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Perfalgan Side Effects

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Common Perfalgan Side Effects


The most commonly reported Perfalgan side effects (click to view or check a box to report):

Thrombocytopenia (8)
Pyrexia (7)
Chills (6)
Toxic Skin Eruption (6)
Hepatitis (6)
Hepatocellular Injury (6)
Hypotension (6)
Renal Failure Acute (6)
Septic Shock (5)
Cholestasis (5)
Blood Alkaline Phosphatase Increased (5)
Liver Injury (4)
Renal Failure (4)
Abdominal Pain (4)
Multi-organ Failure (4)
Hepatitis Fulminant (4)
Pneumonia (3)
Cytolytic Hepatitis (3)
Dyspnoea (3)
Diarrhoea (3)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Perfalgan Side Effects Reported to FDA



Perfalgan Side Effect Report#9912897
Tendon Rupture
This is a report of a 49-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (paracetamol) (dosage: NA, start time:
Apr 10, 2013), combined with:
  • Ciprofloxacin (ciprofloxacin)
  • Orbenine
  • Esomeprazole (esomeprazole)
  • Contramal
and developed a serious reaction and side effect(s): Tendon Rupture after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan (paracetamol) treatment in female patients, resulting in Tendon Rupture side effect.
Perfalgan Side Effect Report#9821221
Type I Hypersensitivity, Bronchospasm, Cardio-respiratory Arrest
This report suggests a potential Perfalgan Type I Hypersensitivity side effect(s) that can have serious consequences. A 65-year-old male patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: NA and used Perfalgan (dosage: NA) starting
Nov 13, 2013. After starting Perfalgan the patient began experiencing various side effects, including: Type I Hypersensitivity, Bronchospasm, Cardio-respiratory ArrestAdditional drugs used concurrently:
  • Erbitux (cetuximab) (960mg; Cyclical, Iv)
  • Polaramine (dexchlorpheniramine Maleate)
  • Solu-medrol (methylprednisolone Sodium Succinate)
Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Type I Hypersensitivity, may still occur.
Perfalgan Side Effect Report#9776124
Diarrhoea, Malaise, Abdominal Pain, Hypotension, Bradycardia, Abdominal Rigidity, Hyperhidrosis, Nausea
This Diarrhoea problem was reported by a physician from FR. A 75-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Oct 04, 2013 this consumer started treatment with Perfalgan (paracetamol) (dosage: ; Iv). The following drugs were being taken at the same time:
  • Dafalgan (500 Mg ; 4/ 1 Day ;)
  • Profenid (ketoprofen) (; Bid ; Oral)
  • Pantoprazole (pantoprazole)
  • Thiocolchicoside
  • Alprazolam (alprazolam) (.25 Mg; 1 Day)
  • Lovenox (enoxaparin Sodium)
When using Perfalgan (paracetamol), the patient experienced the following unwanted symptoms/side effects: Diarrhoea, Malaise, Abdominal Pain, Hypotension, Bradycardia, Abdominal Rigidity, Hyperhidrosis, NauseaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Diarrhoea, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9762792
Renal Failure Chronic, Hypotension, Metabolic Acidosis, Nephritis Allergic, Toxic Skin Eruption
This Renal Failure Chronic side effect was reported by a physician from FR. A 66-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on
May 15, 2013. Concurrently used drugs:
  • Vancomycin
  • Tienam (primaxin)
  • Amlodipine
  • Calcidia
  • Doliprane
  • Pariet
  • Topalgic
  • Transipeg
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Renal Failure Chronic, Hypotension, Metabolic Acidosis, Nephritis Allergic, Toxic Skin EruptionThese side effects may potentially be related to Perfalgan.
Perfalgan Side Effect Report#9746315
Thrombocytopenia, Pyrexia, Purpura, Rash, Haemoglobin Decreased, Histiocytosis Haematophagic, Bacterial Infection
This is a report of a 68-year-old male patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (dosage: 1 Dosage Form, start time:
Jul 10, 2013), combined with:
  • Loperamide Hydrochloride
  • Clindamycin (clindamycin)
  • Metronidazole (metronidazole)
  • Vancomycin (vancomycin)
  • Lasilix /00032601/
  • Speciafoldine
  • Bromazepam
  • Kardegic
and developed a serious reaction and side effect(s): Thrombocytopenia, Pyrexia, Purpura, Rash, Haemoglobin Decreased, Histiocytosis Haematophagic, Bacterial Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan treatment in male patients, resulting in Thrombocytopenia side effect. The patient was hospitalized.
Perfalgan Side Effect Report#9704393
Agranulocytosis, Blood Alkaline Phosphatase Increased, Transaminases Increased
This report suggests a potential Perfalgan Agranulocytosis side effect(s) that can have serious consequences. A 49-year-old female patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: NA and used Perfalgan (dosage: NA) starting
Feb 12, 2013. After starting Perfalgan the patient began experiencing various side effects, including: Agranulocytosis, Blood Alkaline Phosphatase Increased, Transaminases IncreasedAdditional drugs used concurrently:
  • Tranxene (clorazepate Dipotassium) (capsules) (clorazepate Dipotassium)
  • Eupantol (pantoprazole Sodium Sesquihydrate)
  • Rocephine (ceftriaxone Sodium) (cetriaxone Sodium)
  • Kabiven
  • Tiberal
  • Acupan
The patient was hospitalized. Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Agranulocytosis, may still occur.
Perfalgan Side Effect Report#9700191
Hepatocellular Injury, Cholestasis, Hepatocellular Injury, Cholestasis
This Hepatocellular Injury problem was reported by a physician from FR. A 81-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jul 15, 2013 this consumer started treatment with Perfalgan (dosage: NA). The following drugs were being taken at the same time:
  • Fluindione (fluindione)
  • Stilnox
  • Ciprofloxacin
  • Phloroglucinol (phloroqlucinol)
  • Prednisolone Sodium Metazoate
  • Lovenox
  • Tramadol Hcl
  • Profenid (ketoprofen)
When using Perfalgan, the patient experienced the following unwanted symptoms/side effects: Hepatocellular Injury, Cholestasis, Hepatocellular Injury, CholestasisThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatocellular Injury, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9698163
Hepatitis Fulminant, Encephalopathy, Hepatitis Toxic, Toxicity To Various Agents, Autoimmune Hepatitis, Liver Transplant
This Hepatitis Fulminant side effect was reported by a health professional from PT. A 29-year-old female patient (weight:NA) experienced the following symptoms/conditions: urinary tract infection.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on
Feb 04, 2008. Concurrently used drugs:
  • Sulfamethoxazole And Trimethoprim
  • Aulin
  • Ethinylestradiol
  • Gestodene
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Hepatitis Fulminant, Encephalopathy, Hepatitis Toxic, Toxicity To Various Agents, Autoimmune Hepatitis, Liver TransplantThese side effects may potentially be related to Perfalgan. The patient was hospitalized.
Perfalgan Side Effect Report#9696186
Agranulocytosis, Transaminases Increased, Blood Alkaline Phosphatase Increased
This is a report of a 49-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (dosage: NA, start time:
Feb 12, 2013), combined with:
  • Tranxene
  • Eupantol
  • Rocephine
and developed a serious reaction and side effect(s): Agranulocytosis, Transaminases Increased, Blood Alkaline Phosphatase Increased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan treatment in female patients, resulting in Agranulocytosis side effect. The patient was hospitalized.
Perfalgan Side Effect Report#9678764
Pulmonary Embolism, Thrombocytopenia, Haemorrhage, Coagulopathy, Hepatorenal Failure
This report suggests a potential Perfalgan Pulmonary Embolism side effect(s) that can have serious consequences. A 82-year-old female patient (weight: NA) from CH was diagnosed with the following symptoms/conditions: pain,anaesthesia and used Perfalgan (dosage: NA) starting
Aug 07, 2013. After starting Perfalgan the patient began experiencing various side effects, including: Pulmonary Embolism, Thrombocytopenia, Haemorrhage, Coagulopathy, Hepatorenal FailureAdditional drugs used concurrently:
  • Thiopental Sodium (325 Mg, Ivd)
  • Isoflurane
  • Dipyrone
  • Fragmin (dalteparin Sodium) Solution For Injection (2500 Iu; Ivb)
  • Fentanyl Citrate
  • Methadone Hcl
  • Remifentanil Hydrochloride
  • Atracurium Besylate
Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Pulmonary Embolism, may still occur.
Perfalgan Side Effect Report#9645357
Hepatitis Fulminant, Hepatomegaly, Anaemia, Prothrombin Time Shortened
This Hepatitis Fulminant problem was reported by a physician from FR. A 52-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Perfalgan (dosage: NA). The following drugs were being taken at the same time: NA. When using Perfalgan, the patient experienced the following unwanted symptoms/side effects: Hepatitis Fulminant, Hepatomegaly, Anaemia, Prothrombin Time ShortenedAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatitis Fulminant, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9639000
Dermatitis Bullous, Skin Erosion, Renal Failure Acute
This Dermatitis Bullous side effect was reported by a consumer or non-health professional from FR. A 92-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on 201309. Concurrently used drugs:
  • Plavix
  • Doliprane (paracetamol)
  • Crestor
  • Aspegic
  • Coaprovel
  • Atenolol
  • Iperten
  • Omeprazole
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Dermatitis Bullous, Skin Erosion, Renal Failure AcuteThese side effects may potentially be related to Perfalgan. The patient was hospitalized.
Perfalgan Side Effect Report#9560190
Toxic Epidermal Necrolysis, Graft Versus Host Disease In Intestine, Haematuria, Renal Failure Acute, Hepatitis Fulminant, Bone Marrow Transplant, Multi-organ Failure
This is a report of a 41-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (dosage: NA, start time:
Jun 19, 2013), combined with:
  • Heparin Sodium
  • Ceftazidime
  • Gentamicine
  • Ambisome
  • Bactrim
  • Folinic Acid
  • Zelitrex
and developed a serious reaction and side effect(s): Toxic Epidermal Necrolysis, Graft Versus Host Disease In Intestine, Haematuria, Renal Failure Acute, Hepatitis Fulminant, Bone Marrow Transplant, Multi-organ Failure after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan treatment in female patients, resulting in Toxic Epidermal Necrolysis side effect. The patient was hospitalized.
Perfalgan Side Effect Report#9516324
Shock, Rash
This report suggests a potential Perfalgan Shock side effect(s) that can have serious consequences. A 63-year-old female patient (weight: NA) from FR was diagnosed with the following symptoms/conditions: breast operation and used Perfalgan (dosage: NA) starting
Feb 28, 2012. After starting Perfalgan the patient began experiencing various side effects, including: Shock, RashAdditional drugs used concurrently:
  • Diprivan
  • Sufenta (sufentanil Citrate)
  • Tracrium
  • Midazolam Hcl
  • Ketamine
  • Cefazoline
  • Acupan
  • Profenid (ketoprofen)
Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Shock, may still occur.
Perfalgan Side Effect Report#9516071
Eosinophilic Pneumonia, Alveolitis Allergic
This Eosinophilic Pneumonia problem was reported by a physician from FR. A 70-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
May 25, 2010 this consumer started treatment with Perfalgan (dosage: NA). The following drugs were being taken at the same time:
  • Cefamandole
  • Propofol
  • Rocuronium
  • Ephedrine
  • Atropine
  • Sufentanil
  • Ketamine
When using Perfalgan, the patient experienced the following unwanted symptoms/side effects: Eosinophilic Pneumonia, Alveolitis AllergicThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eosinophilic Pneumonia, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9494912
Hepatitis, Pancreatitis
This Hepatitis side effect was reported by a physician from FR. A 24-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on
Jun 25, 2013. Concurrently used drugs:
  • Doliprane
  • Lamaline
  • N-acetylcysteine
  • Sodium Valproate
  • Risperidone
  • Zopiclone
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Hepatitis, PancreatitisThese side effects may potentially be related to Perfalgan. The patient was hospitalized.
Perfalgan Side Effect Report#9456726
Thrombocytopenia, Septic Shock, Multi-organ Failure, Renal Failure, Acute Respiratory Failure, Lung Disorder, Staphylococcal Infection
This is a report of a 83-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (dosage: NA, start time:
May 15, 2013), combined with:
  • Sodium Heparin
  • Teicoplanin (teicoplanin)
  • Esomeprazole
  • Furosemide (furosemide)
  • Methyprednisolone
  • Insulin (insulin)
  • Levothyrox (levothyroxine Sodium) Infusion
  • Bricanyl
and developed a serious reaction and side effect(s): Thrombocytopenia, Septic Shock, Multi-organ Failure, Renal Failure, Acute Respiratory Failure, Lung Disorder, Staphylococcal Infection after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan treatment in female patients, resulting in Thrombocytopenia side effect.
Perfalgan Side Effect Report#9456596
Renal Failure Acute, Vomiting, Pyrexia, Respiratory Tract Inflammation
This report suggests a potential Perfalgan Renal Failure Acute side effect(s) that can have serious consequences. A 49-year-old male patient (weight: NA) from IT was diagnosed with the following symptoms/conditions: postoperative analgesia,antibiotic prophylaxis,anaesthesia and used Perfalgan (dosage: 4 Gram: Total: Iv) starting
May 21, 2013. After starting Perfalgan the patient began experiencing various side effects, including: Renal Failure Acute, Vomiting, Pyrexia, Respiratory Tract InflammationAdditional drugs used concurrently:
  • Cefazoline
  • Propofol (propofol)
  • Remifentanil
  • Omeprazole (omeprazole)
  • Toradol (ketorolac Tromethamine)
  • Morphine
  • Rocuronium Bromide
  • Bemiparin Sodium
The patient was hospitalized. Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Perfalgan Side Effect Report#9456063
Vomiting, Urticaria, Pain, Post Procedural Complication, Contraindication To Medical Treatment
This Vomiting problem was reported by a physician from FR. A 49-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 09, 2013 this consumer started treatment with Perfalgan (dosage: 1 Gm; Iv). The following drugs were being taken at the same time:
  • Contramal
  • Ketoprofen
  • Povidone Iodine (Cut)
  • Sufenta
  • Propofol
  • Metronidazole
  • Ondansetron Hcl
When using Perfalgan, the patient experienced the following unwanted symptoms/side effects: Vomiting, Urticaria, Pain, Post Procedural Complication, Contraindication To Medical TreatmentThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Vomiting, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9403843
Eczema, Toxic Skin Eruption
This Eczema side effect was reported by a physician from FR. A 66-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on
Mar 10, 2013. Concurrently used drugs:
  • Kabiven
  • Ondansetron (ondansetron)
  • Spasfon
  • Alprazolam (alprazolam)
  • Vitamin K1
  • Phocytan
  • Oxaliplatin
  • Irinotecan
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Eczema, Toxic Skin EruptionThese side effects may potentially be related to Perfalgan. The patient was hospitalized.
Perfalgan Side Effect Report#9380516
Agranulocytosis, Septic Shock, Pulmonary Embolism, Failure To Anastomose
This is a report of a 57-year-old male patient (weight: NA) from CH, suffering from the following health symptoms/conditions: NA, who was treated with Perfalgan (dosage: NA, start time:
May 19, 2013), combined with:
  • Dafalgan
  • Cefepime Hcl
  • Clexane
  • Diflucan
  • Durogesic (fentanyl)
  • Fentanyl Citrate
  • Heparin (heparin)
  • Furosemide (furosemide)
and developed a serious reaction and side effect(s): Agranulocytosis, Septic Shock, Pulmonary Embolism, Failure To Anastomose after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan treatment in male patients, resulting in Agranulocytosis side effect. The patient was hospitalized.
Perfalgan Side Effect Report#9298815
Accidental Overdose, International Normalised Ratio Increased, Activated Partial Thromboplastin Time Prolonged, Toxicity To Various Agents
This report suggests a potential Perfalgan Accidental Overdose side effect(s) that can have serious consequences. A male patient (weight: NA) from ZA was diagnosed with the following symptoms/conditions: postoperative analgesia and used Perfalgan (dosage: NA) starting NS. After starting Perfalgan the patient began experiencing various side effects, including: Accidental Overdose, International Normalised Ratio Increased, Activated Partial Thromboplastin Time Prolonged, Toxicity To Various AgentsAdditional drugs used concurrently: NA. Although Perfalgan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Accidental Overdose, may still occur.
Perfalgan Side Effect Report#9263190
Hepatocellular Injury, Subileus, Leukocytosis, Inflammation, Leukocyturia, Enterococcus Test Positive, Pathogen Resistance, Hyponatraemia, Hypokalaemia
This Hepatocellular Injury problem was reported by a physician from FR. A 13-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Jan 24, 2013 this consumer started treatment with Perfalgan (dosage: NA). The following drugs were being taken at the same time:
  • Cefotaxime Sodium (cefotaxime Sodium)
  • Perindopril
  • Phloroglucinol
  • Gentamicin Sulfate
  • Omeprazole (omeprazole)
When using Perfalgan, the patient experienced the following unwanted symptoms/side effects: Hepatocellular Injury, Subileus, Leukocytosis, Inflammation, Leukocyturia, Enterococcus Test Positive, Pathogen Resistance, Hyponatraemia, HypokalaemiaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hepatocellular Injury, may become evident only after a product is in use by the general population.
Perfalgan Side Effect Report#9263157
Circulatory Collapse, Myocardial Stunning, Dyspnoea, Hypoxia, Post Procedural Complication, Myocarditis
This Circulatory Collapse side effect was reported by a physician from FR. A 38-year-old female patient (weight:NA) experienced the following symptoms/conditions: pain.The patient was prescribed Perfalgan (drug dosage: NA), which was initiated on
Nov 23, 2011. Concurrently used drugs:
  • Atropine (1 Mg Total)
  • Naropeine
  • Droleptan
  • Phloroglucinol
  • Suprane
  • Propofol (propofol)
  • Sufentanil
  • Nimbex
.After starting to take Perfalgan the consumer reported adverse symptoms, such as: Circulatory Collapse, Myocardial Stunning, Dyspnoea, Hypoxia, Post Procedural Complication, MyocarditisThese side effects may potentially be related to Perfalgan. The patient was hospitalized.
Perfalgan Side Effect Report#9254739
Neutropenia, Rash, White Blood Cell Count Decreased
This is a report of a 43-year-old female patient (weight: NA) from IT, suffering from the following health symptoms/conditions: pyrexia, who was treated with Perfalgan (paracetamol) (dosage: NA, start time:
Jan 08, 2013), combined with:
  • Vancomycin Hcl
  • Nadroparin Calcium
  • Merrem
and developed a serious reaction and side effect(s): Neutropenia, Rash, White Blood Cell Count Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Perfalgan (paracetamol) treatment in female patients, resulting in Neutropenia side effect. The patient was hospitalized.


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The appearance of Perfalgan on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

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  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Perfalgan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    More About Perfalgan

    Side Effects reported to FDA: 88

    Perfalgan safety alerts: No

    Reported deaths: 17

    Reported hospitalizations: 41

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