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Rebif Side Effects

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Common Rebif Side Effects


The most commonly reported Rebif side effects (click to view or check a box to report):

Multiple Sclerosis Relapse (1675)
Injection Site Erythema (1413)
Fall (1309)
Fatigue (1255)
Influenza Like Illness (1183)
Injection Site Pain (1155)
Headache (1049)
Condition Aggravated (1007)
Multiple Sclerosis (1000)
Depression (884)
Asthenia (824)
Convulsion (818)
Pain (773)
Urinary Tract Infection (726)
Hypoaesthesia (720)
Injection Site Reaction (678)
Nausea (675)
Pyrexia (641)
Pneumonia (639)
Gait Disturbance (619)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Rebif Side Effects Reported to FDA



Rebif Side Effect Report#9997864
Depression, Suicidal Ideation
This is a report of a 17-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: multiple sclerosis,depression, who was treated with Rebif (dosage: NA, start time:
Oct 04, 2012), combined with:
  • Zoloft /01011401/
and developed a serious reaction and side effect(s): Depression, Suicidal Ideation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Depression side effect. The patient was hospitalized.
Rebif Side Effect Report#9996082
Injection Site Reaction, Injection Site Pain
This report suggests a potential Rebif Injection Site Reaction side effect(s) that can have serious consequences. A 44-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple sclerosis and used Rebif (dosage: NA) starting NS. After starting Rebif the patient began experiencing various side effects, including: Injection Site Reaction, Injection Site PainAdditional drugs used concurrently: NA. Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Injection Site Reaction, may still occur.
Rebif Side Effect Report#9995972
Eye Pruritus, Vision Blurred
This Eye Pruritus problem was reported by a consumer or non-health professional from BR. A 53-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: multiple sclerosis. On
Aug 25, 2011 this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time:
  • Isosorbide
  • Losartan
  • Diltiazem
  • Vastarel
  • Clopidogrel
  • Aas
  • Atorvastatin
When using Rebif, the patient experienced the following unwanted symptoms/side effects: Eye Pruritus, Vision BlurredThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Eye Pruritus, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9994365
Fall, Rash, Injection Site Erythema
This Fall side effect was reported by a health professional from US. A 52-year-old female patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis.The patient was prescribed Rebif (drug dosage: NA), which was initiated on
Feb 18, 2008. Concurrently used drugs: NA..After starting to take Rebif the consumer reported adverse symptoms, such as: Fall, Rash, Injection Site ErythemaThese side effects may potentially be related to Rebif.
Rebif Side Effect Report#9994361
Bedridden, Hypertension, Limb Discomfort, Myalgia, Headache
This is a report of a 56-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Rebif (dosage: NA, start time: NS), combined with:
  • Zolpidem Tartrate
  • Vitamin D3
  • Levothyroxine Sodium
  • Hydrocodone W/acetaminophen (5 Mg To 50 Mg)
  • Detrol La
and developed a serious reaction and side effect(s): Bedridden, Hypertension, Limb Discomfort, Myalgia, Headache after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Bedridden side effect.
Rebif Side Effect Report#9989167
Balance Disorder, Hypokinesia, Urinary Incontinence, Asthenia, Chills, Treatment Noncompliance
This report suggests a potential Rebif Balance Disorder side effect(s) that can have serious consequences. A 55-year-old patient (weight: NA) from US was diagnosed with the following symptoms/conditions: multiple sclerosis and used Rebif (dosage: NA) starting 201009. After starting Rebif the patient began experiencing various side effects, including: Balance Disorder, Hypokinesia, Urinary Incontinence, Asthenia, Chills, Treatment NoncomplianceAdditional drugs used concurrently:
  • Vitamin E /00110501/
  • Bupropion Hcl Er
  • Oxybutynin Chloride
Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Balance Disorder, may still occur.
Rebif Side Effect Report#9988220
Hypertension, Stress, Injection Site Atrophy, Injection Site Bruising
This Hypertension problem was reported by a consumer or non-health professional from DE. A 58-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: multiple sclerosis. On NS this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time: NA. When using Rebif, the patient experienced the following unwanted symptoms/side effects: Hypertension, Stress, Injection Site Atrophy, Injection Site BruisingAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Hypertension, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9988217
Pyelonephritis
This Pyelonephritis side effect was reported by a health professional from GR. A 25-year-old female patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis.The patient was prescribed Rebif (drug dosage: NA), which was initiated on
Mar 03, 2014. Concurrently used drugs: NA..After starting to take Rebif the consumer reported adverse symptoms, such as: PyelonephritisThese side effects may potentially be related to Rebif.
Rebif Side Effect Report#9988175
Clavicle Fracture, Fall, Blood Urea Decreased, Neutrophil Count Decreased, Alanine Aminotransferase Increased, White Blood Cell Count Decreased, Injection Site Erythema, Injection Site Pruritus, Injection Site Haematoma
This is a report of a 38-year-old female patient (weight: NA) from FR, suffering from the following health symptoms/conditions: NA, who was treated with Rebif (dosage: NA, start time: 201310), combined with: NA. and developed a serious reaction and side effect(s): Clavicle Fracture, Fall, Blood Urea Decreased, Neutrophil Count Decreased, Alanine Aminotransferase Increased, White Blood Cell Count Decreased, Injection Site Erythema, Injection Site Pruritus, Injection Site Haematoma after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Clavicle Fracture side effect.
Rebif Side Effect Report#9988171
Hypertension, Nausea
This report suggests a potential Rebif Hypertension side effect(s) that can have serious consequences. A 56-year-old female patient (weight: NA) from BR was diagnosed with the following symptoms/conditions: multiple sclerosis and used Rebif (dosage: NA) starting
Sep 11, 2009. After starting Rebif the patient began experiencing various side effects, including: Hypertension, NauseaAdditional drugs used concurrently:
  • Losartan
  • Atenolol
Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypertension, may still occur.
Rebif Side Effect Report#9988169
Postpartum Haemorrhage, Abdominal Pain, Influenza Like Illness, Normal Newborn, Maternal Exposure During Pregnancy
This Postpartum Haemorrhage problem was reported by a physician from FR. A 29-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: multiple sclerosis,mineral supplementation. On 201207 this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time:
  • Iron
When using Rebif, the patient experienced the following unwanted symptoms/side effects: Postpartum Haemorrhage, Abdominal Pain, Influenza Like Illness, Normal Newborn, Maternal Exposure During PregnancyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Postpartum Haemorrhage, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9988167
This Death side effect was reported by a consumer or non-health professional from DE. A 24-year-old male patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis.The patient was prescribed Rebif (drug dosage: NA), which was initiated on 2010. Concurrently used drugs: NA..After starting to take Rebif the consumer reported adverse symptoms, such as: These side effects may potentially be related to Rebif.
Rebif Side Effect Report#9988162
Varicose Vein, Local Swelling, Sensation Of Heaviness, Injection Site Pain
This is a report of a 53-year-old female patient (weight: NA) from BR, suffering from the following health symptoms/conditions: multiple sclerosis, who was treated with Rebif (dosage: NA, start time:
Oct 20, 2005), combined with: NA. and developed a serious reaction and side effect(s): Varicose Vein, Local Swelling, Sensation Of Heaviness, Injection Site Pain after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Varicose Vein side effect.
Rebif Side Effect Report#9988147
Type 2 Diabetes Mellitus, Hypertension, Gait Disturbance, Asthenia, Muscular Weakness
This report suggests a potential Rebif Type 2 Diabetes Mellitus side effect(s) that can have serious consequences. A female patient (weight: NA) from AU was diagnosed with the following symptoms/conditions: multiple sclerosis and used Rebif (dosage: NA) starting 2007. After starting Rebif the patient began experiencing various side effects, including: Type 2 Diabetes Mellitus, Hypertension, Gait Disturbance, Asthenia, Muscular WeaknessAdditional drugs used concurrently: NA. Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Type 2 Diabetes Mellitus, may still occur.
Rebif Side Effect Report#9985575
Premature Baby, Foetal Exposure During Pregnancy
This Premature Baby problem was reported by a consumer or non-health professional from US. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time: NA. When using Rebif, the patient experienced the following unwanted symptoms/side effects: Premature Baby, Foetal Exposure During PregnancyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Premature Baby, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9983598
Insomnia, Initial Insomnia, Fatigue
This Insomnia side effect was reported by a physician from US. A female patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis,hypertension.The patient was prescribed Rebif (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Nifedipine
  • Vesicare /01735901/
  • Lyrica
  • Nexium /01479302/
  • Centrum Silver /01292501/
  • Aspirin /00002701/
  • Vitamin D /00107901/
  • Hydrochloorthiazide
.After starting to take Rebif the consumer reported adverse symptoms, such as: Insomnia, Initial Insomnia, FatigueThese side effects may potentially be related to Rebif.
Rebif Side Effect Report#9983560
Injection Site Ulcer, Injection Site Infection, Impaired Healing
This is a report of a 41-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Rebif (dosage: NA, start time: 201207), combined with: NA. and developed a serious reaction and side effect(s): Injection Site Ulcer, Injection Site Infection, Impaired Healing after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Injection Site Ulcer side effect. The patient was hospitalized.
Rebif Side Effect Report#9981040
Hypertension, Muscular Weakness, Gait Disturbance, Cerebrovascular Accident
This report suggests a potential Rebif Hypertension side effect(s) that can have serious consequences. A 60-year-old male patient (weight: NA) from BR was diagnosed with the following symptoms/conditions: multiple sclerosis and used Rebif (dosage: NA) starting
Dec 18, 2006. After starting Rebif the patient began experiencing various side effects, including: Hypertension, Muscular Weakness, Gait Disturbance, Cerebrovascular AccidentAdditional drugs used concurrently:
  • Aas
  • Captopril
The patient was hospitalized. Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Hypertension, may still occur.
Rebif Side Effect Report#9981019
Nephrotic Syndrome
This Nephrotic Syndrome problem was reported by a physician from LB. A 53-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: multiple sclerosis. On
Feb 24, 2014 this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time: NA. When using Rebif, the patient experienced the following unwanted symptoms/side effects: Nephrotic SyndromeAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Nephrotic Syndrome, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9980867
Disability
This Disability side effect was reported by a physician from US. A 36-year-old female patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis.The patient was prescribed Rebif (drug dosage: NA), which was initiated on NS. Concurrently used drugs: NA..After starting to take Rebif the consumer reported adverse symptoms, such as: DisabilityThese side effects may potentially be related to Rebif.
Rebif Side Effect Report#9972851
Local Swelling, Influenza Like Illness
This is a report of a 45-year-old female patient (weight: NA) from US, suffering from the following health symptoms/conditions: NA, who was treated with Rebif (dosage: NA, start time: 201402), combined with: NA. and developed a serious reaction and side effect(s): Local Swelling, Influenza Like Illness after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Local Swelling side effect.
Rebif Side Effect Report#9970912
Lyme Disease, Injection Site Reaction, Injection Site Pain, Injection Site Erythema, Injection Site Swelling, Injection Site Warmth
This report suggests a potential Rebif Lyme Disease side effect(s) that can have serious consequences. A 56-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Rebif (dosage: NA) starting
Feb 21, 2008. After starting Rebif the patient began experiencing various side effects, including: Lyme Disease, Injection Site Reaction, Injection Site Pain, Injection Site Erythema, Injection Site Swelling, Injection Site WarmthAdditional drugs used concurrently:
  • Aleve /00256202/
Although Rebif demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Lyme Disease, may still occur.
Rebif Side Effect Report#9967043
Angioedema, Red Blood Cell Target Cells Present, Urticaria
This Angioedema problem was reported by a consumer or non-health professional from BR. A 31-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: relapsing-remitting multiple sclerosis. On
Jan 04, 2013 this consumer started treatment with Rebif (dosage: NA). The following drugs were being taken at the same time: NA. When using Rebif, the patient experienced the following unwanted symptoms/side effects: Angioedema, Red Blood Cell Target Cells Present, UrticariaAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Angioedema, may become evident only after a product is in use by the general population.
Rebif Side Effect Report#9966992
Sleep Talking, Chest Discomfort, Abdominal Discomfort, Psychiatric Symptom, Disturbance In Attention
This Sleep Talking side effect was reported by a consumer or non-health professional from EG. A 47-year-old female patient (weight:NA) experienced the following symptoms/conditions: multiple sclerosis.The patient was prescribed Rebif (drug dosage: NA), which was initiated on 201311. Concurrently used drugs:
  • Stugeron
  • Ribavirin
.After starting to take Rebif the consumer reported adverse symptoms, such as: Sleep Talking, Chest Discomfort, Abdominal Discomfort, Psychiatric Symptom, Disturbance In AttentionThese side effects may potentially be related to Rebif.
Rebif Side Effect Report#9966983
Neoplasm Malignant
This is a report of a 66-year-old female patient (weight: NA) from DE, suffering from the following health symptoms/conditions: multiple sclerosis, who was treated with Rebif (dosage: NA, start time:
May 03, 2010), combined with: NA. and developed a serious reaction and side effect(s): Neoplasm Malignant after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rebif treatment in female patients, resulting in Neoplasm Malignant side effect.

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The appearance of Rebif on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.


What are common Rebif Side Effects for Women?

Women Side EffectsReports
Multiple Sclerosis Relapse 1271
Injection Site Erythema 1156
Fall 1038
Fatigue 1012
Injection Site Pain 952
Influenza Like Illness 950
Headache 876
Condition Aggravated 819
Multiple Sclerosis 795
Depression 708

What are common Rebif Side Effects for Men?

Men Side EffectsReports
Multiple Sclerosis Relapse 401
Fall 271
Injection Site Erythema 254
Fatigue 243
Influenza Like Illness 231
Multiple Sclerosis 203
Injection Site Pain 200
Condition Aggravated 187
Depression 175
Headache 171

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Rebif reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Rebif Safety Alerts, Active Ingredients, Usage Information

    NDC44087-0022
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameREBIF
    NameINTERFERON BETA-1A
    Dosage FormINJECTION, SOLUTION
    RouteSUBCUTANEOUS
    On market since20020307
    LabelerEMD Serono, Inc.
    Active Ingredient(s)INTERFERON BETA-1A
    Strength(s)22
    Unit(s)ug/.5mL
    Pharma ClassInterferon-beta [Chemical/Ingredient],Recombinant Human Interferon beta [EPC],Recombinant Proteins [

    More About Rebif

    Side Effects reported to FDA: 21008

    Rebif safety alerts: No

    Reported deaths: 980

    Reported hospitalizations: 11219

    Latest Rebif clinical trials