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Rifampicin Side Effects

Common Rifampicin Side Effects

The most commonly reported Rifampicin side effects (click to view or check a box to report):

Pyrexia (66)
Vomiting (41)
Dyspnoea (39)
Jaundice (34)
Renal Failure Acute (33)
Nausea (27)
Acute Hepatic Failure (24)
Rash (23)
Hepatitis (22)
Lymphadenopathy (21)
Abdominal Pain (20)
Condition Aggravated (20)
Hyponatraemia (20)
Toxic Epidermal Necrolysis (20)
Asthenia (19)
Eosinophilia (18)
Anaemia (18)
Hepatic Function Abnormal (17)
Blood Creatinine Increased (16)
International Normalised Ratio Increased (16)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Rifampicin Side Effects Reported to FDA

The following Rifampicin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Rifampicin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dermatitis Exfoliative, Lymphadenopathy, Pyrexia, Face Oedema, Eosinophilia, Hepatitis, Papule
on Feb 27, 2014 Male from ZA , 34 years of age, was diagnosed with and was treated with Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: dermatitis exfoliative, lymphadenopathy, pyrexia, face oedema, eosinophilia, hepatitis, papule. Rifampicin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Co-trimoxazole
Patient was hospitalized.

Mycobacterium Avium Complex Infection, Condition Aggravated, Gastrointestinal Disorder, Feeling Abnormal
Patient was taking Rifampicin Sandoz. Patient felt the following Rifampicin side effects: mycobacterium avium complex infection, condition aggravated, gastrointestinal disorder, feeling abnormal on Feb 19, 2014 from JP Additional patient health information: Female , 63 years of age, was diagnosed with and. Rifampicin Sandoz dosage: 150 Mg, Unk.
Multiple prescriptions taken:
  • Ethambutol
  • Clarithromycin (200 Mg, Unk)
  • Levofloxacin
Patient was hospitalized.

Pseudolymphoma, Rash Papulosquamous, Pruritus, Rash Maculo-papular, Face Oedema, Rash Pustular, Blister, Pyrexia, Eczema
Adverse event was reported on Feb 19, 2014 by a Female taking Rifampicin (Dosage: N/A) . Location: CA , 19 years of age, After Rifampicin was administered, patient encountered several Rifampicin side effects: pseudolymphoma, rash papulosquamous, pruritus, rash maculo-papular, face oedema, rash pustular, blister, pyrexia, eczema.
Multiple concurrent drugs taken:
  • Vancomycin
  • Heparin Sodium
  • Acetylsalicylic Acid
  • Thiamine
  • Pantoprazole
  • Magnesium Oxide
  • Tramadol
  • Senna


Hepatitis, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
on Feb 19, 2014 Female from FR , 66 years of age, was treated with Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: hepatitis, alanine aminotransferase increased, aspartate aminotransferase increased. Rifampicin dosage: N/A.
Associated medications used:
  • Flagyl
  • Tavanic
  • Lasilix
  • Seretide
  • Kardegic
  • Umuline
  • Cardensiel
  • Inexium



Lupus-like Syndrome, Leukopenia
on Feb 19, 2014 Female from GR , 17 years of age, was diagnosed with and was treated with Rifampicin. Patient felt the following Rifampicin side effects: lupus-like syndrome, leukopenia. Rifampicin dosage: N/A.
Multiple prescriptions taken:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
  • Antibiotics


Addison^s Disease, Skin Hyperpigmentation, Asthenia, Dizziness, Hyponatraemia, Depression
Patient was taking Rifampicin. After Rifampicin was administered, patient encountered several Rifampicin side effects: addison^s disease, skin hyperpigmentation, asthenia, dizziness, hyponatraemia, depression on Feb 11, 2014 from BR Additional patient health information: Female , 45 years of age, was diagnosed with and. Rifampicin dosage: Unk.
Multiple concurrent drugs taken:
  • Isoniazid
  • Pyrazinamide
  • Nph Insulin
  • Enalapril
Patient was hospitalized.

Intentional Overdose, Cardiogenic Shock, Pulmonary Oedema, Acute Coronary Syndrome, Electrocardiogram St Segment Elevation, Dyspnoea, Pruritus, Red Man Syndrome
Adverse event was reported on Jan 31, 2014 by a Male taking Rifampicin (Dosage: Unk) . Location: PL , 19 years of age, Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: intentional overdose, cardiogenic shock, pulmonary oedema, acute coronary syndrome, electrocardiogram st segment elevation, dyspnoea, pruritus, red man syndrome.
Associated medications used:
  • Isoniazid (Unk)
  • Pyrazinamide (Unk)
  • Ketoprofen (Unk)
  • Alcohol (Unk)


Haemorrhage, Haematuria, International Normalised Ratio Increased
on Jan 31, 2014 Female from BR , 59 years of age, was diagnosed with and was treated with Rifampicin. Patient felt the following Rifampicin side effects: haemorrhage, haematuria, international normalised ratio increased. Rifampicin dosage: 600 Mg, Per Day.
Multiple prescriptions taken:
  • Warfarin (52.5 Mg, Per Week)
  • Warfarin (45 Mg, Per Week)
  • Warfarin (80 Mg, Per Week)
  • Warfarin (77.5 Mg, Unk)
  • Warfarin (37.5 Mg, Unk)
  • Pyrazinamide (2 G, Per Day)
  • Isoniazid (400 Mg, Per Day)
  • Ferrous Sulfate


Diabetes Mellitus Inadequate Control
on Jan 31, 2014 Male from JP , 75 years of age, was diagnosed with and was treated with Rifampicin Sandoz. After Rifampicin was administered, patient encountered several Rifampicin side effects: diabetes mellitus inadequate control. Rifampicin Sandoz dosage: N/A.
Multiple concurrent drugs taken:
  • Isoniazid
  • Ethambutol Hydrochloride
  • Pyrazinamide
Patient was hospitalized.

Intracranial Pressure Increased
Patient was taking Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: intracranial pressure increased on Jan 28, 2014 from JP Additional patient health information: Female , 55 years of age, weighting 104.7 lb, was diagnosed with and. Rifampicin dosage: 600 Mg, Daily.
Associated medications used:
  • Isoniazid (500 Mg, Daily)
  • Ethambutol (750 Mg, Daily)
  • Pyrazinamide (1.5 G, Daily)
  • Prednisolone (40 Mg, Daily)
  • Prednisolone (20 Mg, Daily)
  • Meropenem (6 G, Daily)
  • Meropenem
  • Acyclovir (1.5 G, Daily)
Patient was hospitalized.

Inappropriate Antidiuretic Hormone Secretion, Hyponatraemia, Blood Osmolarity Decreased, Urine Sodium Decreased, Hyperaldosteronism, Hypokalaemia, Blood Aldosterone Increased, Renin Increased, Pulmonary Tuberculosis
Adverse event was reported on Jan 24, 2014 by a Female taking Rifampicin (Dosage: N/A) was diagnosed with and. Location: DE , 49 years of age, weighting 67.02 lb, Patient felt the following Rifampicin side effects: inappropriate antidiuretic hormone secretion, hyponatraemia, blood osmolarity decreased, urine sodium decreased, hyperaldosteronism, hypokalaemia, blood aldosterone increased, renin increased, pulmonary tuberculosis.
Multiple prescriptions taken:
  • Isoniazid
  • Ethambutol
  • Pyrazinamide
  • Tolvaptan
Patient was hospitalized.

Ventricular Septal Defect, Atrial Septal Defect, Small For Dates Baby
on Jan 22, 2014 Male from DE , weighting 5.49 lb, was diagnosed with and was treated with Rifampicin. After Rifampicin was administered, patient encountered several Rifampicin side effects: ventricular septal defect, atrial septal defect, small for dates baby. Rifampicin dosage: Unk.
Multiple concurrent drugs taken:
  • Pyrazinamid
  • Ethambutol
  • Truvada (Unk)
  • Lopinavir + Ritonavir (Unk)
  • Isoniazid (Unk)


Neutropenia
on Jan 15, 2014 Male from IT , 73 years of age, was diagnosed with and was treated with Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: neutropenia. Rifampicin dosage: N/A.
Associated medications used:
  • Nicozid
  • Etapiam
  • Pyrazinamide
  • Levopraid
  • Rifabutin
Patient was hospitalized.

Angioedema, Periorbital Oedema, Lip Oedema
Patient was taking Rifampicin. Patient felt the following Rifampicin side effects: angioedema, periorbital oedema, lip oedema on Jan 08, 2014 from ES Additional patient health information: Female , 54 years of age, was diagnosed with and. Rifampicin dosage: N/A.
Multiple prescriptions taken:
  • Isoniazid


Acute Respiratory Distress Syndrome
Adverse event was reported on Jan 08, 2014 by a Female taking Rifampicin (Dosage: Unk) was diagnosed with and. Location: PH , 16 years of age, After Rifampicin was administered, patient encountered several Rifampicin side effects: acute respiratory distress syndrome.
Multiple concurrent drugs taken:
  • Pyrazinamide (Unk)
  • Ethambutol (Unk)
  • Isoniazid (Unk)


Diabetes Mellitus
on Jan 07, 2014 Male from JP , 61 years of age, was diagnosed with and was treated with Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: diabetes mellitus. Rifampicin dosage: Unk.
Associated medications used:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)


Cerebral Infarction, Post Gastric Surgery Syndrome
on Jan 07, 2014 Male from JP , 59 years of age, was diagnosed with and was treated with Rifampicin. Patient felt the following Rifampicin side effects: cerebral infarction, post gastric surgery syndrome. Rifampicin dosage: Unk.
Multiple prescriptions taken:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)


Overdose
Patient was taking Rifampicin. After Rifampicin was administered, patient encountered several Rifampicin side effects: overdose on Jan 06, 2014 from US Additional patient health information: Female , 24 years of age, was diagnosed with and. Rifampicin dosage: 450 Mg/day.
Multiple concurrent drugs taken:
  • Warfarin (5 Mg/day)
  • Warfarin (5.8 Mg/day)
  • Furosemide
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Enalapril
  • Carvedilol


Hepatitis, Renal Failure Chronic
Adverse event was reported on Jan 06, 2014 by a Male taking Rifampicin (Dosage: Unk) was diagnosed with and. Location: JP , 74 years of age, Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: hepatitis, renal failure chronic.
Associated medications used:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)


Diabetes Mellitus, Cerebral Infarction
on Jan 06, 2014 Male from JP , 62 years of age, was diagnosed with and was treated with Rifampicin. Patient felt the following Rifampicin side effects: diabetes mellitus, cerebral infarction. Rifampicin dosage: Unk.
Multiple prescriptions taken:
  • Isoniazid (Unk)
  • Ethambutol (Unk)
  • Pyrazinamide (Unk)


Acute Hepatic Failure, Renal Failure Acute, Respiratory Failure, Hepatic Encephalopathy, Coagulopathy, Distributive Shock, Altered State Of Consciousness
on Jan 06, 2014 Male from TW , 94 years of age, was diagnosed with and was treated with Rifampicin. After Rifampicin was administered, patient encountered several Rifampicin side effects: acute hepatic failure, renal failure acute, respiratory failure, hepatic encephalopathy, coagulopathy, distributive shock, altered state of consciousness. Rifampicin dosage: 600 Mg, Daily.
Multiple concurrent drugs taken:
  • Isoniazid (400 Mg, Daily)
  • Pyrazinamide (750 Mg, Daily)
  • Ethambutol (800 Mg, Daily)
Patient was hospitalized.

Influenza Like Illness, Rash, Leukocytosis, Eosinophilia, Hepatocellular Injury, Pruritus, Rash Maculo-papular, Macule
Patient was taking Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: influenza like illness, rash, leukocytosis, eosinophilia, hepatocellular injury, pruritus, rash maculo-papular, macule on Jan 06, 2014 from PH Additional patient health information: Female , 16 years of age, was diagnosed with and. Rifampicin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol


Anaemia, Neutropenia, Agranulocytosis
Adverse event was reported on Jan 06, 2014 by a Male taking Rifampicin (Dosage: N/A) was diagnosed with and. Location: FR , child 7 years of age, weighting 44.09 lb, Patient felt the following Rifampicin side effects: anaemia, neutropenia, agranulocytosis.
Multiple prescriptions taken:
  • Claforan
  • Vancomycine
  • Nalbuphine
  • Paracetamol
  • Fosfocine


Pneumonia, Suffocation Feeling
on Jan 06, 2014 Male from JP , 48 years of age, was diagnosed with and was treated with Rifampicin Sandoz. After Rifampicin was administered, patient encountered several Rifampicin side effects: pneumonia, suffocation feeling. Rifampicin Sandoz dosage: 750 Mg, Daily.

Jaundice Cholestatic, Asthenia, Dysentery
on Feb 27, 2014 Male from IT , 48 years of age, was diagnosed with and was treated with Rifampicin. Directly after, patient experienced the unwanted or unexpected Rifampicin side effects: jaundice cholestatic, asthenia, dysentery. Rifampicin dosage: N/A. Patient was hospitalized.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


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  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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    Safety Alerts, Active Ingredients, Usage Information

    More About Rifampicin

    Side Effects reported to FDA: 674

    Rifampicin safety alerts: No

    Reported deaths: 134

    Reported hospitalizations: 323

    Latest Rifampicin clinical trials