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Rifampin Side Effects

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Common Rifampin Side Effects


The most commonly reported Rifampin side effects (click to view or check a box to report):

Alanine Aminotransferase Increased (33)
Aspartate Aminotransferase Increased (32)
Hepatitis (27)
Pyrexia (25)
Hepatocellular Damage (24)
Renal Failure Acute (23)
Nausea (23)
Vomiting (18)
Blood Bilirubin Increased (15)
Rash (14)
Thrombocytopenia (13)
Diarrhoea (13)
Asthenia (13)
Dyspnoea (13)
Fatigue (13)
Hypotension (12)
Erythema (11)
Headache (10)
Hepatic Failure (10)
Myalgia (9)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Rifampin Side Effects Reported to FDA



Rifampin Side Effect Report#9890777
Splenic Rupture
This is a report of a 33-year-old female patient (weight: NA) from KR, suffering from the following health symptoms/conditions: spleen tuberculosis,lymph node tuberculosis, who was treated with Rifampin (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Splenic Rupture after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Splenic Rupture side effect. The patient was hospitalized.
Rifampin Side Effect Report#9890484
Nausea, Vomiting, Diarrhoea, Hypotension, Hepatic Enzyme Increased, Renal Failure Acute
This report suggests a potential Rifampin Nausea side effect(s) that can have serious consequences. A 56-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: antibiotic prophylaxis and used Rifampin (dosage: NA) starting
Dec 29, 2013. After starting Rifampin the patient began experiencing various side effects, including: Nausea, Vomiting, Diarrhoea, Hypotension, Hepatic Enzyme Increased, Renal Failure AcuteAdditional drugs used concurrently: NA.The patient was hospitalized. Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Nausea, may still occur.
Rifampin Side Effect Report#9871000
Migraine, Vomiting, Incoherent, Loss Of Consciousness, Brain Oedema, Eye Swelling, Leukoencephalomyelitis
This Migraine problem was reported by a consumer or non-health professional from US. A 17-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: tuberculosis. On
Oct 21, 2013 this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time: NA. When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Migraine, Vomiting, Incoherent, Loss Of Consciousness, Brain Oedema, Eye Swelling, LeukoencephalomyelitisAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Migraine, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9857090
Hypersensitivity Vasculitis
This Hypersensitivity Vasculitis side effect was reported by a health professional from IN. A 14-year-old male patient (weight:NA) experienced the following symptoms/conditions: disseminated tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Pyrazinamide
  • Isoniazid
  • Ethambutol
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Hypersensitivity VasculitisThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9857089
Chest Pain, Vomiting, Blood Pressure Decreased, Secondary Adrenocortical Insufficiency, Hypothalamic Pituitary Adrenal Axis Suppression, Hypotension, Postpartum Hypopituitarism
This is a report of a 46-year-old male patient (weight: NA) from IN, suffering from the following health symptoms/conditions: mycobacterium tuberculosis complex test positive, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
and developed a serious reaction and side effect(s): Chest Pain, Vomiting, Blood Pressure Decreased, Secondary Adrenocortical Insufficiency, Hypothalamic Pituitary Adrenal Axis Suppression, Hypotension, Postpartum Hypopituitarism after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Chest Pain side effect.
Rifampin Side Effect Report#9851979
Acute Respiratory Distress Syndrome, Transaminases Increased, Leukocytosis, Eosinophilia, Hepatocellular Injury, Hypoxia, Lung Infiltration
This report suggests a potential Rifampin Acute Respiratory Distress Syndrome side effect(s) that can have serious consequences. A 16-year-old female patient (weight: NA) from PH was diagnosed with the following symptoms/conditions: lymph node tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Acute Respiratory Distress Syndrome, Transaminases Increased, Leukocytosis, Eosinophilia, Hepatocellular Injury, Hypoxia, Lung InfiltrationAdditional drugs used concurrently:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Acute Respiratory Distress Syndrome, may still occur.
Rifampin Side Effect Report#9844709
Pyrexia, Jaundice, Oliguria, Altered State Of Consciousness, Renal Failure Acute, Hepatic Function Abnormal, Hyperbilirubinaemia, Hepatic Failure
This Pyrexia problem was reported by a health professional from TW. A 94-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Pyrazinamide
  • Isoniazid
  • Ethambutol
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Pyrexia, Jaundice, Oliguria, Altered State Of Consciousness, Renal Failure Acute, Hepatic Function Abnormal, Hyperbilirubinaemia, Hepatic FailureAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Pyrexia, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9760207
Complications Of Transplanted Kidney, Renal Failure Acute
This Complications Of Transplanted Kidney side effect was reported by a health professional from TN. A 60-year-old male patient (weight:NA) experienced the following symptoms/conditions: tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on NS. Concurrently used drugs:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Complications Of Transplanted Kidney, Renal Failure AcuteThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9760193
Renal Failure Acute, Chronic Allograft Nephropathy, Renal Transplant Failure
This is a report of a 42-year-old male patient (weight: NA) from TN, suffering from the following health symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage: ;qd;, start time: NS), combined with:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
and developed a serious reaction and side effect(s): Renal Failure Acute, Chronic Allograft Nephropathy, Renal Transplant Failure after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Renal Failure Acute side effect.
Rifampin Side Effect Report#9760189
Chronic Allograft Nephropathy, Renal Failure, Sepsis
This report suggests a potential Rifampin Chronic Allograft Nephropathy side effect(s) that can have serious consequences. A 27-year-old male patient (weight: NA) from TN was diagnosed with the following symptoms/conditions: tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Chronic Allograft Nephropathy, Renal Failure, SepsisAdditional drugs used concurrently:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Chronic Allograft Nephropathy, may still occur.
Rifampin Side Effect Report#9760187
Renal Failure Acute, Chronic Allograft Nephropathy
This Renal Failure Acute problem was reported by a health professional from TN. A 37-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Renal Failure Acute, Chronic Allograft NephropathyAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Renal Failure Acute, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9760184
Haemodialysis, Graft Loss, Chronic Allograft Nephropathy
This Haemodialysis side effect was reported by a health professional from TN. A 39-year-old male patient (weight:NA) experienced the following symptoms/conditions: tuberculosis.The patient was prescribed Rifampin (drug dosage: ;qd;), which was initiated on NS. Concurrently used drugs:
  • Pyrazinamide
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Haemodialysis, Graft Loss, Chronic Allograft NephropathyThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9760177
Hyperuricaemia, Renal Failure Acute, Graft Loss, Transplant Dysfunction
This is a report of a 38-year-old male patient (weight: NA) from TN, suffering from the following health symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
and developed a serious reaction and side effect(s): Hyperuricaemia, Renal Failure Acute, Graft Loss, Transplant Dysfunction after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Hyperuricaemia side effect.
Rifampin Side Effect Report#9760141
Renal Failure Acute, Graft Loss, Haemodialysis
This report suggests a potential Rifampin Renal Failure Acute side effect(s) that can have serious consequences. A 14-year-old female patient (weight: NA) from TN was diagnosed with the following symptoms/conditions: tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Renal Failure Acute, Graft Loss, HaemodialysisAdditional drugs used concurrently:
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Renal Failure Acute, may still occur.
Rifampin Side Effect Report#9747043
Angioedema
This Angioedema problem was reported by a health professional from US. A 62-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Rifampin (dosage: 600 Mg, Daily). The following drugs were being taken at the same time:
  • Metoprolol (25 Mg, Unk)
  • Atorvastatin (20 Mg, Unk)
  • Calcium (Unk)
  • Vitamin D (Unk)
  • Multivitamins (Daily)
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: AngioedemaThe patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Angioedema, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9722989
Pancytopenia, Pyrexia
This Pancytopenia side effect was reported by a pharmacist from US. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: staphylococcal skin infection.The patient was prescribed Rifampin 300mg Lannett (drug dosage: 600mg, Bid, Oral), which was initiated on NS. Concurrently used drugs:
  • Oxacillin (22, Every 4 Hours, Intravenous)
  • Oxacillin And Rifampin For Mssa For 23 Days.?
.After starting to take Rifampin 300mg Lannett the consumer reported adverse symptoms, such as: Pancytopenia, PyrexiaThese side effects may potentially be related to Rifampin 300mg Lannett. The patient was hospitalized.
Rifampin Side Effect Report#9652072
Panic Attack, Disease Recurrence, Dizziness, Hyperhidrosis, Tremor, Nausea, Vomiting, Agitation
This is a report of a 27-year-old female patient (weight: NA) from IR, suffering from the following health symptoms/conditions: brucellosis,uterine cancer, who was treated with Rifampin (dosage: Once Daily, start time: NS), combined with: NA. and developed a serious reaction and side effect(s): Panic Attack, Disease Recurrence, Dizziness, Hyperhidrosis, Tremor, Nausea, Vomiting, Agitation after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in female patients, resulting in Panic Attack side effect. The patient was hospitalized.
Rifampin Side Effect Report#9641741
Human Herpesvirus 7 Infection, Lethargy, Rash, Myalgia, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
This report suggests a potential Rifampin Human Herpesvirus 7 Infection side effect(s) that can have serious consequences. A 41-year-old female patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: lymph node tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Human Herpesvirus 7 Infection, Lethargy, Rash, Myalgia, Aspartate Aminotransferase Increased, Alanine Aminotransferase IncreasedAdditional drugs used concurrently:
  • Isoniazid
  • Pyrazinamide
  • Ethambutol
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Human Herpesvirus 7 Infection, may still occur.
Rifampin Side Effect Report#9640392
Visual Impairment, Visual Field Defect, Bone Pain, Arthralgia, Liver Disorder
This Visual Impairment problem was reported by a consumer or non-health professional from US. A 15-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pruritus,jaundice. On 1998 this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time: NA. When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Visual Impairment, Visual Field Defect, Bone Pain, Arthralgia, Liver DisorderAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Visual Impairment, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9531975
Haemolysis, Haemoglobin Decreased, Paroxysmal Nocturnal Haemoglobinuria
This Haemolysis side effect was reported by a pharmacist from US. A 58-year-old male patient (weight:NA) experienced the following symptoms/conditions: staphylococcal infection.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on
Jul 26, 2013. Concurrently used drugs:
  • Vancomycin
.After starting to take Rifampin the consumer reported adverse symptoms, such as: Haemolysis, Haemoglobin Decreased, Paroxysmal Nocturnal HaemoglobinuriaThese side effects may potentially be related to Rifampin. The patient was hospitalized.
Rifampin Side Effect Report#9520803
Clostridium Difficile Infection, Neurological Symptom
This is a report of a 48-year-old male patient (weight: NA) from PL, suffering from the following health symptoms/conditions: pulmonary tuberculosis, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Isoniazid
  • Pyrazinamide
and developed a serious reaction and side effect(s): Clostridium Difficile Infection, Neurological Symptom after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Clostridium Difficile Infection side effect.
Rifampin Side Effect Report#9520792
Clostridium Difficile Infection, Cardiac Failure
This report suggests a potential Rifampin Clostridium Difficile Infection side effect(s) that can have serious consequences. A 86-year-old female patient (weight: NA) from PL was diagnosed with the following symptoms/conditions: pulmonary tuberculosis and used Rifampin (dosage: NA) starting NS. After starting Rifampin the patient began experiencing various side effects, including: Clostridium Difficile Infection, Cardiac FailureAdditional drugs used concurrently:
  • Isoniazid
  • Ciprofloxacin
Although Rifampin demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Clostridium Difficile Infection, may still occur.
Rifampin Side Effect Report#9520786
Clostridium Difficile Infection
This Clostridium Difficile Infection problem was reported by a health professional from PL. A 67-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: pulmonary tuberculosis. On NS this consumer started treatment with Rifampin (dosage: NA). The following drugs were being taken at the same time:
  • Isoniazid
  • Pyrazinamide
When using Rifampin, the patient experienced the following unwanted symptoms/side effects: Clostridium Difficile InfectionAlthough all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as Clostridium Difficile Infection, may become evident only after a product is in use by the general population.
Rifampin Side Effect Report#9511249
Malaise, Back Pain, Bone Pain, Headache, Pyrexia, Myalgia, Flank Pain, Nocturia, Bone Marrow Failure
This Malaise side effect was reported by a physician from US. A 64-year-old female patient (weight:NA) experienced the following symptoms/conditions: tuberculosis.The patient was prescribed Rifampin (drug dosage: NA), which was initiated on
Aug 01, 2013. Concurrently used drugs: NA..After starting to take Rifampin the consumer reported adverse symptoms, such as: Malaise, Back Pain, Bone Pain, Headache, Pyrexia, Myalgia, Flank Pain, Nocturia, Bone Marrow FailureThese side effects may potentially be related to Rifampin.
Rifampin Side Effect Report#9433922
Immune Reconstitution Inflammatory Syndrome, Pyrexia, Night Sweats, Erythema, Lymphadenopathy, Skin Warm
This is a report of a 45-year-old male patient (weight: NA) from IL, suffering from the following health symptoms/conditions: tuberculosis, who was treated with Rifampin (dosage: NA, start time: NS), combined with:
  • Isoniazid
  • Ofloxacin
  • Pyrazinamide
  • Ethambutol
  • Rituximab
and developed a serious reaction and side effect(s): Immune Reconstitution Inflammatory Syndrome, Pyrexia, Night Sweats, Erythema, Lymphadenopathy, Skin Warm after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Rifampin treatment in male patients, resulting in Immune Reconstitution Inflammatory Syndrome side effect.


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The appearance of Rifampin on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.

What are common Rifampin Side Effects for Women?

Women Side EffectsReports
Nausea 14
Alanine Aminotransferase Increased 12
Aspartate Aminotransferase Increased 11
Hepatitis 11
Pyrexia 11
Rash 10
Vomiting 10
Fatigue 8
Diarrhoea 7
Erythema 7

Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Rifampin reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
    FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

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    Rifampin Safety Alerts, Active Ingredients, Usage Information

    NDC0069-0112
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameRifampin
    NameRifampin
    Dosage FormINJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
    RouteINTRAVENOUS
    On market since20110510
    LabelerPfizer Laboratories Div Pfizer Inc
    Active Ingredient(s)RIFAMPIN
    Strength(s)600
    Unit(s)mg/10mL
    Pharma ClassRifamycin Antibacterial [EPC],Rifamycins [Chemical/Ingredient]

    Rifampin Dosage, Warnings, Usage.

    Side Effects reported to FDA: 305

    Rifampin safety alerts: 2003

    Reported deaths: 61

    Reported hospitalizations: 125

    Pyrazinamide plus Rifampin for Treatment of Latent Tuberculosis Infection (LTBI)

    Audience: Infectious Disease and other healthcare professionals

    The Centers for Disease Control and Prevention (CDC) notified healthcare professionals of revised recommendations against the use of rifampin plus pyrazinamide for treatment of latent tuberculosis infection, due to high rates of hospitalization and death from liver injury associated with the combined use of these drugs.

    [August 8, 2003 - Letter - CDC]
    [August 8, 2003 - MMWR Article - CDC]

    Latest Rifampin clinical trials