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Rifampin Side Effects

Common Rifampin Side Effects

The most commonly reported Rifampin side effects (click to view or check a box to report):

Alanine Aminotransferase Increased (33)
Aspartate Aminotransferase Increased (32)
Hepatitis (27)
Pyrexia (25)
Hepatocellular Damage (24)
Renal Failure Acute (23)
Nausea (23)
Vomiting (18)
Blood Bilirubin Increased (15)
Rash (14)
Thrombocytopenia (13)
Diarrhoea (13)
Asthenia (13)
Dyspnoea (13)
Fatigue (13)
Hypotension (12)
Erythema (11)
Headache (10)
Hepatic Failure (10)
Myalgia (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Rifampin Side Effects Reported to FDA

The following Rifampin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Rifampin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Coma, Hepatic Encephalopathy
on Jul 30, 2013 Female from FR , 60 years of age, was diagnosed with and was treated with Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: coma, hepatic encephalopathy. Rifampin dosage: 600 Mg, 1x/day.
Associated medications used:
  • Isoniazid (300 Mg, 1x/day)
  • Pyrazinamide (1.5 G, 1x/day)
Patient was hospitalized.

Nausea, Headache, Fatigue, Myalgia, Dyspnoea
Patient was taking Rifampin. Patient felt the following Rifampin side effects: nausea, headache, fatigue, myalgia, dyspnoea on Jul 25, 2013 from US Additional patient health information: Female , 34 years of age, was diagnosed with and. Rifampin dosage: N/A.

Mitochondrial Neurogastrointestinal Encephalopathy, Anaemia, Mitochondrial Toxicity
Adverse event was reported on Jul 22, 2013 by a Male taking Rifampin (Dosage: N/A) was diagnosed with and. Location: BG , 28 years of age, After Rifampin was administered, patient encountered several Rifampin side effects: mitochondrial neurogastrointestinal encephalopathy, anaemia, mitochondrial toxicity.
Multiple concurrent drugs taken:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol


Pyrexia, Dyspnoea, Chest Pain, Rash Maculo-papular, Alanine Aminotransferase Increased
on Jun 26, 2013 Female from TN , 41 years of age, was diagnosed with and was treated with Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: pyrexia, dyspnoea, chest pain, rash maculo-papular, alanine aminotransferase increased. Rifampin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Patient was hospitalized.


Mycobacterium Ulcerans Infection, Condition Aggravated, Skin Graft
on Jun 24, 2013 Male from AU , 19 years of age, was diagnosed with and was treated with Rifampin. Patient felt the following Rifampin side effects: mycobacterium ulcerans infection, condition aggravated, skin graft. Rifampin dosage: N/A.
Multiple prescriptions taken:
  • Moxifloxacin


Heart Rate Increased, Hypotension
Patient was taking Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: heart rate increased, hypotension on Jun 24, 2013 from US Additional patient health information: Female , 64 years of age, weighting 194.0 lb, was diagnosed with and. Rifampin dosage: X2.
Multiple concurrent drugs taken:
  • Propofol
  • Atorvastatin
  • Esomeprazole
  • Naproxen
  • Acetaminophen Plus Hydrocodone
  • Multivitamins
  • Midazolam
  • Fentanyl


Pyrexia, Rash, Product Quality Issue
Adverse event was reported on Jun 19, 2013 by a Male taking Rifampin (Dosage: 200 Mg, 3x/day (every 8 Hrs)) . Location: US , child 12 years of age, Directly after, patient experienced the unwanted or unexpected Rifampin side effects: pyrexia, rash, product quality issue. Patient was hospitalized.

Hepatitis, Diarrhoea, Septic Shock, Respiratory Failure, Continuous Haemodiafiltration, Renal Failure Acute
on Jun 11, 2013 Female from US , 53 years of age, was diagnosed with and was treated with Rifampin. Patient felt the following Rifampin side effects: hepatitis, diarrhoea, septic shock, respiratory failure, continuous haemodiafiltration, renal failure acute. Rifampin dosage: N/A.

Rash, Loss Of Consciousness, Aphasia, Hemiparesis, Haemoglobin Decreased, White Blood Cell Count Decreased, Petechiae, Ecchymosis
on May 30, 2013 Female from TR , 18 years of age, was diagnosed with and was treated with Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: rash, loss of consciousness, aphasia, hemiparesis, haemoglobin decreased, white blood cell count decreased, petechiae, ecchymosis. Rifampin dosage: N/A.
Multiple concurrent drugs taken:
  • Doxycycline
Patient was hospitalized.

Rash Maculo-papular, Post Inflammatory Pigmentation Change, Vasculitis
Patient was taking Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: rash maculo-papular, post inflammatory pigmentation change, vasculitis on May 30, 2013 from TH Additional patient health information: Male , 62 years of age, was diagnosed with and. Rifampin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Ethambutol
  • Amlodipine
  • Metformin
  • Glipizide


Tuberculoma Of Central Nervous System, Optic Nerve Disorder
Adverse event was reported on May 21, 2013 by a Male taking Rifampin (Dosage: N/A) was diagnosed with and. Location: IN , 40 years of age, Patient felt the following Rifampin side effects: tuberculoma of central nervous system, optic nerve disorder.
Multiple prescriptions taken:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
  • Dexamethasone


Dizziness, Abdominal Pain Upper, Pyrexia, Tremor, Malaise, Dehydration, Vomiting
on May 10, 2013 Female from US , 75 years of age, was diagnosed with and was treated with Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: dizziness, abdominal pain upper, pyrexia, tremor, malaise, dehydration, vomiting. Rifampin dosage: N/A. Patient was hospitalized.

Feeling Hot, Flushing, Respiratory Rate Increased, Rash, Fatigue, Unevaluable Event
on May 03, 2013 Female from US , 30 years of age, weighting 122.5 lb, was treated with Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: feeling hot, flushing, respiratory rate increased, rash, fatigue, unevaluable event. Rifampin dosage: N/A.

Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Blood Bilirubin Increased, Bilirubin Conjugated Increased, Blood Alkaline Phosphatase Increased, Jaundice
Patient was taking Rifampin. Patient felt the following Rifampin side effects: aspartate aminotransferase increased, alanine aminotransferase increased, blood bilirubin increased, bilirubin conjugated increased, blood alkaline phosphatase increased, jaundice on Apr 19, 2013 from US Additional patient health information: Male , 64 years of age, weighting 134.3 lb, was diagnosed with and. Rifampin dosage: N/A. Patient was hospitalized.

Thrombocytopenia, Anaemia, Renal Failure Acute, Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased
Adverse event was reported on Apr 17, 2013 by a Female taking Rifampin (Dosage: N/A) was diagnosed with and. Location: US , 31 years of age, weighting 136.2 lb, After Rifampin was administered, patient encountered several Rifampin side effects: thrombocytopenia, anaemia, renal failure acute, blood alkaline phosphatase increased, blood bilirubin increased. Patient was hospitalized.

Systemic Lupus Erythematosus, Pericarditis, Pleurisy
on Apr 09, 2013 Male from CN , 50 years of age, was diagnosed with and was treated with Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: systemic lupus erythematosus, pericarditis, pleurisy. Rifampin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol


Pneumonitis
on Apr 09, 2013 Female from JP , 84 years of age, weighting 96.12 lb, was diagnosed with and was treated with Rifampin. Patient felt the following Rifampin side effects: pneumonitis. Rifampin dosage: N/A.
Multiple prescriptions taken:
  • Isoniazid
  • Ethambutol
  • Prednisolone
Patient was hospitalized.

Respiratory Disorder, Heart Rate Decreased, Procedural Complication, Apnoea, Cardiac Arrest, Tuberculoma Of Central Nervous System
Patient was taking Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: respiratory disorder, heart rate decreased, procedural complication, apnoea, cardiac arrest, tuberculoma of central nervous system on Apr 08, 2013 from CN Additional patient health information: Female , 13 years of age, was diagnosed with and. Rifampin dosage: N/A.
Multiple concurrent drugs taken:
  • Isoniazid (3 Month)
  • Pyrazinamide (3 Month)
Patient was hospitalized.

Product Quality Issue
Adverse event was reported on May 08, 2013 by a Female taking Rifampin (Dosage: Unk) was diagnosed with and. Location: US , 38 years of age, weighting 163.0 lb, Directly after, patient experienced the unwanted or unexpected Rifampin side effects: product quality issue.

Product Quality Issue
on May 08, 2013 Female from US , 16 years of age, weighting 145.0 lb, was diagnosed with and was treated with Rifampin. Patient felt the following Rifampin side effects: product quality issue. Rifampin dosage: Unk.

Mycobacterium Ulcerans Infection, Anaemia, Treatment Failure, Condition Aggravated
on Mar 04, 2013 Patient from ZA , child 4 years of age, was treated with Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: mycobacterium ulcerans infection, anaemia, treatment failure, condition aggravated. Rifampin dosage: N/A.

Tubulointerstitial Nephritis, Fanconi Syndrome, Paralysis, Hypokalaemia, Metabolic Acidosis, Renal Tubular Acidosis, Iga Nephropathy
Patient was taking Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: tubulointerstitial nephritis, fanconi syndrome, paralysis, hypokalaemia, metabolic acidosis, renal tubular acidosis, iga nephropathy on Feb 19, 2013 from KR Additional patient health information: Male , 42 years of age, was diagnosed with and. Rifampin dosage: N/A.
Associated medications used:
  • Isoniazid
  • Ethambutol
Patient was hospitalized.

Hypertension
Adverse event was reported on Feb 05, 2013 by a Female taking Rifampin (Dosage: N/A) was diagnosed with and. Location: IN , 52 years of age, Patient felt the following Rifampin side effects: hypertension.
Multiple prescriptions taken:
  • Amlodipine
Patient was hospitalized.

Accelerated Hypertension, Acute Left Ventricular Failure
on Feb 05, 2013 Male from IN , 48 years of age, was diagnosed with and was treated with Rifampin. After Rifampin was administered, patient encountered several Rifampin side effects: accelerated hypertension, acute left ventricular failure. Rifampin dosage: N/A.
Multiple concurrent drugs taken:
  • Amlodipine
  • Losartan
  • Isoniazid
  • Ethambutol
  • Pyrazinamide
Patient was hospitalized.

Shock, Respiratory Distress, Vomiting, Grand Mal Convulsion, Coma, Metabolic Acidosis, Lactic Acidosis, Rhabdomyolysis, Liver Disorder
on Feb 12, 2013 Male from IN , 31 years of age, was treated with Rifampin. Directly after, patient experienced the unwanted or unexpected Rifampin side effects: shock, respiratory distress, vomiting, grand mal convulsion, coma, metabolic acidosis, lactic acidosis, rhabdomyolysis, liver disorder. Rifampin dosage: 6075 Gms.
Associated medications used:
  • Isoniazid


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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:

     

    Side Effects

    Scale

    Date & Time

    Other Medicine(s) or Treatment(s)

     

     

     

     

    Scale: 1 = very mild to 10 = very bad


    Track Online

  • User Sign In
  • Register to track your side effects

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Discuss Rifampin Side Effects

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    How Effective is Rifampin for You?

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    Safety Alerts, Active Ingredients, Usage Information

    Alternative RIFAMPIN Names:ISONARIF RIFADIN RIFADIN IV RIFAMATE RIFATER

    Active Ingredient: ISONIAZID RIFAMPIN

    Rifampin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 305

    Rifampin safety alerts: 2003

    Reported deaths: 61

    Reported hospitalizations: 125

    Latest Rifampin clinical trials