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Phenergan Side Effects

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Common Phenergan Side Effects


The most commonly reported Phenergan side effects (click to view or check a box to report):

Pain (43)
Nausea (36)
Anxiety (24)
Vomiting (21)
Pain In Extremity (21)
Cholecystitis Chronic (20)
Dyspnoea (20)
Injury (20)
Muscle Spasms (19)
Fatigue (16)
Cholelithiasis (16)
Diarrhoea (16)
Dehydration (14)
Gallbladder Disorder (14)
Emotional Distress (14)
Paraesthesia (14)
Injection Site Pain (14)
Oedema Peripheral (13)
Tremor (12)
Loss Of Consciousness (12)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Phenergan Side Effects Reported to FDA



Phenergan Side Effect Report#9970597
Complex Partial Seizures
This is a report of a 28-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: sleep disorder, who was treated with Phenergan (dosage: To Help Me Sleep, start time: NS), combined with:
  • Lamictal
  • Celebrex
  • Synthroid
  • Geodon
  • Aldactone
  • Cymbalta
  • Tylenol
  • Advil
and developed a serious reaction and side effect(s): Complex Partial Seizures after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan treatment in female patients, resulting in Complex Partial Seizures side effect. The patient was hospitalized and became disabled.
Phenergan Side Effect Report#9874802
Syncope, Irritability, Mood Altered, Heart Rate Irregular, Disturbance In Attention, Vision Blurred, Confusional State, Hypotension, Anxiety
This report suggests a potential Phenergan Syncope side effect(s) that can have serious consequences. A 39-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: nausea,vomiting and used Phenergan (dosage: NA) starting
Jul 01, 2013. After starting Phenergan the patient began experiencing various side effects, including: Syncope, Irritability, Mood Altered, Heart Rate Irregular, Disturbance In Attention, Vision Blurred, Confusional State, Hypotension, AnxietyAdditional drugs used concurrently: NA. Although Phenergan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Syncope, may still occur.
Phenergan Side Effect Report#9870144
Speech Disorder, Hypopnoea, Respiratory Distress, Pulmonary Embolism
This Speech Disorder problem was reported by a consumer or non-health professional from US. A 76-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Phenergan (dosage: NA). The following drugs were being taken at the same time: NA. When using Phenergan, the patient experienced the following unwanted symptoms/side effects: Speech Disorder, Hypopnoea, Respiratory Distress, Pulmonary EmbolismAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Speech Disorder, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#9748462
Injection Site Reaction, Injection Site Rash, Dyspnoea
This Injection Site Reaction side effect was reported by a physician from US. A 41-year-old female patient (weight:NA) experienced the following symptoms/conditions: nausea.The patient was prescribed Phenergan (drug dosage: NA), which was initiated on
Aug 17, 2013. Concurrently used drugs: NA..After starting to take Phenergan the consumer reported adverse symptoms, such as: Injection Site Reaction, Injection Site Rash, DyspnoeaThese side effects may potentially be related to Phenergan.
Phenergan Side Effect Report#9422238
Sedation, Hypertensive Crisis
This is a report of a 75-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Phenergan (dosage: 12.5?, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Sedation, Hypertensive Crisis after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan treatment in female patients, resulting in Sedation side effect. The patient was hospitalized.
Phenergan Side Effect Report#9320013
Completed Suicide, Cardiac Arrest, Respiratory Arrest
This report suggests a potential Phenergan Completed Suicide side effect(s) that can have serious consequences. A 42-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Phenergan (dosage: NA) starting NS. After starting Phenergan the patient began experiencing various side effects, including: Completed Suicide, Cardiac Arrest, Respiratory ArrestAdditional drugs used concurrently:
  • Zolpidem Tartrate
Although Phenergan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Completed Suicide, may still occur.
Phenergan Side Effect Report#9282388
Depression, Exposure During Pregnancy
This Depression problem was reported by a consumer or non-health professional from US. A 45-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: nausea,pregnancy. On NS this consumer started treatment with Phenergan (dosage: NA). The following drugs were being taken at the same time: NA. When using Phenergan, the patient experienced the following unwanted symptoms/side effects: Depression, Exposure During PregnancyThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Depression, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#9238325
Respiratory Depression, Overdose
This Respiratory Depression side effect was reported by a consumer or non-health professional from US. A 33-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Phenergan W/ Codeine (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Phenergan W/ Codeine the consumer reported adverse symptoms, such as: Respiratory Depression, OverdoseThese side effects may potentially be related to Phenergan W/ Codeine.
Phenergan Side Effect Report#9059643
Burning Sensation, Eye Irritation, Convulsion, Cerebrovascular Accident, Nervous System Disorder, Unevaluable Event, Pain, Burning Sensation
This is a report of a 36-year-old male patient (weight: NA) from US, suffering from the following health symptoms/conditions: vomiting, who was treated with Phenergan (dosage: 12-25 Ml 10 Seconds Iv, start time:
Mar 07, 2011), combined with: NA. and developed a serious reaction and side effect(s): Burning Sensation, Eye Irritation, Convulsion, Cerebrovascular Accident, Nervous System Disorder, Unevaluable Event, Pain, Burning Sensation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan treatment in male patients, resulting in Burning Sensation side effect. The patient was hospitalized and became disabled.
Phenergan Side Effect Report#8887355
Somnolence, Confusional State, Somnolence
This report suggests a potential Phenergan Somnolence side effect(s) that can have serious consequences. A 81-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: nausea and used Phenergan (dosage: 12.5 Mg Diluted In 9cc. Of Ns Once Iv Push) starting
Mar 21, 2012. After starting Phenergan the patient began experiencing various side effects, including: Somnolence, Confusional State, SomnolenceAdditional drugs used concurrently: NA. Although Phenergan demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Somnolence, may still occur.
Phenergan Side Effect Report#8799501
Feeling Hot, Coordination Abnormal, Muscle Spasms, Apnoea, Dry Mouth, Irritability, Sleep Disorder, Hallucination, Gait Disturbance
This Feeling Hot problem was reported by a consumer or non-health professional from US. A 55-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: post procedural nausea. On
Sep 14, 2012 this consumer started treatment with Phenergan (dosage: Intravenous Injection Once). The following drugs were being taken at the same time: NA. When using Phenergan, the patient experienced the following unwanted symptoms/side effects: Feeling Hot, Coordination Abnormal, Muscle Spasms, Apnoea, Dry Mouth, Irritability, Sleep Disorder, Hallucination, Gait DisturbanceAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Feeling Hot, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#8586883-2
Urticaria, Hot Flush
This Urticaria side effect was reported by a consumer or non-health professional from United States. A 79-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Phenergan Hcl (drug dosage: NA), which was initiated on
Apr 26, 2010. Concurrently used drugs:
  • Nasonex
  • Levothyroxine Sodium
  • Exjade (1000/1500 Mg Qd, Oral 1000mg Qd, Oral)
  • Exjade (1000/1500 Mg Qd, Oral 1000mg Qd, Oral)
  • Finasteride
  • Vitamin D
  • Omeprazole
  • Vitamin B (no Ingredients/substances)
.After starting to take Phenergan Hcl the consumer reported adverse symptoms, such as: Urticaria, Hot FlushThese side effects may potentially be related to Phenergan Hcl.
Phenergan Side Effect Report#8581681-8
Tremor, Abdominal Pain, Chills, Nausea, Bone Pain, Diarrhoea, Pain, Abasia, Joint Swelling
This is a report of a 36-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Phenergan Hcl (dosage: NA, start time:
Jul 12, 2010), combined with:
  • Tylox
  • Exjade (2000 Mg, Qd, Oral)
and developed a serious reaction and side effect(s): Tremor, Abdominal Pain, Chills, Nausea, Bone Pain, Diarrhoea, Pain, Abasia, Joint Swelling after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan Hcl treatment in female patients, resulting in Tremor side effect. The patient was hospitalized.
Phenergan Side Effect Report#8575051-6
Liver Disorder, Diarrhoea
This report suggests a potential Phenergan Hcl Liver Disorder side effect(s) that can have serious consequences. A female patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Phenergan Hcl (dosage: NA) starting
Jan 01, 2010. After starting Phenergan Hcl the patient began experiencing various side effects, including: Liver Disorder, DiarrhoeaAdditional drugs used concurrently:
  • Zocor
  • Aspirin
  • Ativan
  • Meclizine
  • Triazolam
  • Exjade (1125 Mg, Od, Oral, 500 Mg, Qd, Oral)
  • Exjade (1125 Mg, Od, Oral, 500 Mg, Qd, Oral)
  • Isosorbide Dinitrate
The patient was hospitalized. Although Phenergan Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Liver Disorder, may still occur.
Phenergan Side Effect Report#8474244-6
Cholecystitis Chronic, Abdominal Pain Upper, Nausea, Vomiting, Pain, Cholelithiasis, Chest Pain, Depression, Injury
This Cholecystitis Chronic problem was reported by a health professional from United States. A 26-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On
Apr 01, 2008 this consumer started treatment with Phenergan Hcl (dosage: 25 Mg, 1 Every 6 Hours). The following drugs were being taken at the same time:
  • Nsaid's (2 Per Week)
  • Nexium (40 Mg, Daily)
  • Yasmin
  • Vicodin (1-2 Every 4-6 Hrs)
  • Hyoscyamine (0.125 Mg, Q4hr)
  • Drospirenone And Ethinyl Estradiol
  • Alimentary Tract And Metabolism
  • Alka Seltzer
When using Phenergan Hcl, the patient experienced the following unwanted symptoms/side effects: Cholecystitis Chronic, Abdominal Pain Upper, Nausea, Vomiting, Pain, Cholelithiasis, Chest Pain, Depression, InjuryThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Cholecystitis Chronic, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#8460392-3
Contusion, Haemorrhage
This Contusion side effect was reported by a health professional from United States. A 80-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Phenergan (drug dosage: NA), which was initiated on
Apr 28, 2010. Concurrently used drugs:
  • Magnesium (magnesium)
  • Vitamin D
  • Aspirin
  • Ambien
  • Hydrochlorothiazide
  • Milk Of Magnesia Tab
  • Vitamin C (ascorbic Acid0
  • Revlimid (15 Mg, Qd X 21 Days, Po)
.After starting to take Phenergan the consumer reported adverse symptoms, such as: Contusion, HaemorrhageThese side effects may potentially be related to Phenergan.
Phenergan Side Effect Report#8457750-X
Dystonia, Confusional State, Speech Disorder, Memory Impairment, Tremor, Altered State Of Consciousness, Psychotic Disorder
This is a report of a 77-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: nausea, who was treated with Phenergan Hcl (dosage: NA, start time:
Apr 15, 2012), combined with: NA. and developed a serious reaction and side effect(s): Dystonia, Confusional State, Speech Disorder, Memory Impairment, Tremor, Altered State Of Consciousness, Psychotic Disorder after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan Hcl treatment in female patients, resulting in Dystonia side effect.
Phenergan Side Effect Report#8453611-0
This report suggests a potential Phenergan Hcl Death side effect(s) that can have serious consequences. A 58-year-old male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: NA and used Phenergan Hcl (dosage: NA) starting
Jun 23, 2011. After starting Phenergan Hcl the patient began experiencing various side effects, including:Additional drugs used concurrently:
  • Haldol
  • Morphine
  • Zolinza
  • Roxanol
Although Phenergan Hcl demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Death, may still occur.
Phenergan Side Effect Report#8447952-0
Hypersensitivity, Impaired Work Ability, Convulsion, Craniocerebral Injury
This Hypersensitivity problem was reported by a consumer or non-health professional from United States. A 21-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: labour pain. On
May 09, 1999 this consumer started treatment with Phenergan (dosage: 10 Mg, Iv). The following drugs were being taken at the same time: NA. When using Phenergan, the patient experienced the following unwanted symptoms/side effects: Hypersensitivity, Impaired Work Ability, Convulsion, Craniocerebral InjuryAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypersensitivity, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#8436036-3
Night Sweats, Dehydration, Oedema Peripheral, Malnutrition, Depression, Muscular Weakness, Arthralgia, Skin Discolouration
This Night Sweats side effect was reported by a health professional from United States. A 57-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Phenergan (promethazine Hydrochloride, Dibrompropamidine Isetionate) (drug dosage: NA), which was initiated on
Jul 05, 2011. Concurrently used drugs:
  • Escitalopram Oxalate
  • Abt-267 (abt-267) (Tablets, Once Daily (84 Days))
  • Peginterferon Alfa-2a (180 Mcg, Once Weekly, Subcutaneous)
  • Ribavirin (1200 Mg (600 Mg, Twice A Day), Tablets, Oral)
  • Fluticasone Propionate
  • Kliogest (estradiol, Norethisterone Acetate)
.After starting to take Phenergan (promethazine Hydrochloride, Dibrompropamidine Isetionate) the consumer reported adverse symptoms, such as: Night Sweats, Dehydration, Oedema Peripheral, Malnutrition, Depression, Muscular Weakness, Arthralgia, Skin DiscolourationThese side effects may potentially be related to Phenergan (promethazine Hydrochloride, Dibrompropamidine Isetionate). The patient was hospitalized.
Phenergan Side Effect Report#8428247-8
Diarrhoea, Wheezing, Somnolence, Muscle Spasms, Skin Fissures, Blood Calcium Increased, Infection, Sinusitis, Weight Decreased
This is a report of a 61-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Phenergan (dosage: NA, start time: NS), combined with:
  • Nexium
  • Atenolol
  • Astelin
  • Lidoderm
  • Amoxil/clavulanic
  • Amitriptline Hydrochloride Tab
  • Celebrex
  • Humubid
and developed a serious reaction and side effect(s): Diarrhoea, Wheezing, Somnolence, Muscle Spasms, Skin Fissures, Blood Calcium Increased, Infection, Sinusitis, Weight Decreased after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan treatment in female patients, resulting in Diarrhoea side effect.
Phenergan Side Effect Report#8425525-3
Infusion Site Pain, Infusion Site Erythema
This report suggests a potential Phenergan 25mg Infusion Site Pain side effect(s) that can have serious consequences. A male patient (weight: NA) from United States was diagnosed with the following symptoms/conditions: nausea,antiemetic supportive care and used Phenergan 25mg (dosage: 25mg Periph Iv) starting
May 15, 2012. After starting Phenergan 25mg the patient began experiencing various side effects, including: Infusion Site Pain, Infusion Site ErythemaAdditional drugs used concurrently: NA. Although Phenergan 25mg demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Infusion Site Pain, may still occur.
Phenergan Side Effect Report#8403360-X
Eating Disorder, Nausea, Abdominal Discomfort
This Eating Disorder problem was reported by a physician from United States. A male patient (weight: NA) was diagnosed with the following symptoms/conditions: migraine. On
Apr 13, 2012 this consumer started treatment with Phenergan (dosage: Unk). The following drugs were being taken at the same time:
  • Chantix (0.5 Mg Daily)
  • Chantix (0.5 Mg, 2x/day)
When using Phenergan, the patient experienced the following unwanted symptoms/side effects: Eating Disorder, Nausea, Abdominal DiscomfortAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eating Disorder, may become evident only after a product is in use by the general population.
Phenergan Side Effect Report#8399367-1
Anaphylactic Reaction
This Anaphylactic Reaction side effect was reported by a physician from United States. A 71-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Phenergan (drug dosage: NA), which was initiated on
Jan 01, 2012. Concurrently used drugs:
  • Lisinopril
  • Keflex
  • Nucynta
.After starting to take Phenergan the consumer reported adverse symptoms, such as: Anaphylactic ReactionThese side effects may potentially be related to Phenergan.
Phenergan Side Effect Report#8379658-0
Migraine, Headache
This is a report of a 40-year-old female patient (weight: NA) from United States, suffering from the following health symptoms/conditions: NA, who was treated with Phenergan (dosage: NA, start time:
Jan 01, 2006), combined with:
  • Zomig (One 2.5 Mg Dose)
  • Microdantin
  • Wellbutrin Xl
  • Zomig
  • Zofran
  • Zoloft
and developed a serious reaction and side effect(s): Migraine, Headache after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Phenergan treatment in female patients, resulting in Migraine side effect.


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The appearance of Phenergan on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Phenergan Side Effects for Women?

Women Side EffectsReports
Pain 34
Nausea 30
Anxiety 23
Cholecystitis Chronic 20
Injury 20
Dyspnoea 17
Pain In Extremity 17
Vomiting 17
Cholelithiasis 16
Diarrhoea 16

What are common Phenergan Side Effects for Men?

Men Side EffectsReports
Pain 8
Nausea 6
Burning Sensation 5
Completed Suicide 5
Condition Aggravated 5
Muscle Spasms 5
Paraesthesia 5
Abnormal Behaviour 4
Amnesia 4
Chest Pain 4

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Phenergan reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    How Effective is Phenergan for You?

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    Phenergan Safety Alerts, Active Ingredients, Usage Information

    NDC0641-6082
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NamePHENERGAN
    NamePromethazine Hydrochloride
    Dosage FormINJECTION
    RouteINTRAMUSCULAR; INTRAVENOUS
    On market since19730919
    LabelerWest-ward Pharmaceutical Corp.
    Active Ingredient(s)PROMETHAZINE HYDROCHLORIDE
    Strength(s)25
    Unit(s)mg/mL
    Pharma ClassPhenothiazine [EPC],Phenothiazines [Chemical/Ingredient]

    Phenergan Dosage, Warnings, Usage.

    Side Effects reported to FDA: 352

    Phenergan safety alerts: 2006 2005

    Reported deaths: 24

    Reported hospitalizations: 80

    Promethazine HCl (marketed as Phenergan and generic products)

    Audience: Pediatricians, emergency service professionals and patients
    [Posted 04/25/2006] FDA notified healthcare professionals and patients that cases of breathing problems, some causing death, have been reported to the FDA when the drug was used in children less than two years old. Parents and caregivers should also be careful and get a doctor's advice about giving promethazine HCl in any form to children age two and older. The labeling on all products, brand name and generic, has been changed to reflect these strengthened warnings.

    [April 25, 2006 - Drug Information Page - FDA]

    Latest Phenergan clinical trials