From simple mix-ups to fatal overdoses, medication mistakes happen, on average, once a day to every hospital patient, a new report says. Nationwide, at least 1.5 million people annually are harmed from drug errors, more than half of them in nursing homes, said the Institute of Medicine report, released yesterday.
Many Unfavorable Drug Studies Aren’t Published. Nearly a third of antidepressant drug studies are never published in the medical literature, and nearly all of those happen to show that the drug being tests failed to work.
Only Drugs That are Safe Should be put on the Market. Drug developers are just beginning to come to grips with recent FDA oversight reforms and how they will affect drug safety. But, it appears that industry and consumer advocates are not together on how well the overhaul will be able to prevent future drug safety scandals.

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Pentothal Safety Reports submitted to FDA

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Total Pentothal reports: 5.
Pentothal FDA safety alerts: No.
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Reported Pentothal Side Effects: pulse absent, anaphylactic reaction, anaesthetic complication, haemodynamic instability, cortical laminar necrosis, cerebral haemorrhage, no therapeutic response, intracranial pressure increased, infection, febrile neutropenia, hypotension.
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Pentothal Side Effects Report #5290123-X
Physician from TAIWAN, PROVINCE OF CHINA reported PENTOTHAL problem on Mar 20, 2007. Male patient, 76 years of age, weighting 134.5 lb, was diagnosed with induction of anaesthesia and was treated with PENTOTHAL. After drug was administered, patient experienced the following problems/side effects: hypotension. PENTOTHAL dosage: 10 ML, NOT REPORTED, EPIDURAL. During the same period patient was treated with PROPOFOL, LIDOCAINE, FENTANYL, ROCURONIUM, DESFLURANE. Patient recovered.

Pentothal Side Effects Report #5325389-0
PENTOTHAL problem was reported by a Pharmacist from CANADA on Apr 26, 2007. Male patient, 26 years of age, weighting 179.0 lb, was diagnosed with coma, convulsion prophylaxis and was treated with PENTOTHAL. After drug was administered, patient experienced the following problems/side effects: febrile neutropenia, infection, intracranial pressure increased, no therapeutic response. PENTOTHAL dosage: unknown. During the same period patient was treated with PHENYTOIN, PROPOFOL, FENTANYL, NOREPINEPHRINE BITARTRATE, INSULIN, ROCURONIUM. Patient recovered.

Pentothal Side Effects Report #5325390-7
Pharmacist from CANADA reported PENTOTHAL problem on Apr 26, 2007. Female patient, 29 years of age, weighting 165.0 lb, was diagnosed with coma, pneumonia, convulsion prophylaxis and was treated with PENTOTHAL. After drug was administered, patient experienced the following problems/side effects: neutropenia. PENTOTHAL dosage: unknown. During the same period patient was treated with VANCOMYCIN, PHENYTOIN, PIPERACILLIN AND TAZOBACTAM, ROCURONIUM, PROPOFOL, NOREPINEPHRINE BITARTRATE. Patient recovered.

Pentothal Side Effects Report #5097302-5
PENTOTHAL problem was reported by a Physician from BELGIUM on Aug 22, 2006. Male patient, child 9 years of age, was diagnosed with status epilepticus and was treated with PENTOTHAL. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, cortical laminar necrosis, haemodynamic instability. PENTOTHAL dosage: UP TO 1 MG/KG/HR, INFUSION. During the same period patient was treated with DIAZEPAM, PHENYTOIN, PHENOBARBITAL, VALPROIC ACID, CLONAZEPAM, CHLORMETHIAZOLE, METHYLPREDNISOLONE, VIGABATRIN. Patient recovered.

Pentothal Side Effects Report #5416528-1
Physician from ITALY reported PENTOTHAL problem on Aug 03, 2007. Female patient, 14 years of age, was treated with PENTOTHAL. After drug was administered, patient experienced the following problems/side effects: anaesthetic complication, anaphylactic reaction, pulse absent. PENTOTHAL dosage: 300 MG, ONCE, INTRAVENOUS. During the same period patient was treated with ATRACURIUM BESYLATE, SEVOFLURANE, EUTIROX, OXYGEN. Patient recovered.

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