (5)
Alanine Aminotransferase Increased (5)
Aspartate Aminotransferase Increased (5)
Oedema (5)
White Blood Cell Count Decreased (5)
Vomiting (4)
Neutrophil Count Decreased (4)
Anaemia (4)
Gastric Ulcer (4)
Altered State Of Consciousness (4)
Blood Pressure Decreased (4)
Injection Site Reaction (4)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Penfill Side Effects Reported to FDA

The following Penfill reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Penfill on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Depression
This is a report of a 71-year-old male patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: NA, who was treated with Penfill 30r (insulin Human, Insulin Human Injection, Isophane) (dosage: NA, start time: Apr 14, 2004), combined with:
  • Depas (etizolam)
  • Magmitt (magnesium Oxide)
  • Merislon (betahistine Mesilate)
  • Pletal (50 Mg Milligram(s), Bid, Oral)
  • Mucodyne (carbocisteine)
  • Basen (voglibose)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Depression
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Penfill 30r (insulin Human, Insulin Human Injection, Isophane) treatment in male patients, resulting in depression side effect.

Acanthosis Nigricans, Injection Site Reaction
This report suggests a potential Penfill R Chu Acanthosis Nigricans, Injection Site Reaction side effect(s) that can have serious consequences. A 74-year-old male patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus and used Penfill R Chu (dosage: 36 U, Qd) starting Jan 01, 2005. Soon after starting Penfill R Chu the patient began experiencing various side effects, including:
  • Acanthosis Nigricans
  • Injection Site Reaction
Drugs used concurrently:
  • Penfill N Chu (12 U, Qd)
Although Penfill R Chu demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as acanthosis nigricans, may still occur.

Anti-insulin Antibody Increased, Condition Aggravated, Diabetic Ketoacidotic Hyperglycaemic Coma, Hyperglycaemia, Hypoglycaemia, Psychiatric Symptom
This Anti-insulin Antibody Increased, Condition Aggravated, Diabetic Ketoacidotic Hyperglycaemic Coma, Hyperglycaemia, Hypoglycaemia, Psychiatric Symptom problem was reported by a physician from JAPAN. A 78-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus. On Jan 01, 2002 this consumer started treatment with Penfill 30r Chu (dosage: Not Reported). The following drugs were being taken at the same time: NA. When commencing Penfill 30r Chu, the patient experienced the following unwanted symptoms/side effects:
  • Anti-insulin Antibody Increased
  • Condition Aggravated
  • Diabetic Ketoacidotic Hyperglycaemic Coma
  • Hyperglycaemia
  • Hypoglycaemia
  • Psychiatric Symptom
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as anti-insulin antibody increased, may become evident only after a product is in use by the general population.

Acanthosis Nigricans, Injection Site Reaction
This is a report of a 74-year-old male patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: type 2 diabetes mellitus and was treated with Penfill R Chu (dosage: 36 U, Qd) starting Jan 01, 2005. Concurrently used drugs:
  • Penfill N Chu (12 U, Qd)
Soon after that, the consumer experienced the following side effects:
  • Acanthosis Nigricans
  • Injection Site Reaction
This opens a possibility that Penfill R Chu treatment could cause the above reactions, including acanthosis nigricans, and some male subjects may be more susceptible.


Anti-insulin Antibody Increased, Hypoglycaemia Unawareness
A 43-year-old female patient (weight: NA) from JAPAN with the following symptoms/conditions: diabetes mellitus started Penfill 30r Chu treatment (dosage: Unk, Bid) on NS. Soon after starting Penfill 30r Chu treatment, the subject experienced various side effects, including:
  • Anti-insulin Antibody Increased
  • Hypoglycaemia Unawareness
Concurrently used drugs:
  • Novorapid Chu Flexpen (Unk)
  • Lispro Insulin
This finding indicates that some female patients could be more vulnerable to Penfill 30r Chu.

Anti-insulin Antibody Increased, Condition Aggravated, Diabetic Ketoacidotic Hyperglycaemic Coma, Hyperglycaemia, Hypoglycaemia, Psychiatric Symptom
A 78-year-old male patient from JAPAN (weight: NA) experienced symptoms, such as: type 2 diabetes mellitus and was treated with Penfill 30r Chu(dosage: Not Reported). The treatment was initiated on Jan 01, 2002. After that a consumer reported the following side effect(s):
  • Anti-insulin Antibody Increased
  • Condition Aggravated
  • Diabetic Ketoacidotic Hyperglycaemic Coma
  • Hyperglycaemia
  • Hypoglycaemia
  • Psychiatric Symptom
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Penfill 30r Chu efficacy: NA.The patient was hospitalized.

Altered State Of Consciousness, Epilepsy, Hypoglycaemia, Retrograde Amnesia
In this report, Penfill N Chu was administered for the following condition: type 1 diabetes mellitus.A 39-year-old male consumer from JAPAN (weight: NA) started Penfill N Chu treatment (dosage: Not Reported) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Altered State Of Consciousness
  • Epilepsy
  • Hypoglycaemia
  • Retrograde Amnesia
A possible interaction with other drugs could have contributed to this reaction: NA.The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Penfill N Chu treatment could be related to the listed above side effect(s).

Oedema, Weight Increased
This is a report of the following Penfill 30r Chu side effect(s):
  • Oedema
  • Weight Increased
A 61-year-old female patient from JAPAN (weight: NA) presented with the following condition: type 2 diabetes mellitus and received a treatment with Penfill 30r Chu (dosage: Unk U, Unk) starting: Sep 01, 2004.The following concurrently used drugs could have generated interactions:
  • Actos (/po)
The patient was hospitalized.This report suggests that a Penfill 30r Chu treatment could be associated with the listed above side effect(s).

Altered State Of Consciousness, Epilepsy, Hypoglycaemia, Retrograde Amnesia
This Penfill N Chu report was submitted by a 39-year-old male consumer from JAPAN (weight: NA). The patient was diagnosed with: type 1 diabetes mellitus and Penfill N Chu was administered (dosage: Not Reported) starting: NS. The consumer developed a set of symptoms:
  • Altered State Of Consciousness
  • Epilepsy
  • Hypoglycaemia
  • Retrograde Amnesia
Other drugs used simultaneously: NA.The patient was hospitalized.Those unexpected symptoms could be linked to a Penfill N Chu treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Hepatic Function Abnormal
This is a report of a possible correlation between Penfill R Chu use and the following symptoms/side effect(s):
  • Hepatic Function Abnormal
which could contribute to an assessment of Penfill R Chu risk profile.A 55-year-old female consumer from JAPAN (weight: NA) was suffering from type 2 diabetes mellitus and was treated with Penfill R Chu (dosage: Sliding Scale) starting Sep 30, 2009.Other concurrent medications:
  • Penfill N Chu (Sliding Scale)
  • Novolin R ((6+6+2+0) Iu, Qd)
  • Novolin N ((0+0+0+5) Iu, Qd)
  • Magmitt (990 Mg, Qd)
  • Alosenn /00476901/ (0.5 G, Qd)
The patient was hospitalized.

Hepatic Function Abnormal
A 55-year-old female patient from JAPAN (weight: NA) presented with the following symptoms: type 2 diabetes mellitus and after a treatment with Penfill R Chu (dosage: Sliding Scale) experienced the following side effect(s):
  • Hepatic Function Abnormal
The treatment was started on Sep 30, 2009. Penfill R Chu was used in combination with the following drugs:
  • Penfill N Chu (Sliding Scale)
  • Novolin R ((6+6+2+0) Iu, Qd)
  • Novolin N ((0+0+0+5) Iu, Qd)
  • Magmitt (990 Mg, Qd)
  • Alosenn /00476901/ (0.5 G, Qd)
The patient was hospitalized.This report could alert potential Penfill R Chu consumers.

Altered State Of Consciousness, Hypoglycaemic Coma
In this report, a 60-year-old female patient from JAPAN (weight: NA) was affected by a possible Penfill 50r Chu side effect.The patient was diagnosed with type 2 diabetes mellitus. After a treatment with Penfill 50r Chu (dosage: 16 Iu, Qd, start date: May 16, 2008), the patient experienced the following side effect(s):
  • Altered State Of Consciousness
  • Hypoglycaemic Coma
The following simultaneously used drugs could have led to this reaction: NA.The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Penfill 50r Chu treatment.

Altered State Of Consciousness, Hypoglycaemic Coma
This is a report of a 60-year-old female patient from JAPAN (weight: NA), who used Penfill 50r Chu (dosage: 16 Iu, Qd) for a treatment of type 2 diabetes mellitus. After starting a treatment on May 16, 2008, the patient experienced the following side effect(s):
  • Altered State Of Consciousness
  • Hypoglycaemic Coma
The following drugs could possibly have interacted with the Penfill 50r Chu treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Penfill 50r Chu treatment could be related to side effect(s), such as Altered State Of Consciousness, Hypoglycaemic Coma.

Hypoglycaemia, Hypoglycaemic Coma, Intentional Overdose, Suicide Attempt
This hypoglycaemia side effect was reported by a physician from JAPAN. A female patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus. The patient was prescribed Penfill 30r Chu (dosage: 10+12+0 Iu, Qd), which was started on Aug 27, 2001. Concurrently used drugs: NA. When starting to take Penfill 30r Chu the consumer reported the following symptoms:
  • Hypoglycaemia
  • Hypoglycaemic Coma
  • Intentional Overdose
  • Suicide Attempt
The patient was hospitalized. These side effects may potentially be related to Penfill 30r Chu.

Hypoglycaemia, Suicide Attempt
This is a Penfill N Chu side effect report of a 37-year-old male patient (weight:NA) from JAPAN, suffering from the following symptoms/conditions: type 1 diabetes mellitus, who was treated with Penfill N Chu (dosage:13 Iu, Qd, start time: NS), combined with: NA., and developed a serious reaction and a hypoglycaemia side effect. The patient presented with:
  • Hypoglycaemia
  • Suicide Attempt
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Penfill N Chu treatment in male patients suffering from type 1 diabetes mellitus, resulting in hypoglycaemia.

Hypoglycaemia, Suicide Attempt
This report suggests a potential Penfill N Chu hypoglycaemia side effect(s) that can have serious consequences. A 37-year-old male patient from JAPAN (weight:NA) was diagnosed with the following health condition(s): type 1 diabetes mellitus and used Penfill N Chu (dosage: Unk Iu, Unk) starting NS. Soon after starting Penfill N Chu the patient began experiencing various side effects, including:
  • Hypoglycaemia
  • Suicide Attempt
Drugs used concurrently:NA. The patient was hospitalized. Although Penfill N Chu demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hypoglycaemia, may still occur.

Blood Glucose Increased, Injection Site Reaction
This blood glucose increased problem was reported by a physician from JAPAN. A 50-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): type 2 diabetes mellitus.On Aug 14, 2003 a consumer started treatment with Penfill R Chu (dosage: 4-4-4). The following drugs/medications were being taken at the same time:
  • Penfill 30r Chu (14-18 Iu)
  • Lantus
  • Metformin Hydrochloride (500 Mg, Qd)
  • Alotec (5 Mg, Unk)
When commencing Penfill R Chu, the patient experienced the following unwanted symptoms /side effects:
  • Blood Glucose Increased
  • Injection Site Reaction
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as blood glucose increased, may become evident only after a product is in use by the general population.

Anti-insulin Antibody, Autoantibody Positive, Bladder Perforation, Blood Glucose Fluctuation
This is a Penfill 30r Chu side effect report of a 58-year-old female patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: type 2 diabetes mellitus and was treated with Penfill 30r Chu (dosage: Unk, Unk) starting Jan 01, 2001. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Anti-insulin Antibody
  • Autoantibody Positive
  • Bladder Perforation
  • Blood Glucose Fluctuation
The patient was hospitalized. This opens a possibility that Penfill 30r Chu could cause anti-insulin antibody and that some female patients may be more susceptible.

Anti-insulin Antibody Increased, Hypoglycaemia
A 70-year-old female patient (weight: NA) from JAPAN with the following symptoms: type 2 diabetes mellitus started Penfill R Chu treatment (dosage: NA) on Mar 01, 2006. Soon after starting Penfill R Chu treatment, the consumer experienced several side effects, including:
  • Anti-insulin Antibody Increased
  • Hypoglycaemia
. Concurrently used drugs:
  • Penfill 30r Chu
  • Humalog
  • Lantus
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Penfill R Chu side effects, such as anti-insulin antibody increased.

Anti-insulin Antibody, Hypoglycaemia
This anti-insulin antibody side effect was reported by a physician from JAPAN. A 68-year-old male patient (weight:NA) experienced the following symptoms/conditions: type 2 diabetes mellitus.The patient was prescribed Penfill 30r Chu (dosage: (20-0-10)), which was started on Dec 03, 2007. Concurrently used drugs:
  • Penfill R Chu (Not Reported)
  • Penfill 10r Chu (Not Reported)
  • Penfill N Chu (Not Reported)
  • Penfill R Chu ((4-4-2))
  • Humalog ((4-4-2))
.When starting to take Penfill 30r Chu the consumer reported symptoms, such as:
  • Anti-insulin Antibody
  • Hypoglycaemia
These side effects may potentially be related to Penfill 30r Chu. The patient was hospitalized.

Hypoglycaemic Coma, Intentional Overdose, Suicide Attempt
This is a report of a 65-year-old male patient (weight: NA) from JAPAN, suffering from the following symptoms/conditions: type 2 diabetes mellitus, who was treated with Penfill 50r Chu (dosage: NA, start time: Oct 01, 2003), combined with:
  • Penfill R Chu
  • Insulin
  • Sinlestal (750 Mg, Qd)
  • Penfill 30r Chu
and developed a serious reaction and side effect(s). The consumer presented with:
  • Hypoglycaemic Coma
  • Intentional Overdose
  • Suicide Attempt
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Penfill 50r Chu treatment in male patients, resulting in hypoglycaemic coma side effect.

Anorexia Nervosa, Hypoglycaemia
This report suggests a potential Penfill 30r Chu Anorexia Nervosa, Hypoglycaemia side effect(s) that can have serious consequences. A female patient (weight: NA) from JAPAN was diagnosed with the following symptoms/conditions: type 2 diabetes mellitus and used Penfill 30r Chu (dosage: NA) starting May 01, 2007. Soon after starting Penfill 30r Chu the patient began experiencing various side effects, including:
  • Anorexia Nervosa
  • Hypoglycaemia
Drugs used concurrently:
  • Novorapid Chu
  • Glufast (30 Mg, Qd)
The patient was hospitalized. Although Penfill 30r Chu demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as anorexia nervosa, may still occur.

Hepatic Function Abnormal
This Hepatic Function Abnormal problem was reported by a physician from JAPAN. A 57-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: hyperglycaemia. On Oct 15, 2003 this consumer started treatment with Penfill N Chu (dosage: 8 Iu, Qd). The following drugs were being taken at the same time:
  • Penfill R Chu (24 Iu, Qd)
  • Humalog (24 U, Qd)
  • Humalog
  • Humacart N
  • Flomox
  • Cefaclor
When commencing Penfill N Chu, the patient experienced the following unwanted symptoms/side effects:
  • Hepatic Function Abnormal
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hepatic function abnormal, may become evident only after a product is in use by the general population.

Blood Glucose Fluctuation, Hypoglycaemia
This is a report of a 62-year-old female patient (weight: NA) from JAPAN. The patient developed the following symptoms/conditions: latent autoimmune diabetes in adults and was treated with Penfill 30r Chu (dosage: 20-0-10 Iu, Qd) starting May 25, 2007. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Blood Glucose Fluctuation
  • Hypoglycaemia
The patient was hospitalized. This opens a possibility that Penfill 30r Chu treatment could cause the above reactions, including blood glucose fluctuation, and some female subjects may be more susceptible.

Anorexia Nervosa, Hypoglycaemia
A female patient (weight: NA) from JAPAN with the following symptoms/conditions: type 2 diabetes mellitus started Penfill 30r Chu treatment (dosage: NA) on May 01, 2007. Soon after starting Penfill 30r Chu treatment, the subject experienced various side effects, including:
  • Anorexia Nervosa
  • Hypoglycaemia
Concurrently used drugs:
  • Novorapid Chu
  • Glufast (30 Mg, Qd)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Penfill 30r Chu.

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Why Your Notes are Important

Your notes could be helpful in several ways:

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  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

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    Side Effects reported to FDA: 103

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    Reported deaths: 1

    Reported hospitalizations: 27

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