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Protonix Side Effects

Common Protonix Side Effects


The most commonly reported Protonix side effects (click to view or check a box to report):

Nausea (99)
Pain (89)
Abdominal Pain Upper (78)
Vomiting (68)
Diarrhoea (66)
Dizziness (56)
Condition Aggravated (55)
Headache (54)
Dyspepsia (54)
Malaise (53)
Dyspnoea (53)
Abdominal Pain (50)
Anxiety (47)
Chest Pain (46)
Gastrooesophageal Reflux Disease (42)
Fatigue (38)
Abdominal Distension (38)
Cholecystitis Chronic (38)
Asthenia (37)
Myocardial Infarction (36)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Protonix Side Effects Reported to FDA

The following Protonix reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Protonix on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dizziness
This is a report of a 43-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Protonix (dosage: 40 Mg, Unk, start time: 2013), combined with:
  • Lisinopril (20 Mg, Daily)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Dizziness
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Protonix treatment in male patients, resulting in dizziness side effect.

Diverticulum
This report suggests a potential Protonix Diverticulum side effect(s) that can have serious consequences. A 88-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Protonix (dosage: Unk) starting NS. Soon after starting Protonix the patient began experiencing various side effects, including:
  • Diverticulum
Drugs used concurrently: NA.The patient was hospitalized. Although Protonix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as diverticulum, may still occur.

Oesophageal Perforation, Off Label Use
This Oesophageal Perforation, Off Label Use problem was reported by a consumer or non-health professional from US. A 44-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease,cardiac failure congestive. On NS this consumer started treatment with Protonix (dosage: 40 Mg, 3x/day). The following drugs were being taken at the same time:
  • Lasix (40 Mg, 1x/day)
When commencing Protonix, the patient experienced the following unwanted symptoms/side effects:
  • Oesophageal Perforation
  • Off Label Use
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as oesophageal perforation, may become evident only after a product is in use by the general population.


This is a report of a 10-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Protonix (dosage: 40 Mg, Unk) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
    This opens a possibility that Protonix treatment could cause the above reactions, including death, and some female subjects may be more susceptible.


    Diarrhoea, Dizziness, Fatigue, Hyperhidrosis, Asthenia, Nausea, Abdominal Pain
    A 52-year-old female patient (weight: NA) from US with the following symptoms/conditions: dyspepsia started Protonix treatment (dosage: 2 Pills/day?taken By Mouth) on Jan 22, 2014. Soon after starting Protonix treatment, the subject experienced various side effects, including:
    • Diarrhoea
    • Dizziness
    • Fatigue
    • Hyperhidrosis
    • Asthenia
    • Nausea
    • Abdominal Pain
    Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Protonix.

    Bone Density Decreased, Malaise, Productive Cough, Oropharyngeal Pain, Throat Irritation
    A 62-year-old female patient from US (weight: NA) experienced symptoms, such as: gastrooesophageal reflux disease,abdominal pain upper and was treated with Protonix(dosage: 40 Mg, Unk). The treatment was initiated on 2012. After that a consumer reported the following side effect(s):
    • Bone Density Decreased
    • Malaise
    • Productive Cough
    • Oropharyngeal Pain
    • Throat Irritation
    Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Protonix efficacy: NA.

    Musculoskeletal Discomfort
    In this report, Protonix was administered for the following condition: NA.A 53-year-old male consumer from US (weight: NA) started Protonix treatment (dosage: Unk) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
    • Musculoskeletal Discomfort
    A possible interaction with other drugs could have contributed to this reaction:
    • Viagra (Unk)
    Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Protonix treatment could be related to the listed above side effect(s).

    Neoplasm Malignant
    This is a report of the following Protonix side effect(s):
    • Neoplasm Malignant
    A 73-year-old female patient from US (weight: NA) presented with the following condition: gastrooesophageal reflux disease and received a treatment with Protonix (dosage: Unk, 1x/day) starting: NS.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Protonix treatment could be associated with the listed above side effect(s).

    Arthropathy, Off Label Use
    This Protonix report was submitted by a 58-year-old female consumer from US (weight: NA). The patient was diagnosed with: musculoskeletal discomfort,diabetes mellitus and Protonix was administered (dosage: 40 Mg, 1x/day) starting: NS. The consumer developed a set of symptoms:
    • Arthropathy
    • Off Label Use
    Other drugs used simultaneously:
    • Lantus (Unk, 2x/day)
    The patient was hospitalized.Those unexpected symptoms could be linked to a Protonix treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

    Feeling Jittery, Malaise
    This is a report of a possible correlation between Protonix use and the following symptoms/side effect(s):
    • Feeling Jittery
    • Malaise
    which could contribute to an assessment of Protonix risk profile.A 65-year-old female consumer from US (weight: NA) was suffering from NA and was treated with Protonix (dosage: Unk) starting 201401.Other concurrent medications:
    • Toprol Xl (Unk)
    • Aspirin (Unk)


    Vitamin B12 Deficiency, Clostridium Difficile Infection, Predisposition To Disease
    A 62-year-old female patient from US (weight: NA) presented with the following symptoms: gastrooesophageal reflux disease,dyspepsia and after a treatment with Protonix (dosage: NA) experienced the following side effect(s):
    • Vitamin B12 Deficiency
    • Clostridium Difficile Infection
    • Predisposition To Disease
    The treatment was started on NS. Protonix was used in combination with the following drugs: NA.This report could alert potential Protonix consumers.

    Feeling Jittery
    In this report, a 65-year-old female patient from US (weight: NA) was affected by a possible Protonix side effect.The patient was diagnosed with NA. After a treatment with Protonix (dosage: Unk, start date: NS), the patient experienced the following side effect(s):
    • Feeling Jittery
    The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Protonix treatment.

    Pain
    This is a report of a 83-year-old female patient from US (weight: NA), who used Protonix (dosage: Unk) for a treatment of gastrooesophageal reflux disease. After starting a treatment on NS, the patient experienced the following side effect(s):
    • Pain
    The following drugs could possibly have interacted with the Protonix treatment NA.Taken together, these observations suggest that a Protonix treatment could be related to side effect(s), such as Pain.

    Nausea, Malaise, Abdominal Discomfort
    This nausea side effect was reported by a consumer or non-health professional from US. A 57-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Protonix (dosage: Unk, 2x/day), which was started on 2013. Concurrently used drugs:
    • Celexa (Unk, 1x/day)
    • Mycophenolate Mofetil (500 Mg, 4x/day)
    • Tacrolimus (1 Mg, 3x/day)
    • Baby Aspirin (Unk, 1x/day)
    When starting to take Protonix the consumer reported the following symptoms:
    • Nausea
    • Malaise
    • Abdominal Discomfort
    These side effects may potentially be related to Protonix.

    Extravasation, Swelling
    This is a Protonix side effect report of a 83-year-old male patient (weight:NA) from US, suffering from the following symptoms/conditions: gastrointestinal haemorrhage, who was treated with Protonix (dosage:As Continuous Drip, start time: Jan 02, 2014), combined with: NA., and developed a serious reaction and a extravasation side effect. The patient presented with:
    • Extravasation
    • Swelling
    which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Protonix treatment in male patients suffering from gastrointestinal haemorrhage, resulting in extravasation.

    Hernia, Abdominal Discomfort
    This report suggests a potential Protonix hernia side effect(s) that can have serious consequences. A 57-year-old male patient from US (weight:NA) was diagnosed with the following health condition(s): gastrooesophageal reflux disease and used Protonix (dosage: 40 Mg, 2x/day) starting 201311. Soon after starting Protonix the patient began experiencing various side effects, including:
    • Hernia
    • Abdominal Discomfort
    Drugs used concurrently:NA. Although Protonix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hernia, may still occur.

    Pulmonary Embolism, Bronchitis, Malaise, Gastrooesophageal Reflux Disease
    This pulmonary embolism problem was reported by a consumer or non-health professional from US. A 54-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): gastrooesophageal reflux disease,depression,migraine.On NS a consumer started treatment with Protonix (dosage: 40 Mg, 1x/day). The following drugs/medications were being taken at the same time:
    • Celexa (40 Mg, 1x/day)
    • Topamax (50 Mg, 2x/day)
    • Imitrex (Unk)
    • Acetaminophen W/oxycodone (7.5/325 Mg, As Needed)
    • Tramadol (50 Mg, As Needed)
    • Spiriva (Unk, 1x/day)
    • Albuterol (Unk)
    • Ventolin Hfa (Unk)
    When commencing Protonix, the patient experienced the following unwanted symptoms /side effects:
    • Pulmonary Embolism
    • Bronchitis
    • Malaise
    • Gastrooesophageal Reflux Disease
    The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as pulmonary embolism, may become evident only after a product is in use by the general population.

    Pneumonia Viral, Pulmonary Oedema, Viral Sepsis, Diabetic Ulcer, Renal Failure Acute, Blood Glucose Increased
    This is a Protonix side effect report of a 59-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Protonix (dosage: 40 Mg, 1x/day) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
    • Pneumonia Viral
    • Pulmonary Oedema
    • Viral Sepsis
    • Diabetic Ulcer
    • Renal Failure Acute
    • Blood Glucose Increased
    This opens a possibility that Protonix could cause pneumonia viral and that some female patients may be more susceptible.

    Pharyngeal Haemorrhage, Off Label Use
    A 78-year-old female patient (weight: NA) from US with the following symptoms: anaemia,haemorrhage started Protonix treatment (dosage: Unk (by Splitting 80 Mg Tablet In To Half), 2x/day) on 2002. Soon after starting Protonix treatment, the consumer experienced several side effects, including:
    • Pharyngeal Haemorrhage
    • Off Label Use
    . Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Protonix side effects, such as pharyngeal haemorrhage.

    Dizziness, Headache, Diarrhoea, Abdominal Pain Upper, Nausea
    This dizziness side effect was reported by a consumer or non-health professional from US. A 63-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Protonix (dosage: 30 Once Daily Taken By Mouth), which was started on Dec 06, 2013. Concurrently used drugs: NA..When starting to take Protonix the consumer reported symptoms, such as:
    • Dizziness
    • Headache
    • Diarrhoea
    • Abdominal Pain Upper
    • Nausea
    These side effects may potentially be related to Protonix.

    Diarrhoea, Abdominal Pain, Abdominal Distension, Gastrooesophageal Reflux Disease
    This is a report of a 48-year-old female patient (weight: NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Protonix (dosage: Unk, start time: NS), combined with:
    • Zantac (Unk)
    and developed a serious reaction and side effect(s). The consumer presented with:
    • Diarrhoea
    • Abdominal Pain
    • Abdominal Distension
    • Gastrooesophageal Reflux Disease
    which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Protonix treatment in female patients, resulting in diarrhoea side effect.

    Gastric Ulcer Haemorrhage, Thrombosis
    This report suggests a potential Protonix Gastric Ulcer Haemorrhage, Thrombosis side effect(s) that can have serious consequences. A 76-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Protonix (dosage: Unk) starting 2002. Soon after starting Protonix the patient began experiencing various side effects, including:
    • Gastric Ulcer Haemorrhage
    • Thrombosis
    Drugs used concurrently:
    • Lyrica (75 Mg, 2x/day)
    • Altace (5 Mg, 2x/day)
    • Coreg (12.5 Mg, 2x/day)
    • Warfarin (2.5 Mg, Daily)
    • Carafate (Unk, 1x/day)
    • Levothyroxine (75 Ug, Daily)
    Although Protonix demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as gastric ulcer haemorrhage, may still occur.

    Laboratory Test Abnormal, Blood Test Abnormal, Gastrointestinal Stoma Complication
    This Laboratory Test Abnormal, Blood Test Abnormal, Gastrointestinal Stoma Complication problem was reported by a consumer or non-health professional from US. A 56-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: gastrooesophageal reflux disease. On NS this consumer started treatment with Protonix (dosage: 40 Mg, 1x/day). The following drugs were being taken at the same time:
    • Marinol (Unk)
    • Synthroid (Unk)
    • Baclofen (Unk)
    • Klonopin (Unk)
    • Robaxin (Unk)
    • Potassium (Unk)
    • Miralax (Unk, 3x/day)
    • Peri-colace (2 Df, 4x/day)
    When commencing Protonix, the patient experienced the following unwanted symptoms/side effects:
    • Laboratory Test Abnormal
    • Blood Test Abnormal
    • Gastrointestinal Stoma Complication
    The patient was hospitalized and became disabled.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as laboratory test abnormal, may become evident only after a product is in use by the general population.

    Dyspnoea, Arthritis, Lung Disorder
    This is a report of a 55-year-old female patient (weight: NA) from US. The patient developed the following symptoms/conditions: NA and was treated with Protonix (dosage: 40 Mg, Daily) starting 2012. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
    • Dyspnoea
    • Arthritis
    • Lung Disorder
    This opens a possibility that Protonix treatment could cause the above reactions, including dyspnoea, and some female subjects may be more susceptible.

    Dizziness, Somnolence
    A 73-year-old female patient (weight: NA) from US with the following symptoms/conditions: gastrooesophageal reflux disease,diabetes mellitus started Protonix treatment (dosage: 40 Mg, Daily) on 2004. Soon after starting Protonix treatment, the subject experienced various side effects, including:
    • Dizziness
    • Somnolence
    Concurrently used drugs:
    • Glipizide (5 Mg, Unk)
    • Januvia (100 Mg, Unk)
    This finding indicates that some female patients could be more vulnerable to Protonix.

    1 of 58 



    Top 10 Protonix Side Effects for Women

    Women Side EffectsReports
    Nausea 78
    Pain 72
    Abdominal Pain Upper 66
    Diarrhoea 52
    Vomiting 52
    Headache 49
    Malaise 45
    Dizziness 40
    Cholecystitis Chronic 38
    Dyspepsia 38

    Top 10 Protonix Side Effects for Men

    Men Side EffectsReports
    Dyspnoea 22
    Nausea 20
    Hypertension 19
    Myocardial Infarction 19
    Condition Aggravated 18
    Pain 17
    Dizziness 16
    Dyspepsia 16
    Vomiting 16
    Anxiety 15

    Keep Track of Side Effects

    Note Your Observations

    It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

    Why Your Notes are Important

    Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Protonix Side Effects

    Did You Have a Protonix Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Protonix for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Protonix Safety Alerts, Active Ingredients, Usage Information

    NDC0008-0841
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameProtonix Delayed-Release
    NamePANTOPRAZOLE SODIUM
    Dosage FormTABLET, DELAYED RELEASE
    RouteORAL
    On market since20000501
    LabelerWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.
    Active Ingredient(s)PANTOPRAZOLE SODIUM
    Strength(s)40
    Unit(s)mg/1
    Pharma ClassProton Pump Inhibitor [EPC],Proton Pump Inhibitors [MoA]

    Protonix Dosage, Warnings, Usage.

    Side Effects reported to FDA: 1426

    Protonix safety alerts: 2004

    Reported deaths: 68

    Reported hospitalizations: 449

    Protonix I.V. (pantoprazole sodium)

    Audience: Pharmacists, nurses and other healthcare professionals in institutional settings

    Wyeth and FDA informed healthcare professionals of reports of glass vial breakage of Protonix I.V. during attempts to connect vials to spiked intravenous system adaptors. This may be a safety issue for pharmacists or nurses when preparing Protonix I.V. for Injection vials in combination with spiked intravenous system adaptors, both during manual assembly and while utilizing mechanical assistance.

    [August 2004 - Letter - Wyeth]

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