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Thyroxine Side Effects

Common Thyroxine Side Effects


The most commonly reported Thyroxine side effects (click to view or check a box to report):

Cerebral Haemorrhage (5)
Idiopathic Thrombocytopenic Purpura (4)
Carotid Arteriosclerosis (2)
Bradycardia (2)
Diarrhoea (2)
Dyspnoea (2)
Erythema Multiforme (2)
Dizziness (2)
Hyperthyroidism (2)
Leukocytoclastic Vasculitis (2)
Urticaria (2)
Supraventricular Extrasystoles (2)
Thrombocytopenia (2)
Rash (2)
Ocular Hyperaemia (2)
Platelet Count Decreased (2)
Muscular Weakness (1)
Musculoskeletal Pain (1)
Pain In Extremity (1)
Operative Haemorrhage (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Thyroxine Side Effects Reported to FDA

The following Thyroxine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Thyroxine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Cellulitis Gangrenous, Pyrexia, Diarrhoea, Vomiting, Abdominal Pain, Chest Pain, Musculoskeletal Pain, Haemodynamic Instability, Dyspnoea
This is a report of a 50-year-old male patient (weight: NA) from GR, suffering from the following symptoms/conditions: thyroidectomy, who was treated with Thyroxine (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Cellulitis Gangrenous
  • Pyrexia
  • Diarrhoea
  • Vomiting
  • Abdominal Pain
  • Chest Pain
  • Musculoskeletal Pain
  • Haemodynamic Instability
  • Dyspnoea
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Thyroxine treatment in male patients, resulting in cellulitis gangrenous side effect. The patient was hospitalized.

Dizziness, Diarrhoea, Hypertension, Hypotension, Dyspnoea
This report suggests a potential Thyroxine Dizziness, Diarrhoea, Hypertension, Hypotension, Dyspnoea side effect(s) that can have serious consequences. A 78-year-old patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Thyroxine (dosage: NA) starting 201305. Soon after starting Thyroxine the patient began experiencing various side effects, including:
  • Dizziness
  • Diarrhoea
  • Hypertension
  • Hypotension
  • Dyspnoea
Drugs used concurrently: NA. Although Thyroxine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as dizziness, may still occur.

Exfoliative Rash, Muscular Weakness, Hypocalcaemia, Fatigue
This Exfoliative Rash, Muscular Weakness, Hypocalcaemia, Fatigue problem was reported by a consumer or non-health professional from GR. A 61-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: thyroidectomy. On NS this consumer started treatment with Thyroxine (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Thyroxine, the patient experienced the following unwanted symptoms/side effects:
  • Exfoliative Rash
  • Muscular Weakness
  • Hypocalcaemia
  • Fatigue
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as exfoliative rash, may become evident only after a product is in use by the general population.

Fibromyalgia, Irritable Bowel Syndrome, Balance Disorder, Thinking Abnormal, Memory Impairment, Weight Increased, Depression, Product Substitution Issue
This is a report of a female patient (weight: NA) from US. The patient developed the following symptoms/conditions: hypothyroidism and was treated with Thyroxine (dosage: NA) starting May 20, 2013. Concurrently used drugs:
  • Vitamin D
  • Estradiol
  • Prometrium
  • Cystone
Soon after that, the consumer experienced the following side effects:
  • Fibromyalgia
  • Irritable Bowel Syndrome
  • Balance Disorder
  • Thinking Abnormal
  • Memory Impairment
  • Weight Increased
  • Depression
  • Product Substitution Issue
This opens a possibility that Thyroxine treatment could cause the above reactions, including fibromyalgia, and some female subjects may be more susceptible.


Sensation Of Heaviness, Gait Disturbance, Pain In Extremity
A 77-year-old female patient (weight: NA) from GB with the following symptoms/conditions: hypothyroidism,intermittent claudication,blood cholesterol increased started Thyroxine treatment (dosage: NA) on 2006. Soon after starting Thyroxine treatment, the subject experienced various side effects, including:
  • Sensation Of Heaviness
  • Gait Disturbance
  • Pain In Extremity
Concurrently used drugs:
  • Aspirin
  • Simvastatin
This finding indicates that some female patients could be more vulnerable to Thyroxine.

Hyperthyroidism, Ocular Hyperaemia, Erythema Multiforme, Supraventricular Extrasystoles, Carotid Arteriosclerosis, Bradycardia
A 66-year-old female patient from COUNTRY NOT SPECIFIED (weight: NA) experienced symptoms, such as: hypothyroidism and was treated with Thyroxine(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Hyperthyroidism
  • Ocular Hyperaemia
  • Erythema Multiforme
  • Supraventricular Extrasystoles
  • Carotid Arteriosclerosis
  • Bradycardia
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Thyroxine efficacy: NA.The patient was hospitalized.

Hyperthyroidism, Ocular Hyperaemia, Erythema Multiforme, Supraventricular Extrasystoles, Carotid Arteriosclerosis, Bradycardia
In this report, Thyroxine was administered for the following condition: hypothyroidism.A 66-year-old female consumer from COUNTRY NOT SPECIFIED (weight: NA) started Thyroxine treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Hyperthyroidism
  • Ocular Hyperaemia
  • Erythema Multiforme
  • Supraventricular Extrasystoles
  • Carotid Arteriosclerosis
  • Bradycardia
A possible interaction with other drugs could have contributed to this reaction:
  • Clonazepam(clonazepam)
  • Rosuvastatin(rosuvastatin)
  • Cinnarizine(cinnarizine)
  • Telmisartan/amlodipine(tablet) (telmisartan, Amlodipine)
  • Pantoprazole(pantoprazole)
The patient was hospitalized.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Thyroxine treatment could be related to the listed above side effect(s).

Medulloblastoma Recurrent
This is a report of the following Thyroxine (levothyroxine Sodium0 side effect(s):
  • Medulloblastoma Recurrent
A 11-year-old male patient from UNITED KINGDOM (weight: NA) presented with the following condition: NA and received a treatment with Thyroxine (levothyroxine Sodium0 (dosage: NA) starting: May 04, 2011.The following concurrently used drugs could have generated interactions:
  • Zomacton (somatropin) Powder And Solvent For Solution For Injection (1 Mg)
This report suggests that a Thyroxine (levothyroxine Sodium0 treatment could be associated with the listed above side effect(s).

Operative Haemorrhage, Serotonin Syndrome, Platelet Count Decreased
This Thyroxine report was submitted by a 60-year-old female consumer from UNITED KINGDOM (weight: NA). The patient was diagnosed with: NA and Thyroxine was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Operative Haemorrhage
  • Serotonin Syndrome
  • Platelet Count Decreased
Other drugs used simultaneously:
  • Fentanyl (2545 Mcg;x1;)
  • Propofol
  • Paroxetine (no Pref. Name)
  • Isoflurane In Oxygen And Air
Those unexpected symptoms could be linked to a Thyroxine treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura
This is a report of a possible correlation between Thyroxine use and the following symptoms/side effect(s):
  • Cerebral Haemorrhage
  • Idiopathic Thrombocytopenic Purpura
which could contribute to an assessment of Thyroxine risk profile.A 64-year-old male consumer from (weight: NA) was suffering from NA and was treated with Thyroxine (dosage: NA) starting Oct 15, 2010.Other concurrent medications:
  • Simvastatin (40mg - Daily - Oral)


Rash, Acne, Urticaria, Pruritus
A female patient from UNITED STATES (weight: NA) presented with the following symptoms: thyroid disorder,blood cholesterol abnormal and after a treatment with Thyroxine (dosage: NA) experienced the following side effect(s):
  • Rash
  • Acne
  • Urticaria
  • Pruritus
The treatment was started on NS. Thyroxine was used in combination with the following drugs:
  • Simvastatin
  • Fish Oil
  • Amlodipine Besylate (10 Mg, 1x/day)
  • Calcium
This report could alert potential Thyroxine consumers.

Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
In this report, a 64-year-old male patient from UNITED KINGDOM (weight: NA) was affected by a possible Thyroxine side effect.The patient was diagnosed with hypothyroidism,hypercholesterolaemia. After a treatment with Thyroxine (dosage: 50 Ug, Unk, start date: Oct 15, 2010), the patient experienced the following side effect(s):
  • Cerebral Haemorrhage
  • Idiopathic Thrombocytopenic Purpura
  • Thrombocytopenia
The following simultaneously used drugs could have led to this reaction:
  • Simvastatin (40 Mg, Qd)
The findings here stress that side effects should be taken into consideration when evaluating a Thyroxine treatment.

Blood Bilirubin Increased, Rash, Febrile Neutropenia
This is a report of a 50-year-old female patient from CANADA (weight: NA), who used Thyroxine (dosage: NA) for a treatment of hypothyroidism,colorectal cancer metastatic. After starting a treatment on Jun 17, 2010, the patient experienced the following side effect(s):
  • Blood Bilirubin Increased
  • Rash
  • Febrile Neutropenia
The following drugs could possibly have interacted with the Thyroxine treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Thyroxine treatment could be related to side effect(s), such as Blood Bilirubin Increased, Rash, Febrile Neutropenia.

Platelet Count Decreased, Cerebral Haemorrhage
This platelet count decreased side effect was reported by a health professional from UNITED KINGDOM. A 64-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Thyroxine (dosage: NA), which was started on Oct 15, 2010. Concurrently used drugs:
  • Simvastatin (40 Mg, Daily, Oral)
When starting to take Thyroxine the consumer reported the following symptoms:
  • Platelet Count Decreased
  • Cerebral Haemorrhage
These side effects may potentially be related to Thyroxine.

Lymphocytosis
This is a Thyroxine side effect report of a 68-year-old female patient (weight:NA) from UNITED KINGDOM, suffering from the following symptoms/conditions: hypothyroidism,rheumatoid arthritis, who was treated with Thyroxine (dosage:100 Ug, 1x/day, start time: Nov 01, 2009), combined with:
  • Meloxicam (7.5 Mg, 1x/day)
  • Enbrel (50 Mg, Weekly)
  • Prednisolone (7.5 Mg, 1x/day)
, and developed a serious reaction and a lymphocytosis side effect. The patient presented with:
  • Lymphocytosis
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Thyroxine treatment in female patients suffering from hypothyroidism,rheumatoid arthritis, resulting in lymphocytosis.

Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
This report suggests a potential Thyroxine cerebral haemorrhage side effect(s) that can have serious consequences. A 64-year-old male patient from UNITED KINGDOM (weight:NA) was diagnosed with the following health condition(s): hypothyroidism,hypercholesterolaemia and used Thyroxine (dosage: NA) starting Oct 15, 2010. Soon after starting Thyroxine the patient began experiencing various side effects, including:
  • Cerebral Haemorrhage
  • Idiopathic Thrombocytopenic Purpura
  • Thrombocytopenia
Drugs used concurrently:
  • Simvastatin (40 Mg, Daily)
Although Thyroxine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as cerebral haemorrhage, may still occur.

Cerebral Haemorrhage, Idiopathic Thrombocytopenic Purpura
This cerebral haemorrhage problem was reported by a health professional from . A 64-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Oct 15, 2010 a consumer started treatment with Thyroxine (dosage: NA). The following drugs/medications were being taken at the same time:
  • Simvastatin (40mg - Daily - Oral)
When commencing Thyroxine, the patient experienced the following unwanted symptoms /side effects:
  • Cerebral Haemorrhage
  • Idiopathic Thrombocytopenic Purpura
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as cerebral haemorrhage, may become evident only after a product is in use by the general population.

Swelling Face, Urticaria
This is a Thyroxine side effect report of a 69-year-old patient (weight: NA) from UNITED KINGDOM. The patient developed the following symptoms/conditions: NA and was treated with Thyroxine (dosage: NA) starting Nov 24, 2005. Concurrently used drugs:
  • Aspirin
  • Lisinopril
  • Bendrofluazide
  • Ferrous Sulfate Tab
  • Diclofenac (75mg Daily)
Soon after that, the consumer experienced the following of symptoms:
  • Swelling Face
  • Urticaria
This opens a possibility that Thyroxine could cause swelling face and that some patients may be more susceptible.

Leukocytoclastic Vasculitis
A female patient (weight: NA) from AUSTRALIA with the following symptoms: hypothyroidism,depression started Thyroxine treatment (dosage: Daily Dose: 100 Microgram(s)) on Jan 01, 2002. Soon after starting Thyroxine treatment, the consumer experienced several side effects, including:
  • Leukocytoclastic Vasculitis
. Concurrently used drugs:
  • Luvox (Daily Dose: 50 Milligram(s))
This finding indicates that some patients can be more vulnerable to developing Thyroxine side effects, such as leukocytoclastic vasculitis.

Leukocytoclastic Vasculitis
This leukocytoclastic vasculitis side effect was reported by a physician from AUSTRALIA. A female patient (weight:NA) experienced the following symptoms/conditions: ill-defined disorder,depression.The patient was prescribed Thyroxine (dosage: NA), which was started on Jan 01, 2002. Concurrently used drugs:
  • Luvox (Daily Dose: 50 Milligram(s))
.When starting to take Thyroxine the consumer reported symptoms, such as:
  • Leukocytoclastic Vasculitis
These side effects may potentially be related to Thyroxine.



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Thyroxine Side Effects

    Did You Have a Thyroxine Side Effect?

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    Yes, Moderate
    Yes, Minor
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    How Effective is Thyroxine for You?

    Exceeded Expectations
    Effective
    Somewhat Effective
    Not Effective

    Thyroxine Safety Alerts, Active Ingredients, Usage Information

    NDC0378-1800
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameLevothyroxine Sodium
    Namelevothyroxine sodium
    Dosage FormTABLET
    RouteORAL
    On market since20021101
    LabelerMylan Pharmaceuticals Inc.
    Active Ingredient(s)LEVOTHYROXINE SODIUM
    Strength(s)25
    Unit(s)ug/1
    Pharma Classl-Thyroxine [EPC],Thyroxine [Chemical/Ingredient]

    More About Thyroxine

    Side Effects reported to FDA: 20

    Thyroxine safety alerts: 2004

    Reported deaths: 5

    Reported hospitalizations: 5

    Levoxyl (levothyroxine sodium)

    Audience: Endocrinologists and other healthcare professionals

    FDA and King Pharmaceuticals notified healthcare professionals of revisions to the PRECAUTIONS, ADVERSE REACTIONS and DOSAGE AND ADMINISTRATION sections of labeling, describing reports of choking, gagging, tablets stuck in throat and dysphagia while taking Levoxyl. These reports have predominately occurred when Levoxyl tablets were not taken with water. It is recommended that Levoxyl tablets be taken with a full glass of water.

    [September 17, 2004 - Letter - King Pharmaceuticals]

    Latest Thyroxine clinical trials